Answers to Inquiry

Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A ALIMENTARY TRACT AND METABOLISM 176,5588 A01 STOMATOLOGICAL PREPARATIONS 0,0742 A01A STOMATOLOGICAL PREPARATIONS 0,0742 A01AB Antiinfectives and antiseptics for local oral treatment 0,0742 A01AB09 Miconazole(O) 7174,4 g 0,2 g 0,0742 A01AB12 Hexetidine(O) 1154880 ml A01AB81 Neomycin+Benzocaine(dental) 14050 pieces A01AB82 Demeclocycline+Triamcinolone(dental) 780 g A01AD Other agents for local oral treatment A01AD80 Lidocaine+Cetylpyridinium chloride(gingival) 154380 g A01AD81 Lidocaine+Cetrimide(O) 53485 g A01AD82 Choline salicylate(O) 645600 pieces A01AD83 Lidocaine+Chamomille extract(O) 391340 g A01AD90 Lidocaine+Paraformaldehyde(dental) 444 g A02 DRUGS FOR ACID RELATED DISORDERS 56,2174 A02A ANTACIDS 1,1870 Combinations and complexes of aluminium, calcium and magnesium A02AD 1,1870 compounds A02AD81 Aluminium hydroxide+Magnesium hydroxide(O) 851440 pieces 10 pieces 0,1761 A02AD81 Aluminium hydroxide+Magnesium hydroxide(O) 3907014 ml 50 ml 0,1616 A02AD83 Calcium carbonate+Magnesium carbonate(O) 4107672 pieces 10 pieces 0,8494 DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL A02B 55,0304 REFLUX DISEASE (GORD) A02BA H2-receptor antagonists 1,3430 A02BA02 Ranitidine(O) 192291,75 g 0,3 g 1,3254 A02BA02 Ranitidine(P) 2568 g 0,3 g 0,0177 A02BC Proton pump inhibitors 53,6743 A02BC01 Omeprazole(O) 283739,28 g 0,02 g 29,3346 A02BC02 Pantoprazole(O) 258796,44 g 0,04 g 13,3779 A02BC02 Pantoprazole(P) 461,6 g 0,04 g 0,0239 A02BC03 Lansoprazole(O) 4,2 g 0,03 g 0,0003 A02BC05 Esomeprazole(O) 155634,92 g 0,03 g 10,7270 A02BC05 Esomeprazole(P) 3055,6 g 0,03 g 0,2106 A02BC08 Vonoprazan(O) 4 g A02BD Combinations for eradication of Helicobacter pylori 0,0011 A02BD08 Bismuth subcitrate+Tetracycline+Metronidazole (O) 6240 pieces 12 pieces 0,0011 Other drugs for peptic ulcer and gastro-oesophageal reflux disease A02BX 0,0120 (GORD) A02BX02 Sucralfate(O) 22800 g 4 g 0,0118 A02BX03 Pirenzepine(O) 10 g 0,1 g 0,0002 A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS 8,2131 A03A DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS 7,2698 A03AA Synthetic anticholinergics, esters with tertiary amino group 1,0663 A03AA04 Mebeverine(O) 154704 g 0,3 g 1,0663 A03AB Synthetic anticholinergics, quaternary ammonium compounds 0,0003 A03AB02 Glycopyrronium(P) 0,046 g 0,3 mg 0,0003 A03AD Papaverine and derivatives 4,5268 A03AD01 Papaverine hydrochloride(P) 66,8 g 0,1 g 0,0014 A03AD02 Drotaverine(O) 215250,88 g 0,1 g 4,4508 A03AD02 Drotaverine(P) 3608 g 0,1 g 0,0746 A03AX Other drugs for functional gastrointestinal disorders 1,6764 A03AX13 Simeticone(O) 405384,432 g 0,5 g 1,6764 A03B BELLADONNA AND DERIVATIVES, PLAIN 0,0828 A03BA Belladonna alkaloids, tertiary amines 0,0728 A03BA01 Atropine(O, P) 12,81 g 0,0015 g 0,0177 A03BA01 Atropine(P) 40,02 g 0,0015 g 0,0552 Belladonna alkaloids, semisynthetic, quaternary ammonium A03BB 0,0100 compounds A03BB01 Hyoscine butylbromide(O) 21,4 g 0,06 g 0,0007 1/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A03BB01 Hyoscine butylbromide(P) 266,8 g 0,06 g 0,0092 A03BB01 Hyoscine butylbromide(R) 1,92 g 0,06 g 0,0001 A03F PROPULSIVES 0,8605 A03FA Propulsives 0,8605 A03FA01 Metoclopramide(O) 10342 g 0,03 g 0,7128 A03FA01 Metoclopramide(P) 1687,1 g 0,03 g 0,1163 A03FA03 Domperidone(O) 455,91 g 0,03 g 0,0314 A04 ANTIEMETICS AND ANTINAUSEANTS 0,1210 A04A ANTIEMETICS AND ANTINAUSEANTS 0,1210 A04AA Serotonin (5-HT3) antagonists 0,1122 A04AA01 Ondansetron(P) 113,02 g 0,016 g 0,0146 A04AA02 Granisetron(O) 60,23 g 0,002 g 0,0623 A04AA02 Granisetron(P) 49,83 g 0,003 g 0,0343 A04AA05 Palonosetron(P) 0,008 g 0,25 mg 0,0001 A04AA80 Palonosetron+Netupitant(O) 449 pieces 1 pieces 0,0009 A04AD Other antiemetics 0,0088 A04AD01 Scopolamine(TD) 10 pieces 1 pieces <0,0001 A04AD12 Aprepitant(O) 285,855 g 0,165 g 0,0036 A04AD81 Fosaprepitant(P) 238,35 g 0,095 g 0,0052 A05 BILE AND LIVER THERAPY 2,0881 A05A BILE THERAPY 0,5485 A05AA Bile acids and derivatives 0,5485 A05AA02 Ursodeoxycholic acid(O) 198962,5 g 0,75 g 0,5485 A05B LIVER THERAPY, LIPOTROPICS 1,5396 A05BA Liver therapy 1,5396 A05BA03 Silymarin(O) 2121160 pieces A05BA80 Phospholipids from Soya Beans(O) 1380900 pieces 3 pieces 0,9518 A05BA80 Phospholipids from Soya Beans(O) 1705700 pieces 6 pieces 0,5878 A05BA80 Phospholipids from Soya Beans(P) 975 pieces A05BA81 Silibinin(P) 56 g A06 DRUGS FOR CONSTIPATION 16,4173 A06A DRUGS FOR CONSTIPATION 16,4173 A06AB Contact laxatives 7,5294 A06AB02 Bisacodyl(O) 14242,8 g 0,01 g 2,9450 A06AB02 Bisacodyl(R) 986,3 g 0,01 g 0,2039 A06AB06 Senna glycosides(O) 6380 pieces 1 pieces 0,0132 A06AB08 Sodium picosulfate(O) 10551,9264 g 0,005 g 4,3637 A06AB80 Sodium picosulfate+Magnesium oxide+Citric acid(O) 3426 pieces 2 pieces 0,0035 A06AC Bulk-forming laxatives <0,0001 A06AC01 Hemicellulose of Ispaghula(O) 0,585 g 7 g <0,0001 A06AD Osmotically acting laxatives 7,9377 A06AD11 Lactulose(O) 24311273,4 g 6,7 g 7,5028 A06AD15 Macrogol(O) 2103400 g 10 g 0,4349 Macrogol+Sodium citrate+Citric acid+Sodium chloride+Potassium A06AD80 21500 ml chloride(O) Sodium sulphate, anhydrous+Potassium chloride+Sodium A06AD81 40940 pieces chloride+Macrogol+Sodium hydrogen carbonate(O) Macrogol+Sodium sulphate, anhydrous+Sodium chloride+Potassium A06AD83 5843 pieces chloride+Ascorbic acid+Sodium ascorbate(O) Sodium sulphate, anhydrous+magnesium sulfate A06AD85 934912 ml heptahydrate+Potassium sulphate(O) A06AG Enemas 0,9313 A06AG11 Laurilsulfate, incl. combinations+Sorbitol+Sodium citrate(R) 450392 pieces 1 pieces 0,9313 A06AH Peripheral opioid receptor antagonists 0,0189 A06AH03 Naloxegol(O) 228,75 g 25 mg 0,0189 ANTIDIARRHEALS, INTESTINAL A07 4,6470 ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS A07A INTESTINAL ANTIINFECTIVES 0,0010 A07AA Antibiotics 0,0010 2/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A07AA02 Nystatin(O) 60000000 U 1500000 U 0,0001 A07AA11 Rifaximin(O) 252 g 0,6 g 0,0009 A07AA12 Fidaxomicin(O) 4 g 0,4 g <0,0001 A07B INTESTINAL ADSORBENTS 0,5281 A07BC Other intestinal adsorbents 0,5281 A07BC05 Diosmectidum(O) 2298540 g 9 g 0,5281 A07C ELECTROLYTES WITH CARBOHYDRATES A07CA Oral rehydration salt formulations A07CA80 Sodium chloride+Potassium chloride+Sodium citrate+Glucose(O) 48820 pieces A07D ANTIPROPULSIVES 1,0787 A07DA Antipropulsives 1,0787 A07DA03 Loperamide(O) 5217,02 g 0,01 g 1,0787 A07E INTESTINAL ANTIINFLAMMATORY AGENTS 2,2662 A07EA Corticosteroids acting locally 0,0088 A07EA06 Budesonide(O) 38,4 g 0,009 g 0,0088 A07EA06 Budesonide(R) 2,5375 g A07EC Aminosalicylic acid and similar agents 2,2574 A07EC01 Sulfasalazine(O) 791900 g 2 g 0,8187 A07EC02 Mesalazine(O) 953300 g 1,5 g 1,3141 A07EC02 Mesalazine(R) 90360 g 1,5 g 0,1246 A07F ANTIDIARRHEAL MICROORGANISMS 0,7730 A07FA Antidiarrheal microorganisms 0,7730 A07FA02 Saccharomyces boulardii(O) 373845 g 1 g 0,7730 A07X OTHER ANTIDIARRHEALS A07XA Other antidiarrheals A07XA04 Racecadotril(O) 3490,64 g A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS 0,0649 A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS 0,0649 A08AA Centrally acting antiobesity products 0,0643 A08AA62 Bupropione+Naltrexone(O) 124432 pieces 4 pieces 0,0643 A08AB Peripherally acting antiobesity products 0,0006 A08AB01 Orlistat(O) 105,84 g 0,36 g 0,0006 A09 DIGESTIVES, INCL. ENZYMES 1,6015 A09A DIGESTIVES, INCL. ENZYMES 1,6015 A09AA Enzyme preparations 1,6015 A09AA02 Lipase+Amylase+Protease(O) 3098159 pieces 4 pieces 1,6015 A10 DRUGS USED IN DIABETES 65,0155 A10A INSULINS AND ANALOGUES 16,1124 A10AB Insulins and analogues for injection, fast-acting 6,0895 A10AB01 Insulin (human)(P) 996000 U 40 U 0,0515 A10AB04 Insulin lispro(P) 22677000 U 40 U 1,1722 A10AB05 Insulin aspart(P) 81877500 U 40 U 4,2325 A10AB06 Insulin glulisine(P) 12250500 U 40 U 0,6333 A10AC Insulins and analogues for injection, intermediate-acting 0,0743 A10AC01 Insulin (human)(P) 1437000 U 40 U 0,0743 Insulins and analogues for injection, intermediate- or long-acting A10AD 0,9251 combined with fast-acting A10AD04 Insulin lispro(P) 5487000 U 40 U 0,2836 A10AD05 Insulin aspart(P) 12409500 U 40 U 0,6415 A10AE Insulins and analogues for injection, long-acting 9,0235 A10AE04 Insulin glargine(P) 100768500 U 40 U 5,2090 A10AE05 Insulin detemir(P) 51253500 U 40 U 2,6494 A10AE06 Insulin degludec(P) 18664500 U 40 U 0,9648 A10AE54 Insulin glargine+Lixisenatide(P) 3873000 U 40 U 0,2002 A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS 48,9031 A10BA Biguanides 20,7978 A10BA02 Metformin(O) 20116659 g 2 g 20,7978 A10BB Sulfonylureas 12,7685 A10BB07 Glipizide(O) 919,2 g 0,01 g 0,1901 3/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A10BB09 Gliclazide(O) 206602,2 g 0,06 g 7,1199 A10BB12 Glimepiride(O) 5279,79 g 0,002 g 5,4586 A10BD Combinations of oral blood glucose lowering drugs 6,9312 A10BD07 Metformin+Sitagliptin(O) 2027816 pieces 2 pieces 2,0965 A10BD08 Metformin+Vildagliptin(O) 1276740 pieces 2 pieces 1,3200 A10BD10 Metformin+Saxagliptin(O) 335820 pieces 2 pieces 0,3472 A10BD11 Metformin+Linagliptin(O) 1038300 pieces 2 pieces 1,0735 A10BD15 Metformin+Dapagliflozin(O) 547456 pieces 2 pieces 0,5660 A10BD19 Linagliptin+Empagliflozin(O) 143970 pieces 1 pieces 0,2977 A10BD20 Metformin+Empagliflozin(O) 1010580 pieces 2 pieces 1,0448 A10BD21 Saxagliptin+Dapagliflozin(O) 87836 pieces 1 pieces 0,1816 A10BD23 Metformin+Ertugliflozin(O) 1960 pieces 1 pieces 0,0041 A10BF Alpha glucosidase inhibitors 0,0009 A10BF01 Acarbose(O) 131,25 g 0,3 g 0,0009 A10BG Thiazolidinediones 0,1301 A10BG03 Pioglitazone(O) 1887,06 g 0,03 g 0,1301 A10BH Dipeptyl peptidase 4 (DPP-4) inhibitors 3,9646 A10BH01 Sitagliptin(O) 59508,4 g 0,1 g 1,2305 A10BH02 Vildagliptin(O) 8541 g 0,1 g 0,1766 A10BH03 Saxagliptin(O) 567,6 g 5 mg 0,2347 A10BH05 Linagliptin(O) 5616,75 g 5 mg 2,3228 A10BJ Glucagon-like peptide-1 (GLP-1) analogues 2,0412 A10BJ01 Exenatide(P) 7,72 g 0,286 mg 0,0558 A10BJ02 Liraglutide(P) 911,232 g 1,5 mg 1,2561 A10BJ03 Lixisenatide(P) 0,8871 g 20 mcg 0,0917 A10BJ05 Dulaglutide(P) 14,037 g 0,16 mg 0,1814 A10BJ06 Semaglutide(P) 24,269 g 0,11 mg 0,4562 A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors 2,2688 A10BK01 Dapagliflozin(O) 4434,15 g 10 mg 0,9169 A10BK03 empagliflozin(O) 11436,75 g 17,5 mg 1,3513 A10BK04 Ertugliflozin(O) 2,94 g 10 mg 0,0006 A11 VITAMINS 12,5386 A11A MULTIVITAMINS, COMBINATIONS 1,4917 A11AA Multivitamins with minerals 1,4917 A11AA03 Multivitamins+Mineral elements(O) 721440 pieces 1 pieces 1,4917 A11B MULTIVITAMINS, PLAIN 0,0003 A11BA Multivitamins, plain 0,0003 A11BA80 Multivitamins(O) 1250 ml 10 ml 0,0003 A11C VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO 2,4546 A11CC Vitamin D and analogues 2,4546 A11CC04 Calcitriol(O) 0,0974 g 0,001 mg 0,2013 A11CC05 Colecalciferol(O) 435900000 U 400 U 2,2533 A11CC05 Colecalciferol(P) 10000000 U VITAMIN B1, PLAIN AND IN COMBINATION WITH VITAMIN B6 AND A11D 1,8820 B12 A11DA Vitamin B1, plain 0,3818 A11DA01 Thiamine(P) 9232 g 0,05 g 0,3818 A11DA03 Benfotiamine(O) 1747420 pieces A11DB Vitamin B1 in combination with vitamin B6 and/or vitamin B12 1,5002 A11DB80 Thiamine+Pyridoxine(P) 3300 pieces 1 pieces 0,0068 A11DB81 Benfotiamine+Pyridoxine(O) 206250 pieces 3 pieces 0,1422 A11DB84 Thiamine+Pyridoxine+Cyanocobalamin(O) 572570 pieces 1 pieces 1,1839 A11DB85 Thiamine+Pyridoxine+Cyanocobalamin+Lidocaine(P) 80920 pieces 1 pieces 0,1673 A11E VITAMIN B-COMPLEX, INCL. COMBINATIONS 0,6135 A11EA Vitamin B-complex, plain 0,6135 Thiamine+Nicotinamide+Riboflavin+Calcium A11EA80 296700 pieces 1 pieces 0,6135 pantothenate+Pyridoxine(O) A11G ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS 0,1727 A11GA Ascorbic acid (vitamin C), plain 0,1727 A11GA01 Ascorbic acid(P) 16702,5 g 0,2 g 0,1727 4/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A11H OTHER PLAIN VITAMIN PREPARATIONS 0,0640 A11HA Other plain vitamin preparations 0,0640 A11HA02 Pyridoxine(O) 90 g 0,16 g 0,0012 A11HA02 Pyridoxine(P) 4434,5 g 0,16 g 0,0573 A11HA03 Tocopherol(O) 40 g 0,2 g 0,0004 A11HA08 Tocofersolan(O) 495 g 0,2 g 0,0051 A11J OTHER VITAMIN PRODUCTS, COMBINATIONS 5,8598 A11JB Vitamins with minerals 5,8598 A11JB81 Pyridoxine+Magnesium(O) 7201900 pieces 4 pieces 3,7229 Thiamine+Riboflavin+Pyridoxine+Cyanocobalamin+Ascorbic A11JB82 acid+Biotin+Nicotinamide+Calcium 1033470 pieces 1 pieces 2,1369 pantothenate+Calcium+Magnesium+Folic acid+Zinc(O) A12 MINERAL SUPPLEMENTS 9,0463 A12A CALCIUM 5,4182 A12AA Calcium 0,7933 A12AA03 Calcium gluconate(P) 24775 g 3 g 0,0171 A12AA04 Calcium carbonate(O) 1126150 g 3 g 0,7762 A12AX Calcium, combinations with vitamin D and/or other drugs 4,6249 A12AX80 Calcium+Colecalciferol(O) 600000 pieces 1 pieces 1,2406 A12AX80 Calcium+Colecalciferol(O) 3273480 pieces 2 pieces 3,3843 A12B POTASSIUM 3,0809 A12BA Potassium 3,0809 A12BA01 Potassium chloride(O) 319140 g 3 g 0,2200 A12BA02 Potassium citrate(O) 432 g 4 g 0,0002 A12BA80 Potassium chloride+Potassium hydrogen carbonate(O) 7900 pieces A12BA81 Potassium aspartate+Magnesium aspartate(O) 4102350 pieces 3 pieces 2,8275 A12BA81 Potassium aspartate+Magnesium aspartate(P) 16085 pieces 1 pieces 0,0333 A12C OTHER MINERAL SUPPLEMENTS 0,5472 A12CC Magnesium 0,5472 A12CC04 Magnesium citrate(O) 529247,912 g 2 g 0,5472 A12CX Other mineral products A12CX83 Phosphate(O) 11200 pieces A14 ANABOLIC AGENTS FOR SYSTEMIC USE 0,0021 A14A ANABOLIC STEROIDS 0,0021 A14AB Estren derivatives 0,0021 A14AB01 Nandrolone(P) 2 g 0,002 g 0,0021 A14B OTHER ANABOLIC AGENTS A14BX Other anabolic agents A14BX80 Riboxine(O) 90 g A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS 0,5117 A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS 0,5117 A16AA Amino acids and derivatives 0,0022 A16AA01 Levocarnitine(O) 1680 g 2 g 0,0017 A16AA02 Ademetionine(O) 395 g A16AA04 Mercaptamine(O) 120 g 2 g 0,0001 A16AA05 Carglumic acid(O) 22 g 0,2 g 0,0002 A16AA06 Betaine(O) 180 g 6 g 0,0001 A16AA80 L-arginiin(O) 90 g A16AA81 Glycine(O) 900 g A16AB Enzymes 0,0063 A16AB02 Imiglucerase(P) 196400 U 300 U 0,0014 A16AB03 Agalsidase alfa(P) 1,323 g 0,001 g 0,0027 A16AB04 Agalsidase beta(P) 2,32 g 0,005 g 0,0010 A16AB07 Alglucosidase alfa(P) 60 g 0,1 g 0,0012 A16AB09 Idursulfase(P) 1,344 g A16AX Various alimentary tract and metabolism products 0,5033 A16AX01 Thioctic acid(O) 142794 g 0,6 g 0,4921 A16AX01 Thioctic acid(P) 327 g 0,6 g 0,0011 A16AX03 Sodium phenylbutyrate(O) 3000 g 20 g 0,0003 A16AX05 Zinc(O) 681,25 g 0,15 g 0,0094 5/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A16AX07 Sapropterin(O) 684 g A16AX10 Eliglustat(O) 18,816 g 0,168 g 0,0002 A16AX15 Telotristat(O) 45 g 0,75 g 0,0001 A16AX80 Creatine(O) 450 g A16AX81 Copper histidine(P) 0,105 g B BLOOD AND BLOOD FORMING ORGANS 107,7585 B01 ANTITHROMBOTIC AGENTS 83,1567 B01A ANTITHROMBOTIC AGENTS 83,1567 B01AA Vitamin K antagonists 2,9920 B01AA03 Warfarin(O) 10852,5 g 0,0075 g 2,9920 B01AB Heparin group 3,1593 B01AB01 Heparin sodium(P) 680500000 U 10000 U 0,1407 B01AB04 Dalteparin sodium(P) 1850000 U 2500 U 0,0015 B01AB05 Enoxaparin sodium(hem, P) 590108000 U 2000 U 0,6101 B01AB05 Enoxaparin sodium(P) 1827824000 U 2000 U 1,8897 B01AB06 Nadroparin calcium(P) 10849000 U 2850 U 0,0079 B01AB12 Bemiparin sodium(P) 615835000 U 2500 U 0,5093 B01AC Platelet aggregation inhibitors, excl. heparin 57,8181 B01AC04 Clopidogrel(O) 157415,25 g 0,075 g 4,3399 B01AC06 Acetylsalicylic acid (O) 5467750 pieces 1 pieces 11,3058 B01AC07 Dipyridamole(O) 44,1 g 0,4 g 0,0002 B01AC09 Epoprostenol(P) 0,003 g B01AC11 Iloprost(I) 0,121 g 0,15 mg 0,0017 B01AC11 Iloprost(P) 0,009 g 50 mcg 0,0004 B01AC16 Eptifibatide(P) 72,56 g 0,2 g 0,0008 B01AC24 Ticagrelor(O) 97450,08 g 0,18 g 1,1194 B01AC80 Acetylsalicylic acid +Magnesium oxide(O) 19852800 pieces 1 pieces 41,0500 B01AD Enzymes 0,0024 B01AD01 Streptokinase(P) 107500000 U 1500000 U 0,0001 B01AD02 Alteplase(P) 90,83 g 0,1 g 0,0019 B01AD11 Tenecteplase(P) 6,75 g 0,04 g 0,0003 B01AE Direct thrombin inhibitors 2,7763 B01AE07 Dabigatran etexilate(O) 402802,4 g 0,3 g 2,7763 B01AF Direct factor Xa inhibitors 16,4061 B01AF01 Rivaroxaban(O) 88914,18 g 0,02 g 9,1925 B01AF02 Apixaban(O) 34884,9 g 10 mg 7,2132 B01AF03 Edoxaban(O) 10,8 g 60 mg 0,0004 B01AX Other antithrombotic agents 0,0027 B01AX05 Fondaparinux sodium(P) 3,225 g 0,0025 g 0,0027 B02 ANTIHEMORRHAGICS 0,1720 B02A ANTIFIBRINOLYTICS 0,1528 B02AA Amino acids 0,1528 B02AA01 Aminocaproic acid(P) 12980 g 16 g 0,0017 B02AA02 Tranexamic acid(O) 108820 g 2 g 0,1125 B02AA02 Tranexamic acid(P) 37348 g 2 g 0,0386 B02B VITAMIN K AND OTHER HEMOSTATICS 0,0193 B02BA Vitamin K 0,0040 B02BA01 Phytomenadione(O, P) 36,94 g 0,02 g 0,0038 B02BA01 Phytomenadione(P) 1,62 g 0,02 g 0,0002 B02BB Fibrinogen 0,0001 B02BB01 Fibrinogen human(P) 135 g 5 g 0,0001 B02BC Local hemostatics B02BC81 Fibrinogen human+Human thrombin(epil) 665 pieces B02BD Blood coagulation factors B02BD01 Human prothrombin complex(P) 273000 U B02BD02 Human coagulation factor VIII(P) 3261500 U B02BD03 Factor VIII inhibitor bypassing activity(P) 940000 U B02BD04 Human coagulation factor IX(P) 655200 U B02BD05 Human coagulation factor VII(P) 192000 U 6/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day B02BD06 Von Willebrand factor, human+Human coagulation factor VIII(P) 2369250 U B02BD08 Coagulation factor VIIa(P) 6350000 U B02BD10 Von Willebrand factor, human(P) 26000 U B02BD80 Turoctocog alfa(P) 50000 U B02BD81 Simoctocog alfa(P) 2248500 U B02BD83 Efmoroctocog alfa(P) 76000 U B02BX Other systemic hemostatics 0,0152 B02BX01 Etamsylate(P) 1010 g B02BX04 Romiplostim(P) 0,02 g 30 mcg 0,0014 B02BX05 Eltrombopag(O) 325,5 g 50 mg 0,0135 B02BX06 Emicizumab(P) 2,7 g 15 mg 0,0004 B03 ANTIANEMIC PREPARATIONS 24,4292 B03A IRON PREPARATIONS 4,2694 B03AA Iron bivalent, oral preparations 2,5532 B03AA07 Ferrous sulphate(O) 246957 g 0,2 g 2,5532 B03AB Iron trivalent, oral preparations B03AB80 Iron (III) hydroxide polymaltose complex(O) 82826,5 g B03AC Iron, parenteral preparations 0,0931 B03AC01 Dextriferron(P) 804,5 g 0,1 g 0,0166 B03AC02 Iron (III) hydroxide sucrose complex(P) 1409,5 g 0,1 g 0,0291 B03AC06 Iron (III)-hydroxide dextran complex(P) 1604 g 0,1 g 0,0332 B03AC80 Iron (III) isomaltoside 1000 complex(P) 685 g 0,1 g 0,0142 B03AD Iron in combination with folic acid 1,6231 B03AD02 Ferrous fumarate+Folic acid(O) 596310 pieces 1 pieces 1,2330 B03AD03 Ferrous sulphate+Folic acid(O) 188650 pieces 1 pieces 0,3901 B03AE Iron in other combinations B03AE81 Ferrous gluconate+Manganese gluconate+Copper gluconate(O) 1680000 ml B03AE82 Ferrous fumarate+Folic acid+Ascorbic acid(O) 52270 pieces B03B VITAMIN B12 AND FOLIC ACID 19,2386 B03BA Vitamin B12 (cyanocobalamin and analogues) 6,5241 B03BA01 Cyanocobalamin(O) 11,25 g 1 mg 0,0233 B03BA01 Cyanocobalamin(P) 62,69 g 0,02 mg 6,4813 B03BA03 Hydroxocobalamin(P) 0,189 g 0,02 mg 0,0195 B03BB Folic acid and derivatives 12,7145 B03BB01 Folic acid(O) 2459,625 g 0,4 mg 12,7145 B03X OTHER ANTIANEMIC PREPARATIONS 0,9213 B03XA Other antianemic preparations 0,9213 B03XA02 Darbepoetin alfa(P) 1,4251 g 0,0045 mg 0,6548 B03XA03 Methoxy polyethylene glycol-epoetin beta(P) 0,3031 g 4 mcg 0,1567 B03XA80 Epoetin beta(P) 53100000 U 1000 U 0,1098 B05 BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS B05A BLOOD AND RELATED PRODUCTS B05AA Blood substitutes and plasma protein fractions B05AA01 Albumin(P) 635690 g B05AA06 Gelatin agents(P) 9215000 ml B05AA80 Hydroxyethyl starch+Sodium chloride(P) 16000 ml B05AA81 Dextran+Sodium chloride(P) 45500 ml Gelatine+Sodium chloride+Potassium chloride+Magnesium B05AA83 357500 ml chloride+Sodium lactate(P) B05AA86 human plasma proteins(P) 242000 ml B05B I.V. SOLUTIONS B05BA Solutions for parenteral nutrition B05BA01 Amino acids(P) 646900 ml B05BA02 Fat emulsions(P) 166000 ml B05BA03 Carbohydrates(P) 4000 g B05BA03 Carbohydrates(P) 71342500 ml B05BA10 Combinations(P) 15803944 ml B05BB