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20, AVENUE APPIA – CH-1211 GENEVA 27 – SWITZERLAND – TEL CENTRAL +41 22 791 2111 – FAX CENTRAL +41 22 791 3111 – WWW.WHO.INT Ref.: C.L.26.2025 Amendments to the International Health Regulations (2005) The Director-General of the World Health Organization presents his compliments to States Parties to the International Health Regulations (2005) (hereinafter referred to as the “IHR”) and has the honour to refer to circular letter C.L.40.2024 of 19 September 2024 notifying the amendments to the IHR adopted by the Seventy-seventh World Health Assembly through resolution WHA77.17 (2024) (hereinafter referred to as the “2024 amendments”), and due to enter into force on 19 September 2025. A. Notification of rejections and reservations submitted pursuant to Articles 59, 61 and 62 of the IHR In accordance with paragraph 2 of Article 65 of the IHR, the Director-General has the honour to notify States Parties of the rejections of the 2024 amendments submitted by Argentina, Austria, Brazil, Canada, the Czech Republic, Germany, Israel, Italy, the Kingdom of the Netherlands, the Philippines, and the United States of America pursuant to Articles 59, 61 and 62 of the IHR. 1 In accordance with paragraph 2 of Article 65 of the IHR, the Director-General has further the honour to notify States Parties of the reservations to the 2024 amendments submitted by the Holy See and Switzerland pursuant to Articles 59 and 62 of the IHR. Pursuant to Article 63 of the IHR, and subject to the conditions set forth therein, a rejection or reservation may at any time be withdrawn by a State Party by notifying the Director-General, which would result in the application of the amendments to that State Party. B. Declarations and statements The Director-General has the honour to inform States Parties of the declarations submitted by Croatia, Cyprus, France, Hungary, Ireland, Latvia, Malta and South Africa in accordance with paragraph 3 of Article 59 of the IHR, as well as of the statement submitted by Türkiye. The communications received from States Parties referred to under the headings A. and B. ... above are presented in the Enclosure according to the alphabetical order of the names of the States Parties in English. 1 Seven of the above-referenced States Parties provided an explanation for their rejection, which related to their need to await completion of relevant domestic processes, and which could be followed by a withdrawal of their rejection pursuant to Article 63 of the IHR. ... ENCL.: (1)  Page 2 C.L.26.2025 C. Procedure regarding objections to reservations The following paragraphs provide information about the applicable deadlines for States Parties intending to object to any of the aforementioned reservations. Those deadlines vary depending on whether the amendments to the IHR adopted by the Seventy-fifth World Health Assembly through resolution WHA75.12 (2022) (hereinafter referred to as the “2022 amendments”) apply to the State Party concerned. i. For States Parties to which the 2022 amendments apply In accordance with paragraph 4(c) of Article 62 of the IHR, any State Party intending to object to any of the above-mentioned reservations may notify the Director-General accordingly within three months from the date of this notification, i.e. no later than 8 November 2025. Any such notification shall be sent to [email protected]. In accordance with paragraph 4 of Article 62 of the IHR, “States Parties objecting to a reservation to an amendment to these Regulations should provide the Director-General with reasons for the objection”. ii. For States Parties to which the 2022 amendments do not apply In accordance with paragraph 4(b) of Article 62 of the IHR, any State Party intending to object to any of the above-mentioned reservations may notify the Director-General accordingly within six months from the date of this notification, i.e. no later than 8 February 2026. Any such notification shall be sent to [email protected]. In accordance with paragraph 4 of Article 62 of the IHR, “States Parties objecting to a reservation to an amendment to these Regulations should provide the Director-General with reasons for the objection”. In accordance with paragraph 5 of Article 62 of the IHR, unless a reservation has been objected to by one third of States Parties within the above-mentioned deadlines (i.e., 8 November 2025 and 8 February 2026), said reservation shall be deemed to be accepted and the amendment shall enter into force for the reserving State Party, subject to the reservation. The Director-General of the World Health Organization takes this opportunity to renew to States Parties to the IHR the assurance of his highest consideration. GENEVA, 8 August 2025 Jonathan DEARDEN 250658-TRA-SE Translated from Spanish Permanent Mission of Argentina to the international organizations in Geneva CMF/Usk IV/150 