Solutions affecting the electrolyte balance 7/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day B05BB01 Electrolytes(P) 172929500 ml B05BB03 Trometamol(P) 200 ml B05BC Solutions producing osmotic diuresis B05BC01 Mannitol(P) 906000 ml B05C IRRIGATING SOLUTIONS B05CX Other irrigating solutions B05CX10 Combinations(NA) 216000 ml B05D PERITONEAL DIALYTICS B05DA Isotonic solutions B05DA80 Isotonic solutions(P) 8390000 ml B05DB Hypertonic solutions B05DB80 hypertonic solutions(P) 142416000 ml Amino acids+Sodium chloride+Calcium chloride dihydrate+Magnesium B05DB81 570000 ml chloride hexahydrate+Sodium lactate(P) B05Z HEMODIALYTICS AND HEMOFILTRATES B05ZB Hemofiltrates Sodium chloride+Potassium chloride+Calcium chloride B05ZB80 dihydrate+Magnesium chloride+Glucose+Sodium hydrogen 21960000 ml carbonate(P) Calcium chloride dihydrate+Magnesium chloride hexahydrate+Sodium B05ZB82 chloride+Sodium hydrogen carbonate+Potassium chloride+Disodium 13690000 ml phosphate dihydrate(P) Calcium chloride dihydrate+Magnesium chloride hexahydrate+Lactic B05ZB84 780000 ml acid+Sodium hydrogen carbonate+Sodium chloride(P) B05ZB85 Sodium citrate+Sodium chloride(P) 2429000 ml Magnesium chloride hexahydrate+Sodium chloride+Potassium B05ZB86 chloride+Disodium phosphate dihydrate+Sodium hydrogen 1340000 ml carbonate(P) B05X I.V. SOLUTION ADDITIVES B05XA Electrolyte solutions B05XA01 Potassium chloride(P) 975 g B05XA01 Potassium chloride(P) 3432400 ml B05XA02 Sodium hydrogen carbonate(P) 1540500 ml B05XA03 Sodium chloride(P) 494726200 ml B05XA05 Magnesium sulphate(P) 418300 ml B05XA06 Potassium dihydrogen phosphate(P) 400 ml B05XA07 Calcium chloride(P) 242600 ml B05XA14 Sodium glycerophosphate, hydrated(P) 100200 ml B05XA80 Electrolytes(P) 112700 ml B05XB Amino acids B05XB01 Arginine(P) 3100 ml B05XB02 Alanyl glutamine(P) 39500 ml B05XC Vitamins B05XC80 Vitamins(P) 848,12 g B05XC80 Vitamins(P) 221500 ml B06 OTHER HEMATOLOGICAL AGENTS 0,0006 B06A OTHER HEMATOLOGICAL AGENTS 0,0006 B06AC Drugs usedin hereditary angioedema 0,0006 B06AC01 C1-inhibitor(P) 106000 U 1400 U 0,0002 B06AC02 Icatibant(P) 3,18 g 0,03 g 0,0002 B06AC04 Conestat alfa(P) 302400 U 3500 U 0,0002 C CARDIOVASCULAR SYSTEM 429,8975 C01 CARDIAC THERAPY 23,3946 C01A CARDIAC GLYCOSIDES 2,4668 C01AA Digitalis glycosides 2,4668 C01AA05 Digoxin(O) 295,775 g 0,25 mg 2,4463 C01AA05 Digoxin(P) 2,4625 g 0,25 mg 0,0204 8/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C01AA06 Lanatoside C(O) 0,045 g 0,001 g 0,0001 C01B ANTIARRHYTHMICS, CLASS I AND III 5,7179 C01BA Antiarrhythmics, class Ia C01BA13 Hydroquinidine(O) 252 g C01BB Antiarrhythmics, class Ib 0,0236 C01BB02 Mexiletine(O) 120 g 0,8 g 0,0003 C01BB80 Aethacizin(O) 2250 g 0,2 g 0,0233 C01BC Antiarrhythmics, class Ic 3,7064 C01BC03 Propafenone(O) 517383 g 0,3 g 3,5660 C01BC03 Propafenone(P) 568,75 g 0,3 g 0,0039 C01BC04 Flecainide(O) 13178 g 0,2 g 0,1362 C01BC04 Flecainide(P) 24 g 0,2 g 0,0002 C01BD Antiarrhythmics, class III 1,9879 C01BD01 Amiodarone(O) 185604 g 0,2 g 1,9189 C01BD01 Amiodarone(P) 5508,75 g 0,2 g 0,0570 C01BD07 Dronedarone(O) 4656 g 0,8 g 0,0120 C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES 0,8703 C01CA Adrenergic and dopaminergic agents 0,8692 C01CA01 Etilefrine(O) 3,825 g 0,05 g 0,0002 C01CA02 Isoprenaline(P) 0,537 g 0,09 g <0,0001 C01CA03 Norepinephrine(P) 330,244 g 0,006 g 0,1138 C01CA04 Dopamine(P) 1327 g 0,5 g 0,0055 C01CA06 Phenylephrine(P) 230,7 g 0,004 g 0,1193 C01CA07 Dobutamine(P) 772,5 g 0,5 g 0,0032 C01CA17 Midodrine(O) 4,375 g 0,03 g 0,0003 C01CA24 Epinephrine(I) 3,834 g C01CA24 Epinephrine(P) 140,712 g 0,5 mg 0,5819 C01CA26 Ephedrine(P) 1090,75 g 0,05 g 0,0451 C01CE Phosphodiesterase inhibitors 0,0006 C01CE02 Milrinone(P) 14,88 g 0,05 g 0,0006 C01CX Other cardiac stimulants 0,0004 C01CX08 Levosimendan(P) 2,25 g 11 mg 0,0004 C01CX80 Ammonia(I) 1162880 ml C01D VASODILATORS USED IN CARDIAC DISEASES 6,2037 C01DA Organic nitrates 6,2008 C01DA02 Glyceryl trinitrate(P) 224,1 g C01DA02 Glyceryl trinitrate(SL) 511,128 g 0,0025 g 0,4227 C01DA08 Isosorbide dinitrate(O) 9764 g 0,06 g 0,3365 C01DA08 Isosorbide dinitrate(SL) 258,75 g 0,02 g 0,0268 C01DA14 Isosorbide mononitrate(O) 104750,2 g 0,04 g 5,4148 C01DX Other vasodilatators used in cardiac diseases 0,0029 C01DX80 Meldonium(O) 1050 g 0,75 g 0,0029 C01E OTHER CARDIAC PREPARATIONS 8,1360 C01EA Prostaglandins 0,0003 C01EA01 Alprostadil(P) 0,0644 g 0,5 mg 0,0003 C01EB Other cardiac preparations 8,1357 C01EB10 Adenosine(P) 92,312 g 0,015 g 0,0127 C01EB15 Trimetazidine(O) 149704,8 g 0,04 g 7,7387 C01EB16 Ibuprofen(P) 0,92 g 0,03 g 0,0001 C01EB17 Ivabradine(O) 1590,12 g 0,01 g 0,3288 C01EB18 Ranolazine(O) 39690 g 1,5 g 0,0547 C01EB21 Regadenoson(P) 0,148 g 0,4 mg 0,0008 C01EB80 Hawthorn berry(O) 92720 ml C02 ANTIHYPERTENSIVES 3,7643 C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING 2,4247 C02AC Imidazoline receptor agonists 2,4247 C02AC01 Clonidine(O) 5,025 g 0,45 mg 0,0231 C02AC01 Clonidine(P) 3,901 g 0,45 mg 0,0179 C02AC05 Moxonidine(O) 345,8476 g 0,3 mg 2,3837 C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING 1,3058 9/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C02CA Alpha-adrenoreceptor antagonists 1,3058 C02CA01 Prazosin(O) 2,91 g 0,005 g 0,0012 C02CA04 Doxazosin(O) 2523,652 g 0,004 g 1,3046 C02D ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON 0,0007 C02DD Nitroferricyanide derivatives 0,0007 C02DD01 Sodium nitroprusside(P) 16 g 0,05 g 0,0007 C02K OTHER ANTIHYPERTENSIVES 0,0331 C02KX Antihypertensives for pulmonary arterial hypertension 0,0331 C02KX01 Bosentan(O) 1225 g 0,25 g 0,0101 C02KX02 Ambrisentan(O) 42,75 g 7,5 mg 0,0118 C02KX04 Macitentan(O) 3 g 10 mg 0,0006 C02KX05 Riociguat(O) 23,058 g 4,5 mg 0,0106 C03 DIURETICS 26,1197 C03A LOW-CEILING DIURETICS, THIAZIDES 1,4557 C03AA Thiazides, plain 1,4557 C03AA03 Hydrochlorothiazide(O) 17600,5 g 0,025 g 1,4557 C03B LOW-CEILING DIURETICS, EXCL. THIAZIDES 2,3798 C03BA Sulfonamides, plain 2,3798 C03BA11 Indapamide(O) 2877,285 g 2,5 mg 2,3798 C03C HIGH-CEILING DIURETICS 18,9909 C03CA Sulfonamides, plain 18,9909 C03CA01 Furosemide(O) 72206,2 g 0,04 g 3,7326 C03CA01 Furosemide(P) 5071,8 g 0,04 g 0,2622 C03CA04 Torasemide(O) 108268,65 g 0,015 g 14,9246 C03CA04 Torasemide(P) 519,4 g 0,015 g 0,0716 C03D POTASSIUM-SPARING AGENTS 3,2787 C03DA Aldosterone antagonists 3,2787 C03DA01 Spironolactone(O) 118923,75 g 0,075 g 3,2787 DIURETICS AND POTASSIUM-SPARING AGENTS IN C03E 0,0146 COMBINATION C03EA Low-ceiling diuretics and potassium-sparing agents 0,0146 C03EA81 Hydrochlorothiazide+Amiloride(O) 7050 pieces 1 pieces 0,0146 C04 PERIPHERAL VASODILATORS 2,6811 C04A PERIPHERAL VASODILATORS 2,6811 C04AC Nicotinic acid and derivatives 0,0002 C04AC01 Nicotinic acid(P) 15 g 0,2 g 0,0002 C04AD Purine derivatives 1,7456 C04AD02 Xantinol nicotinate(O) 297 g 0,9 g 0,0007 C04AD03 Pentoxifylline(O) 842104 g 1 g 1,7412 C04AD03 Pentoxifylline(P) 528 g 0,3 g 0,0036 C04AX Other peripheral vasodilators 0,9353 C04AX21 Naftidrofuryl(O) 271415 g 0,6 g 0,9353 C05 VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL C05A FISSURES FOR TOPICAL USE C05AA Corticosteroids C05AA82 Hydrocortisone+Cinchocaine(R) 58620 pieces C05AA84 Fluocortolone+Lidocaine(R) 186520 pieces C05AA84 Fluocortolone+Lidocaine(R) 187095 g C05AE Muscle relaxants C05AE01 Glyceryl trinitrate(R) 30 g Other agents for treatment of hemorrhoids and anal fissures for topical C05AX use C05AX81 Xeroformium+Zinc sulphate+Extract of Belladonna(R) 2230 pieces C05AX83 Yeast cell extract+Shark liver oil(R) 25 g C05AX83 Yeast cell extract+Shark liver oil(R) 307452 pieces C05AX85 Hippopheae oleum(R) 30 pieces C05B ANTIVARICOSE THERAPY C05BA Heparins or heparinoids for topical use C05BA01 Chondroitin polysulfate(C) 51360 g 10/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C05BA03 Heparin sodium(C) 7751250 g C05BB Sclerosing agents for local injection C05BB02 Lauromacrogol 400(P) 96,9 g C05C CAPILLARY STABILIZING AGENTS C05CA Bioflavonoids C05CA01 Rutoside(O) 249885 pieces C05CA03 Diosmin(O) 331950 g C05CA04 Troxerutin(C) 3455980 g C05CA04 Troxerutin(O) 212160 g C05CA53 Diosmin+Hesperidine(O) 2220 pieces C07 BETA BLOCKING AGENTS 55,1998 C07A BETA BLOCKING AGENTS 55,1988 C07AA Beta blocking agents, non-selective 1,7930 C07AA05 Propranolol(O) 47315,5 g 0,16 g 0,6115 C07AA07 Sotalol(O) 91423,2 g 0,16 g 1,1815 C07AB Beta blocking agents, selective 52,7835 C07AB02 Metoprolol(O) 1907206,1 g 0,15 g 26,2904 C07AB02 Metoprolol(P) 97,6 g 0,15 g 0,0013 C07AB03 Atenolol(O) 19616,25 g 0,075 g 0,5408 C07AB07 Bisoprolol(O) 14796,3 g 0,01 g 3,0595 C07AB09 Esmolol(P) 0,5 g 2,5 g <0,0001 C07AB12 Nebivolol(O) 55354,51 g 0,005 g 22,8915 C07AG Alpha and beta blocking agents 0,6223 C07AG01 Labetalol(O) 27925 g 0,6 g 0,0962 C07AG01 Labetalol(P) 1097,5 g 0,6 g 0,0038 C07AG02 Carvedilol(O) 9471,5625 g 0,0375 g 0,5223 C07B BETA BLOCKING AGENTS AND THIAZIDES 0,0010 C07BB Beta blocking agents, selective, and thiazides 0,0010 C07BB07 Bisoprolol+Hydrochlorothiazide(O) 480 pieces 1 pieces 0,0010 C08 CALCIUM CHANNEL BLOCKERS 46,5513 SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY C08C 44,9857 VASCULAR EFFECTS C08CA Dihydropyridine derivatives 44,9857 C08CA01 Amlodipine(O) 61417,5 g 0,005 g 25,3988 C08CA02 Felodipine(O) 6751,5 g 0,005 g 2,7920 C08CA05 Nifedipine(O) 16632,24 g 0,03 g 1,1464 C08CA06 Nimodipine(O) 459 g 0,3 g 0,0032 C08CA06 Nimodipine(P) 3,75 g 0,05 g 0,0002 C08CA08 Nitrendipine(O) 45226,74 g 0,02 g 4,6758 C08CA09 Lacidipine(O) 6492,976 g 0,004 g 3,3564 C08CA13 Lercanidipine(O) 36818,1 g 0,01 g 7,6129 SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT C08D 1,5656 CARDIAC EFFECTS C08DA Phenylalkylamine derivatives 1,4753 C08DA01 Verapamil(O) 171228 g 0,24 g 1,4752 C08DA01 Verapamil(P) 12,65 g 0,24 g 0,0001 C08DB Benzothiazepine derivatives 0,0902 C08DB01 Diltiazem(O) 10474,2 g 0,24 g 0,0902 C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM 203,0954 C09A ACE INHIBITORS, PLAIN 75,3170 C09AA ACE inhibitors, plain 75,3170 C09AA01 Captopril(O) 942,5 g 0,05 g 0,0390 C09AA02 Enalapril(O) 43829,85 g 0,01 g 9,0628 C09AA02 Enalapril(P) 9,3625 g 0,01 g 0,0019 C09AA03 Lisinopril(O) 0,56 g 0,01 g 0,0001 C09AA04 Perindopril(O) 12741,54 g 0,004 g 6,5865 C09AA05 Ramipril(O) 65538,64 g 2,5 mg 54,2062 C09AA09 Fosinopril(O) 38351,6 g 0,015 g 5,2867 C09AA10 Trandolapril(O) 129,528 g 0,002 g 0,1339 C09B ACE INHIBITORS, COMBINATIONS 53,2135 11/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C09BA ACE inhibitors and diuretics 28,4447 C09BA02 Enalapril+Hydrochlorothiazide(O) 3166190 pieces 1 pieces 6,5468 C09BA04 Perindopril+Indapamide(O) 8714640 pieces 1 pieces 18,0194 C09BA05 Ramipril+Hydrochlorothiazide(O) 1251870 pieces 1 pieces 2,5885 C09BA09 Fosinopril+Hydrochlorothiazide(O) 623854 pieces 1 pieces 1,2900 C09BB ACE inhibitors and calcium channel blockers 11,6784 C09BB03 Lisinopril+Amlodipine(O) 826200 pieces 1 pieces 1,7083 C09BB04 Perindopril+Amlodipine(O) 3760440 pieces 1 pieces 7,7755 C09BB07 Ramipril+Amlodipine(O) 715620 pieces 1 pieces 1,4797 C09BB10 Trandolapril+Verapamil(O) 345716 pieces 1 pieces 0,7148 C09BX ACE inhibitors, other combinations 13,0905 C09BX01 Perindopril+Amlodipine+Indapamide(O) 6330870 pieces 1 pieces 13,0905 C09C ANGIOTENSIN II RECEPTOR BLOCKERS (ARBS), PLAIN 43,0625 C09CA Angiotensin II receptor blockers (ARBs), plain 43,0625 C09CA01 Losartan(O) 94693,7 g 0,05 g 3,9160 C09CA02 Eprosartan(O) 1226,4 g 0,6 g 0,0042 C09CA03 Valsartan(O) 157357,76 g 0,08 g 4,0671 C09CA06 Candesartan(O) 39225,568 g 0,008 g 10,1384 C09CA07 Telmisartan(O) 426417,76 g 0,04 g 22,0428 C09CA08 Olmesartan medoxomil(O) 27991,88 g 0,02 g 2,8940 C09D ANGIOTENSIN II RECEPTOR BLOCKERS (ARBS), COMBINATIONS 31,5023 C09DA Angiotensin II receptor blockers (ARBs) and diuretics 14,7201 C09DA01 Losartan+Hydrochlorothiazide(O) 939154 pieces 1 pieces 1,9419 C09DA03 Valsartan+Hydrochlorothiazide(O) 825356 pieces 1 pieces 1,7066 C09DA06 Candesartan+Hydrochlorothiazide(O) 1044152 pieces 1 pieces 2,1590 C09DA07 Telmisartan+Hydrochlorothiazide(O) 4056654 pieces 1 pieces 8,3880 C09DA08 Olmesartan medoxomil+Hydrochlorothiazide(O) 253680 pieces 1 pieces 0,5245 C09DB Angiotensin II receptor blockers (ARBs) and calcium channel blockers 12,4258 C09DB01 Valsartan+Amlodipine(O) 154244 pieces 1 pieces 0,3189 C09DB02 Olmesartan medoxomil+Amlodipine(O) 2631132 pieces 1 pieces 5,4404 C09DB04 Telmisartan+Amlodipine(O) 3157952 pieces 1 pieces 6,5298 C09DB07 Candesartan+Amlodipine(O) 66080 pieces 1 pieces 0,1366 C09DX Angiotensin II receptor blockers (ARBs), other combinations 4,3564 C09DX01 Valsartan+Amlodipine+Hydrochlorothiazide(O) 2352 pieces 1 pieces 0,0049 C09DX03 Olmesartan medoxomil+Amlodipine+Hydrochlorothiazide(O) 1914808 pieces 1 pieces 3,9593 C09DX04 Valsartan+Sacubitril(O) 189728 pieces 1 pieces 0,3923 C10 LIPID MODIFYING AGENTS 69,0915 C10A LIPID MODIFYING AGENTS, PLAIN 67,6265 C10AA HMG CoA reductase inhibitors 66,5854 C10AA01 Simvastatin(O) 72665,36 g 0,03 g 5,0084 C10AA03 Pravastatin(O) 4533 g 0,03 g 0,3124 C10AA04 Fluvastatin(O) 15646,4 g 0,06 g 0,5392 C10AA05 Atorvastatin(O) 244735,5 g 0,02 g 25,3022 C10AA07 Rosuvastatin(O) 171315,16 g 0,01 g 35,4231 C10AB Fibrates 0,6214 C10AB05 Fenofibrate(O) 60108 g 0,2 g 0,6214 C10AC Bile acid sequestrants 0,0018 C10AC01 Colestyramine(O) 10000 g 14 g 0,0015 C10AC04 Colesevelam(O) 562,5 g 3,75 g 0,0003 C10AX Other lipid modifying agents 0,4179 C10AX09 Ezetimibe(O) 1964,76 g 0,01 g 0,4063 C10AX13 Evolocumab(P) 37,94 g 10 mg 0,0078 C10AX14 Alirocumab(P) 9,9 g 5,4 mg 0,0038 C10AX80 Omega-3-acid ethyl esters 90(O) 174692 pieces C10B LIPID MODIFYING AGENTS, COMBINATIONS 1,4650 HMG CoA reductase inhibitors in combination with other lipid modifying C10BA 0,6065 agents C10BA06 Rosuvastatin+Ezetimibe(O) 293310 pieces 1 pieces 0,6065 12/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C10BX HMG CoA reductase inhibitors, other combinations 0,8585 C10BX03 Atorvastatin+Amlodipine(O) 170280 pieces 1 pieces 0,3521 C10BX11 Atorvastatin+Amlodipine+Perindopril(O) 235410 pieces 1 pieces 0,4868 C10BX15 Atorvastatin+Perindopril(O) 9510 pieces 1 pieces 0,0197 D DERMATOLOGICALS 1,8669 D01 ANTIFUNGALS FOR DERMATOLOGICAL USE 1,2267 D01A ANTIFUNGALS FOR TOPICAL USE D01AC Imidazole and triazole derivatives D01AC01 Clotrimazole(C) 200 ml D01AC01 Clotrimazole(C) 662762,2 g D01AC05 Isoconazole(C) 224100 g D01AC08 Ketoconazole(C) 419839,8 g D01AC08 Ketoconazole(C) 1463040 ml D01AC80 Isoconazole+Diflucortolone(C) 530370 g D01AC81 Clotrimazole+Hexamidine(C) 149040 g D01AE Other antifungals for topical use D01AE14 Ciclopirox(C) 4613,4 ml D01AE15 Terbinafine(C) 630651 g D01AE16 Amorolfine(C) 20 g D01AE16 Amorolfine(C) 29172,5 ml D01AE22 Naftifine(C) 216310 ml D01AE22 Naftifine(C) 290235 g D01B ANTIFUNGALS FOR SYSTEMIC USE 1,2267 D01BA Antifungals for systemic use 1,2267 D01BA01 Griseofulvin(O) 585 g 0,5 g 0,0024 D01BA02 Terbinafine(O) 148024,5 g 0,25 g 1,2243 D02 EMOLLIENTS AND PROTECTIVES D02A EMOLLIENTS AND PROTECTIVES D02AB Zinc products D02AB80 Zinc oxide(C) 409860 g D02AE Carbamide products D02AE01 Urea(C) 109450 g D02AF Salicylic acid preparations D02AF81 Salicylic acid+Lactic acid(C) 15 ml D02B PROTECTIVES AGAINST UV-RADIATION D02BA Protectives against UV-radiation for topical use D02BA01 4-Aminobenzoic acid(O) 14160 g D03 PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS D03A CICATRIZANTS D03AX Other cicatrizants D03AX03 Dexpanthenol(C) 4235255 g D03AX81 Heparin sodium+Allantoin+Extract of Cepae(C) 129420 g D03AX83 Dexpanthenol+Chlorhexidine(C) 1952130 g D05 ANTIPSORIATICS 0,0536 D05A ANTIPSORIATICS FOR TOPICAL USE D05AA Tars D05AA85 Coal tar+Salicylic acid(C) 315400 ml D05AC Antracen derivatives D05AC01 Dithranol(C) 1500 g D05AX Other antipsoriatics for topical use D05AX02 Calcipotriol(C) 210 g D05AX80 Calcipotriol+Betamethasone(C) 822210 g D05B ANTIPSORIATICS FOR SYSTEMIC USE 0,0536 D05BB Retinoids for treatment of psoriasis 0,0536 D05BB02 Acitretin(O) 906,9 g 0,035 g 0,0536 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR D06 DERMATOLOGICAL USE D06A ANTIBIOTICS FOR TOPICAL USE D06AA Tetracycline and derivatives D06AA04 Tetracycline(C) 3035 g 13/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day D06AX Other antibiotics for topical use D06AX01 Fusidic acid(C) 212160 g D06AX02 Chloramphenicol(C) 375 g D06AX09 Mupirocin(C) 4335 g D06AX80 Bacitracin+Neomycin(C) 170440 g D06AX84 Chloramphenicol+Methyluracil(C) 1600 g D06B CHEMOTHERAPEUTICS FOR TOPICAL USE D06BA Sulfonamides D06BA01 Silver sulfadiazine(C) 1528200 g D06BB Antivirals D06BB03 Aciclovir(C) 257101 g D06BB04 Podophyllotoxin(C) 2826 ml D06BB06 Penciclovir(C) 4084 g D06BB10 Imiquimod(C) 3160 g D06BX Other chemotherapeutics D06BX01 Metronidazole (C) 136960 g D06BX02 Ingenol mebutate(C) 0,0002 g D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS D07A CORTICOSTEROIDS, PLAIN D07AA Corticosteroids, weak (group I) D07AA02 Hydrocortisone(C) 632620 g D07AB Corticosteroids, moderately potent (group II) D07AB09 Triamcinolone(C) 40290 g D07AC Corticosteroids, potent (group III) D07AC01 Betamethasone(C) 151155 g D07AC04 Fluocinolone acetonide(C) 30 g D07AC13 Mometasone(C) 325780 ml D07AC13 Mometasone(C) 1162600 g D07AC14 Methylprednisolone aceponate(C) 577100 g D07AC17 Fluticasone(C) 56400 g D07AD Corticosteroids, very potent (group IV) D07AD01 Clobetasol(C) 91200 ml D07AD01 Clobetasol(C) 935425 g D07B CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS D07BA Corticosteroids, weak, combinations with antiseptics D07BA80 Hydrocortisone+Chlorhexidine(C) 367740 g D07BC Corticosteroids, potent, combinations with antiseptics D07BC80 Betamethasone+Salicylic acid(C) 5105 g D07BC80 Betamethasone+Salicylic acid(C) 909000 ml D07C CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS D07CA Corticosteroids, weak, combinations with antibiotics D07CA83 Hydrocortisone+Fusidic acid(C) 82290 g D07CC Corticosteroids, potent, combinations with antibiotics D07CC80 Betamethasone+Fusidic acid(C) 522780 g D07CC83 Betamethasone+Gentamicin(C) 200 g D07X CORTICOSTEROIDS, OTHER COMBINATIONS D07XA Corticosteroids, weak, other combinations D07XA81 Prednisolone+Salicylic acid(C) 199500 ml D07XC Corticosteroids, potent, other combinations D07XC03 Mometasone+Salicylic acid(C) 10350 g D08 ANTISEPTICS AND DISINFECTANTS D08A ANTISEPTICS AND DISINFECTANTS D08AG Iodine products D08AG02 Povidone, iodinated(C) 969130 ml D08AG02 Povidone, iodinated(C) 3450150 g D08AG03 Iodine(C) 795620 ml D08AJ Quaternary ammonium compounds D08AJ81 Octenidine+Phenoxyethanol(C) 9997450 ml D08AX Other antiseptics and disinfectants D08AX82 Tar+Castor oil+Xeroformium(C) 9960 g 14/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day D08AX83 Brilliant Green(C) 286130 ml D10 ANTI-ACNE PREPARATIONS 0,5178 D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE D10AD Retinoids for topical use in acne D10AD01 Tretinoin(C) 30570 g D10AD03 Adapalene(C) 134130 g D10AD80 Adapalene+Benzoyl peroxide(C) 25410 g D10AD81 Tretinoin+Erythromycin(C) 58080 g D10AF Antiinfectives for treatment of acne D10AF02 Erythromycin(C) 256900 ml D10AF81 Clindamycin+Benzoyl peroxide(C) 301575 g D10AF82 Clindamycin+Tretinoin(C) 150720 g D10AX Other anti-acne preparations for topical use D10AX03 Azelaic acid(C) 262410 g D10B ANTI-ACNE PREPARATIONS FOR SYSTEMIC USE 0,5178 D10BA Retinoids for treatment of acne 0,5178 D10BA01 Isotretinoin(O) 7513,2 g 0,03 g 0,5178 D11 OTHER DERMATOLOGICAL PREPARATIONS 0,0687 D11A OTHER DERMATOLOGICAL PREPARATIONS 0,0687 D11AH Agents for dermatitis, excluding corticosteroids 0,0064 D11AH01 Tacrolimus(C) 56700 g D11AH02 Pimecrolimus(C) 196500 g D11AH05 Dupilumab(P) 66 g 21,4 mg 0,0064 D11AX Other dermatologicals 0,0624 D11AX01 Minoxidil(C) 93600 ml D11AX10 Finasteride(O) 30,156 g 0,001 g 0,0624 D11AX16 Eflornithine(C) 210 g D11AX22 Ivermectin(C) 71700 g D11AX82 Hydroquinone+Fluocinolone acetonide+Tretinoin(C) 30 g G GENITO URINARY SYSTEM AND SEX HORMONES 56,5981 G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS 0,9380 ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS G01A 0,9380 WITH CORTICOSTEROIDS G01AA Antibiotics 0,1489 G01AA10 Clindamycin(V) 7200,7 g 0,1 g 0,1489 G01AA80 Nystatin+Neomycin+Polymyxin B(V) 60 pieces G01AC Quinoline derivatives 0,0431 G01AC05 Dequalinium(V) 417,3 g 20 mg 0,0431 G01AF Imidazole derivatives 0,7460 G01AF01 Metronidazole (V) 12514 g 0,5 g 0,0518 G01AF02 Clotrimazole(V) 28968,8 g 0,1 g 0,5990 G01AF05 Econazole(V) 4606,2 g 0,1 g 0,0952 G02 OTHER GYNECOLOGICALS 4,3078 G02A UTEROTONICS 0,0956 G02AB Ergot alkaloids 0,0018 G02AB01 Methylergometrine(P) 0,1738 g 0,2 mg 0,0018 G02AD Prostaglandins 0,0938 G02AD02 Dinoprostone(P) 0,46 g G02AD02 Dinoprostone(V) 2,0649 g 0,5 mg 0,0085 G02AD06 Misoprostol(O) 8,2488 g 0,2 mg 0,0853 G02B CONTRACEPTIVES FOR TOPICAL USE 2,6245 G02BA Intrauterine contraceptives 0,0190 G02BA03 Levonorgestrel(V) 9176 pieces 1 pieces 0,0190 G02BB Intravaginal contraceptives 2,6055 G02BB01 Etonogestrel+Ethinylestradiol(V) 44021 pieces 0,036 pieces 2,5284 G02BB81 Benzalkonium chloride(V) 37300 pieces 1 pieces 0,0771 G02BB81 Benzalkonium chloride(V) 48240 g G02C OTHER GYNECOLOGICALS 1,5877 G02CA Sympathomimetics, labour repressants G02CA80 Hexoprenaline(P) 0,0222 g 15/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day G02CB Prolactine inhibitors 0,1534 G02CB01 Bromocriptine(O) 308,05 g 0,005 g 0,1274 G02CB03 Cabergoline(O) 6,3 g 0,5 mg 0,0261 G02CX Other gynecologicals 1,4342 G02CX01 Atosiban(P) 0,9375 g 0,165 g <0,0001 G02CX03 Agni casti fructus(O) 396270 pieces 1 pieces 0,8194 G02CX04 Cimicifugae rhizoma(O) 594690 pieces 2 pieces 0,6148 G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM 31,9661 G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE 25,5811 G03AA Progestogens and estrogens, fixed combinations 20,5113 G03AA07 Levonorgestrel+Ethinylestradiol(O) 174027 pieces 1 pieces 0,3598 G03AA09 Desogestrel+Ethinylestradiol(O) 471996 pieces 0,75 pieces 1,3013 G03AA10 Gestodene+Ethinylestradiol(O) 24164 pieces 1 pieces 0,0500 G03AA10 Gestodene+Ethinylestradiol(O) 2257689 pieces 0,75 pieces 6,2244 G03AA12 Drospirenone+Ethinylestradiol(O) 1144052 pieces 1 pieces 2,3656 G03AA12 Drospirenone+Ethinylestradiol(O) 1887102 pieces 0,75 pieces 5,2027 G03AA13 Norelgestromin+Ethinylestradiol(TD) 93681 pieces 0,107 pieces 1,8103 G03AA15 Chlormadinone+Ethinylestradiol(O) 184716 pieces 0,75 pieces 0,5093 G03AA16 Dienogest+Ethinylestradiol(O) 361200 pieces 1 pieces 0,7469 G03AA16 Dienogest+Ethinylestradiol(O) 704109 pieces 0,75 pieces 1,9412 G03AB Progestogens and estrogens, sequential preparations 0,1749 G03AB05 Desogestrel+Ethinylestradiol(O) 4092 pieces 0,75 pieces 0,0113 G03AB08 Dienogest+Estradiol valerate(O) 79128 pieces 1 pieces 0,1636 G03AC Progestogens 4,8117 G03AC08 Etonogestrel(P) 66,572 g 68 mcg 2,0243 G03AC09 Desogestrel(O) 1348060 pieces 1 pieces 2,7874 G03AD Emergency contraceptives 0,0832 G03AD01 Levonorgestrel(O) 58,026 g 1,5 mg 0,0800 G03AD02 Ulipristal(O) 46,65 g 0,03 g 0,0032 G03B ANDROGENS 0,2302 G03BA 3-oxoandrosten (4) derivatives 0,2302 G03BA03 Testosterone(C) 22,5 g 0,05 g 0,0009 G03BA03 Testosterone(O) 7,2 g 0,12 g 0,0001 G03BA03 Testosterone(P) 1994,25 g 0,018 g 0,2291 G03BA03 Testosterone(TD) 2,576 g 0,05 g 0,0001 G03C ESTROGENS 1,6383 G03CA Natural and semisynthetic estrogens, plain 1,6328 G03CA03 Estradiol(C, V) 106075 g G03CA03 Estradiol(O) 774,816 g 2 mg 0,8011 G03CA03 Estradiol(TD) 0,0336 g 0,05 mg 0,0014 G03CA03 Estradiol(TD) 21,3343 g 1,53 mg 0,0288 G03CA03 Estradiol(TD) 68,8835 g 1 mg 0,1424 G03CA03 Estradiol(V) 5,3221 g 0,025 mg 0,4402 G03CA04 Estriol(O) 0,45 g 0,002 g 0,0005 G03CA04 Estriol(V) 21,1275 g 0,2 mg 0,2184 G03CA80 Estradiol+Prednisolone(C) 77725 g G03CX Other estrogens 0,0055 G03CX01 Tibolone(O) 6,65 g 2,5 mg 0,0055 G03D PROGESTOGENS 1,4796 G03DA Pregnen (4) derivatives 0,6687 G03DA02 Medroxyprogesterone(O) 46,05 g 0,005 g 0,0190 G03DA02 Medroxyprogesterone(P) 266,055 g 0,007 g 0,0786 G03DA04 Progesterone(O) 30234 g 0,3 g 0,2084 G03DA04 Progesterone(P) 201,225 g 0,005 g 0,0832 G03DA04 Progesterone(V) 12163,95 g 0,09 g 0,2795 G03DB Pregnadien derivatives 0,8109 G03DB01 Dydrogesterone(O) 3106,6 g 0,01 g 0,6424 G03DB08 Dienogest(O) 163,016 g 2 mg 0,1685 G03F PROGESTOGENS AND ESTROGENS IN COMBINATION 2,1512 16/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day G03FA Progestogens and estrogens, fixed combinations 1,6917 G03FA01 Norethisterone+Estradiol(O) 526260 pieces 1 pieces 1,0882 G03FA14 Dydrogesterone+Estradiol(O) 116452 pieces 1 pieces 0,2408 G03FA17 Drospirenone+Estradiol(O) 175420 pieces 1 pieces 0,3627 G03FA80 Medroxyprogesterone+Estradiol(O) 168 pieces G03FB Progestogens and estrogens, sequential preparations 0,4595 G03FB05 Norethisterone+Estradiol(O) 174916 pieces 1 pieces 0,3617 G03FB08 Dydrogesterone+Estradiol(O) 47320 pieces 1 pieces 0,0978 G03G GONADOTROPINS AND OTHER OVULATION STIMULANTS 0,3838 G03GA Gonadotropins 0,1569 G03GA01 Chorionic gonadotrophin(P) 40000 U 250 U 0,0003 G03GA05 Follitropin alfa(P) 4909125 U 75 U 0,1353 G03GA07 Lutropin alfa(P) 384075 U 75 U 0,0106 G03GA08 Choriogonadotropin alfa(P) 0,9128 g 0,25 mg 0,0075 G03GA30 Follitropin alfa+Lutropin alfa(P) 1490 doses 1 doses 0,0031 G03GB Ovulation stimulants, synthetic 0,2269 G03GB02 Clomifene(O) 987,7 g 0,009 g 0,2269 G03H ANTIANDROGENS 0,4714 G03HA Antiandrogens, plain 0,1183 G03HA01 Cyproterone(O) 5722,5 g 0,1 g 0,1183 G03HB Antiandrogens and estrogens 0,3531 G03HB01 Cyproterone+Estrogen(O) 128058 pieces 0,75 pieces 0,3531 OTHER SEX HORMONES AND MODULATORS OF THE GENITAL G03X 0,0305 SYSTEM G03XA Antigonadotropins and similar agents 0,0008 G03XA01 Danazol(O) 240 g 0,6 g 0,0008 G03XB Progesterone receptor modulators 0,0296 G03XB01 Mifepristone(O) 803,4 g 0,6 g 0,0028 G03XB02 Ulipristal(O) 64,96 g 5 mg 0,0269 G04 UROLOGICALS 19,3862 G04B UROLOGICALS 3,1912 G04BD Drugs for urinary frequency and incontinence 1,8302 G04BD04 Oxybutynin(O) 4754,4 g 0,015 g 0,6554 G04BD06 Propiverine(O) 8,82 g 0,03 g 0,0006 G04BD07 Tolterodine(O) 519,736 g 0,004 g 0,2687 G04BD08 Solifenacin(O) 588,6 g 0,005 g 0,2434 G04BD09 Trospium chloride(O) 3496,95 g 0,04 g 0,1808 G04BD12 Mirabegron(O) 11640 g 50 mg 0,4814 G04BE Drugs used in erectile dysfunction 1,3477 G04BE01 Alprostadil(P) 0,0722 g 0,02 mg 0,0075 G04BE01 Alprostadil(urethral) 0,006 g 0,25 mg <0,0001 G04BE03 Sildenafil(O) 24328 g 0,05 g 1,0061 G04BE08 Tadalafil(O) 1339,24 g 0,01 g 0,2769 G04BE09 Vardenafil(O) 30,72 g 0,01 g 0,0064 G04BE10 Avanafil(O) 2460 g 0,1 g 0,0509 G04BX Other urologicals 0,0133 G04BX14 Dapoxetin(O) 192,87 g 0,03 g 0,0133 G04BX80 Centaury+Lovage root+Rosemary leaf(O) 1028220 pieces G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY 16,1950 G04CA Alpha-adrenoreceptor antagonists 13,3268 G04CA01 Alfuzosin(O) 8090,4 g 7,5 mg 2,2305 G04CA02 Tamsulosin(O) 1511,76 g 0,4 mg 7,8147 G04CA04 Silodosin(O) 573,12 g 8 mg 0,1481 G04CA52 Tamsulosin+Dutasteride(O) 1515420 pieces 1 pieces 3,1335 G04CB Testosterone-5-alpha reductase inhibitors 0,5733 G04CB01 Finasteride(O) 341,05 g 0,005 g 0,1410 G04CB02 Dutasteride(O) 104,535 g 0,5 mg 0,4323 G04CX Other drugs used in benign prostatic hypertrophy 2,2949 G04CX02 Sabalis serrulatae fructus(O) 355152 g 0,32 g 2,2949 17/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES H 29,7102 AND INSULINS H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES 0,4330 H01A ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES 0,1540 H01AA ACTH 0,0001 H01AA02 Tetracosactide(P) 0,0107 g 0,25 mg 0,0001 H01AB Thyrotropin 0,0007 H01AB01 Thyrotropin alfa(P) 0,3078 g 0,9 mg 0,0007 H01AC Somatropin and somatropin agonists 0,1364 H01AC01 Somatropin(P) 131899,5347 U 2 U 0,1364 H01AX Other anterior pituitary lobe hormones and analogues 0,0168 H01AX01 Pegvisomant(P) 81,3 g 0,01 g 0,0168 H01B POSTERIOR PITUITARY LOBE HORMONES 0,1520 H01BA Vasopressin and analogues 0,0949 H01BA01 Argipressin(P) 12600 U 40 U 0,0007 H01BA02 Desmopressin(N) 0,0383 g 0,025 mg 0,0032 H01BA02 Desmopressin(P) 0,0191 g 0,004 mg 0,0098 H01BA02 Desmopressin(SL) 9,4284 g 0,24 mg 0,0812 H01BB Oxytocin and analogues 0,0571 H01BB01 Demoxytocin(O) 1206500 U 100 U 0,0249 H01BB02 Oxytocin(P) 227900 U 15 U 0,0314 H01BB03 Carbetocin(P) 0,0348 g 0,1 mg 0,0007 H01C HYPOTHALAMIC HORMONES 0,1271 H01CA Gonadotropin-releasing hormones H01CA01 Gonadorelin(P) 0,0041 g H01CB Somatostatin and analogues 0,1057 H01CB02 Octreotide(P) 13,1715 g 0,7 mg 0,0389 H01CB03 Lanreotide(P) 84,18 g 3 mg 0,0580 H01CB05 Pasireotide(P) 5,07 g 1,2 mg 0,0087 H01CC Anti-gonadotropin-releasing hormones 0,0214 H01CC02 Cetrorelix(P) 2,5893 g 0,25 mg 0,0214 H02 CORTICOSTEROIDS FOR SYSTEMIC USE 8,7530 H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN 8,7469 H02AA Mineralocorticoids 0,1618 H02AA02 Fludrocortisone(O) 7,825 g 0,1 mg 0,1618 H02AB Glucocorticoids 8,5851 H02AB01 Betamethasone(P) 18,488 g 1,5 mg 0,0255 H02AB02 Dexamethasone(O) 833,815 g 1,5 mg 1,1494 H02AB02 Dexamethasone(P) 743,1 g 1,5 mg 1,0243 H02AB04 Methylprednisolone(O) 7413,2 g 7,5 mg 2,0438 H02AB04 Methylprednisolone(P) 5143,765 g 0,02 g 0,5318 H02AB06 Prednisolone(O) 12503 g 0,01 g 2,5853 H02AB06 Prednisolone(P) 2400,45 g 0,01 g 0,4963 H02AB08 Triamcinolone(O) 13,4 g 7,5 mg 0,0037 H02AB08 Triamcinolone(P) 1572,9 g 7,5 mg 0,4336 H02AB09 Hydrocortisone(O) 3511,15 g 0,03 g 0,2420 H02AB09 Hydrocortisone(P) 716,2 g 0,03 g 0,0494 H02B CORTICOSTEROIDS FOR SYSTEMIC USE, COMBINATIONS 0,0060 H02BX Corticosteroids for systemic use, combinations 0,0060 H02BX80 Hydrocortisone+Lidocaine(P) 87,5 g 0,03 g 0,0060 H03 THYROID THERAPY 20,4827 H03A THYROID PREPARATIONS 19,1590 H03AA Thyroid hormones 19,1590 H03AA01 Levothyroxine sodium(O) 1389,735 g 0,15 mg 19,1572 H03AA02 Liothyronine(O) 0,0528 g 0,06 mg 0,0018 H03AA03 Levothyroxine sodium+Liothyronine(O) 1500 pieces H03AA04 Tiratricol(O) 0,63 g H03B ANTITHYROID PREPARATIONS 1,3237 H03BA Thiouracils 0,1460 18/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day H03BA02 Propylthiouracil(O) 7061,8 g 0,1 g 0,1460 H03BB Sulfur-containing imidazole derivatives 1,1777 H03BB02 Thiamazole(O) 5695,5 g 0,01 g 1,1777 H03BC Perchlorates H03BC02 Sodium perchlorate(O) 24 g H04 PANCREATIC HORMONES 0,0011 H04A GLYCOGENOLYTIC HORMONES 0,0011 H04AA Glycogenolytic hormones 0,0011 H04AA01 Glucagon(P) 0,53 g 0,001 g 0,0011 H05 CALCIUM HOMEOSTASIS 0,0404 H05B ANTI-PARATHYROID AGENTS 0,0404 H05BX Other anti-parathyroid agents 0,0404 H05BX01 Cinacalcet(O) 949,2 g 0,06 g 0,0327 H05BX02 Paricalcitol(O) 0,0074 g 2 mcg 0,0077 J ANTIINFECTIVES FOR SYSTEMIC USE 19,2087 J01 ANTIBACTERIALS FOR SYSTEMIC USE 11,9736 J01A TETRACYCLINES 1,3846 J01AA Tetracyclines 1,3846 J01AA02 Doxycycline(O) 66939 g 0,1 g 1,3841 J01AA08 Minocycline(O) 7,5 g 0,2 g 0,0001 J01AA12 Tigecycline(P) 20 g 0,1 g 0,0004 J01C BETA-LACTAM ANTIBACTERIALS, PENICILLINS 4,2870 J01CA Penicillins with extended spectrum 1,6833 J01CA01 Ampicillin(P) 23700 g 6 g 0,0082 J01CA04 Amoxicillin(O) 1215205 g 1,5 g 1,6751 J01CE Beta-lactamase sensitive penicillins 0,1596 J01CE01 Benzylpenicillin(P) 34860 g 3,6 g 0,0200 J01CE02 Phenoxymethylpenicillin(O) 133958,4 g 2 g 0,1385 J01CE08 Benzathine benzylpenicillin(P) 1803,6 g 3,6 g 0,0010 J01CE80 Benzathine benzylpenicillin+Procaine benzylpenicillin(P) 34,2 g 3,6 g <0,0001 J01CF Beta-lactamase resistant penicillins 0,0976 J01CF04 Oxacillin(P) 94300 g 2 g 0,0975 J01CF05 Flucloxacillin(O) 140 g 2 g 0,0001 J01CR Combinations of penicillins, incl. beta-lactamase inhibitors 2,3465 J01CR01 Ampicillin+Sulbactam(P) 125827 g 6 g 0,0434 J01CR02 Amoxicillin+Clavulanic acid(O) 1464285,55 g 1,5 g 2,0185 J01CR02 Amoxicillin+Clavulanic acid(P) 241480 g 3 g 0,1664 J01CR04 Sultamicillin(O) 56457 g 1,5 g 0,0778 J01CR05 Piperacillin+Tazobactam(P) 273328 g 14 g 0,0404 J01D OTHER BETA-LACTAM ANTIBACTERIALS 1,6932 J01DB First-generation cephalosporins 0,2473 J01DB01 Cefalexin(O) 60 g 2 g 0,0001 J01DB04 Cefazolin(P) 105710 g 3 g 0,0729 J01DB05 Cefadroxil(O) 168641 g 2 g 0,1744 J01DC Second-generation cephalosporins 1,3172 J01DC01 Cefoxitin(P) 10452 g 6 g 0,0036 J01DC02 Cefuroxime(O) 257183 g 0,5 g 1,0636 J01DC02 Cefuroxime(P) 283935 g 3 g 0,1957 J01DC10 Cefprozil(O) 26277 g 1 g 0,0543 J01DD Third-generation cephalosporins 0,0523 J01DD01 Cefotaxime(P) 46930 g 4 g 0,0243 J01DD02 Ceftazidime(P) 13712 g 4 g 0,0071 J01DD04 Ceftriaxone(P) 19600 g 2 g 0,0203 J01DD81 Ceftazidime+Avibactam(P) 2120 g 6 g 0,0007 J01DE Fourth-generation cephalosporins 0,0101 J01DE01 Cefepime(P) 19630 g 4 g 0,0101 J01DH Carbapenems 0,0662 J01DH02 Meropenem(P) 45205 g 3 g 0,0312 J01DH03 Ertapenem(P) 10333 g 1 g 0,0214 J01DH51 Imipenem+Cilastatin(P) 13210 g 2 g 0,0137 19/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J01DI Other cephalosporins and penems <0,0001 J01DI54 Ceftolozane+Tazobactam(P) 60 g 3 g <0,0001 J01E SULFONAMIDES AND TRIMETHOPRIM 0,4532 J01EA Trimethoprim and derivatives 0,0229 J01EA01 Trimethoprim(O) 4431 g 0,4 g 0,0229 J01EE Combinations of sulfonamides and trimethoprim, incl. derivatives 0,4303 J01EE01 Sulfamethoxazole+Trimethoprim(O) 400 pieces 4 pieces 0,0002 J01EE01 Sulfamethoxazole+Trimethoprim(O) 374500 pieces 2 pieces 0,3872 J01EE01 Sulfamethoxazole+Trimethoprim(O) 719100 ml 40 ml 0,0372 J01EE01 Sulfamethoxazole+Trimethoprim(P) 55570 ml 20 ml 0,0057 J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS 2,4893 J01FA Macrolides 2,3132 J01FA01 Erythromycin(O) 50 g 1 g 0,0001 J01FA01 Erythromycin(P) 130 g 1 g 0,0003 J01FA09 Clarithromycin(O) 417627 g 0,5 g 1,7271 J01FA09 Clarithromycin(P) 3239,5 g 1 g 0,0067 J01FA10 Azithromycin(O) 84004,4 g 0,3 g 0,5790 J01FA10 Azithromycin(P) 7 g 0,5 g <0,0001 J01FF Lincosamides 0,1761 J01FF01 Clindamycin(O) 95548,8 g 1,2 g 0,1646 J01FF01 Clindamycin(P) 10005 g 1,8 g 0,0115 J01G AMINOGLYCOSIDE ANTIBACTERIALS 0,0241 J01GB Other aminoglycosides 0,0241 J01GB01 Tobramycin(I) 100,352 g 0,112 g 0,0019 J01GB01 Tobramycin(I) 470,4 g 0,3 g 0,0032 J01GB03 Gentamicin(P) 1631,025 g 0,24 g 0,0141 J01GB06 Amikacin(P) 2415 g 1 g 0,0050 J01M QUINOLONE ANTIBACTERIALS 0,7739 J01MA Fluoroquinolones 0,7739 J01MA01 Ofloxacin(O) 3308 g 0,4 g 0,0171 J01MA02 Ciprofloxacin(O) 267965 g 1 g 0,5541 J01MA02 Ciprofloxacin(P) 12164,5 g 0,8 g 0,0314 J01MA06 Norfloxacin(O) 46536 g 0,8 g 0,1203 J01MA12 Levofloxacin(O) 3202,5 g 0,5 g 0,0132 J01MA12 Levofloxacin(P) 385 g 0,5 g 0,0016 J01MA14 Moxifloxacin(O) 6818 g 0,4 g 0,0352 J01MA14 Moxifloxacin(P) 184 g 0,4 g 0,0010 J01X OTHER ANTIBACTERIALS 0,8682 J01XA Glycopeptide antibacterials 0,0229 J01XA01 Vancomycin(P) 22075 g 2 g 0,0228 J01XA02 Teicoplanin(P) 13,6 g 0,4 g 0,0001 J01XB Polymyxins 0,0019 J01XB01 Colistin(I, P) 1740000000 U 9000000 U 0,0004 J01XB01 Colistin(P) 6430000000 U 9000000 U 0,0015 J01XC Steroid antibacterials 0,0002 J01XC01 Fusidic acid(O) 150 g 1,5 g 0,0002 J01XD Imidazole derivatives 0,2389 J01XD01 Metronidazole (O) 193175 g 2 g 0,1997 J01XD01 Metronidazole (P) 28415 g 1,5 g 0,0392 J01XE Nitrofuran derivatives 0,5830 J01XE01 Nitrofurantoin(O) 56394 g 0,2 g 0,5830 J01XX Other antibacterials 0,0213 J01XX01 Fosfomycin(O) 4881 g 3 g 0,0034 J01XX08 Linezolid(O) 8862 g 1,2 g 0,0153 J01XX08 Linezolid(P) 1482 g 1,2 g 0,0026 J01XX09 Daptomycin(P) 21 g 0,28 g 0,0002 J02 ANTIMYCOTICS FOR SYSTEMIC USE 0,3666 J02A ANTIMYCOTICS FOR SYSTEMIC USE 0,3666 J02AA Antibiotics 0,0089 20/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J02AA01 Amphotericin(O) 315 g J02AA01 Amphotericin(P) 151,35 g 0,035 g 0,0089 J02AB Imidazole derivatives 0,0002 J02AB02 Ketoconazole(O) 20 g 0,2 g 0,0002 J02AC Triazole derivatives 0,3493 J02AC01 Fluconazole(O) 12330,4 g 0,2 g 0,1275 J02AC01 Fluconazole(P) 3068,6 g 0,2 g 0,0317 J02AC02 Itraconazole(O) 15006,2 g 0,2 g 0,1551 J02AC03 Voriconazole(O) 2446,4 g 0,4 g 0,0126 J02AC03 Voriconazole(P) 212,8 g 0,4 g 0,0011 J02AC04 Posaconazole(O) 2971,2 g 0,3 g 0,0205 J02AC05 Isavuconazole(O) 39,2 g 0,2 g 0,0004 J02AC05 Isavuconazole(P) 30,4 g 0,2 g 0,0003 J02AX Other antimycotics for systemic use 0,0081 J02AX04 Caspofungin(P) 76,95 g 0,05 g 0,0032 J02AX06 Anidulafungin(P) 240,1 g 0,1 g 0,0050 J04 ANTIMYCOBACTERIALS 0,1140 J04A DRUGS FOR TREATMENT OF TUBERCULOSIS 0,0943 J04AB Antibiotics 0,0302 J04AB01 Cycloserine(O) 7000 g 0,75 g 0,0193 J04AB02 Rifampicin(O) 3090 g 0,6 g 0,0106 J04AB02 Rifampicin(P) 84 g 0,6 g 0,0003 J04AC Hydrazides 0,0031 J04AC01 Isoniazid(O) 450 g 0,3 g 0,0031 J04AD Thiocarbamide derivatives 0,0110 J04AD01 Protionamide(O) 4000 g 0,75 g 0,0110 J04AK Other drugs for treatment of tuberculosis 0,0096 J04AK03 Terizidone(O) 137,5 g J04AK05 Bedaquiline(O) 225,6 g 86 mg 0,0054 J04AK06 Delamanid(O) 408 g 0,2 g 0,0042 J04AM Combinations of drugs for treatment of tuberculosis 0,0403 J04AM02 Rifampicin+Isoniazid(O) 12000 pieces 4 pieces 0,0062 J04AM02 Rifampicin+Isoniazid(O) 33000 pieces 2 pieces 0,0341 J04B DRUGS FOR TREATMENT OF LEPRA 0,0196 J04BA Drugs for treatment of lepra 0,0196 J04BA01 Clofazimine(O) 380 g 0,1 g 0,0079 J04BA02 Dapsone(O) 285 g 0,05 g 0,0118 J05 ANTIVIRALS FOR SYSTEMIC USE 6,7546 J05A DIRECT ACTING ANTIVIRALS 6,7546 J05AB Nucleosides and nucleotides excl. reverse transcriptase inhibitors 0,3683 J05AB01 Aciclovir(O) 317568,62 g 4 g 0,1642 J05AB01 Aciclovir(P) 2950 g 4 g 0,0015 J05AB06 Ganciclovir(P) 196 g 0,5 g 0,0008 J05AB11 Valaciclovir(O) 277732 g 3 g 0,1914 J05AB14 Valganciclovir(O) 4537 g 0,9 g 0,0104 J05AD Phosphonic acid derivatives 0,0011 J05AD01 Foscarnet sodium(P) 3420 g 6,5 g 0,0011 J05AF Nucleoside and nucleotide reverse transcriptase inhibitors 0,1005 J05AF01 Zidovudine(O) 356 g 0,6 g 0,0012 J05AF01 Zidovudine(P) 25 g 0,6 g 0,0001 J05AF05 Lamivudine(O) 1210 g 0,3 g 0,0083 J05AF06 Abacavir(O) 1850,4 g 0,6 g 0,0064 J05AF07 Tenofovir disoproxil(O) 58,8 g 0,245 g 0,0005 J05AF10 Entecavir(O) 19,875 g 0,5 mg 0,0822 J05AF13 Tenofovir alafenamide(O) 21 g 25 mg 0,0017 J05AG Non-nucleoside reverse transcriptase inhibitors 0,9683 J05AG03 Efavirenz(O) 76320 g 0,6 g 0,2630 J05AG05 Rilpivirine(O) 8527,5 g 25 mg 0,7053 J05AH Neuraminidase inhibitors 0,2697 21/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J05AH02 Oseltamivir(O) 19565,25 g 0,15 g 0,2697 J05AP Antivirals for treatment of HCV infections 0,1316 J05AP01 Ribavirin(O) 1013,6 g 1 g 0,0021 J05AP54 Elbasvir+Grazoprevir(O) 5208 pieces 1 pieces 0,0108 J05AP55 Sofosbuvir+Velpatasvir(O) 6188 pieces 1 pieces 0,0128 J05AP57 Glecaprevir+Pibrentasvir(O) 153720 pieces 3 pieces 0,1059 J05AR Antivirals for treatment of HIV infections, combinations 3,9775 J05AR01 Zidovudine+Lamivudine(O) 128640 pieces 2 pieces 0,1330 J05AR02 Lamivudine+Abacavir(O) 367740 pieces 1 pieces 0,7604 J05AR03 Tenofovir disoproxil+Emtricitabine(O) 783120 pieces 1 pieces 1,6193 J05AR09 Elvitegravir+Cobicistat+Emtricitabine+Tenofovir disoproxil(O) 6120 pieces 1 pieces 0,0127 J05AR13 Lamivudine+Abacavir+Dolutegravir(O) 183990 pieces 1 pieces 0,3804 J05AR14 Darunavir+Cobicistat(O) 517620 pieces 1 pieces 1,0703 J05AR18 Emtricitabine+Tenofovir alafenamide+Elvitegravir+Cobicistat(O) 720 pieces 1 pieces 0,0015 J05AX Other antivirals 0,9376 J05AX08 Raltegravir(O) 342474 g 0,8 g 0,8852 J05AX12 Dolutegravir(O) 1267,05 g 50 mg 0,0524 J06 IMMUNE SERA AND IMMUNOGLOBULINS J06A IMMUNE SERA J06AA Immune sera J06AA03 Snake venom antiserum(P) 20 pieces J06B IMMUNOGLOBULINS J06BA Immunoglobulins, normal human J06BA01 Immunoglobulins, normal human, for extravascular a(P) 10863,6 g J06BA02 Immunoglobulins, normal human, for intravascular a(P) 107765 g J06BA80 Human normal immunoglobulin(P) 500 g J06BB Specific immunoglobulins J06BB01 Human Anti-D Immunoglobulin(P) 2385000 U J06BB02 Tetanus immunoglobulin(P) 25000 U J06BB03 Varicella zoster immunoglobulin(P) 4375 U J06BB04 Hepatitis B immunoglobulin(P) 2560 U J06BB05 