No. 169/2025 The Permanent Mission of the Argentine Republic to the international organizations in Geneva presents its compliments to the World Health Organization and has the honour to refer to resolution WHA77.17 of 1 June 2024 whereby the Seventy-seventh World Health Assembly adopted the amendments to the International Health Regulations (IHR). Following a thorough review of the legal, institutional and budgetary implications, the Argentine Republic hereby rejects the amendments to the International Health Regulations (IHR) 2024 under the terms stipulated in article 61 of the said Regulations. The Permanent Mission of the Argentine Republic to the international organizations in Geneva conveys to the World Health Organization the renewed assurances of its highest consideration. Geneva, 18 July 2025 [Official seal] [Signature] World Health Organization Geneva Permanent Mission bmeia.gv.at/oev-genf of Austria to the United Nations in Geneva [email protected] Ns 2025-0.567.468 Note Verbale The Permanent Mission of Austria to the United Nations and other International Organ- isations in Geneva presents its compliments to the Director-General of the World Health Organization (WHO), and has the honour to refer to the Circular Letter dated 19 Sep- tember 2024, no. C.L.40.2024, concerning the amendments to the International Health Regulations (2005) adopted by the Seventy-seventh World Health Assembly. In accordance with Article 22 of the Constitution of the World Health Organization as well as Article 59, paragraph ibis, and Article 61 of the International Health Regulations (2005) (hereinafter referred to as "IHR"), the Republic of Austria rejects the amend- ments to the IHR adopted by the Seventy-seventh World Health Assembly through Res- olution WHA77.17 of 1 June 2024 (hereinafter referred to as "2024 amendments"), as notified by the Director-General of the World Health Organization on 19 September 2024. The rejection is of preliminary nature and will be withdrawn once the Parliament of Aus- tria has approved the 2024 amendments to the IHR. The Permanent Mission of Austria to the United Nations and other International Organ- isations in Geneva avails itself of this opportunity to renew to the Director-General of the World Health Organization the assura f its highest consideration. To the Director-General Dr. Tedros Adhanom Ghebreyesus World Health Organization 20, Avenue Appia CH-1211 Genève E-Mail to: [email protected] Cc: [email protected] 35-37, Avenue Giuseppe Motta, CH-1202 Genève Tel. +41 22 748 20 - 48, E-mail: [email protected], Website: www.bmeia.gv.at/oev-genf/  tt H PERMANENT MISSION OF THE REPUBLIC OF CROATIA TO THE UNITED NATIONS OFFICE AND OTHER INTERNATIONAL ORGANIZATIONS GENEVA No.64125 The Permanent Mission of the Republic of Croatia to the United Nations Office in Geneva presents its compliments to the World Health Organization in Geneva and has the honor to deliver the letter from Prof. Dr. Irena Hrsti6, Minister of Health of the Republic of Croatia, addressed to Dr. Tedros Adhanom Ghebreyesus, Director-General of WHO, in accordance with wHo c.L.40/2024. The Permanent Mission of the Republic of Croatia to the United Nations Office in Geneva avails itself of this opportunity to World Health Organization in Geneva the assurances of its highest /'l'l "i1 Geneva, l0 July 2025 Dr Tedros Adhanom Ghebreyesus Director-General World Health Organization Jonathan DEARDEN 250694a-TRA-FE Translated from French Permanent Mission of France to the Office of the United Nations and the international organizations in Switzerland CC/am/2025-0286471 Geneva, 17 July 2025 The Permanent Mission of France to the Office of the United Nations and other international organizations in Switzerland presents its compliments to the World Health Organization at Geneva and has the honour to refer to its circular letter C.L.40.2024 notifying States Parties of amendments to the International Health Regulations (2005). In accordance with Article 59, paragraph 3, of the International Health Regulations (2005), this Mission hereby informs Dr Tedros Adhanom Ghebreyesus, Director-General of the World Health Organization, that France requires an extension of the period to effect the legal and administrative adjustments necessary for the full implementation of the amendments to the International Health Regulations. In accordance with the Article referred to above, the necessary legal and administrative arrangements will be in place to facilitate the implementation of the amendments by 19 September 2026 at the latest. The Permanent Mission of France to the Office of the United Nations and other international organizations in Switzerland takes this opportunity to convey to the World Health Organization at Geneva the renewed assurances of its highest consideration. [Official seal] [Signature] World Health Organization Avenue Appia 2 1211 Geneva