Rabies immunoglobulin(P) 3000 U J06BB09 Cytomegalovirus immunoglobulin(P) 70000 U J06BB16 Palivizumab(P) 60,1 g J07 VACCINES J07A BACTERIAL VACCINES J07AE Cholera vaccines J07AE01 Cholera, inactivated, whole cell(O) 20 doses J07AG Hemophilus influenzae B vaccines J07AG01 Haemophilus influenzae B, purified antigen conjugated(P) 190 doses J07AH Meningococcal vaccines Meningococcus, tetravalent purified polysaccharides antigen J07AH08 520 doses conjugated(P) J07AH09 Meningococcus B, multicomponent vaccine(P) 163 doses J07AL Pneumococcal vaccines J07AL01 Pneumococcus, purified polysaccharides antigen(P) 337 doses J07AL02 Pneumococcus, purified polysaccharides antigen conjugated(P) 2523 doses Pneumococcus, purified polysaccharides antigen+Haemophilus J07AL52 232 doses influenzae, conjugated(P) J07AM Tetanus vaccines J07AM51 Tetanus toxoid+Diphtheria toxoid(P) 28872 doses J07AN Tuberculosis vaccines J07AN01 Tuberculosis, live attenuated(P) 23950 doses J07AP Typhoid vaccines J07AP03 Typhoid, purified polysaccharide antigen(P) 2112 doses J07AX Other bacterial vaccines J07AX80 Diphtheria-tetanus-pertussis(P) 18985 doses J07B VIRAL VACCINES 22/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J07BA Encephalitis vaccines J07BA01 Encephalitis, tick borne, inactivated, whole virus(P) 120044 doses J07BB Influenza vaccines J07BB02 Influenza, inactivated, split virus or surface antigen(P) 167327 doses J07BC Hepatitis vaccines J07BC01 Hepatitis B, purified antigen(P) 4390 doses J07BC02 Hepatitis A, inactivated, whole virus(P) 8119 doses J07BC80 Hepatitis A, inactivated, whole virus+Hepatitis B, purified antigen(P) 3039 doses J07BD Measles vaccines Measles, live attunated+Rubella, live attenuated+Mumps, J07BD52 49093 doses live,attenuated(P) J07BF Poliomyelitis vaccines J07BF03 Poliomyelitis, trivalent, inactivated, whole virus(P) 672 doses J07BG Rabies vaccines J07BG01 Rabies, inactivated, whole virus(P) 2446 doses J07BH Rota virus diarrhea vaccines J07BH02 Rota virus, pentavalent, live, reassorted(O) 65364 doses J07BK Varicella zoster vaccines J07BK01 Varicella, live attenuated(P) 1338 doses J07BK02 Zoster, live attenuated(P) 55 doses J07BK03 Zoster, purified antigen(P) 2 doses J07BL Yellow fever vaccines J07BL01 Yellow fever, live attenuated(P) 1836 doses J07BM Papillomavirus vaccines J07BM02 Papillomavirus (human types 16, 18)(P) 26 doses J07BM03 Papillomavirus (human types 6, 11, 16, 18, 31, 33, 45, 52, 58)(P) 15253 doses J07C BACTERIAL AND VIRAL VACCINES, COMBINED J07CA Bacterial and viral vaccines, combined Diphtheria toxoid+Pertussis, purified antigen+Tetanus J07CA02 16251 doses toxoid+Poliomyelitis, trivalent, inactivated, whole virus(P) Diphtheria toxoid+Tetanus toxoid+Pertussis, purified J07CA06 antigen+Poliomyelitis, trivalent, inactivated, whole virus+Haemophilus 11167 doses influenzae B, purified antigen conjugated(P) Diphtheria toxoid+Poliomyelitis, trivalent, inactivated, whole J07CA09 virus+Pertussis, purified antigen+Haemophilus influenzae B, purified 39406 doses antigen conjugated+Hepatitis B, purified antigen+Tetanus toxoid(P) L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS 11,8547 L01 ANTINEOPLASTIC AGENTS L01A ALKYLATING AGENTS L01AA Nitrogen mustard analogues L01AA01 Cyclophosphamide(O) 757,5 g L01AA01 Cyclophosphamide(P) 3928 g L01AA02 Chlorambucil(O) 23 g L01AA03 Melphalan(O) 8,4 g L01AA03 Melphalan(P) 30,8 g L01AA06 Ifosfamide(P) 2477 g L01AA07 Trofosfamide(O) 15 g L01AA09 Bendamustine(P) 267,55 g L01AB Alkyl sulfonates L01AB01 Busulfan(O) 5,2 g L01AB01 Busulfan(P) 9,6 g L01AB02 Treosulfan(P) 625 g L01AC Ethylene imines L01AC01 Thiotepa(P) 5,78 g L01AD Nitrosoureas L01AD01 Carmustine(P) 7,7 g 23/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L01AD02 Lomustine(O) 28,6 g L01AX Other alkylating agents L01AX03 Temozolomide(O) 753,6 g L01AX04 Dacarbazine(P) 470 g L01B ANTIMETABOLITES L01BA Folic acid analogues L01BA01 Methotrexate(P) 1737,05 g L01BA04 Pemetrexed(P) 233 g L01BB Purine analogues L01BB02 Mercaptopurine(O) 346,75 g L01BB03 Tioguanine(O) 10 g L01BB04 Cladribine(P) 0,26 g L01BB05 Fludarabine(P) 19,5 g L01BB07 Nelarabine(P) 10,5 g L01BC Pyrimidine analogues L01BC01 Cytarabine(P) 2276,5 g L01BC02 Fluorouracil(P) 18445 g L01BC05 Gemcitabine(P) 5022,0536 g L01BC06 Capecitabine(O) 259620 g L01BC07 Azacitidine(P) 184,1 g L01BC83 Trifluridine+Tipiracil(O) 7760 pieces L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS L01CA Vinca alkaloids and analogues L01CA01 Vinblastine(P) 3,18 g L01CA02 Vincristine(P) 2,29 g L01CA04 Vinorelbine(O) 2,3 g L01CA04 Vinorelbine(P) 17,95 g L01CB Podophyllotoxin derivatives L01CB01 Etoposide(O) 235 g L01CB01 Etoposide(P) 509,9 g L01CD Taxanes L01CD01 Paclitaxel(P) 763,3 g L01CD02 Docetaxel(P) 443,52 g L01CD04 Cabazitaxel(P) 1,44 g L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES L01DA Actinomycines L01DA01 Dactinomycin(P) 0,0425 g L01DB Anthracyclines and related substances L01DB01 Doxorubicin(P) 130,1 g L01DB02 Daunorubicin(P) 8,22 g L01DB03 Epirubicin(P) 253,9 g L01DB06 Idarubicin(O) 0,09 g L01DB06 Idarubicin(P) 1,41 g L01DB07 Mitoxantrone(P) 2,46 g L01DB11 Pixantrone(P) 0,783 g L01DC Other cytotoxic antibiotics L01DC01 Bleomycin(P) 5175000 U L01DC03 Mitomycin(P) 6,2 g L01X OTHER ANTINEOPLASTIC AGENTS L01XA Platinum compounds L01XA01 Cisplatin(P) 228,3 g L01XA02 Carboplatin(P) 1941 g L01XA03 Oxaliplatin(P) 884,4 g L01XB Methylhydrazines L01XB01 Procarbazine(O) 152,5 g L01XC Monoclonal antibodies L01XC02 Rituximab(P) 2109,376 g L01XC03 Trastuzumab(P) 1724,55 g L01XC05 Gemtuzumab ozogamicin(P) 0,005 g L01XC06 Cetuximab(P) 132,5 g 24/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L01XC07 Bevacizumab(P) 1134,4 g L01XC08 Panitumumab(P) 109,3 g L01XC11 Ipilimumab(P) 0,8 g L01XC12 Brentuximab vedotin(P) 11,5 g L01XC13 Pertuzumab(P) 122,64 g L01XC14 Trastuzumab emtansine(P) 35,74 g L01XC15 Obinutuzumab(P) 90 g L01XC17 Nivolumab(P) 147,18 g L01XC18 Pembrolizumab(P) 261,65 g L01XC19 Blinatumomab(P) 0,0014 g L01XC21 Ramucirumab(P) 2,1 g L01XC24 Daratumumab(P) 379,6 g L01XC26 Inotuzumab ozogamicin(P) 0,004 g L01XC28 Durvalumab(P) 342 g L01XC32 Atezolizumab(P) 31,2 g L01XD Sensitizers used in photodynamic/radiation therapy L01XD04 Aminolevulinic acid(O) 25,5 g L01XE Protein kinase inhibitors L01XE01 Imatinib(O) 14424 g L01XE02 Gefitinib(O) 1305 g L01XE03 Erlotinib(O) 156 g L01XE04 Sunitinib(O) 381,85 g L01XE05 Sorafenib(O) 3494,4 g L01XE06 Dasatinib(O) 660 g L01XE07 Lapatinib(O) 175 g L01XE08 Nilotinib(O) 6630,4 g L01XE09 Temsirolimus(P) 0,39 g L01XE10 Everolimus(O) 34,65 g L01XE11 Pazopanib(O) 15228 g L01XE13 Afatinib(O) 95,48 g L01XE14 Bosutinib(O) 319,2 g L01XE16 Crizotinib(O) 720 g L01XE17 Axitinib(O) 55,776 g L01XE18 Ruxolitinib(O) 249,2 g L01XE21 regorafenib(O) 342,72 g L01XE23 Dabrafenib(O) 3753 g L01XE24 Ponatinib(O) 2,7 g L01XE25 Trametinib(O) 26,37 g L01XE26 Cabozantinib(O) 324,44 g L01XE27 Ibrutinib(O) 5569,2 g L01XE28 Ceritinib(O) 112,5 g L01XE29 Lenvatinib(O) 3,6 g L01XE31 Nintedanib(O) 5775 g L01XE33 Palbociclib(O) 193,725 g L01XE35 Osimertinib(O) 160,8 g L01XE36 Alectinib(O) 67,2 g L01XE39 Midostaurin(O) 21 g L01XE42 Ribociclib(O) 1461,6 g L01XE43 Brigatinib(O) 181,08 g L01XE44 Lorlatinib(O) 6 g L01XX Other antineoplastic agents L01XX01 Amsacrine(P) 0,45 g L01XX02 Asparaginase(P) 1300000 U L01XX05 Hydroxycarbamide(O) 225350 g L01XX11 Estramustine(O) 193,2 g L01XX14 Tretinoin(O) 21 g L01XX17 Topotecan(P) 2,608 g L01XX19 Irinotecan(P) 729 g L01XX23 Mitotane(O) 1650 g L01XX24 Pegaspargase(P) 262500 U 25/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L01XX27 Arsenic trioxide(P) 0,8 g L01XX32 Bortezomib(P) 8,9565 g L01XX35 Anagrelide(O) 2 g L01XX41 Eribulin(P) 0,1989 g L01XX42 Panobinostat(O) 0,48 g L01XX45 Carfilzomib(P) 2,76 g L01XX46 Olaparib(O) 5854,4 g L01XX47 Idelalisib(O) 27 g L01XX50 Ixazomib(O) 0,54 g L01XX52 Venetoclax(O) 31,36 g L01XX54 Niraparib(O) 14 g L02 ENDOCRINE THERAPY 4,6931 L02A HORMONES AND RELATED AGENTS 0,6059 L02AB Progestogens 0,0099 L02AB02 Medroxyprogesterone(O) 4785 g 1 g 0,0099 L02AE Gonadotropin releasing hormone analogues 0,5960 L02AE01 Buserelin(N) 1,95 g 1,2 mg 0,0034 L02AE03 Goserelin(P) 8,4276 g 0,129 mg 0,1351 L02AE04 Triptorelin(P) 0,2366 g 0,1 mg 0,0049 L02AE04 Triptorelin(P) 29,3325 g 0,134 mg 0,4526 L02B HORMONE ANTAGONISTS AND RELATED AGENTS 4,0873 L02BA Anti-estrogens 0,7950 L02BA01 Tamoxifen(O) 5953,8 g 0,02 g 0,6155 L02BA03 Fulvestrant(P) 720,5 g 8,3 mg 0,1795 L02BB Anti-androgens 1,4856 L02BB03 Bicalutamide(O) 35558,6 g 0,05 g 1,4705 enzalutamide L02BB04 1097,6 g 0,16 g 0,0142 (O) L02BB05 Apalutamide(O) 108 g 0,24 g 0,0009 L02BG Aromatase inhibitors 1,7417 L02BG03 Anastrozole(O) 296,324 g 1 mg 0,6127 L02BG04 Letrozole(O) 1207,95 g 2,5 mg 0,9991 L02BG06 Exemestane(O) 1570,5 g 0,025 g 0,1299 L02BX Other hormone antagonists and related agents 0,0649 L02BX03 Abiraterone(O) 31410 g 1 g 0,0649 L03 IMMUNOSTIMULANTS 0,6755 L03A IMMUNOSTIMULANTS 0,6755 L03AA Colony stimulating factors 0,0747 L03AA02 Filgrastim(P) 8,9256 g 0,35 mg 0,0527 L03AA13 Pegfilgrastim(P) 3,186 g 0,3 mg 0,0220 L03AB Interferons 0,4833 L03AB04 Interferon alfa-2a(P) 35925000000 U 2000000 U 0,0371 L03AB07 Interferon beta-1a(P) 0,6841 g 0,0043 mg 0,3289 L03AB08 Interferon beta-1b(P) 1,2492E+11 U 4000000 U 0,0646 L03AB11 Peginterferon alfa-2a(P) 0,0158 g 0,026 mg 0,0013 L03AB13 Peginterferon beta-1a(P) 0,2211 g 8,9 mcg 0,0514 L03AX Other immunostimulants 0,1175 L03AX03 BCG bacteria(P) 4,3375 g 1,8 mg 0,0050 L03AX13 Glatiramer acetate(P) 1078,24 g 0,02 g 0,1115 L03AX15 Mifamurtide(P) 0,332 g 0,7 mg 0,0010 L03AX16 Plerixafor(P) 0,336 g 16,8 mg <0,0001 L03AX80 Methyluracil(R) 420 g L04 IMMUNOSUPPRESSANTS 6,4862 L04A IMMUNOSUPPRESSANTS 6,4862 L04AA Selective immunosuppressants 1,0819 L04AA03 Antilymphocyte immunoglobulin (horse)(P) 23,75 g L04AA04 Rabbit anti-T-lymphocyte immunoglobulin(P) 15,05 g 0,1 g 0,0003 L04AA06 Mycophenolic acid(O) 274562,4 g 2 g 0,2839 L04AA06 Mycophenolic acid(P) 302 g 2 g 0,0003 L04AA10 Sirolimus(O) 16,65 g 0,003 g 0,0115 26/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L04AA13 Leflunomide(O) 5106,6 g 0,02 g 0,5280 L04AA18 Everolimus(O) 0,36 g 1,5 mg 0,0005 L04AA23 Natalizumab(P) 48,9 g 0,01 g 0,0101 L04AA24 Abatacept(P) 162,5 g 0,027 g 0,0124 L04AA25 Eculizumab(P) 37,8 g 0,064 g 0,0012 L04AA27 Fingolimod(O) 5,124 g 0,5 mg 0,0212 Tofacitinib L04AA29 52,92 g 10 mg 0,0109 (O) L04AA31 Teriflunomide(O) 670,712 g 14 mg 0,0991 L04AA32 Apremilast(O) 0,69 g 60 mg <0,0001 L04AA33 Vedolizumab(P) 91,5 g 5,4 mg 0,0350 L04AA34 Alemtuzumab(P) 0,78 g 0,13 mg 0,0124 L04AA36 Ocrelizumab(P) 82,5 g 3,29 mg 0,0519 L04AA40 Cladribine(O) 0,52 g 0,34 mg 0,0032 L04AB Tumor necrosis factor alpha (TNF-alpha) inhibitors 1,1249 L04AB01 Etanercept(P) 700,4 g 0,007 g 0,2069 L04AB02 Infliximab(P) 978,1 g 3,75 mg 0,5393 L04AB04 Adalimumab(P) 403,64 g 2,9 mg 0,2878 L04AB05 Certolizumab pegol(P) 31,2 g 14 mg 0,0046 L04AB06 Golimumab(P) 69,3 g 1,66 mg 0,0863 L04AC Interleukin inhibitors 0,3520 L04AC02 Basiliximab(P) 0,76 g 0,04 g <0,0001 L04AC03 Anakinra(P) 100,6005 g 0,1 g 0,0021 L04AC05 Ustekinumab(P) 47,275 g 0,54 mg 0,1810 L04AC07 Tocilizumab(P) 725,88 g 0,02 g 0,0750 L04AC10 Secukinumab(P) 379,5 g 10 mg 0,0785 L04AC13 Ixekizumab(P) 3,68 g 2,9 mg 0,0026 L04AC14 Sarilumab(P) 53,3 g 14,3 mg 0,0077 L04AC16 Guselkumab(P) 4,3 g 1,79 mg 0,0050 L04AC18 Risankizumab(P) 0,45 g L04AD Calcineurin inhibitors 0,4759 L04AD01 Ciclosporin(O) 28028,75 g 0,25 g 0,2318 L04AD01 Ciclosporin(P) 55 g 0,25 g 0,0005 L04AD02 Tacrolimus(O) 588,8525 g 5 mg 0,2435 L04AD02 Tacrolimus(P) 0,2 g 5 mg 0,0001 L04AX Other immunosuppressants 3,4515 L04AX01 Azathioprine(O) 27750 g 0,15 g 0,3825 L04AX02 Thalidomide(O) 697,2 g 0,1 g 0,0144 L04AX03 Methotrexate(O) 3360 g 2,5 mg 2,7790 L04AX03 Methotrexate(P) 34,43 g 2,5 mg 0,0285 L04AX04 Lenalidomide(O) 350,91 g 0,01 g 0,0726 L04AX05 Pirfenidone(O) 22540,14 g 2,4 g 0,0194 Pomalidomide L04AX06 10,416 g 3 mg 0,0072 (O) L04AX07 Dimethyl fumarate(O) 34345,92 g 0,48 g 0,1480 M MUSCULO-SKELETAL SYSTEM 84,1176 M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS 68,8640 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON- M01A 68,8533 STEROIDS M01AB Acetic acid derivatives and related substances 8,9049 M01AB01 Indometacin(O) 3876,5 g 0,1 g 0,0802 M01AB05 Diclofenac(O) 343897,375 g 0,1 g 7,1108 M01AB05 Diclofenac(P) 9036,75 g 0,1 g 0,1869 M01AB05 Diclofenac(R) 14496,5 g 0,1 g 0,2997 M01AB16 Aceclofenac(O) 40644 g 0,2 g 0,4202 M01AB82 Diclofenac+Omeprazole(O) 39035,25 g 0,1 g 0,8071 M01AC Oxicams 4,0574 M01AC01 Piroxicam(O) 1453,2 g 0,02 g 0,1502 M01AC05 Lornoxicam(O) 1963,84 g 0,012 g 0,3384 M01AC05 Lornoxicam(P) 12,96 g 0,012 g 0,0022 27/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day M01AC06 Meloxicam(O) 25638,6 g 0,015 g 3,5342 M01AC06 Meloxicam(P) 234,7 g 0,015 g 0,0324 M01AE Propionic acid derivatives 39,3010 M01AE01 Ibuprofen(O) 15104167,6 g 1,2 g 26,0260 M01AE01 Ibuprofen(P) 4052 g 1,2 g 0,0070 M01AE02 Naproxen(O) 546426,1 g 0,5 g 2,2597 M01AE03 Ketoprofen(O) 128869,875 g 0,15 g 1,7764 M01AE03 Ketoprofen(P) 13796 g 0,15 g 0,1902 M01AE17 Dexketoprofen(O) 69992,5 g 0,075 g 1,9297 M01AE17 Dexketoprofen(P) 4123 g 0,075 g 0,1137 M01AE52 Naproxen+Esomeprazole(O) 1689585 g 0,5 g 6,9872 M01AE82 Ibuprofen+Phenylephrine(O) 6542,4 g 1,2 g 0,0113 M01AG Fenamates 0,0035 M01AG02 Tolfenamic acid(O) 508 g 0,3 g 0,0035 M01AH Coxibs 8,3387 M01AH01 Celecoxib(O) 61777 g 0,2 g 0,6387 M01AH05 Etoricoxib(O) 223434,12 g 60 mg 7,7000 M01AX Other antiinflammatory and antirheumatic agents, non-steroids 8,2477 M01AX01 Nabumetone(O) 144040 g 1 g 0,2978 M01AX05 Glucosamine(O) 5767132,71 g 1,5 g 7,9499 M01C SPECIFIC ANTIRHEUMATIC AGENTS 0,0108 M01CC Penicillamine and similar agents 0,0108 M01CC01 Penicillamine(O) 2600 g 0,5 g 0,0108 M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN M02AA Antiinflammatory preparations, non-steroids for topical use M02AA10 Ketoprofen(C) 1189550 g M02AA12 Naproxen(C) 920975 g M02AA13 Ibuprofen(C) 902350 g M02AA15 Diclofenac(C) 385499 pieces M02AA15 Diclofenac(C) 35872477,25 g M02AA81 Ibuprofen+Levomenthol(C) 1766400 g M02AC Preparations with salicylic acid derivatives M02AC80 Methyl salicylate+Levomenthol+Eucalyptus oil+Turpentine oil(C) 79663 g M02AX Other topical products for joint and muscular pain M02AX80 Nicoboxil+Nonivamide(C) 183540 g M02AX86 Camphor+Methyl salicylate+Levomenthol(C) 12900 g M02AX90 Camphor+Salicylic acid+Turpentine oil+Venenum Viperae berus(C) 1063050 g Benzyl nicotinate+Nonivamide+Camphor+Turpentine oil+Dimethyl M02AX92 963080 g sulfoxide(C) M03 MUSCLE RELAXANTS 0,9908 M03A MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS M03AB Choline derivatives M03AB01 Suxamethonium chloride(P) 3615,5 g M03AC Other quaternary ammonium compounds M03AC04 Atracurium besilate(P) 1391,5 g M03AC06 Pipecuronium bromide(P) 31,2 g M03AC09 Rocuronium bromide(P) 976 g M03AX Other muscle relaxants, peripherally acting agents M03AX01 Botulinum toxin(P) 1345200 U M03B MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS 0,9908 M03BX Other centrally acting agents 0,9908 M03BX01 Baclofen(O) 4624,25 g 0,05 g 0,1912 M03BX01 Baclofen(P) 2,8218 g 0,55 mg 0,0106 M03BX02 Tizanidine(O) 4573,68 g 0,012 g 0,7881 M03BX04 Tolperisone(O) 81 g 0,2 g 0,0008 M03C MUSCLE RELAXANTS, DIRECTLY ACTING AGENTS 28/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day M03CA Dantrolene and derivatives M03CA01 Dantrolene(P) 15,12 g M04 ANTIGOUT PREPARATIONS 9,4479 M04A ANTIGOUT PREPARATIONS 9,4479 M04AA Preparations inhibiting uric acid production 9,4323 M04AA01 Allopurinol(O) 1286950 g 0,4 g 6,6526 M04AA03 Febuxostat(O) 107546,88 g 0,08 g 2,7797 M04AB Preparations increasing uric acid excretion 0,0055 M04AB03 Benzbromarone(O) 268 g 0,1 g 0,0055 M04AC Preparations with no effect on uric acid metabolism 0,0100 M04AC01 Colchicine(O) 4,855 g 1 mg 0,0100 M05 DRUGS FOR TREATMENT OF BONE DISEASES 4,8148 M05B DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION 4,8148 M05BA Bisphosphonates 0,9000 M05BA03 Pamidronic acid(P) 22,62 g 0,06 g 0,0008 M05BA04 Alendronic acid(O) 742 g 0,01 g 0,1534 M05BA06 Ibandronic acid(O) 1344,15 g 0,005 g 0,5559 M05BA06 Ibandronic acid(P) 1,83 g 0,006 g 0,0006 M05BA07 Risedronic acid(O) 436,1 g 0,005 g 0,1803 M05BA08 Zoledronic acid(P) 17,232 g 0,004 g 0,0089 M05BB Bisphosphonates, combinations 2,7503 M05BB03 Alendronic acid+Colecalciferol(O) 13301,12 g 10 mg 2,7503 M05BX Other drugs affecting bone structure and mineralization 1,1646 M05BX04 Denosumab(P) 185,864 g 0,33 mg 1,1646 M05BX05 Burosumab(P) 0,53 g N NERVOUS SYSTEM 134,1934 N01 ANESTHETICS N01A ANESTHETICS, GENERAL N01AB Halogenated hydrocarbons N01AB06 Isoflurane(I) 14400 ml N01AB07 Desflurane(I) 73440 ml N01AB08 Sevoflurane(I) 778750 ml N01AF Barbiturates, plain N01AF03 Thiopental(P) 2130 g N01AH Opioid anesthetics N01AH01 Fentanyl(I) 30,872 g N01AH01 Fentanyl(P) 2,003 g N01AH06 Remifentanil(P) 15,115 g N01AX Other general anesthetics N01AX03 Ketamine(P) 419 g N01AX07 Etomidate(P) 74,2 g N01AX10 Propofol(P) 64708,5 g N01AX11 Sodium oxybate(P) 1660 g N01AX13 Nitrous oxide(I) 11116000 ml N01AX14 Esketamine(P) 374,5 g N01B ANESTHETICS, LOCAL N01BA Esters of aminobenzoic acid N01BA02 Procaine(P) 1,25 g N01BB Amides N01BB01 Bupivacaine(Infilt, P) 3084,45 g N01BB01 Bupivacaine(P) 285,4 g N01BB02 Lidocaine(C) 1300 ml N01BB02 Lidocaine(C) 2215,5 g N01BB02 Lidocaine(NA) 85200 ml N01BB02 Lidocaine(O) 65100 g N01BB02 Lidocaine(P) 25379,1 g N01BB03 Mepivacaine(dental) 1565,7 g N01BB08 Articaine(P) 2,4 g N01BB09 Ropivacaine(P) 733,9 g 29/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N01BB80 Articaine+Epinephrine(dental) 1236070 ml N01BB80 Articaine+Epinephrine(O) 230310 ml N01BB81 Bupivacaine+Epinephrine(P) 250400 ml N01BB82 Lidocaine+Epinephrine(dental) 180 ml N01BB82 Lidocaine+Epinephrine(P) 62400 ml N01BB83 Lidocaine+Prilocaine(C) 53650 g N01BB86 Lidocaine+Chlorhexidine(urethral) 1096175 g N01BB87 Mepivacaine+Epinephrine(P) 90 ml N01BC Esters of benzoic acid N01BC01 Cocaine(NA) 285 g N01BX Other local anesthetics N01BX04 Capsaicin(C) 77,486 g N02 ANALGESICS 23,5231 N02A OPIOIDS 7,7385 N02AA Natural opium alkaloids 0,7684 N02AA01 Morphine(O) 6033 g 0,1 g 0,1247 N02AA01 Morphine(P) 700,8 g 0,03 g 0,0483 N02AA05 Oxycodone(O) 17711,05 g 0,075 g 0,4883 N02AA05 Oxycodone(P) 27,65 g 0,03 g 0,0019 N02AA08 Dihydrocodeine(O) 7401 g 0,15 g 0,1020 N02AA55 Oxycodone+Naloxone(O) 115,2 g 75 mg 0,0032 N02AB Phenylpiperidine derivatives 0,1536 N02AB02 Pethidine(P) 22 g 0,4 g 0,0001 N02AB02 Pethidine(P, V) 3034 g 0,4 g 0,0157 N02AB03 Fentanyl(O) 2,9792 g N02AB03 Fentanyl(SL) 2,986 g 0,6 mg 0,0103 N02AB03 Fentanyl(TD) 74,0196 g 1,2 mg 0,1275 N02AE Oripavine derivatives 0,0101 N02AE01 Buprenorphine(TD) 5,8666 g 1,2 mg 0,0101 N02AJ Opioids in combination with non-opioid analgesics 4,9355 N02AJ06 Codeine+Paracetamol(O) 5858890 pieces 3 pieces 4,0382 N02AJ13 Tramadol+Paracetamol(O) 1880,25 g 150 mg 0,0259 N02AJ14 Tramadol+Dexketoprofen(O) 63216 g 150 mg 0,8714 N02AX Other opioids 1,8708 N02AX02 Tramadol(O) 266855 g 0,3 g 1,8393 N02AX02 Tramadol(P) 4571 g 0,3 g 0,0315 N02AX02 Tramadol(R) 1 g 0,3 g <0,0001 N02B OTHER ANALGESICS AND ANTIPYRETICS 14,8474 N02BA Salicylic acid and derivatives 0,9048 N02BA01 Acetylsalicylic acid (O) 1109871,96 g 3 g 0,7650 N02BA80 Acetylsalicylic acid +Ascorbic acid(O) 202830 g 3 g 0,1398 N02BB Pyrazolones 0,0021 N02BB02 Metamizole sodium(O) 235 g 3 g 0,0002 N02BB02 Metamizole sodium(P, V) 2810 g 3 g 0,0019 N02BE Anilides 13,9405 N02BE01 Paracetamol(O) 13820637,2 g 3 g 9,5257 N02BE01 Paracetamol(P) 291250 g 3 g 0,2007 N02BE01 Paracetamol(R) 67488,55 g 3 g 0,0465 N02BE52 Paracetamol+Pseudoephedrine+Diphenhydramine(O) 58784 g 3 g 0,0405 N02BE75 Paracetamol+Guaifenesin+Phenylephrine(O) 255404,5 g 3 g 0,1760 Paracetamol+Chlorphenamine+Pseudoephedrine+Dextromethorphan( N02BE81 429356 g 3 g 0,2959 O) N02BE83 Paracetamol+Caffeine(O) 194850 g 3 g 0,1343 N02BE84 Paracetamol+Phenylephrine+Ascorbic acid(O) 1296233,75 g 3 g 0,8934 N02BE85 Paracetamol+Pheniramine+Ascorbic acid(O) 106990,4 g 3 g 0,0737 Paracetamol+Phenylephrine+Terpin hydrate+Ascorbic N02BE86 408894 g 3 g 0,2818 acid+Caffeine(O) N02BE87 Paracetamol+Pseudoephedrine(O) 66250 g 3 g 0,0457 N02BE91 Paracetamol+Ascorbic acid(O) 3696 g 3 g 0,0025 N02BE92 Paracetamol+Codeine(O) 918760 g 3 g 0,6332 30/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N02BE94 Paracetamol+Codeine+Caffeine(O) 1760004 g 3 g 1,2131 N02BE95 Paracetamol+Phenylephrine(O) 73835 g 3 g 0,0509 N02BE97 Paracetamol+Pseudoephedrine+Dextromethorphan(O) 473518 g 3 g 0,3264 N02C ANTIMIGRAINE PREPARATIONS 0,9372 N02CC Selective serotonin (5HT1) agonists 0,9278 N02CC01 Sumatriptan(N) 1,96 g 0,02 g 0,0002 N02CC01 Sumatriptan(O) 19058,4 g 0,05 g 0,7881 N02CC03 Zolmitriptan(O) 49,09 g 2,5 mg 0,0406 N02CC04 Rizatriptan(O) 69,75 g 0,01 g 0,0144 N02CC07 Frovatriptan(O) 102,125 g 2,5 mg 0,0845 N02CD Calcitonin gene-related peptide (CGRP) antagonists 0,0094 N02CD01 Erenumab(P) 11,34 g 2,5 mg 0,0094 N03 ANTIEPILEPTICS 10,9169 N03A ANTIEPILEPTICS 10,9169 N03AA Barbiturates and derivatives 0,4606 N03AA02 Phenobarbital(O) 19655 g 0,1 g 0,4064 N03AA02 Phenobarbital(P) 70 g 0,1 g 0,0014 N03AA03 Primidone(O) 31900 g 1,25 g 0,0528 N03AB Hydantoin derivatives 0,0414 N03AB02 Phenytoin(O) 5810 g 0,3 g 0,0400 N03AB02 Phenytoin(P) 197,5 g 0,3 g 0,0014 N03AD Succinimide derivatives 0,0138 N03AD01 Ethosuximide(O) 8350 g 1,25 g 0,0138 N03AE Benzodiazepine derivatives 0,5706 N03AE01 Clonazepam(O) 2207,76 g 0,008 g 0,5706 N03AE01 Clonazepam(P) 0,005 g 0,008 g <0,0001 N03AF Carboxamide derivatives 2,8644 N03AF01 Carbamazepine(O) 991171 g 1 g 2,0495 N03AF02 Oxcarbazepine(O) 393825 g 1 g 0,8143 N03AF03 Rufinamide(O) 400 g 1,4 g 0,0006 N03AG Fatty acid derivatives 1,6063 N03AG01 Valproic acid(O) 1153930 g 1,5 g 1,5907 N03AG01 Valproic acid(P) 1043,1 g 1,5 g 0,0014 N03AG04 Vigabatrin(O) 13750 g 2 g 0,0142 N03AX Other antiepileptics 5,3597 N03AX03 Sultiame(O) 3990 g 0,4 g 0,0206 N03AX09 Lamotrigine(O) 98749,28 g 0,3 g 0,6806 N03AX11 Topiramate(O) 34845 g 0,3 g 0,2402 N03AX12 Gabapentin(O) 1308465 g 1,8 g 1,5031 N03AX14 Levetiracetam(O) 440850 g 1,5 g 0,6077 N03AX14 Levetiracetam(P) 260 g 1,5 g 0,0004 N03AX16 Pregabalin(O) 334306,35 g 0,3 g 2,3042 N03AX17 Stiripentol(O) 1245 g 1 g 0,0026 N03AX18 Lacosamide(O) 7,7 g 0,3 g 0,0001 N03AX22 perampanel(O) 1,344 g 8 mg 0,0003 N04 ANTI-PARKINSON DRUGS 3,7744 N04A ANTICHOLINERGIC AGENTS 0,6093 N04AA Tertiary amines 0,6093 N04AA01 Trihexyphenidyl(O) 2946,6 g 0,01 g 0,6093 N04B DOPAMINERGIC AGENTS 3,1652 N04BA Dopa and dopa derivatives 1,4237 N04BA03 Levodopa +Carbidopa+Entacapone(O) 71752,5 g 0,45 g 0,3297 N04BA80 Levodopa +Benserazide(O) 310370 g 0,6 g 1,0696 N04BA81 Levodopa +Carbidopa(intestin) 18676 g N04BA81 Levodopa +Carbidopa(O) 7085,9 g 0,6 g 0,0244 N04BB Adamantane derivatives 0,3031 N04BB01 Amantadine(O) 29320 g 0,2 g 0,3031 N04BB01 Amantadine(P) 36 g N04BC Dopamine agonists 0,7715 N04BC04 Ropinirole(O) 1045,667 g 0,006 g 0,3604 31/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N04BC05 Pramipexole(O) 466,1869 g 2,5 mg 0,3856 N04BC07 Apomorphine(P) 246,9 g 20 mg 0,0255 N04BD Monoamine oxidase type B inhibitors 0,6669 N04BD02 Rasagiline(O) 322,51 g 0,001 g 0,6669 N05 PSYCHOLEPTICS 43,6288 N05A ANTIPSYCHOTICS 9,5838 N05AA Phenothiazines with aliphatic side-chain 0,1621 N05AA01 Chlorpromazine(O) 12357 g 0,3 g 0,0852 N05AA01 Chlorpromazine(P) 54 g 0,1 g 0,0011 N05AA02 Levomepromazine(O) 10969 g 0,3 g 0,0756 N05AA02 Levomepromazine(P, V) 12,5 g 0,1 g 0,0003 N05AB Phenothiazines with piperazine structure 0,0698 N05AB02 Fluphenazine(P) 3,5 g 0,001 g 0,0072 N05AB03 Perphenazine(O) 423,2 g 0,03 g 0,0292 N05AB03 Perphenazine(P) 161,218 g 0,01 g 0,0333 N05AB04 Prochlorperazine(O) 2,94 g 0,1 g 0,0001 N05AC Phenothiazines with piperidine structure 0,0012 N05AC01 Periciazine(O) 28,8 g 0,05 g 0,0012 N05AC02 Thioridazine(O) 2,5 g 0,3 g <0,0001 N05AD Butyrophenone derivatives 1,0330 N05AD01 Haloperidol(O) 2091,99 g 0,008 g 0,5407 N05AD01 Haloperidol(P) 805,525 g 0,008 g 0,2082 N05AD03 Melperone(O) 38880 g 0,3 g 0,2680 N05AD08 Droperidol(P) 19,45 g 2,5 mg 0,0161 N05AE Indole derivatives 0,0995 N05AE03 Sertindole(O) 739,424 g 0,016 g 0,0956 N05AE04 Ziprasidone(O) 149,28 g 0,08 g 0,0039 N05AE05 Lurasidone(O) 2,604 g 60 mg 0,0001 N05AF Thioxanthene derivatives 0,8720 N05AF01 Flupentixol(O) 364,4 g 0,006 g 0,1256 N05AF01 Flupentixol(P) 109 g 0,004 g 0,0563 N05AF03 Chlorprothixene(O) 29695 g 0,3 g 0,2047 N05AF05 Zuclopenthixol(O) 1368 g 0,03 g 0,0943 N05AF05 Zuclopenthixol(P) 47,5 g 0,03 g 0,0033 N05AF05 Zuclopenthixol(P) 2813,6 g 0,015 g 0,3878 N05AG Diphenylbutylpiperidine derivatives 0,0001 N05AG02 Pimozide(O) 0,225 g 0,004 g 0,0001 N05AH Diazepines, oxazepines and thiazepines 5,4396 N05AH02 Clozapine(O) 91236,75 g 0,3 g 0,6288 N05AH03 Olanzapine(O) 10312,68 g 0,01 g 2,1324 N05AH03 Olanzapine(P) 154,4 g 0,01 g 0,0319 N05AH04 Quetiapine(O) 511891 g 0,4 g 2,6461 N05AH05 Asenapine(SL) 3 g 20 mg 0,0003 N05AL Benzamides 0,1453 N05AL01 Sulpiride(O) 21868,5 g 0,8 g 0,0565 N05AL05 Amisulpride(O) 17172 g 0,4 g 0,0888 N05AN Lithium 0,2623 N05AN01 Lithium(O) 114180 g 0,9 g 0,2623 N05AX Other antipsychotics 1,4989 N05AX08 Risperidone(O) 1623,2 g 0,005 g 0,6713 N05AX08 Risperidone(P) 22,275 g 2,7 mg 0,0171 N05AX12 Aripiprazole(O) 4895,16 g 0,015 g 0,6748 N05AX12 Aripiprazole(P) 8,8725 g 0,015 g 0,0012 N05AX12 Aripiprazole(P) 394,4 g 0,0133 g 0,0613 N05AX13 Paliperidone(P) 87,9 g 2,5 mg 0,0727 N05AX15 Cariprazine(O) 0,756 g 3 mg 0,0005 N05B ANXIOLYTICS 13,0269 N05BA Benzodiazepine derivatives 13,0262 N05BA01 Diazepam(O) 26947,05 g 0,01 g 5,5719 N05BA01 Diazepam(P) 490,7 g 0,01 g 0,1015 32/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N05BA01 Diazepam(R) 60,15 g 0,01 g 0,0124 N05BA02 Chlordiazepoxide(O) 0,5 g 0,03 g <0,0001 N05BA04 Oxazepam(O) 6,5 g 0,05 g 0,0003 N05BA06 Lorazepam(O) 735,555 g 2,5 mg 0,6084 N05BA06 Lorazepam(P) 10,76 g 2,5 mg 0,0089 N05BA08 Bromazepam(O) 5716,95 g 0,01 g 1,1821 N05BA09 Clobazam(O) 333 g 0,02 g 0,0344 N05BA12 Alprazolam(O) 2655,47 g 0,001 g 5,4908 N05BA80 Phenazepam(O) 7,525 g 0,001 g 0,0156 N05BB Diphenylmethane derivatives 0,0002 N05BB01 Hydroxyzine(O) 6,3 g 0,075 g 0,0002 N05BE Azaspirodecanedione derivatives 0,0005 N05BE01 Buspirone(O) 7,2 g 0,03 g 0,0005 N05C HYPNOTICS AND SEDATIVES 21,0181 N05CD Benzodiazepine derivatives 0,3026 N05CD02 Nitrazepam(O) 272,85 g 0,005 g 0,1128 N05CD05 Triazolam(O) 0,03 g 0,25 mg 0,0002 N05CD08 Midazolam(O) 0,24 g N05CD08 Midazolam(O) 974,8997 g 0,015 g 0,1344 N05CD08 Midazolam(P) 400,2199 g 0,015 g 0,0552 N05CF Benzodiazepine related drugs 20,3792 N05CF01 Zopiclone(O) 58842,525 g 7,5 mg 16,2226 N05CF02 Zolpidem(O) 20102 g 0,01 g 4,1565 N05CM Other hypnotics and sedatives 0,3363 N05CM09 Valerianae radix(O) 468750 pieces 3 pieces 0,3231 N05CM18 Dexmedetomidine(P) 6,3842 g 1 mg 0,0132 N06 PSYCHOANALEPTICS 39,8858 N06A ANTIDEPRESSANTS 34,7835 N06AA Non-selective monoamine reuptake inhibitors 1,9432 N06AA04 Clomipramine(O) 4674,15 g 0,1 g 0,0966 N06AA04 Clomipramine(P) 2,5 g 0,1 g 0,0001 N06AA09 Amitriptyline(O) 53941,75 g 0,075 g 1,4872 N06AA10 Nortriptyline(O) 13032,5 g 0,075 g 0,3593 N06AB Selective serotonin reuptake inhibitors 20,5822 N06AB03 Fluoxetine(O) 32820,04 g 0,02 g 3,3931 N06AB04 Citalopram(O) 13807,26 g 0,02 g 1,4275 N06AB05 Paroxetine(O) 22974,6 g 0,02 g 2,3752 N06AB06 Sertraline(O) 130599,3 g 0,05 g 5,4008 N06AB08 Fluvoxamine(O) 305,5 g 0,1 g 0,0063 N06AB10 Escitalopram(O) 38589,16 g 0,01 g 7,9791 N06AF Monoamine oxidase inhibitors, non-selective 0,0050 N06AF04 Tranylcypromine(O) 24 g 0,01 g 0,0050 N06AG Monoamine oxidase type A inhibitors 0,0001 N06AG02 Moclobemide(O) 15 g 0,3 g 0,0001 N06AX Other antidepressants 12,2531 N06AX03 Mianserin(O) 24,3 g 0,06 g 0,0008 N06AX05 Trazodone(O) 6357 g 0,3 g 0,0438 N06AX11 Mirtazapine(O) 33217,02 g 0,03 g 2,2894 N06AX12 Bupropione(O) 107356,5 g 0,3 g 0,7399 N06AX14 Tianeptine(O) 25214,625 g 0,0375 g 1,3903 N06AX16 Venlafaxine(O) 167874,6 g 0,1 g 3,4712 N06AX18 Reboxetine(O) 1,44 g 0,008 g 0,0004 N06AX21 Duloxetine(O) 67255,62 g 0,06 g 2,3178 N06AX22 Agomelatine(O) 17253,6 g 0,025 g 1,4270 N06AX26 Vortioxetine(O) 2768,36 g 10 mg 0,5724 PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND N06B 1,3297 NOOTROPICS N06BA Centrally acting sympathomimetics 1,0734 N06BA04 Methylphenidate(O) 14412,18 g 0,03 g 0,9933 N06BA07 Modafinil(O) 1064 g 0,3 g 0,0073 33/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N06BA09 Atomoxetine(O) 2814,504 g 0,08 g 0,0727 N06BA12 Lisdexamfetamine dimesylate(O) 8,1 g N06BC Xanthine derivatives N06BC81 Caffeine citrate(O, P) 51,2 g N06BX Other psychostimulants and nootropics 0,2563 N06BX03 Piracetam (O) 281304 g 2,4 g 0,2424 N06BX13 Idebenone(O) 918 g 0,9 g 0,0021 N06BX18 Vinpocetine(O) 85,5 g 15 mg 0,0118 N06BX83 Aminobutyric acid(O) 25320 g N06D ANTI-DEMENTIA DRUGS 3,7727 N06DA Anticholinesterases 0,9913 N06DA02 Donepezil(O) 3595,48 g 7,5 mg 0,9913 N06DX Other anti-dementia drugs 2,7814 N06DX01 Memantine(O) 4312,64 g 0,02 g 0,4459 N06DX02 Ginkgo folium(O) 135543,6 g 0,12 g 2,3355 N06DX80 cerebrolysine(P) 4,304 g N07 OTHER NERVOUS SYSTEM DRUGS 12,4644 N07A PARASYMPATHOMIMETICS 0,3831 N07AA Anticholinesterases 0,3831 N07AA01 neostigmine(P) 31,43 g 0,002 g 0,0325 N07AA02 Pyridostigmine bromide(O) 28146 g 0,18 g 0,3233 N07AA03 Distigmine bromide(O) 0,5 g 0,005 g 0,0002 N07AA80 Neostigmine+Glycopyrronium(P) 13110 ml 1 ml 0,0271 N07B DRUGS USED IN ADDICTIVE DISORDERS 3,5444 N07BA Drugs used in nicotine dependence 1,9211 N07BA01 Nicotine(O) 17724,55 g 0,03 g 1,2216 N07BA01 Nicotine(TD) 4436,775 g 0,014 g 0,6553 N07BA03 Varenicline(O) 42,751 g 2 mg 0,0442 N07BB Drugs used in alcohol dependence 0,4070 N07BB01 Disulfiram(O) 33255 g 0,2 g 0,3438 N07BB01 Disulfiram(P) 51 g N07BB03 Acamprosate(O) 55,944 g 2 g 0,0001 N07BB04 Naltrexone(O) 1207,4 g 50 mg 0,0499 N07BB05 nalmefene(O) 115,164 g 18 mg 0,0132 N07BC Drugs used in opioid dependence 1,2163 N07BC02 Methadone(O) 14155 g 0,025 g 1,1707 N07BC51 Buprenorphine+Naloxone(SL) 176,148 g 8 mg 0,0455 N07C ANTIVERTIGO PREPARATIONS 8,5003 N07CA Antivertigo preparations 8,5003 N07CA01 Betahistine(O) 84375,6 g 0,024 g 7,2694 N07CA02 Cinnarizine(O) 51543,75 g 0,09 g 1,1842 N07CA03 Flunarizine(O) 3,15 g 0,01 g 0,0007 N07CA80 Cinnarizine+Dimenhydrinate(O) 2005 g 90 mg 0,0461 N07X OTHER NERVOUS SYSTEM DRUGS 0,0366 N07XX Other nervous system drugs 0,0366 N07XX02 Riluzole(O) 1481,2 g 0,1 g 0,0306 N07XX06 Tetrabenazine(O) 249,2 g 0,1 g 0,0052 N07XX07 Fampridine(O) 7,84 g 20 mg 0,0008 N07XX14 Edaravone(P) 2,7 g P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS 0,9680 P01 ANTIPROTOZOALS 0,7483 AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL P01A DISEASES P01AB Nitroimidazole derivatives P01AB01 Metronidazole (O, V) 1962 g P01B ANTIMALARIALS 0,7483 P01BA Aminoquinolines 0,7036 P01BA02 Hydroxychloroquine(O) 175440 g 0,516 g 0,7030 P01BA03 Primaquine(O) 4,5 g 0,015 g 0,0006 34/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day P01BB Biguanides 0,0440 P01BB51 Proguanil+Atovaquone(O) 1740 pieces 16 pieces 0,0002 P01BB51 Proguanil+Atovaquone(O) 84612 pieces 4 pieces 0,0437 P01BC Methanolquinolines <0,0001 P01BC02 Mefloquine(O) 6 g 1 g <0,0001 P01BD Diaminopyrimidines 0,0006 P01BD01 Pyrimethamine(O) 23,25 g 0,075 g 0,0006 P01C AGENTS AGAINST LEISHMANIASIS AND TRYPANOSOMIASIS <0,0001 P01CX Other agents against leishmaniasis and trypanosomiasis <0,0001 P01CX01 Pentamidine isethionate(P) 1,5 g 0,28 g <0,0001 P02 ANTHELMINTICS 0,2197 P02B ANTITREMATODALS 0,0003 P02BA Quinoline derivatives and related substances 0,0003 P02BA01 Praziquantel(O) 385,2 g 3 g 0,0003 P02C ANTINEMATODAL AGENTS 0,2194 P02CA Benzimidazole derivatives 0,2191 P02CA01 Mebendazole(O) 19592 g 0,2 g 0,2026 P02CA03 Albendazole(O) 3200 g 0,4 g 0,0165 P02CF Avermectines 0,0003 P02CF01 Ivermectin(O) 1,956 g 12 mg 0,0003 ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND P03 REPELLENTS P03A ECTOPARASITICIDES, INCL. SCABICIDES P03AC Pyrethrines, incl. synthetic compounds P03AC04 Permethrin(C) 58600 g P03AX Other ectoparasiticides, incl. scabicides P03AX01 Benzyl benzoate(C) 344730 g R RESPIRATORY SYSTEM 93,8787 R01 NASAL PREPARATIONS 38,4271 DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR R01A 35,6572 TOPICAL USE R01AA Sympathomimetics, plain 22,8751 R01AA05 Oxymetazoline(N) 315,3 g 0,4 mg 1,6299 R01AA07 Xylometazoline(N) 8219,765 g 0,8 mg 21,2452 R01AB Sympathomimetics, combinations excl. corticosteroids 3,0493 R01AB83 Xylometazoline+Ipratropium bromide(N) 238100 ml 0,8 ml 0,6154 R01AB85 Xylometazoline+Dexpanthenol(N) 941680 ml 0,8 ml 2,4339 R01AC Antiallergic agents, excl. corticosteroids 0,3321 R01AC03 Azelastine(N) 89,93 g 0,56 mg 0,3321 R01AD Corticosteroids 9,4007 R01AD01 Beclometasone(N) 7,57 g 0,4 mg 0,0391 R01AD05 Budesonide(N) 41,513 g 0,2 mg 0,4292 R01AD08 Fluticasone(N) 92,313 g 0,2 mg 0,9544 R01AD09 Mometasone(N) 402,346 g 0,2 mg 4,1597 R01AD12 Fluticasone furoate(N) 179,8368 g 0,11 mg 3,3805 R01AD81 Fluticasone+Azelastine(N) 847080 doses 4 doses 0,4379 R01AX Other nasal preparations R01AX06 Mupirocin(N) 21 g R01AX83 Retinol+Tocopherol(N) 156860 ml R01B NASAL DECONGESTANTS FOR SYSTEMIC USE 2,7699 R01BA Sympathomimetics 2,7699 R01BA02 Pseudoephedrine(O) 179500,68 g 0,24 g 1,5465 R01BA81 Pseudoephedrine+Triprolidine(O) 33867,12 g 0,24 g 0,2918 R01BA84 Pseudoephedrine+Guaifenesin(O) 10288,8 g 0,24 g 0,0886 R01BA89 Pseudoephedrine+Loratadine(O) 18224,64 g 0,24 g 0,1570 R01BA93 Pseudoephedrine+Cetirizine(O) 79625,28 g 0,24 g 0,6860 R02 THROAT PREPARATIONS 2,8356 R02A THROAT PREPARATIONS 2,8356 R02AA Antiseptics 2,3211 R02AA06 Cetylpyridinium chloride(O) 122526 pieces 35/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day R02AA82 Benzydamine+Cetylpyridinium chloride(O) 1197750 ml R02AA82 Benzydamine+Cetylpyridinium chloride(O) 1908656 pieces 6 pieces 0,6578 R02AA89 Povidone, iodinated+Allantoin(O) 357870 ml R02AA92 Dequalinium+Cinchocaine(O) 1039020 pieces 6 pieces 0,3581 R02AA94 Amylmetacresol+Dichlorobenzyl alcohol(O) 1028304 pieces 6 pieces 0,3544 R02AA95 Amylmetacresol+Dichlorobenzyl alcohol+Levomenthol(O) 1749528 pieces 6 pieces 0,6029 R02AA96 Amylmetacresol+Dichlorobenzyl alcohol+Ascorbic acid(O) 634872 pieces 6 pieces 0,2188 R02AA98 Cetylpyridinium chloride+Benzocaine(O) 374886 pieces 6 pieces 0,1292 R02AD Anesthetics, local 0,1534 R02AD80 Lidocaine+Propyl parahydroxybenzoate(O) 445060 pieces 6 pieces 0,1534 R02AX Other throat preparations 0,3611 R02AX01 Flurbiprofen(O) 7683,97 g 44 mg 0,3611 R02AX80 Thyme herb+Sage leaf(O) 32475 ml R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES 27,2911 R03A ADRENERGICS, INHALANTS 19,3775 R03AC Selective beta-2-adrenoceptor agonists 4,1496 R03AC02 Salbutamol(I) 989,816 g 0,8 mg 2,5583 R03AC02 Salbutamol(I) 1754,6 g 0,01 g 0,3628 R03AC04 Fenoterol(I) 63,84 g 0,6 mg 0,2200 R03AC12 Salmeterol(I) 4,98 g 0,1 mg 0,1030 R03AC13 Formoterol(I) 6,6281 g 0,024 mg 0,5710 R03AC18 Indacaterol(I) 24,264 g 0,15 mg 0,3345 Adrenergics in combination with corticosteroids or other drugs, excl. R03AK 11,8364 anticholinergics R03AK06 Salmeterol+Fluticasone(I) 572040 doses 4 doses 0,2957 R03AK06 Salmeterol+Fluticasone(I) 2364240 doses 2 doses 2,4443 R03AK07 Formoterol+Budesonide(I) 1114560 doses 2 doses 1,1523 R03AK07 Formoterol+Budesonide(I) 5776080 doses 4 doses 2,9858 R03AK08 Formoterol+Beclometasone(I) 2948220 doses 4 doses 1,5240 R03AK10 Vilanterol+Fluticasone furoate(I) 1635690 doses 1 doses 3,3821 R03AK13 Salbutamol+Beclometasone(I) 100800 doses 4 doses 0,0521 Adrenergics in combinations with anticholinergics incl. triple R03AL 3,3915 combinations with corticosteroids R03AL01 Fenoterol+Ipratropium bromide(I) 185820 ml 16 ml 0,0240 R03AL01 Fenoterol+Ipratropium bromide(I) 2399000 doses 6 doses 0,8267 R03AL03 Vilanterol+Umeclidinium(I) 326820 doses 1 doses 0,6758 R03AL04 Indacaterol+Glycopyrronium(I) 218220 doses 1 doses 0,4512 R03AL05 Formoterol+Aclidinium(I) 351840 doses 2 doses 0,3638 R03AL06 Olodaterol+Tiotropium(I) 669060 doses 2 doses 0,6917 R03AL07 Formoterol+Glycopyrronium(I) 37920 doses 4 doses 0,0196 R03AL08 Vilanterol+Umeclidinium+Fluticasone furoate(I) 39270 doses 1 doses 0,0812 R03AL09 Formoterol+Glycopyrronium+Beclometasone(I) 498120 doses 4 doses 0,2575 OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, R03B 4,8834 INHALANTS R03BA Glucocorticoids 1,6251 R03BA01 Beclometasone(I) 0,3 g 1,5 mg 0,0004 R03BA02 Budesonide(I) 160,48 g 1,5 mg 0,2212 R03BA02 Budesonide(I) 312,276 g 0,8 mg 0,8071 R03BA05 Fluticasone(I) 173,037 g 0,6 mg 0,5963 R03BB Anticholinergics 3,2583 R03BB01 Ipratropium bromide(I) 22,028 g 0,12 mg 0,3796 R03BB01 Ipratropium bromide(I) 27,645 g 0,3 mg 0,1905 R03BB04 Tiotropium(I) 3,4869 g 0,005 mg 1,4420 R03BB05 Aclidinium(I) 131,7238 g 0,644 mg 0,4229 R03BB06 Glycopyrronium(I) 8,9866 g 44 mcg 0,4223 R03BB07 Umeclidinium(I) 10,6656 g 55 mcg 0,4010 R03C ADRENERGICS FOR SYSTEMIC USE 0,1451 R03CC Selective beta-2-adrenoceptor agonists 0,1451 R03CC02 Salbutamol(O) 841,8 g 0,012 g 0,1451 R03CC02 Salbutamol(P) 0,1475 g 0,012 g <0,0001 36/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day R03CC03 Terbutaline(O) 0,5 g 0,015 g 0,0001 OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY R03D 2,8850 DISEASES R03DA Xanthines 1,2529 R03DA04 Theophylline(O) 238710 g 0,4 g 1,2340 R03DA05 Aminophylline(P) 5500,8 g 0,6 g 0,0190 R03DC Leukotriene receptor antagonists 1,5850 R03DC03 Montelukast(O) 7665,672 g 0,01 g 1,5850 R03DX Other systemic drugs for obstructive airway diseases 0,0471 R03DX05 Omalizumab(P) 198 g 0,016 g 0,0256 R03DX09 Mepolizumab(P) 19,8 g 3,6 mg 0,0114 R03DX10 Benralizumab(P) 2,64 g 0,54 mg 0,0101 R05 COUGH AND COLD PREPARATIONS 7,7293 EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH R05C 7,5640 SUPPRESSANTS R05CA Expectorants 0,0954 R05CA03 Guaifenesin(O) 41503,2 g 0,9 g 0,0954 R05CA12 Hederae helicis folium(O) 155796 pieces R05CA12 Hederae helicis folium(O) 7816865 ml R05CA86 Iceland moss(O) 9437400 ml Distillate of rectified essential oils of eucalyptus, sweet orange, myrtle R05CA87 1369500 pieces and lemon(O) R05CA88 Thyme herb+Wild thyme+Plantain(O) 489600 ml R05CA89 Thyme herb+Hederae helicis folium(O) 376700 ml R05CA91 Thyme herb+Marshmallow root(O) 5122950 ml R05CA92 Thyme herb(O) 270620 pieces R05CB Mucolytics 7,4687 R05CB01 Acetylcysteine(I, P) 75 g R05CB01 Acetylcysteine(O) 1029638,8 g 0,5 g 4,2580 R05CB01 Acetylcysteine(P) 7065 g R05CB02 Bromhexine(O) 8138 g 0,024 g 0,7011 R05CB03 Carbocisteine(O) 187155 g 1,5 g 0,2580 R05CB06 Ambroxol(O) 129473,7 g 0,12 g 2,2310 R05CB13 Dornase alfa(I) 24,885 g 2,5 mg 0,0206 COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH R05D 0,1072 EXPECTORANTS R05DB Other cough suppressants 0,1072 R05DB09 Oxeladin(O) 4148 g 0,08 g 0,1072 R05F COUGH SUPPRESSANTS AND EXPECTORANTS, COMBINATIONS 0,0581 R05FA Opium derivatives and expectorants 0,0581 R05FA80 Codeine+Guaifenesin(O) 842700 ml 30 ml 0,0581 R05X OTHER COLDPREPARATIONS R05XA Other cold combination preparations Gentian root+Primula flower+Common sorrel+Elder flower+Verbena R05XA80 3764,8 g herb(O) Gentian root+Primula flower+Common sorrel+Elder flower+Verbena R05XA80 1815140 pieces herb(O) R05XA82 Ibuprofen+Pseudoephedrine(O) 10704 g R06 ANTIHISTAMINES FOR SYSTEMIC USE 17,5952 R06A ANTIHISTAMINES FOR SYSTEMIC USE 17,5952 R06AA Aminoalkyl ethers 0,4752 R06AA02 Diphenhydramine(O) 38 g 0,2 g 0,0004 R06AA02 Diphenhydramine(P) 19 g R06AA04 Clemastine(O) 418,64 g 0,002 g 0,4328 R06AA04 Clemastine(P) 40,64 g 0,002 g 0,0420 R06AE Piperazine derivatives 8,8925 R06AE07 Cetirizine(O) 40649,015 