Translation Note Verbale No. The Permanent Mission of the Federal Republic of Germany to the Office of the United Nations and to the other International Organizations presents its compliments to the Director-General of the World Health Organization and has the honour to communicate the following: On 1 June 2024, the final day of the Seventy-seventh World Health Assembly, the States Parties adopted the amendments to the International Health Regulations (2005) annexed to Resolution WHA77.17. On 19 September 2024, the Director-General notified the adoption by the Health Assembly of the amended International Health Regulations (ref. C.L.40.2024). In view of the imminent end of the period for rejection on 19 July 2025, the Federal Republic of Germany greatly regrets that it must declare that the requirements of the national constitution for the implementation of the amendments will not be achieved before 19 September 2025. The requisite legislative process is still ongoing. Accordingly, in compliance with Article 22 of the Constitution of the World Health Organization and Article 61 of the International Health Regulations, the Federal Republic of Germany hereby notifies the Director-General of its rejection of the aforementioned amendments to the International Health Regulations. In accordance with Article 63 (1) of the International Health Regulations, the Federal Republic of Germany will notify the Director-General of the withdrawal of the rejection as soon as the national requirements for the implementation of the amendments have been achieved. The Permanent Mission of the Federal Republic of Germany to the Office of the United Nations and to the other International Organizations avails itself of this opportunity to renew to the Director-General of the World Health Organization the assurance of its high consideration. NV-CDS-569-2025 The Permanent Mission of the Republic of the Philippines to the United Nations Office and other International Organizations in Geneva presents its compliments to the Director-General of the World Health Organization and, with reference to the notification C.L.40.2024 dated 19 September 2024 on the amendments to the International Health Regulations (2005) adopted by the Seventy-seventh World Health Assembly on 1 June 2024, has the honor to inform the Director-General as follows:  The Philippines welcomes the 2024 amendments to the International Health Regulations (2005) and is undertaking steps to implement the same.  In accordance with domestic legal requirements, international instruments and changes thereto may not enter into force for the Philippines before such requirements are met. Therefore, the Philippines formally registers its rejection of the 2024 amendments to the International Health Regulations (2005) as conveyed via C.L.40.2024 in accordance with Article 61.  The Philippines will notify the Director-General of the withdrawal of this rejection upon completion of domestic requirements in accordance with Article 63 of the International Health Regulations (2005). The Permanent Mission of the Republic of the Philippines to the United Nations Office and other International Organizations in Geneva avails itself of this opportunity to renew to the Director-General of the World Health Organization the assurances of its highest consideration. Geneva, 16 July 2025 THE DIRECTOR GENERAL World Health Organization 20 Avenue Appia CH 1211 Geneva 27 14-16 Allée David-Morse, 1202 Geneva, Switzerland Tel. No.: (+41) 22-7161930 / Fax: (+41) 22-7161932 email: [email protected] www.genevapm.dfa.gov.ph  :ilap SOUTH AFRICAN PERMANENT MISSION GENEVA Nations Business centre, Rue du Pr6-de-la Bichette 1, 3rd floor, 1202 Geneva wutv.safricaun.ch [email protected] Ref:26112025 The Permanent Mission of the Republic of South Africa to the United Nations Office at Geneva and other international Organizations in Switzerland presents its compliments to the Director-General of the World Health Organization (WHO) and has the honour to refer to the amendments adopted by the Seventy-seventh World Health Assembly through resolution WHA77.17 (2024) ("the 2024 amendments") and the notification of said amendments to States Parties via circular letter C.L. 40.2024 of 19 September 2024. South Africa hereby submits a declaration pursuant to paragraph 3 of Article 59 of the lnternational Health Regulations (2005), thereby informing that South Africa shall enjoy twelve additional months from the entry into force of the 2024lHR amendments, that is, until 19 September 2026, to adjust its legislative and administrative arrangements fully with the 2024 amendments. The Permanent Mission of the Republic of south Africa to the United Nations office at Geneva and other international Organizations in Switzerland avails itself of this opportunity to renew to the Director-General of the World Health Organization (WHO), the