g 0,01 g 8,4051 R06AE09 Levocetirizine(O) 1178,64 g 0,005 g 0,4874 R06AX Other antihistamines for systemic use 8,2275 37/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day R06AX13 Loratadine(O) 18664,5 g 0,01 g 3,8593 R06AX15 Mebhydrolin(O) 20 g 0,2 g 0,0002 R06AX17 Ketotifen(O) 2,37 g 0,002 g 0,0025 R06AX22 Ebastine(O) 7019,3 g 0,01 g 1,4514 R06AX27 Desloratadine(O) 2180,54 g 0,005 g 0,9017 R06AX28 Rupatadine(O) 1049,64 g 0,01 g 0,2170 R06AX29 Bilastine(O) 17365,8 g 20 mg 1,7954 R07 OTHER RESPIRATORY SYSTEM PRODUCTS 0,0004 R07A OTHER RESPIRATORY SYSTEM PRODUCTS 0,0004 R07AA Lung surfactants 0,0004 R07AA81 Porcine lung phospholipids(endotrach) 30,36 g 0,16 g 0,0004 S SENSORY ORGANS 33,3145 S01 OPHTHALMOLOGICALS 33,3145 S01A ANTIINFECTIVES S01AA Antibiotics S01AA01 Chloramphenicol(S) 245840 ml S01AA02 Chlortetracycline(S) 1,25 g S01AA12 Tobramycin(S) 42815 ml S01AA12 Tobramycin(S) 54271 g S01AA13 Fusidic acid(S) 52300 g S01AD Antivirals S01AD02 Trifluridine(S) 5 ml S01AD03 Aciclovir(S) 3397,5 g S01AE Fluoroquinolones S01AE03 Ciprofloxacin(S) 18435 ml S01AE05 Levofloxacin(S) 26495 ml S01AE07 Moxifloxacin(S) 18080 ml S01AX Other antiinfectives S01AX18 Povidone, iodinated(S) 488 ml S01B ANTIINFLAMMATORY AGENTS S01BA Corticosteroids, plain S01BA01 Dexamethasone(S) 90 pieces S01BA01 Dexamethasone(S) 14680,3 g S01BA01 Dexamethasone(S) 156465 ml S01BA02 Hydrocortisone(S) 4143 g S01BA09 Clobetasone(S) 33500 ml S01BA14 Loteprednol(S) 6595 ml S01BC Antiinflammatory agents, non-steroids S01BC03 Diclofenac(S) 50 ml S01BC05 Ketorolac(S) 6500 ml S01BC10 Nepafenac(S) 20630 ml S01BC11 Bromfenac(S) 10470 ml ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN S01C COMBINATION S01CA Corticosteroids and antiinfectives in combination S01CA80 Dexamethasone+Neomycin+Polymyxin B(S) 59170 ml S01CA81 Dexamethasone+Tobramycin(S) 15708 g S01CA81 Dexamethasone+Tobramycin(S) 43765 ml S01CA82 Dexamethasone+Chloramphenicol(S) 49059,5 g S01CA82 Dexamethasone+Chloramphenicol(S) 477140 ml S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS 33,3145 S01EA Sympathomimetics in glaucoma therapy 0,0183 S01EA05 Brimonidine(S) 1770 ml 0,2 ml 0,0183 S01EB Parasympathomimetics 0,0136 S01EB01 Pilocarpine(S) 2010 ml 0,4 ml 0,0104 S01EB02 Carbachol(S) 624 ml 0,4 ml 0,0032 S01EC Carbonic anhydrase inhibitors 3,7336 S01EC01 Acetazolamide(O) 25465 g 0,75 g 0,0702 S01EC01 Acetazolamide(P) 104,5 g 0,75 g 0,0003 S01EC03 Dorzolamide(S) 136500 ml 0,3 ml 0,9408 38/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day S01EC04 Brinzolamide(S) 162820 ml 0,2 ml 1,6833 S01EC80 Brinzolamide+Brimonidine(S) 100490 ml 0,2 ml 1,0389 S01ED Beta blocking agents 20,6756 S01ED01 Timolol(S) 23420 ml 0,2 ml 0,2421 S01ED01 Timolol(S) 219055 g 40 mg 11,3236 S01ED02 Betaxolol(S) 94910 ml 0,2 ml 0,9812 S01ED80 Timolol+Dorzolamide(S) 308050 ml 0,2 ml 3,1848 S01ED81 Timolol+Travoprost(S) 46380 ml 0,2 ml 0,4795 S01ED82 Timolol+Bimatoprost(S) 118551 ml 0,2 ml 1,2257 S01ED83 Timolol+Brinzolamide(S) 234105 ml 0,2 ml 2,4203 S01ED84 Timolol+Latanoprost(S) 72285 ml 0,2 ml 0,7473 S01ED85 Timolol+Tafluprost(S) 6869,7 ml 0,2 ml 0,0710 S01EE Prostaglandin analogues 8,8734 S01EE01 Latanoprost(S) 280272,5 ml 0,1 ml 5,7952 S01EE03 Bimatoprost(S) 255 ml 0,1 ml 0,0053 S01EE04 Travoprost(S) 73700 ml 0,1 ml 1,5239 S01EE05 Tafluprost(S) 224739 ml 0,3 ml 1,5490 S01F MYDRIATICS AND CYCLOPLEGICS S01FA Anticholinergics S01FA01 Atropine(S) 230 ml S01FA04 Cyclopentolate(S) 34620 ml S01FA06 Tropicamide(S) 17985 ml S01FB Sympathomimetics excl. antiglaucoma preparations S01FB01 Phenylephrine(S) 8595 ml S01G DECONGESTANTS AND ANTIALLERGICS S01GA Sympathomimetics used as decongestants S01GA02 Tetryzoline(S) 311940 ml S01GX Other antiallergics S01GX01 Cromoglicic acid(S) 117340 ml S01GX07 Azelastine(S) 40794 ml S01GX09 Olopatadine(S) 20210 ml S01H LOCAL ANESTHETICS S01HA Local anesthetics S01HA03 Tetracaine(S) 18280 ml S01HA04 Proxymetacaine(S) 46275 ml S01J DIAGNOSTIC AGENTS S01JA Colouring agents S01JA01 Fluorescein(P) 6120 ml S01JA81 Fluorescein+Oxybuprocaine+Chlorobutanol(S) 2825 ml S01K SURGICAL AIDS S01KA Viscoelastic substances S01KA02 Hypromellose(S) 5760 g S01L OCULAR VASCULAR DISORDER AGENTS S01LA Antineovascularisation agents S01LA01 Verteporfin(P) 3 pieces S01LA04 Ranibizumab(S) 4 pieces S01LA05 aflibercept(S) 228 pieces S01X OTHER OPHTHALMOLOGICALS S01XA Other ophthalmologicals S01XA03 Sodium chloride(S) 598,5 g S01XA18 Ciclosporin(S) 2484 ml S01XA80 Retinol+Dexpanthenol(S) 9457 g S01XA81 Carbomer(S) 191970 g S01XA82 Hypromellose(S) 195910 ml S01XA85 Hypromellose+Dextran(S) 457785 ml S02 OTOLOGICALS S02C CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION S02CA Corticosteroids and antiinfectives in combination S02CA81 Dexamethasone+Neomycin+Acetic acid, glacial(A) 3130 ml 39/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day S02CA82 Hydrocortisone+Ciprofloxacin(A) 134260 ml S02D OTHER OTOLOGICALS S02DA Analgesics and anesthetics S02DA81 Phenazone+Lidocaine(A) 1005 ml T HERBAL MEDICINAL PRODUCTS T01 HERBAL MEDICINAL PRODUCTS T01R HERBAL MEDICINAL PRODUCTS T01RS Herbal medicinal products T01RS01 herbal preparation(O) 716180 pieces T01RS01 herbal preparation(O) 8394970 ml T01RS02 homeopathic preparations(A) 7460 ml T01RS02 homeopathic preparations(C) 582550 g T01RS02 homeopathic preparations(O) 1540 g T01RS02 homeopathic preparations(O) 1194750 pieces T01RS02 homeopathic preparations(O) 1512010 ml V VARIOUS 0,2168 V01 ALLERGENS V01A ALLERGENS V01AA Allergen extracts V01AA02 Grass pollen(O) 136 pieces V01AA02 Grass pollen(P) 93 pieces V01AA03 House dust mites(O) 341 pieces V01AA03 House dust mites(P) 3 ml V01AA03 House dust mites(P) 258 pieces V01AA05 Tree pollen(P) 419 pieces V01AA05 Tree pollen(SL) 755 pieces V01AA07 Allergen products (insects)(P) 318 pieces V01AA10 Flowers(O) 7 pieces V01AA11 Animals(O) 29 pieces V01AA80 Tree and grass pollen(O) 162 pieces V01AA80 Tree and grass pollen(P) 57 pieces V01AA83 Grass pollen+Flowers(O) 24 pieces V01AA84 Tree and flower pollen(O) 33 pieces V03 ALL OTHER THERAPEUTIC PRODUCTS 0,2168 V03A ALL OTHER THERAPEUTIC PRODUCTS 0,2168 V03AB Antidotes V03AB14 Protamine sulfate(P) 275 g V03AB15 Naloxone(N) 1,8792 g V03AB15 Naloxone(P) 1,096 g V03AB16 Ethanol(P) 12500 ml V03AB17 Methylthioninium chloride(P) 157,5 g V03AB19 Physostigmine(P) 0,07 g V03AB24 Digitalis antitoxin(P) 1 g V03AB25 Flumazenil(P) 0,225 g V03AB33 Hydroxocobalamin(P) 40 g V03AB34 Fomepizole(P) 40 g V03AB35 Sugammadex(P) 66 g V03AB37 Idarucizumab(P) 225 g V03AC Iron chelating agents V03AC01 Deferoxamine(P) 7,5 g V03AC03 Deferasirox(O) 5929,2 g V03AE Drugs for treatment of hyperkalemia and hyperphosphatemia 0,1461 V03AE01 Polystyrene sulfonate(O, R) 1828723 g 45 g 0,0840 V03AE02 Sevelamer(O) 135792 g 6,4 g 0,0439 V03AE03 Lanthan(O) 19845 g 2,25 g 0,0182 V03AF Detoxifying agents for antineoplastic treatment 0,0707 V03AF01 Mesna(P) 5412 g V03AF03 Calcium folinate(O) 30,15 g 0,06 g 0,0010 V03AF07 Rasburicase(P) 0,6165 g 0,014 g 0,0001 V03AF09 Glucarpidase(P) 22000 U 40/41  Estonian Statistics on Medicines 2019 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day V03AF10 Sodium levofolinate(P) 1009,3 g 0,03 g 0,0696 V03AH Drugs for treatment of hypoglycemia V03AH01 Diazoxide(O) 55 g V03AN Medical gases V03AN01 Oxygen(I) 488368000 ml V03AN05 Air, medicinal(I) 2730000 ml V03AX Other therapeutic products V03AX01 Yohimbic acid(O) 0,25 g V04 DIAGNOSTIC AGENTS V04C OTHER DIAGNOSTIC AGENTS V04CD Tests for pituitary function V04CD01 Metyrapone(O) 12,5 g V04CD04 Corticorelin(P) 0,0002 g V04CF Tuberculosis diagnostics V04CF01 Tuberculin(P) 3600 U V04CJ Tests for thyreoidea function V04CJ02 Protirelin(P) 0,005 g V04CL Tests for allergic diseases V04CL83 Benzylpenicilloyl polylysine(P) 5 pieces V04CX Other diagnostic agents V04CX01 Indocyanine green(P) 6,625 g V04CX03 Methacholine(I) 45,036 g V04CX06 Hexaminolevulinate(P) 27,37 g V04CX09 Patent blue(P) 2,5 g V04CX87 Carbon monoxide+Helium(I) 20000 ml V07 ALL OTHER NON-THERAPEUTIC PRODUCTS V07A ALL OTHER NON-THERAPEUTIC PRODUCTS V07AB Solvents and diluting agents, incl. irrigating solutions V07AB80 Sodium chloride(P) 7171200 ml V07AB83 Water for injection(NA) 13359950 ml V08 CONTRAST MEDIA V08A X-RAY CONTRAST MEDIA, IODINATED V08AA Watersoluble, nephrotropic, high osmolar X-ray contrast media V08AA01 Sodium amidotrizoate+Meglumine Amidotrizoate(P) 6000 ml V08AB Watersoluble, nephrotropic, low osmolar X-ray contrast media V08AB02 Iohexol(P) 1748980 g V08AB05 Iopromide(P) 1216456,5 g V08AB09 Iodixanol(P) 2589464 g V08AD Non-watersoluble X-ray contrast media V08AD01 Ethyl esters of iodised fatty acids(P) 76,8 g V08B X-RAY CONTRAST MEDIA, NON-IODINATED V08BA Barium sulfate containing X-ray contrast media V08BA01 Barium sulfate(O) 151388,8 g V08BA01 Barium sulfate(O, R) 10400 g V08C MAGNETIC RESONANCE IMAGING CONTRAST MEDIA V08CA Paramagnetic contrast media V08CA01 Gadopentetic acid(P) 3520 ml V08CA02 Gadoteric acid(P) 47250 ml V08CA09 Gadobutrol(P) 80180 ml V08CA10 Gadoxetic acid(P) 4090 ml V08D ULTRASOUND CONTRAST MEDIA V08DA Ultrasound contrast media V08DA05 Sulfur hexafluoride, phospholipid microspheres(P) 200 ml V09 DIAGNOSTIC RADIOPHARMACEUTICALS V09A CENTRAL NERVOUS SYSTEM V09AB Iodine (123I) compounds V09AB03 Ioflupane (123I)(P) 175 ml 41/41 Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A ALIMENTARY TRACT AND METABOLISM 184,6875 A01 STOMATOLOGICAL PREPARATIONS 0,0691 A01A STOMATOLOGICAL PREPARATIONS 0,0691 A01AB Antiinfectives and antiseptics for local oral treatment 0,0691 A01AB08 Neomycin(O) 200 pieces A01AB09 Miconazole(O) 6699,2 g 0,2 g 0,0691 A01AB12 Hexetidine(O) 1386880 ml A01AB82 Demeclocycline+Triamcinolone(dental) 770 g A01AD Other agents for local oral treatment A01AD80 Lidocaine+Cetylpyridinium chloride(gingival) 199970 g A01AD81 Lidocaine+Cetrimide(O) 50250 g A01AD82 Choline salicylate(O) 160048 pieces A01AD83 Lidocaine+Chamomille extract(O) 386240 g A01AD90 Lidocaine+Paraformaldehyde(dental) 198 g A02 DRUGS FOR ACID RELATED DISORDERS 61,1483 A02A ANTACIDS 1,2544 Combinations and complexes of aluminium, calcium and A02AD 1,2544 magnesium compounds A02AD81 Aluminium hydroxide+Magnesium hydroxide(O) 950000 pieces 10 pieces 0,1959 A02AD81 Aluminium hydroxide+Magnesium hydroxide(O) 4863894 ml 50 ml 0,2006 A02AD83 Calcium carbonate+Magnesium carbonate(O) 4160664 pieces 10 pieces 0,8580 DRUGS FOR PEPTIC ULCER AND GASTRO- A02B 59,8939 OESOPHAGEAL REFLUX DISEASE (GORD) A02BA H2-receptor antagonists 0,0212 A02BA02 Ranitidine(P) 1971,75 g 0,3 g 0,0136 A02BA03 Famotidine(O) 148 g 0,04 g 0,0076 A02BC Proton pump inhibitors 59,8616 A02BC01 Omeprazole(O) 303243,2 g 0,02 g 31,2654 A02BC02 Pantoprazole(O) 303796,5 g 0,04 g 15,6612 A02BC02 Pantoprazole(P) 395,6 g 0,04 g 0,0204 A02BC03 Lansoprazole(O) 13,86 g 0,03 g 0,0010 A02BC05 Esomeprazole(O) 184510,48 g 0,03 g 12,6824 A02BC05 Esomeprazole(P) 3364 g 0,03 g 0,2312 A02BC08 Vonoprazan(O) 4 g A02BD Combinations for eradication of Helicobacter pylori 0,0016 A02BD08 Bismuth subcitrate+Tetracycline+Metronidazole (O) 9600 pieces 12 pieces 0,0016 Other drugs for peptic ulcer and gastro-oesophageal reflux A02BX 0,0094 disease (GORD) A02BX02 Sucralfate(O) 15790 g 4 g 0,0081 A02BX03 Pirenzepine(O) 60 g 0,1 g 0,0012 DRUGS FOR FUNCTIONAL GASTROINTESTINAL A03 8,5944 DISORDERS DRUGS FOR FUNCTIONAL GASTROINTESTINAL A03A 7,6949 DISORDERS A03AA Synthetic anticholinergics, esters with tertiary amino group 1,4436 A03AA04 Mebeverine(O) 210024 g 0,3 g 1,4436 A03AD Papaverine and derivatives 4,6591 A03AD01 Papaverine hydrochloride(P) 102 g 0,1 g 0,0021 A03AD02 Drotaverine(O) 222498,4 g 0,1 g 4,5881 A03AD02 Drotaverine(P) 3344 g 0,1 g 0,0690 A03AX Other drugs for functional gastrointestinal disorders 1,5921 A03AX13 Simeticone(O) 386047,5729 g 0,5 g 1,5921 A03B BELLADONNA AND DERIVATIVES, PLAIN 0,0823 A03BA Belladonna alkaloids, tertiary amines 0,0710 A03BA01 Atropine(O, P) 17,52 g 0,0015 g 0,0241 A03BA01 Atropine(P) 34,16 g 0,0015 g 0,0470 Belladonna alkaloids, semisynthetic, quaternary ammonium A03BB 0,0112 compounds A03BB01 Hyoscine butylbromide(O) 30,4 g 0,06 g 0,0010 A03BB01 Hyoscine butylbromide(P) 296,6 g 0,06 g 0,0102 1/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A03F PROPULSIVES 0,8173 A03FA Propulsives 0,8173 A03FA01 Metoclopramide(O) 10122,5 g 0,03 g 0,6958 A03FA01 Metoclopramide(P) 1544,8 g 0,03 g 0,1062 A03FA03 Domperidone(O) 222,9 g 0,03 g 0,0153 A04 ANTIEMETICS AND ANTINAUSEANTS 0,1167 A04A ANTIEMETICS AND ANTINAUSEANTS 0,1167 A04AA Serotonin (5-HT3) antagonists 0,1082 A04AA01 Ondansetron(P) 185,74 g 0,016 g 0,0239 A04AA02 Granisetron(O) 56,95 g 0,002 g 0,0587 A04AA02 Granisetron(P) 34,23 g 0,003 g 0,0235 A04AA80 Palonosetron+Netupitant(O) 963 pieces 1 pieces 0,0020 A04AD Other antiemetics 0,0086 A04AD01 Scopolamine(TD) 45 pieces 1 pieces 0,0001 A04AD12 Aprepitant(O) 233,985 g 0,165 g 0,0029 A04AD81 Fosaprepitant(P) 256,05 g 0,095 g 0,0056 A05 BILE AND LIVER THERAPY 2,0206 A05A BILE THERAPY 0,5389 A05AA Bile acids and derivatives 0,5389 A05AA02 Ursodeoxycholic acid(O) 195987,5 g 0,75 g 0,5389 A05B LIVER THERAPY, LIPOTROPICS 1,4818 A05BA Liver therapy 1,4818 A05BA03 Silymarin(O) 2076650 pieces A05BA80 Phospholipids from Soya Beans(O) 1349910 pieces 3 pieces 0,9279 A05BA80 Phospholipids from Soya Beans(O) 1611640 pieces 6 pieces 0,5539 A05BA80 Phospholipids from Soya Beans(P) 1045 pieces A06 DRUGS FOR CONSTIPATION 17,0341 A06A DRUGS FOR CONSTIPATION 17,0341 A06AB Contact laxatives 7,3954 A06AB02 Bisacodyl(O) 14101,2 g 0,01 g 2,9078 A06AB02 Bisacodyl(R) 719,6 g 0,01 g 0,1484 A06AB06 Senna glycosides(O) 4880 pieces 1 pieces 0,0101 A06AB08 Sodium picosulfate(O) 10490,3565 g 0,005 g 4,3264 A06AB80 Sodium picosulfate+Magnesium oxide+Citric acid(O) 2768 pieces 2 pieces 0,0029 A06AD Osmotically acting laxatives 8,6893 A06AD11 Lactulose(O) 26737036,2 g 6,7 g 8,2289 A06AD15 Macrogol(O) 2232640 g 10 g 0,4604 Macrogol+Sodium citrate+Citric acid+Sodium A06AD80 28200 ml chloride+Potassium chloride(O) Sodium sulphate, anhydrous+Potassium chloride+Sodium A06AD81 33932 pieces chloride+Macrogol+Sodium hydrogen carbonate(O) Macrogol+Sodium sulphate, anhydrous+Sodium A06AD83 chloride+Potassium chloride+Ascorbic acid+Sodium 5859 pieces ascorbate(O) Sodium sulphate, anhydrous+magnesium sulfate A06AD85 825088 ml heptahydrate+Potassium sulphate(O) A06AG Enemas 0,9134 A06AG11 Laurilsulfate, incl. combinations+Sorbitol+Sodium citrate(R) 442972 pieces 1 pieces 0,9134 A06AH Peripheral opioid receptor antagonists 0,0359 A06AH03 Naloxegol(O) 435,75 g 25 mg 0,0359 ANTIDIARRHEALS, INTESTINAL A07 4,2629 ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS A07A INTESTINAL ANTIINFECTIVES 0,0027 A07AA Antibiotics 0,0027 A07AA02 Nystatin(O) 120000000 U 1500000 U 0,0002 A07AA11 Rifaximin(O) 698,4 g 0,6 g 0,0024 A07AA12 Fidaxomicin(O) 28 g 0,4 g 0,0001 A07B INTESTINAL ADSORBENTS 0,3750 A07BC Other intestinal adsorbents 0,3750 2/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A07BC05 Diosmectidum(O) 1636560 g 9 g 0,3750 A07C ELECTROLYTES WITH CARBOHYDRATES A07CA Oral rehydration salt formulations Sodium chloride+Potassium chloride+Sodium A07CA80 67280 pieces citrate+Glucose(O) A07D ANTIPROPULSIVES 0,9140 A07DA Antipropulsives 0,9140 A07DA03 Loperamide(O) 4432,352 g 0,01 g 0,9140 A07E INTESTINAL ANTIINFLAMMATORY AGENTS 2,3751 A07EA Corticosteroids acting locally 0,0096 A07EA06 Budesonide(O) 42,03 g 0,009 g 0,0096 A07EA06 Budesonide(R) 1,0304 g A07EC Aminosalicylic acid and similar agents 2,3655 A07EC01 Sulfasalazine(O) 802500 g 2 g 0,8274 A07EC02 Mesalazine(O) 1022258 g 1,5 g 1,4053 A07EC02 Mesalazine(R) 96600 g 1,5 g 0,1328 A07F ANTIDIARRHEAL MICROORGANISMS 0,5961 A07FA Antidiarrheal microorganisms 0,5961 A07FA02 Saccharomyces boulardii(O) 289067,5 g 1 g 0,5961 A07X OTHER ANTIDIARRHEALS A07XA Other antidiarrheals A07XA04 Racecadotril(O) 2480 g A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS 0,0543 A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS 0,0543 A08AA Centrally acting antiobesity products 0,0538 A08AA62 Bupropione+Naltrexone(O) 104272 pieces 4 pieces 0,0538 A08AB Peripherally acting antiobesity products 0,0005 A08AB01 Orlistat(O) 95,76 g 0,36 g 0,0005 A09 DIGESTIVES, INCL. ENZYMES 1,6877 A09A DIGESTIVES, INCL. ENZYMES 1,6877 A09AA Enzyme preparations 1,6875 A09AA02 Lipase+Amylase+Protease(O) 3273341 pieces 4 pieces 1,6875 A09AC Enzyme and acid preparations, combinations 0,0002 A09AC80 Pepsin+Betaine(O) 300 pieces 3 pieces 0,0002 A10 DRUGS USED IN DIABETES 66,9614 A10A INSULINS AND ANALOGUES 15,9557 A10AB Insulins and analogues for injection, fast-acting 6,0469 A10AB01 Insulin (human)(P) 1110000 U 40 U 0,0572 A10AB04 Insulin lispro(P) 21273000 U 40 U 1,0967 A10AB05 Insulin aspart(P) 82890000 U 40 U 4,2731 A10AB06 Insulin glulisine(P) 12024000 U 40 U 0,6199 A10AC Insulins and analogues for injection, intermediate-acting 0,0653 A10AC01 Insulin (human)(P) 1266000 U 40 U 0,0653 Insulins and analogues for injection, intermediate- or long- A10AD 0,8005 acting combined with fast-acting A10AD04 Insulin lispro(P) 4824000 U 40 U 0,2487 A10AD05 Insulin aspart(P) 10704000 U 40 U 0,5518 A10AE Insulins and analogues for injection, long-acting 9,0431 A10AE04 Insulin glargine(P) 95778000 U 40 U 4,9375 A10AE05 Insulin detemir(P) 41920500 U 40 U 2,1611 A10AE06 Insulin degludec(P) 33693900 U 40 U 1,7370 A10AE54 Insulin glargine+Lixisenatide(P) 4026000 U 40 U 0,2075 A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS 51,0057 A10BA Biguanides 21,2264 A10BA02 Metformin(O) 20587506 g 2 g 21,2264 A10BB Sulfonylureas 12,2232 A10BB01 Glibenclamide(O) 0,018 g 0,01 g <0,0001 A10BB07 Glipizide(O) 855,9 g 0,01 g 0,1765 3/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A10BB09 Gliclazide(O) 205800 g 0,06 g 7,0729 A10BB12 Glimepiride(O) 4824,12 g 0,002 g 4,9738 A10BD Combinations of oral blood glucose lowering drugs 7,6158 A10BD07 Metformin+Sitagliptin(O) 1793120 pieces 2 pieces 1,8488 A10BD08 Metformin+Vildagliptin(O) 1392960 pieces 2 pieces 1,4362 A10BD10 Metformin+Saxagliptin(O) 315960 pieces 2 pieces 0,3258 A10BD11 Metformin+Linagliptin(O) 1196340 pieces 2 pieces 1,2335 A10BD15 Metformin+Dapagliflozin(O) 789208 pieces 2 pieces 0,8137 A10BD19 Linagliptin+Empagliflozin(O) 183900 pieces 1 pieces 0,3792 A10BD20 Metformin+Empagliflozin(O) 1343460 pieces 2 pieces 1,3852 A10BD21 Saxagliptin+Dapagliflozin(O) 92624 pieces 1 pieces 0,1910 A10BD23 Metformin+Ertugliflozin(O) 1232 pieces 1 pieces 0,0025 A10BF Alpha glucosidase inhibitors 0,0011 A10BF01 Acarbose(O) 162,75 g 0,3 g 0,0011 A10BG Thiazolidinediones 0,1208 A10BG03 Pioglitazone(O) 1757,7 g 0,03 g 0,1208 A10BH Dipeptyl peptidase 4 (DPP-4) inhibitors 4,1024 A10BH01 Sitagliptin(O) 48127,1 g 0,1 g 0,9924 A10BH02 Vildagliptin(O) 8460 g 0,1 g 0,1745 A10BH03 Saxagliptin(O) 538,35 g 5 mg 0,2220 A10BH05 Linagliptin(O) 6579,6 g 5 mg 2,7135 A10BJ Glucagon-like peptide-1 (GLP-1) analogues 2,9082 A10BJ01 Exenatide(P) 5,224 g 0,286 mg 0,0377 A10BJ02 Liraglutide(P) 639,36 g 1,5 mg 0,8789 A10BJ03 Lixisenatide(P) 0,5677 g 20 mcg 0,0585 A10BJ05 Dulaglutide(P) 24,786 g 0,16 mg 0,3194 A10BJ06 Semaglutide(P) 86,079 g 0,11 mg 1,6136 A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors 2,8077 A10BK01 Dapagliflozin(O) 5586,3 g 10 mg 1,1519 A10BK03 empagliflozin(O) 14047,35 g 17,5 mg 1,6552 A10BK04 Ertugliflozin(O) 2,52 g 10 mg 0,0005 A11 VITAMINS 13,2321 A11A MULTIVITAMINS, COMBINATIONS 1,5026 A11AA Multivitamins with minerals 1,5026 A11AA03 Multivitamins+Mineral elements(O) 728670 pieces 1 pieces 1,5026 A11B MULTIVITAMINS, PLAIN 0,0001 A11BA Multivitamins, plain 0,0001 A11BA80 Multivitamins(O) 500 ml 10 ml 0,0001 A11C VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO 3,8756 A11CC Vitamin D and analogues 3,8756 A11CC04 Calcitriol(O) 0,1007 g 0,001 mg 0,2077 A11CC05 Colecalciferol(O) 711500000 U 400 U 3,6679 A11CC05 Colecalciferol(P) 7500000 U VITAMIN B1, PLAIN AND IN COMBINATION WITH VITAMIN A11D 1,6079 B6 AND B12 A11DA Vitamin B1, plain 0,4309 A11DA01 Thiamine(O, P, V) 1050 g 0,05 g 0,0433 A11DA01 Thiamine(P) 9398,5 g 0,05 g 0,3876 A11DA03 Benfotiamine(O) 1754230 pieces A11DB Vitamin B1 in combination with vitamin B6 and/or vitamin B12 1,1770 A11DB80 Thiamine+Pyridoxine(P) 2345 pieces 1 pieces 0,0048 A11DB81 Benfotiamine+Pyridoxine(O) 207900 pieces 3 pieces 0,1429 A11DB84 Thiamine+Pyridoxine+Cyanocobalamin(O) 428260 pieces 1 pieces 0,8831 A11DB85 Thiamine+Pyridoxine+Cyanocobalamin+Lidocaine(P) 70895 pieces 1 pieces 0,1462 A11E VITAMIN B-COMPLEX, INCL. COMBINATIONS 0,6892 A11EA Vitamin B-complex, plain 0,6892 Thiamine+Nicotinamide+Riboflavin+Calcium A11EA80 334250 pieces 1 pieces 0,6892 pantothenate+Pyridoxine(O) A11G ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS 0,1285 A11GA Ascorbic acid (vitamin C), plain 0,1285 4/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A11GA01 Ascorbic acid(P) 12460 g 0,2 g 0,1285 A11H OTHER PLAIN VITAMIN PREPARATIONS 0,0545 A11HA Other plain vitamin preparations 0,0545 A11HA02 Pyridoxine(O) 90 g 0,16 g 0,0012 A11HA02 Pyridoxine(P) 3746,5 g 0,16 g 0,0483 A11HA03 Tocopherol(O) 120 g 0,2 g 0,0012 A11HA03 Tocopherol(P) 10,5 g 0,2 g 0,0001 A11HA08 Tocofersolan(O) 363 g 0,2 g 0,0037 A11J OTHER VITAMIN PRODUCTS, COMBINATIONS 5,3736 A11JA Combinations of vitamins A11JA80 Combinations of vitamins(O) 800 ml A11JB Vitamins with minerals 5,3736 A11JB81 Pyridoxine+Magnesium(O) 6924650 pieces 4 pieces 3,5698 Thiamine+Riboflavin+Pyridoxine+Cyanocobalamin+Ascorbic A11JB82 acid+Biotin+Nicotinamide+Calcium 874785 pieces 1 pieces 1,8039 pantothenate+Calcium+Magnesium+Folic acid+Zinc(O) A12 MINERAL SUPPLEMENTS 8,9424 A12A CALCIUM 5,3412 A12AA Calcium 0,8646 A12AA03 Calcium gluconate(P) 36475 g 3 g 0,0251 A12AA04 Calcium carbonate(O) 1221425 g 3 g 0,8396 A12AX Calcium, combinations with vitamin D and/or other drugs 4,4766 A12AX80 Calcium+Colecalciferol(O) 573690 pieces 1 pieces 1,1830 A12AX80 Calcium+Colecalciferol(O) 3194460 pieces 2 pieces 3,2936 A12B POTASSIUM 3,1279 A12BA Potassium 3,1279 A12BA01 Potassium chloride(O) 357570 g 3 g 0,2458 A12BA02 Potassium citrate(O) 2484 g 4 g 0,0013 A12BA80 Potassium chloride+Potassium hydrogen carbonate(O) 7200 pieces A12BA81 Potassium aspartate+Magnesium aspartate(O) 4151450 pieces 3 pieces 2,8535 A12BA81 Potassium aspartate+Magnesium aspartate(P) 13255 pieces 1 pieces 0,0273 A12C OTHER MINERAL SUPPLEMENTS 0,4733 A12CC Magnesium 0,4733 A12CC04 Magnesium citrate(O) 459040,2 g 2 g 0,4733 A12CX Other mineral products A12CX83 Phosphate(O) 11900 pieces A14 ANABOLIC AGENTS FOR SYSTEMIC USE 0,0030 A14A ANABOLIC STEROIDS 0,0030 A14AB Estren derivatives 0,0030 A14AB01 Nandrolone(P) 2,95 g 0,002 g 0,0030 A14B OTHER ANABOLIC AGENTS A14BX Other anabolic agents A14BX80 Riboxine(O) 90 g OTHER ALIMENTARY TRACT AND METABOLISM A16 0,5605 PRODUCTS OTHER ALIMENTARY TRACT AND METABOLISM A16A 0,5605 PRODUCTS A16AA Amino acids and derivatives 0,0018 A16AA01 Levocarnitine(O) 1750 g 2 g 0,0018 A16AA02 Ademetionine(O) 280 g A16AA81 Glycine(O) 480 g A16AB Enzymes 0,0056 A16AB02 Imiglucerase(P) 162800 U 300 U 0,0011 A16AB03 Agalsidase alfa(P) 1,281 g 0,001 g 0,0026 A16AB04 Agalsidase beta(P) 1,69 g 0,005 g 0,0007 A16AB07 Alglucosidase alfa(P) 55,4 g 0,1 g 0,0011 A16AB09 Idursulfase(P) 1,152 g A16AX Various alimentary tract and metabolism products 0,5531 A16AX01 Thioctic acid(O) 157770 g 0,6 g 0,5422 A16AX01 Thioctic acid(P) 177 g 0,6 g 0,0006 5/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A16AX03 Sodium phenylbutyrate(O) 2250 g 20 g 0,0002 A16AX05 Zinc(O) 618,75 g 0,15 g 0,0085 A16AX07 Sapropterin(O) 720 g A16AX10 Eliglustat(O) 108,192 g 0,168 g 0,0013 A16AX15 Telotristat(O) 67,5 g 0,75 g 0,0002 A16AX80 Creatine(O) 450 g A16AX81 Copper histidine(P) 0,23 g B BLOOD AND BLOOD FORMING ORGANS 109,6746 B01 ANTITHROMBOTIC AGENTS 82,5895 B01A ANTITHROMBOTIC AGENTS 82,5895 B01AA Vitamin K antagonists 2,0593 B01AA03 Warfarin(O) 7490 g 0,0075 g 2,0593 B01AB Heparin group 3,1858 B01AB01 Heparin sodium(P) 604000000 U 10000 U 0,1245 B01AB05 Enoxaparin sodium(hem, P) 762976000 U 2000 U 0,7867 B01AB05 Enoxaparin sodium(P) 1755668000 U 2000 U 1,8102 B01AB06 Nadroparin calcium(P) 7353000 U 2850 U 0,0053 B01AB12 Bemiparin sodium(P) 556640000 U 2500 U 0,4591 B01AC Platelet aggregation inhibitors, excl. heparin 54,7718 B01AC04 Clopidogrel(O) 155659,2 g 0,075 g 4,2797 B01AC06 Acetylsalicylic acid (O) 4273554 pieces 1 pieces 8,8124 B01AC11 Iloprost(I) 0,089 g 0,15 mg 0,0012 B01AC11 Iloprost(P) 0,0047 g 50 mcg 0,0002 B01AC16 Eptifibatide(P) 62,94 g 0,2 g 0,0006 B01AC24 Ticagrelor(O) 98666,4 g 0,18 g 1,1303 Selexipag B01AC27 3,12 g 1,8 mg 0,0036 (O) B01AC80 Acetylsalicylic acid +Magnesium oxide(O) 19661700 pieces 1 pieces 40,5438 B01AD Enzymes 0,0026 B01AD01 Streptokinase(P) 12500000 U 1500000 U <0,0001 B01AD02 Alteplase(P) 108,02 g 0,1 g 0,0022 B01AD11 Tenecteplase(P) 7,45 g 0,04 g 0,0004 B01AE Direct thrombin inhibitors 2,7382 B01AE07 Dabigatran etexilate(O) 398360,15 g 0,3 g 2,7382 B01AF Direct factor Xa inhibitors 19,8302 B01AF01 Rivaroxaban(O) 102828,25 g 0,02 g 10,6019 B01AF02 Apixaban(O) 43141,8 g 10 mg 8,8961 B01AF03 Edoxaban(O) 9665,1 g 60 mg 0,3322 B01AX Other antithrombotic agents 0,0015 B01AX01 Defibrotide(P) 66 g 1,75 g 0,0001 B01AX05 Fondaparinux sodium(P) 1,75 g 0,0025 g 0,0014 B02 ANTIHEMORRHAGICS 0,1855 B02A ANTIFIBRINOLYTICS 0,1578 B02AA Amino acids 0,1578 B02AA01 Aminocaproic acid(P) 6515 g 16 g 0,0008 B02AA02 Tranexamic acid(O) 111570 g 2 g 0,1150 B02AA02 Tranexamic acid(P) 40637,5 g 2 g 0,0419 B02B VITAMIN K AND OTHER HEMOSTATICS 0,0277 B02BA Vitamin K 0,0037 B02BA01 Phytomenadione(O) 1,5 g 0,02 g 0,0002 B02BA01 Phytomenadione(O, P) 23,3 g 0,02 g 0,0024 B02BA01 Phytomenadione(P) 11,12 g 0,02 g 0,0011 B02BB Fibrinogen 0,0001 B02BB01 Fibrinogen human(P) 262 g 5 g 0,0001 B02BC Local hemostatics B02BC81 Fibrinogen human+Human thrombin(epil) 687 pieces B02BD Blood coagulation factors B02BD01 Human prothrombin complex(P) 207200 U B02BD02 Human coagulation factor VIII(P) 3485000 U B02BD03 Factor VIII inhibitor bypassing activity(P) 120000 U B02BD04 Human coagulation factor IX(P) 726800 U 6/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day B02BD05 Human coagulation factor VII(P) 192000 U Von Willebrand factor, human+Human coagulation factor B02BD06 2075250 U VIII(P) B02BD08 Coagulation factor VIIa(P) 6050000 U B02BD80 Turoctocog alfa(P) 40000 U B02BD81 Simoctocog alfa(P) 414000 U B02BD83 Efmoroctocog alfa(P) 2870750 U B02BX Other systemic hemostatics 0,0239 B02BX01 Etamsylate(P) 625 g B02BX04 Romiplostim(P) 0,0718 g 30 mcg 0,0049 B02BX05 Eltrombopag(O) 390,6 g 50 mg 0,0161 B02BX06 Emicizumab(P) 21,045 g 15 mg 0,0029 B03 ANTIANEMIC PREPARATIONS 26,8983 B03A IRON PREPARATIONS 4,2523 B03AA Iron bivalent, oral preparations 2,3296 B03AA07 Ferrous sulphate(O) 225945 g 0,2 g 2,3296 B03AB Iron trivalent, oral preparations B03AB80 Iron (III) hydroxide polymaltose complex(O) 83378,5 g B03AC Iron, parenteral preparations 0,1080 B03AC01 Dextriferron(P) 1274 g 0,1 g 0,0263 B03AC02 Iron (III) hydroxide sucrose complex(P) 1351,5 g 0,1 g 0,0279 B03AC06 Iron (III)-hydroxide dextran complex(P) 1534 g 0,1 g 0,0316 B03AC80 Ferric derisomaltose(P) 1076,5 g 0,1 g 0,0222 B03AD Iron in combination with folic acid 1,8147 B03AD02 Ferrous fumarate+Folic acid(O) 508550 pieces 1 pieces 1,0487 B03AD03 Ferrous sulphate+Folic acid(O) 371500 pieces 1 pieces 0,7661 B03AE Iron in other combinations Ferrous gluconate+Manganese gluconate+Copper B03AE81 1696000 ml gluconate(O) B03AE82 Ferrous fumarate+Folic acid+Ascorbic acid(O) 43600 pieces B03B VITAMIN B12 AND FOLIC ACID 21,6311 B03BA Vitamin B12 (cyanocobalamin and analogues) 6,4352 B03BA01 Cyanocobalamin(O) 7,9 g 1 mg 0,0163 B03BA01 Cyanocobalamin(P) 62,055 g 0,02 mg 6,3981 B03BA03 Hydroxocobalamin(P) 0,2016 g 0,02 mg 0,0208 B03BB Folic acid and derivatives 15,1959 B03BB01 Folic acid(O) 2947,7 g 0,4 mg 15,1959 B03X OTHER ANTIANEMIC PREPARATIONS 1,0149 B03XA Other antianemic preparations 1,0149 B03XA02 Darbepoetin alfa(P) 1,6123 g 0,0045 mg 0,7388 B03XA03 Methoxy polyethylene glycol-epoetin beta(P) 0,292 g 4 mcg 0,1505 B03XA80 Epoetin beta(P) 60912000 U 1000 U 0,1256 B05 BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS B05A BLOOD AND RELATED PRODUCTS B05AA Blood substitutes and plasma protein fractions B05AA01 Albumin(P) 701430 g B05AA06 Gelatin agents(P) 8840000 ml B05AA81 Dextran+Sodium chloride(P) 23500 ml Gelatine+Sodium chloride+Potassium chloride+Magnesium B05AA83 670000 ml chloride+Sodium lactate(P) B05AA86 human plasma proteins(P) 505400 ml B05B I.V. SOLUTIONS B05BA Solutions for parenteral nutrition B05BA01 Amino acids(P) 799000 ml B05BA02 Fat emulsions(P) 156900 ml B05BA03 Carbohydrates(P) 7160 g B05BA03 Carbohydrates(P) 67562600 ml B05BA10 Combinations(P) 17156734 ml B05BB Solutions affecting the electrolyte balance B05BB01 Electrolytes(P) 188802500 ml B05BB81 Sodium chloride+Glucose(P) 250000 ml 7/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day B05BC Solutions producing osmotic diuresis B05BC01 Mannitol(P) 954000 ml B05C IRRIGATING SOLUTIONS B05CX Other irrigating solutions B05CX10 Combinations(NA) 346000 ml B05D PERITONEAL DIALYTICS B05DA Isotonic solutions B05DA80 Isotonic solutions(P) 8830000 ml B05DB Hypertonic solutions B05DB80 hypertonic solutions(P) 138214000 ml Amino acids+Sodium chloride+Calcium chloride B05DB81 220000 ml dihydrate+Magnesium chloride hexahydrate+Sodium lactate(P) B05Z HEMODIALYTICS AND HEMOFILTRATES B05ZB Hemofiltrates Sodium chloride+Potassium chloride+Calcium chloride B05ZB80 dihydrate+Magnesium chloride+Glucose+Sodium hydrogen 20430000 ml carbonate(P) Calcium chloride dihydrate+Magnesium chloride hexahydrate+Sodium chloride+Sodium hydrogen B05ZB82 9150000 ml carbonate+Potassium chloride+Disodium phosphate dihydrate(P) Calcium chloride dihydrate+Magnesium chloride B05ZB84 hexahydrate+Lactic acid+Sodium hydrogen carbonate+Sodium 1020000 ml chloride(P) B05ZB85 Sodium citrate+Sodium chloride(P) 2017000 ml Magnesium chloride hexahydrate+Sodium chloride+Potassium B05ZB86 chloride+Disodium phosphate dihydrate+Sodium hydrogen 7080000 ml carbonate(P) B05X I.V. SOLUTION ADDITIVES B05XA Electrolyte solutions B05XA01 Potassium chloride(P) 1650 g B05XA01 Potassium chloride(P) 3601200 ml B05XA02 Sodium hydrogen carbonate(P) 1765500 ml B05XA03 Sodium chloride(P) 491307700 ml B05XA05 Magnesium sulphate(P) 416900 ml B05XA07 Calcium chloride(P) 168500 ml B05XA14 Sodium glycerophosphate, hydrated(P) 105600 ml B05XA80 Electrolytes(P) 137700 ml B05XB Amino acids B05XB01 Arginine(P) 3300 ml B05XB02 Alanyl glutamine(P) 45000 ml B05XC Vitamins B05XC80 Vitamins(P) 3597,52 g B05XC80 Vitamins(P) 183400 ml B06 OTHER HEMATOLOGICAL AGENTS 0,0014 B06A OTHER HEMATOLOGICAL AGENTS 0,0014 B06AA Enzymes B06AA03 Hyaluronidase(P) 90640 U B06AB Heme products B06AB01 Hemin(P) 40 ml B06AB80 hemoderivate of calf blood, deproteinized(O) 100 pieces B06AC Drugs usedin hereditary angioedema 0,0014 B06AC01 C1-inhibitor(P) 486000 U 1400 U 0,0007 B06AC02 Icatibant(P) 8,1 g 0,03 g 0,0006 B06AC04 Conestat alfa(P) 163800 U 3500 U 0,0001 C CARDIOVASCULAR SYSTEM 450,0066 C01 CARDIAC THERAPY 21,9418 C01A CARDIAC GLYCOSIDES 2,0279 C01AA Digitalis glycosides 2,0279 C01AA05 Digoxin(O) 243,6725 g 0,25 mg 2,0099 8/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C01AA05 Digoxin(P) 2,145 g 0,25 mg 0,0177 C01AA06 Lanatoside C(O) 0,18 g 0,001 g 0,0004 C01B ANTIARRHYTHMICS, CLASS I AND III 5,3353 C01BA Antiarrhythmics, class Ia <0,0001 C01BA01 Quinidine(O) 20 g 1,2 g <0,0001 C01BA13 Hydroquinidine(O) 234 g C01BB Antiarrhythmics, class Ib 0,0235 C01BB02 Mexiletine(O) 100 g 0,8 g 0,0003 C01BB80 Aethacizin(O) 2257,5 g 0,2 g 0,0233 C01BC Antiarrhythmics, class Ic 3,4495 C01BC03 Propafenone(O) 478569 g 0,3 g 3,2895 C01BC03 Propafenone(P) 548,45 g 0,3 g 0,0038 C01BC04 Flecainide(O) 15113 g 0,2 g 0,1558 C01BC04 Flecainide(P) 39 g 0,2 g 0,0004 C01BD Antiarrhythmics, class III 1,8622 C01BD01 Amiodarone(O) 174018 g 0,2 g 1,7942 C01BD01 Amiodarone(P) 5400,75 g 0,2 g 0,0557 C01BD07 Dronedarone(O) 4800 g 0,8 g 0,0124 C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES 0,6378 C01CA Adrenergic and dopaminergic agents 0,6363 C01CA01 Etilefrine(O) 1,8375 g 0,05 g 0,0001 C01CA02 Isoprenaline(P) 0,65 g 0,09 g <0,0001 C01CA03 Norepinephrine(P) 400,9 g 0,006 g 0,1378 C01CA04 Dopamine(P) 2606,6 g 0,5 g 0,0107 C01CA06 Phenylephrine(P) 211,7 g 0,004 g 0,1091 C01CA07 Dobutamine(P) 1491,25 g 0,5 g 0,0062 C01CA17 Midodrine(O) 6,45 g 0,03 g 0,0004 C01CA24 Epinephrine(I) 4,392 g C01CA24 Epinephrine(intraoss, P) 0,05 g 0,5 mg 0,0002 C01CA24 Epinephrine(P) 80,152 g 0,5 mg 0,3306 C01CA26 Ephedrine(P) 998 g 0,05 g 0,0412 C01CE Phosphodiesterase inhibitors 0,0009 C01CE02 Milrinone(P) 21,38 g 0,05 g 0,0009 C01CX Other cardiac stimulants 0,0006 C01CX08 Levosimendan(P) 3,25 g 11 mg 0,0006 C01CX80 Ammonia(I) 1381960 ml C01D VASODILATORS USED IN CARDIAC DISEASES 5,8804 C01DA Organic nitrates 5,8772 C01DA02 Glyceryl trinitrate(P) 206,7 g C01DA02 Glyceryl trinitrate(SL) 507,812 g 0,0025 g 0,4189 C01DA05 Pentaerithrityl tetranitrate(O) 3 g 0,12 g 0,0001 C01DA08 Isosorbide dinitrate(O) 644 g 0,06 g 0,0221 C01DA08 Isosorbide dinitrate(SL) 236,35 g 0,02 g 0,0244 C01DA14 Isosorbide mononitrate(O) 104977,4 g 0,04 g 5,4118 C01DX Other vasodilatators used in cardiac diseases 0,0032 C01DX80 Meldonium(O) 1155 g 0,75 g 0,0032 C01DX80 Meldonium(P) 25 g 0,75 g 0,0001 C01E OTHER CARDIAC PREPARATIONS 8,0604 C01EA Prostaglandins 0,0002 C01EA01 Alprostadil(P) 0,0556 g 0,5 mg 0,0002 C01EB Other cardiac preparations 8,0602 C01EB10 Adenosine(P) 109,104 g 0,015 g 0,0150 C01EB15 Trimetazidine(O) 147291,9 g 0,04 g 7,5931 C01EB16 Ibuprofen(P) 1,16 g 0,03 g 0,0001 C01EB17 Ivabradine(O) 1774,92 g 0,01 g 0,3660 C01EB18 Ranolazine(O) 61890 g 1,5 g 0,0851 C01EB21 Regadenoson(P) 0,168 g 0,4 mg 0,0009 C01EB80 Hawthorn berry(O) 63440 ml C02 ANTIHYPERTENSIVES 4,0447 C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING 2,4305 C02AC Imidazoline receptor agonists 2,4305 9/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C02AC01 Clonidine(O) 5,7075 g 0,45 mg 0,0262 C02AC01 Clonidine(P) 2,783 g 0,45 mg 0,0128 C02AC02 Guanfacine(O) 0,084 g 3 mg 0,0001 C02AC05 Moxonidine(O) 347,9358 g 0,3 mg 2,3916 C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING 1,5733 C02CA Alpha-adrenoreceptor antagonists 1,5733 C02CA01 Prazosin(O) 3,56 g 0,005 g 0,0015 C02CA04 Doxazosin(O) 3049,028 g 0,004 g 1,5718 C02D ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON 0,0011 C02DD Nitroferricyanide derivatives 0,0011 C02DD01 Sodium nitroprusside(P) 25,47 g 0,05 g 0,0011 C02K OTHER ANTIHYPERTENSIVES 0,0399 C02KX Antihypertensives for pulmonary arterial hypertension 0,0399 C02KX01 Bosentan(O) 1505 g 0,25 g 0,0124 C02KX02 Ambrisentan(O) 48,75 g 7,5 mg 0,0134 C02KX04 Macitentan(O) 4,5 g 10 mg 0,0009 C02KX05 Riociguat(O) 28,623 g 4,5 mg 0,0131 C03 DIURETICS 27,3596 C03A LOW-CEILING DIURETICS, THIAZIDES 1,3934 C03AA Thiazides, plain 1,3934 C03AA03 Hydrochlorothiazide(O) 16893,5 g 0,025 g 1,3934 C03B LOW-CEILING DIURETICS, EXCL. THIAZIDES 2,3642 C03BA Sulfonamides, plain 2,3642 C03BA11 Indapamide(O) 2866,35 g 2,5 mg 2,3642 C03C HIGH-CEILING DIURETICS 20,2193 C03CA Sulfonamides, plain 20,2193 C03CA01 Furosemide(O) 68271,8 g 0,04 g 3,5195 C03CA01 Furosemide(P) 6259,9 g 0,04 g 0,3227 C03CA04 Torasemide(O) 118656,9 g 0,015 g 16,3119 C03CA04 Torasemide(P) 474,1 g 0,015 g 0,0652 C03D POTASSIUM-SPARING AGENTS 3,3628 C03DA Aldosterone antagonists 3,3628 C03DA01 Spironolactone(O) 122271,25 g 0,075 g 3,3618 C03DA04 Eplerenone(O) 24,75 g 0,05 g 0,0010 DIURETICS AND POTASSIUM-SPARING AGENTS IN C03E 0,0199 COMBINATION C03EA Low-ceiling diuretics and potassium-sparing agents 0,0199 C03EA81 Hydrochlorothiazide+Amiloride(O) 9630 pieces 1 pieces 0,0199 C04 PERIPHERAL VASODILATORS 2,6475 C04A PERIPHERAL VASODILATORS 2,6475 C04AC Nicotinic acid and derivatives 0,0006 C04AC01 Nicotinic acid(P) 54 g 0,2 g 0,0006 C04AD Purine derivatives 1,6190 C04AD02 Xantinol nicotinate(O) 81 g 0,9 g 0,0002 C04AD03 Pentoxifylline(O) 783720 g 1 g 1,6161 C04AD03 Pentoxifylline(P) 403,5 g 0,3 g 0,0028 C04AX Other peripheral vasodilators 1,0279 C04AX21 Naftidrofuryl(O) 299090 g 0,6 g 1,0279 C05 VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL C05A FISSURES FOR TOPICAL USE C05AA Corticosteroids C05AA82 Hydrocortisone+Cinchocaine(R) 64212 pieces C05AA84 Fluocortolone+Lidocaine(R) 118650 pieces C05AA84 Fluocortolone+Lidocaine(R) 244530 g C05AE Muscle relaxants C05AE01 Glyceryl trinitrate(R) 30 g Other agents for treatment of hemorrhoids and anal fissures for C05AX topical use C05AX81 Xeroformium+Zinc sulphate+Extract of Belladonna(R) 1870 pieces C05AX83 Yeast cell extract+Shark liver oil(R) 321900 pieces 10/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C05B ANTIVARICOSE THERAPY C05BA Heparins or heparinoids for topical use C05BA03 Heparin sodium(C) 7321300 g C05BB Sclerosing agents for local injection C05BB02 Lauromacrogol 400(P) 55,425 g C05BB04 Sodium tetradecyl sulphate(P) 0,3 g C05C CAPILLARY STABILIZING AGENTS C05CA Bioflavonoids C05CA01 Rutoside(O) 204810 pieces C05CA03 Diosmin(O) 455430 g C05CA04 Troxerutin(C) 3592900 g C05CA04 Troxerutin(O) 205860 g C05CA53 Diosmin+Hesperidine(O) 2700 pieces C05CX Other capillary stabilizing agents C05CX80 Vigne rouge extract(O) 54 g C05CX81 Aescin(O) 80 pieces C07 BETA BLOCKING AGENTS 56,9879 C07A BETA BLOCKING AGENTS 56,9871 C07AA Beta blocking agents, non-selective 1,6890 C07AA05 Propranolol(O) 49375,4 g 0,16 g 0,6363 C07AA07 Sotalol(O) 81674,4 g 0,16 g 1,0526 C07AB Beta blocking agents, selective 54,5936 C07AB02 Metoprolol(O) 1991991,45 g 0,15 g 27,3841 C07AB02 Metoprolol(P) 106,55 g 0,15 g 0,0015 C07AB03 Atenolol(O) 18654,75 g 0,075 g 0,5129 C07AB07 Bisoprolol(O) 17943,6 g 0,01 g 3,7001 C07AB09 Esmolol(P) 0,5 g 2,5 g <0,0001 C07AB12 Nebivolol(O) 55757,03 g 0,005 g 22,9950 C07AG Alpha and beta blocking agents 0,7046 C07AG01 Labetalol(O) 27670 g 0,6 g 0,0951 C07AG01 Labetalol(P) 1475,5 g 0,6 g 0,0051 C07AG02 Carvedilol(O) 10992 g 0,0375 g 0,6044 C07B BETA BLOCKING AGENTS AND THIAZIDES 0,0007 C07BB Beta blocking agents, selective, and thiazides 0,0007 C07BB07 Bisoprolol+Hydrochlorothiazide(O) 360 pieces 1 pieces 0,0007 C08 CALCIUM CHANNEL BLOCKERS 46,4845 SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY C08C 45,0090 VASCULAR EFFECTS C08CA Dihydropyridine derivatives 45,0090 C08CA01 Amlodipine(O) 63552,75 g 0,005 g 26,2100 C08CA02 Felodipine(O) 6126,975 g 0,005 g 2,5268 C08CA05 Nifedipine(O) 14290,72 g 0,03 g 0,9823 C08CA06 Nimodipine(O) 402 g 0,3 g 0,0028 C08CA06 Nimodipine(P) 3,65 g 0,05 g 0,0002 C08CA08 Nitrendipine(O) 42779,64 g 0,02 g 4,4107 C08CA09 Lacidipine(O) 6126,624 g 0,004 g 3,1584 C08CA13 Lercanidipine(O) 37427,4 g 0,01 g 7,7178 SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT C08D 1,4755 CARDIAC EFFECTS C08DA Phenylalkylamine derivatives 1,3680 C08DA01 Verapamil(O) 159208 g 0,24 g 1,3679 C08DA01 Verapamil(P) 13,85 g 0,24 g 0,0001 C08DB Benzothiazepine derivatives 0,1075 C08DB01 Diltiazem(O) 12508,2 g 0,24 g 0,1075 C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM 210,3541 C09A ACE INHIBITORS, PLAIN 75,8991 C09AA ACE inhibitors, plain 75,8991 C09AA01 Captopril(O) 923,5 g 0,05 g 0,0381 C09AA02 Enalapril(O) 40891,23 g 0,01 g 8,4321 C09AA02 Enalapril(P) 9,5688 g 0,01 g 0,0020 C09AA03 Lisinopril(O) 5,04 g 0,01 g 0,0010 11/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C09AA04 Perindopril(O) 14762,7 g 0,004 g 7,6104 C09AA05 Ramipril(O) 66657,77 g 2,5 mg 54,9811 C09AA09 Fosinopril(O) 34269,2 g 0,015 g 4,7110 C09AA10 Trandolapril(O) 119,616 g 0,002 g 0,1233 C09B ACE