assurances of its highest consideration. Geneva, 19 July 2025 itt ! ''r.l i: Director-General of the World Health Organization Email: dqoffice@who. int  *tr' MINISTRY HEALTH REPUBLIC OF SOUTH AFRICA PRETORIA Private Bag X399, PRETORIA,0001, DrAB Xuma Building, 11 12 Voorlrekker Rd, PreloriaTownlands 351-JR, Pretoria,0187 Tel: (012)395 8000 Fax: (012) 395 9165 CAPE TOVVTI Privale Bag X9070, CAPE TOWN, 8000, Room 413, 120 Plein Street, CAPE TO\ JN, 8000 Tel: (021 ) 465 740718 FaK {021 } 465 1575 19 July 2425 Dr. Tedros Adhanom Ghebreyesus Director-General World Health Organization Avenue Appia 20 1211 Geneva2T SWITZERLAND Dear Dr. Ghebreyesus, Subjec* Declaration in accordance with paragraph 3 of Article 59 of the lnternational Health Regulations (2005) I have the honour to refer to the amendments to the lnternational Health Regulations (2005), adopted by the Seventy-seventh World Health Assembly through resolution WH477.17 QAzq ("the 2024 amendments") and notified to States Parties via circular letter C.L. 40.2A24 of 19 September 2024. South Africa welcomes the 2O24 amendments and, pursuant to paragraph 3 of Article 59 of the lnternational Health Regulations (2005), submits its declaration to the'Director-General, noting the need for outstanding adjustments regarding its domestic legislative and administrative arrangements. Accordingly, South Africa shall enjoy twelve additional months from the entry into force of the 2024 amendments, that is, until 19 September 2026, to adjust the above-referenced arrangements with the 2024 amendments. South Africa looks forward to a well-considered and sustainable approach to the implementation of the amended lnternational Health Regulations (2005) in order to advance global public health. Sincerely, t. DR P.A. MOTSOALEDI, MP Minister of Health Republic of South Africa Jonathan DEARDEN 250694b-TRA-FE Translated from French The Swiss Confederation Permanent Mission of Switzerland to the Office of the United Nations and other international organizations in Geneva 852-05-04-07-63 The Permanent Mission of Switzerland to the Office of the United Nations and other international organizations in Geneva presents its compliments to the World Health Organization (WHO) and with reference to the decision of the Federal Council dated 20 June 2025, has the honour to notify it that Switzerland accepts the amendments made in 2024 to the International Health Regulations (2005) (IHR), with the following reservation and declarations, in accordance with Article 62, paragraph 2, of the said Regulations: Reservation concerning Annex 1, Part A, paragraph 2 (c), ch. vi and paragraph 3 (i) Switzerland makes a reservation with regard to the question of managing misinformation and disinformation in core capacities for risk communication. It intends to pursue its objective and evidence-based activities regarding risks, as specified under its legislation (Epidemics Act of 28 September 2012, art.9, para. 1) and with strict regard for freedom of expression, the media and science as guaranteed under articles 16, 17 and 20 of the Federal Constitution of the Swiss Confederation of 18 April 1999. Interpretative declaration on Annex 1, Part A, paragraph 2 (c), ch. v and paragraph 3 (h) With regard to the obligations concerning the implementation, maintenance and strengthening of core capacities in respect of access to health services and health products needed for action, as referred to in Annex 1, the Swiss Confederation or its cantons will apply the Regulations in accordance with the division of jurisdiction specified by the Federal Constitution of the Swiss Confederation of 18 April 1999 in the areas of health (art. 117 et seq.), federalism (art. 3 and 42 et seq.) and according to the principle of subsidiarity (art. 5 (a)). Declaration under Article 4, paragraph 4 The competent National IHR Authority is the Federal Office of Public Health (OFSP), Schwartzenburgerstrasse 157, 3003 Berne, Switzerland, tel. +41 58 462 21 11, [email protected] The Permanent Mission of Switzerland to the Office of the United Nations and the other international organizations in Geneva takes this opportunity to convey to the World Health Organization (WHO) the renewed assurances of its highest consideration. Geneva, 10 July 2025 [Official seal] [Signature] World Health Organization Geneva Saatja: [email protected] Teema: WHO: C.L.26.2025 (2024 IHR amendments) Kuupäev: 2025-08-08 13:26 Tähelepanu! Tegemist on välisvõrgust saabunud kirjaga. Tundmatu saatja korral palume linke ja faile mitte avada. Dear States Parties to the International health Regulations (2005) (IHR) Please find attached, in the six official languages, C.L.26.2025 regarding the amendments to the IHR adopted through resolution WHA77.17 (2024). Best regards, Department of Governing Bodies World Health Organization ***DO NOT RESPOND TO THIS E-MAIL. YOU WILL NOT RECEIVE A REPLY***