INHIBITORS, COMBINATIONS 56,7495 C09BA ACE inhibitors and diuretics 29,2415 C09BA02 Enalapril+Hydrochlorothiazide(O) 2792120 pieces 1 pieces 5,7575 C09BA04 Perindopril+Indapamide(O) 9573390 pieces 1 pieces 19,7410 C09BA05 Ramipril+Hydrochlorothiazide(O) 1235530 pieces 1 pieces 2,5477 C09BA09 Fosinopril+Hydrochlorothiazide(O) 579612 pieces 1 pieces 1,1952 C09BB ACE inhibitors and calcium channel blockers 12,8524 C09BB03 Lisinopril+Amlodipine(O) 847020 pieces 1 pieces 1,7466 C09BB04 Perindopril+Amlodipine(O) 4185870 pieces 1 pieces 8,6315 C09BB07 Ramipril+Amlodipine(O) 903030 pieces 1 pieces 1,8621 C09BB10 Trandolapril+Verapamil(O) 296856 pieces 1 pieces 0,6121 C09BX ACE inhibitors, other combinations 14,6556 C09BX01 Perindopril+Amlodipine+Indapamide(O) 7107240 pieces 1 pieces 14,6556 C09C ANGIOTENSIN II RECEPTOR BLOCKERS (ARBS), PLAIN 43,2749 C09CA Angiotensin II receptor blockers (ARBs), plain 43,2749 C09CA01 Losartan(O) 85044 g 0,05 g 3,5073 C09CA02 Eprosartan(O) 840 g 0,6 g 0,0029 C09CA03 Valsartan(O) 170325,12 g 0,08 g 4,3903 C09CA06 Candesartan(O) 41969,312 g 0,008 g 10,8179 C09CA07 Telmisartan(O) 413416,96 g 0,04 g 21,3123 C09CA08 Olmesartan medoxomil(O) 31464,44 g 0,02 g 3,2441 ANGIOTENSIN II RECEPTOR BLOCKERS (ARBS), C09D 34,4306 COMBINATIONS C09DA Angiotensin II receptor blockers (ARBs) and diuretics 15,8037 C09DA01 Losartan+Hydrochlorothiazide(O) 790330 pieces 1 pieces 1,6297 C09DA03 Valsartan+Hydrochlorothiazide(O) 899388 pieces 1 pieces 1,8546 C09DA06 Candesartan+Hydrochlorothiazide(O) 1151244 pieces 1 pieces 2,3739 C09DA07 Telmisartan+Hydrochlorothiazide(O) 4563908 pieces 1 pieces 9,4111 C09DA08 Olmesartan medoxomil+Hydrochlorothiazide(O) 259140 pieces 1 pieces 0,5344 Angiotensin II receptor blockers (ARBs) and calcium channel C09DB 13,5511 blockers C09DB01 Valsartan+Amlodipine(O) 216428 pieces 1 pieces 0,4463 C09DB02 Olmesartan medoxomil+Amlodipine(O) 3087112 pieces 1 pieces 6,3658 C09DB04 Telmisartan+Amlodipine(O) 3201632 pieces 1 pieces 6,6020 C09DB07 Candesartan+Amlodipine(O) 66416 pieces 1 pieces 0,1370 C09DX Angiotensin II receptor blockers (ARBs), other combinations 5,0759 C09DX01 Valsartan+Amlodipine+Hydrochlorothiazide(O) 2352 pieces 1 pieces 0,0048 C09DX03 Olmesartan medoxomil+Amlodipine+Hydrochlorothiazide(O) 2176244 pieces 1 pieces 4,4876 C09DX04 Valsartan+Sacubitril(O) 282940 pieces 1 pieces 0,5834 C10 LIPID MODIFYING AGENTS 80,1865 C10A LIPID MODIFYING AGENTS, PLAIN 77,9115 C10AA HMG CoA reductase inhibitors 76,7312 C10AA01 Simvastatin(O) 67853,92 g 0,03 g 4,6640 C10AA03 Pravastatin(O) 4074 g 0,03 g 0,2800 C10AA04 Fluvastatin(O) 15836,8 g 0,06 g 0,5443 C10AA05 Atorvastatin(O) 295816,2 g 0,02 g 30,4997 C10AA07 Rosuvastatin(O) 197584,23 g 0,01 g 40,7432 C10AB Fibrates 0,6614 C10AB05 Fenofibrate(O) 64152 g 0,2 g 0,6614 C10AC Bile acid sequestrants 0,0012 C10AC01 Colestyramine(O) 7800 g 14 g 0,0011 C10AC02 Colestipol(O) 250 g 20 g <0,0001 C10AX Other lipid modifying agents 0,5177 C10AX09 Ezetimibe(O) 2427,32 g 0,01 g 0,5005 12/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C10AX13 Evolocumab(P) 58,94 g 10 mg 0,0122 C10AX14 Alirocumab(P) 13,2 g 5,4 mg 0,0050 C10AX80 Omega-3-acid ethyl esters 90(O) 188944 pieces C10B LIPID MODIFYING AGENTS, COMBINATIONS 2,2750 C10BA Combinations of various lipid modifying agents 1,5405 C10BA05 Atorvastatin+Ezetimibe(O) 18660 pieces 1 pieces 0,0385 C10BA06 Rosuvastatin+Ezetimibe(O) 728400 pieces 1 pieces 1,5020 C10BX Lipid modifying agents in combination with other drugs 0,7345 C10BX03 Atorvastatin+Amlodipine(O) 83250 pieces 1 pieces 0,1717 C10BX11 Atorvastatin+Amlodipine+Perindopril(O) 213330 pieces 1 pieces 0,4399 C10BX13 Rosuvastatin+Perindopril+Indapamide(O) 37800 pieces 1 pieces 0,0779 C10BX15 Atorvastatin+Perindopril(O) 21840 pieces 1 pieces 0,0450 D DERMATOLOGICALS 1,7338 D01 ANTIFUNGALS FOR DERMATOLOGICAL USE 1,0595 D01A ANTIFUNGALS FOR TOPICAL USE D01AC Imidazole and triazole derivatives D01AC01 Clotrimazole(C) 569708,6 g D01AC05 Isoconazole(C) 261742,01 g D01AC08 Ketoconazole(C) 723219 g D01AC08 Ketoconazole(C) 773160 ml D01AC80 Isoconazole+Diflucortolone(C) 435645 g D01AC81 Clotrimazole+Hexamidine(C) 145020 g D01AE Other antifungals for topical use D01AE14 Ciclopirox(C) 1762,2 ml D01AE15 Terbinafine(C) 586469 g D01AE16 Amorolfine(C) 29580 ml D01AE22 Naftifine(C) 182360 ml D01AE22 Naftifine(C) 233895 g D01B ANTIFUNGALS FOR SYSTEMIC USE 1,0595 D01BA Antifungals for systemic use 1,0595 D01BA01 Griseofulvin(O) 977,5 g 0,5 g 0,0040 D01BA02 Terbinafine(O) 127966 g 0,25 g 1,0555 D02 EMOLLIENTS AND PROTECTIVES D02A EMOLLIENTS AND PROTECTIVES D02AB Zinc products D02AB80 Zinc oxide(C) 408780 g D02AE Carbamide products D02AE01 Urea(C) 78150 g D02AF Salicylic acid preparations D02AF81 Salicylic acid+Lactic acid(C) 2009,01 g D02B PROTECTIVES AGAINST UV-RADIATION D02BA Protectives against UV-radiation for topical use D02BA01 4-Aminobenzoic acid(O) 9720 g PREPARATIONS FOR TREATMENT OF WOUNDS AND D03 ULCERS D03A CICATRIZANTS D03AX Other cicatrizants D03AX03 Dexpanthenol(C) 3814745 g D03AX81 Heparin sodium+Allantoin+Extract of Cepae(C) 115500 g D03AX83 Dexpanthenol+Chlorhexidine(C) 1914240 g ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, D04 ETC. ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, D04A ETC. D04AA Antihistamines for topical use D04AA09 Chloropyramine(P) 10 g D05 ANTIPSORIATICS 0,0534 D05A ANTIPSORIATICS FOR TOPICAL USE D05AA Tars D05AA85 Coal tar+Salicylic acid(C) 588000 ml D05AC Antracen derivatives 13/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day D05AC01 Dithranol(C) 4550 g D05AX Other antipsoriatics for topical use D05AX02 Calcipotriol(C) 210 g D05AX80 Calcipotriol+Betamethasone(C) 853350 g D05B ANTIPSORIATICS FOR SYSTEMIC USE 0,0534 D05BB Retinoids for treatment of psoriasis 0,0534 D05BB02 Acitretin(O) 906,3 g 0,035 g 0,0534 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR D06 DERMATOLOGICAL USE D06A ANTIBIOTICS FOR TOPICAL USE D06AX Other antibiotics for topical use D06AX01 Fusidic acid(C) 210705 g D06AX09 Mupirocin(C) 2310 g D06AX80 Bacitracin+Neomycin(C) 155540 g D06AX84 Chloramphenicol+Methyluracil(C) 4000 g D06B CHEMOTHERAPEUTICS FOR TOPICAL USE D06BA Sulfonamides D06BA01 Silver sulfadiazine(C) 1533900 g D06BB Antivirals D06BB03 Aciclovir(C) 199734 g D06BB04 Podophyllotoxin(C) 1253 ml D06BB06 Penciclovir(C) 28 g D06BB10 Imiquimod(C) 6467 g D06BB81 Aciclovir+Hydrocortisone(C) 31168 g D06BX Other chemotherapeutics D06BX01 Metronidazole (C) 123150 g D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS D07A CORTICOSTEROIDS, PLAIN D07AA Corticosteroids, weak (group I) D07AA02 Hydrocortisone(C) 590660 g D07AC Corticosteroids, potent (group III) D07AC01 Betamethasone(C) 139380 g D07AC04 Fluocinolone acetonide(C) 435 g D07AC13 Mometasone(C) 332200 ml D07AC13 Mometasone(C) 1176620 g D07AC14 Methylprednisolone aceponate(C) 587385 g D07AC17 Fluticasone(C) 51435 g D07AD Corticosteroids, very potent (group IV) D07AD01 Clobetasol(C) 89625 ml D07AD01 Clobetasol(C) 935100 g D07B CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS D07BA Corticosteroids, weak, combinations with antiseptics D07BA80 Hydrocortisone+Chlorhexidine(C) 350700 g D07BC Corticosteroids, potent, combinations with antiseptics D07BC80 Betamethasone+Salicylic acid(C) 17435 g D07BC80 Betamethasone+Salicylic acid(C) 937650 ml D07C CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS D07CA Corticosteroids, weak, combinations with antibiotics D07CA83 Hydrocortisone+Fusidic acid(C) 77550 g D07CC Corticosteroids, potent, combinations with antibiotics D07CC80 Betamethasone+Fusidic acid(C) 570150 g D07X CORTICOSTEROIDS, OTHER COMBINATIONS D07XA Corticosteroids, weak, other combinations D07XA81 Prednisolone+Salicylic acid(C) 229500 ml D07XC Corticosteroids, potent, other combinations D07XC03 Mometasone+Salicylic acid(C) 225,6 g D08 ANTISEPTICS AND DISINFECTANTS D08A ANTISEPTICS AND DISINFECTANTS 14/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day D08AG Iodine products D08AG02 Povidone, iodinated(C) 1095050 ml D08AG02 Povidone, iodinated(C) 3596810 g D08AG03 Iodine(C) 921240 ml D08AJ Quaternary ammonium compounds D08AJ81 Octenidine+Phenoxyethanol(C) 11705950 ml D08AX Other antiseptics and disinfectants D08AX82 Tar+Castor oil+Xeroformium(C) 7350 g D08AX83 Brilliant Green(C) 268060 ml D10 ANTI-ACNE PREPARATIONS 0,5408 D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE D10AD Retinoids for topical use in acne D10AD01 Tretinoin(C) 26850 g D10AD03 Adapalene(C) 109650 g D10AD80 Adapalene+Benzoyl peroxide(C) 95220 g D10AD81 Tretinoin+Erythromycin(C) 28110 g D10AF Antiinfectives for treatment of acne D10AF02 Erythromycin(C) 229900 ml D10AF81 Clindamycin+Benzoyl peroxide(C) 304875 g D10AF82 Clindamycin+Tretinoin(C) 128820 g D10AX Other anti-acne preparations for topical use D10AX03 Azelaic acid(C) 317250 g D10B ANTI-ACNE PREPARATIONS FOR SYSTEMIC USE 0,5408 D10BA Retinoids for treatment of acne 0,5408 D10BA01 Isotretinoin(O) 7868,4 g 0,03 g 0,5408 D11 OTHER DERMATOLOGICAL PREPARATIONS 0,0800 D11A OTHER DERMATOLOGICAL PREPARATIONS 0,0800 D11AH Agents for dermatitis, excluding corticosteroids 0,0184 D11AH01 Tacrolimus(C) 66390 g D11AH02 Pimecrolimus(C) 222240 g D11AH05 Dupilumab(P) 190,8 g 21,4 mg 0,0184 D11AX Other dermatologicals 0,0617 D11AX01 Minoxidil(C) 166680 ml D11AX10 Finasteride(O) 29,904 g 0,001 g 0,0617 D11AX16 Eflornithine(C) 870 g D11AX21 Brimonidine(C) 120 g D11AX22 Ivermectin(C) 73140 g D11AX24 Deoxycholic acid(P) 0,08 g G GENITO URINARY SYSTEM AND SEX HORMONES 56,3570 G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS 0,8710 ANTIINFECTIVES AND ANTISEPTICS, EXCL. G01A 0,8710 COMBINATIONS WITH CORTICOSTEROIDS G01AA Antibiotics 0,1081 G01AA01 Nystatin(O) 600000 U G01AA10 Clindamycin(V) 5243,5 g 0,1 g 0,1081 G01AA80 Nystatin+Neomycin+Polymyxin B(V) 48 pieces G01AC Quinoline derivatives 0,0433 G01AC05 Dequalinium(V) 419,64 g 20 mg 0,0433 G01AF Imidazole derivatives 0,7196 G01AF01 Metronidazole (V) 12554 g 0,5 g 0,0518 G01AF02 Clotrimazole(V) 27767,8 g 0,1 g 0,5726 G01AF05 Econazole(V) 4617,6 g 0,1 g 0,0952 G02 OTHER GYNECOLOGICALS 4,1361 G02A UTEROTONICS 0,0959 G02AB Ergot alkaloids 0,0020 G02AB01 Methylergometrine(P) 0,1944 g 0,2 mg 0,0020 G02AD Prostaglandins 0,0938 G02AD02 Dinoprostone(P) 0,14 g G02AD02 Dinoprostone(V) 1,8499 g 0,5 mg 0,0076 G02AD06 Misoprostol(O) 8,3624 g 0,2 mg 0,0862 G02B CONTRACEPTIVES FOR TOPICAL USE 2,5451 15/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day G02BA Intrauterine contraceptives 0,0176 G02BA03 Levonorgestrel(V) 8520 pieces 1 pieces 0,0176 G02BB Intravaginal contraceptives 2,5275 G02BB01 Etonogestrel+Ethinylestradiol(V) 42954 pieces 0,036 pieces 2,4604 G02BB81 Benzalkonium chloride(V) 32560 pieces 1 pieces 0,0671 G02BB81 Benzalkonium chloride(V) 40680 g G02C OTHER GYNECOLOGICALS 1,4951 G02CA Sympathomimetics, labour repressants G02CA80 Hexoprenaline(P) 0,0164 g G02CB Prolactine inhibitors 0,1403 G02CB01 Bromocriptine(O) 276 g 0,005 g 0,1138 G02CB03 Cabergoline(O) 6,42 g 0,5 mg 0,0265 G02CX Other gynecologicals 1,3548 G02CX01 Atosiban(P) 0,5962 g 0,165 g <0,0001 G02CX03 Agni casti fructus(O) 378870 pieces 1 pieces 0,7813 G02CX04 Cimicifugae rhizoma(O) 556290 pieces 2 pieces 0,5736 SEX HORMONES AND MODULATORS OF THE GENITAL G03 30,7035 SYSTEM G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE 24,3650 G03AA Progestogens and estrogens, fixed combinations 19,6630 G03AA07 Levonorgestrel+Ethinylestradiol(O) 205436 pieces 1 pieces 0,4236 G03AA09 Desogestrel+Ethinylestradiol(O) 423549 pieces 0,75 pieces 1,1645 G03AA10 Gestodene+Ethinylestradiol(O) 9324 pieces 1 pieces 0,0192 G03AA10 Gestodene+Ethinylestradiol(O) 2165163 pieces 0,75 pieces 5,9530 G03AA12 Drospirenone+Ethinylestradiol(O) 1203552 pieces 1 pieces 2,4818 G03AA12 Drospirenone+Ethinylestradiol(O) 1732962 pieces 0,75 pieces 4,7646 G03AA13 Norelgestromin+Ethinylestradiol(TD) 91479 pieces 0,107 pieces 1,7630 G03AA15 Chlormadinone+Ethinylestradiol(O) 155673 pieces 0,75 pieces 0,4280 G03AA16 Dienogest+Ethinylestradiol(O) 368004 pieces 1 pieces 0,7588 G03AA16 Dienogest+Ethinylestradiol(O) 693399 pieces 0,75 pieces 1,9064 G03AB Progestogens and estrogens, sequential preparations 0,1742 G03AB05 Desogestrel+Ethinylestradiol(O) 3432 pieces 0,75 pieces 0,0094 G03AB08 Dienogest+Estradiol valerate(O) 79884 pieces 1 pieces 0,1647 G03AC Progestogens 4,4487 G03AC08 Etonogestrel(P) 56,372 g 68 mcg 1,7095 G03AC09 Desogestrel(O) 1328376 pieces 1 pieces 2,7392 G03AD Emergency contraceptives 0,0792 G03AD01 Levonorgestrel(O) 56,0355 g 1,5 mg 0,0770 G03AD02 Ulipristal(O) 30,96 g 0,03 g 0,0021 G03B ANDROGENS 0,2331 G03BA 3-oxoandrosten (4) derivatives 0,2331 G03BA03 Testosterone(C) 6 g 0,05 g 0,0002 G03BA03 Testosterone(O) 14,4 g 0,12 g 0,0002 G03BA03 Testosterone(P) 2021,5 g 0,018 g 0,2316 G03BA03 Testosterone(TD) 25,76 g 0,05 g 0,0011 G03C ESTROGENS 1,4872 G03CA Natural and semisynthetic estrogens, plain 1,4772 G03CA03 Estradiol(C, V) 74225 g G03CA03 Estradiol(O) 794,332 g 2 mg 0,8190 G03CA03 Estradiol(TD) 0,021 g 0,05 mg 0,0009 G03CA03 Estradiol(TD) 35,5572 g 1,53 mg 0,0479 G03CA03 Estradiol(TD) 75,012 g 1 mg 0,1547 G03CA03 Estradiol(V) 3,3127 g 0,025 mg 0,2732 G03CA04 Estriol(V) 17,6025 g 0,2 mg 0,1815 G03CA80 Estradiol+Prednisolone(C) 66250 g G03CX Other estrogens 0,0100 G03CX01 Tibolone(O) 12,11 g 2,5 mg 0,0100 G03D PROGESTOGENS 1,7406 G03DA Pregnen (4) derivatives 1,0147 G03DA02 Medroxyprogesterone(O) 57,6 g 0,005 g 0,0238 G03DA02 Medroxyprogesterone(P) 250,485 g 0,007 g 0,0738 16/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day G03DA04 Progesterone(O) 18807 g 0,3 g 0,1293 G03DA04 Progesterone(P) 218,7812 g 0,005 g 0,0902 G03DA04 Progesterone(V) 30450,45 g 0,09 g 0,6977 G03DB Pregnadien derivatives 0,7259 G03DB01 Dydrogesterone(O) 2592,2 g 0,01 g 0,5345 G03DB08 Dienogest(O) 185,64 g 2 mg 0,1914 G03F PROGESTOGENS AND ESTROGENS IN COMBINATION 2,1009 G03FA Progestogens and estrogens, fixed combinations 1,6631 G03FA01 Norethisterone+Estradiol(O) 512568 pieces 1 pieces 1,0570 G03FA14 Dydrogesterone+Estradiol(O) 127316 pieces 1 pieces 0,2625 G03FA17 Drospirenone+Estradiol(O) 166656 pieces 1 pieces 0,3437 G03FB Progestogens and estrogens, sequential preparations 0,4378 G03FB05 Norethisterone+Estradiol(O) 156464 pieces 1 pieces 0,3226 G03FB08 Dydrogesterone+Estradiol(O) 55832 pieces 1 pieces 0,1151 G03G GONADOTROPINS AND OTHER OVULATION STIMULANTS 0,3707 G03GA Gonadotropins 0,1481 G03GA01 Chorionic gonadotrophin(P) 45000 U 250 U 0,0004 G03GA05 Follitropin alfa(P) 4505175 U 75 U 0,1239 G03GA07 Lutropin alfa(P) 564975 U 75 U 0,0155 G03GA08 Choriogonadotropin alfa(P) 0,7398 g 0,25 mg 0,0061 G03GA30 Follitropin alfa+Lutropin alfa(P) 1075 doses 1 doses 0,0022 G03GB Ovulation stimulants, synthetic 0,2226 G03GB02 Clomifene(O) 971,5 g 0,009 g 0,2226 G03H ANTIANDROGENS 0,3996 G03HA Antiandrogens, plain 0,0810 G03HA01 Cyproterone(O) 3927,5 g 0,1 g 0,0810 G03HB Antiandrogens and estrogens 0,3187 G03HB01 Cyproterone+Estrogen(O) 115899 pieces 0,75 pieces 0,3187 OTHER SEX HORMONES AND MODULATORS OF THE G03X 0,0063 GENITAL SYSTEM G03XA Antigonadotropins and similar agents 0,0006 G03XA01 Danazol(O) 180 g 0,6 g 0,0006 G03XB Progesterone receptor modulators 0,0057 G03XB01 Mifepristone(O) 794,4 g 0,6 g 0,0027 G03XB02 Ulipristal(O) 7,14 g 5 mg 0,0029 G04 UROLOGICALS 20,6464 G04B UROLOGICALS 3,4825 G04BC Urinary concrement solvents G04BC81 Sodium citrate+Potassium hydrogen carbonate+Citric acid(O) 650 pieces G04BD Drugs for urinary frequency and incontinence 1,9961 G04BD04 Oxybutynin(O) 4611,3 g 0,015 g 0,6339 G04BD06 Propiverine(O) 8,82 g 0,03 g 0,0006 G04BD07 Tolterodine(O) 481,6 g 0,004 g 0,2483 G04BD08 Solifenacin(O) 827,1 g 0,005 g 0,3411 G04BD09 Trospium chloride(O) 3661,2 g 0,04 g 0,1887 G04BD12 Mirabegron(O) 14146,5 g 50 mg 0,5834 G04BE Drugs used in erectile dysfunction 1,4762 G04BE01 Alprostadil(P) 0,0455 g 0,02 mg 0,0047 G04BE01 Alprostadil(urethral) 0,144 g 0,25 mg 0,0012 G04BE03 Sildenafil(O) 25530,8 g 0,05 g 1,0529 G04BE08 Tadalafil(O) 1726,52 g 0,01 g 0,3560 G04BE09 Vardenafil(O) 47,12 g 0,01 g 0,0097 G04BE10 Avanafil(O) 2506,8 g 0,1 g 0,0517 G04BX Other urologicals 0,0102 G04BX14 Dapoxetin(O) 147,96 g 0,03 g 0,0102 G04BX80 Centaury+Lovage root+Rosemary leaf(O) 1031520 pieces G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY 17,1640 17/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day G04CA Alpha-adrenoreceptor antagonists 14,2023 G04CA01 Alfuzosin(O) 8265,3 g 7,5 mg 2,2725 G04CA02 Tamsulosin(O) 1543,772 g 0,4 mg 7,9584 G04CA04 Silodosin(O) 747,32 g 8 mg 0,1926 G04CA52 Tamsulosin+Dutasteride(O) 1832520 pieces 1 pieces 3,7788 G04CB Testosterone-5-alpha reductase inhibitors 0,5732 G04CB01 Finasteride(O) 393,67 g 0,005 g 0,1624 G04CB02 Dutasteride(O) 99,63 g 0,5 mg 0,4109 G04CX Other drugs used in benign prostatic hypertrophy 2,3884 G04CX02 Sabalis serrulatae fructus(O) 370646,4 g 0,32 g 2,3884 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX H 30,5130 HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND H01 0,4578 ANALOGUES ANTERIOR PITUITARY LOBE HORMONES AND H01A 0,1824 ANALOGUES H01AA ACTH 0,0002 H01AA02 Tetracosactide(P) 0,0293 g 0,25 mg 0,0002 H01AB Thyrotropin 0,0004 H01AB01 Thyrotropin alfa(P) 0,1548 g 0,9 mg 0,0004 H01AC Somatropin and somatropin agonists 0,1621 H01AC01 Somatropin(P) 157203,9153 U 2 U 0,1621 H01AX Other anterior pituitary lobe hormones and analogues 0,0197 H01AX01 Pegvisomant(P) 95,4 g 0,01 g 0,0197 H01B POSTERIOR PITUITARY LOBE HORMONES 0,1423 H01BA Vasopressin and analogues 0,0909 H01BA01 Argipressin(P) 24000 U 40 U 0,0012 H01BA02 Desmopressin(N) 0,0306 g 0,025 mg 0,0025 H01BA02 Desmopressin(P) 0,0218 g 0,004 mg 0,0112 H01BA02 Desmopressin(SL) 8,8398 g 0,24 mg 0,0760 H01BB Oxytocin and analogues 0,0514 H01BB01 Demoxytocin(O) 970000 U 100 U 0,0200 H01BB02 Oxytocin(P) 216600 U 15 U 0,0298 H01BB03 Carbetocin(P) 0,078 g 0,1 mg 0,0016 H01C HYPOTHALAMIC HORMONES 0,1331 H01CA Gonadotropin-releasing hormones H01CA01 Gonadorelin(P) 0,0042 g H01CB Somatostatin and analogues 0,1142 H01CB02 Octreotide(P) 12,359 g 0,7 mg 0,0364 H01CB03 Lanreotide(P) 101,19 g 3 mg 0,0696 H01CB05 Pasireotide(P) 4,79 g 1,2 mg 0,0082 H01CC Anti-gonadotropin-releasing hormones 0,0189 H01CC02 Cetrorelix(P) 2,2953 g 0,25 mg 0,0189 H02 CORTICOSTEROIDS FOR SYSTEMIC USE 8,9526 H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN 8,9476 H02AA Mineralocorticoids 0,1683 H02AA02 Fludrocortisone(O) 8,16 g 0,1 mg 0,1683 H02AB Glucocorticoids 8,7794 H02AB01 Betamethasone(P) 13,968 g 1,5 mg 0,0192 H02AB02 Dexamethasone(O) 852,84 g 1,5 mg 1,1724 H02AB02 Dexamethasone(P) 1039,8 g 1,5 mg 1,4294 H02AB04 Methylprednisolone(O) 7298,8 g 7,5 mg 2,0067 H02AB04 Methylprednisolone(P) 4466,85 g 0,02 g 0,4605 H02AB06 Prednisolone(O) 12583 g 0,01 g 2,5947 H02AB06 Prednisolone(P) 2013,65 g 0,01 g 0,4152 H02AB08 Triamcinolone(O) 10 g 7,5 mg 0,0027 H02AB08 Triamcinolone(P) 1447,6 g 7,5 mg 0,3980 H02AB09 Hydrocortisone(O) 3493,05 g 0,03 g 0,2401 H02AB09 Hydrocortisone(P) 585,8 g 0,03 g 0,0403 H02B CORTICOSTEROIDS FOR SYSTEMIC USE, COMBINATIONS 0,0050 18/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day H02BX Corticosteroids for systemic use, combinations 0,0050 H02BX80 Hydrocortisone+Lidocaine(P) 72,125 g 0,03 g 0,0050 H03 THYROID THERAPY 21,0621 H03A THYROID PREPARATIONS 19,9294 H03AA Thyroid hormones 19,9294 H03AA01 Levothyroxine sodium(O) 1449,575 g 0,15 mg 19,9275 H03AA02 Liothyronine(O) 0,0553 g 0,06 mg 0,0019 H03AA03 Levothyroxine sodium+Liothyronine(O) 500 pieces H03B ANTITHYROID PREPARATIONS 1,1327 H03BA Thiouracils 0,0920 H03BA02 Propylthiouracil(O) 4463,5 g 0,1 g 0,0920 H03BB Sulfur-containing imidazole derivatives 1,0407 H03BB02 Thiamazole(O) 5046,75 g 0,01 g 1,0407 H03BC Perchlorates H03BC02 Sodium perchlorate(O) 48 g H04 PANCREATIC HORMONES 0,0011 H04A GLYCOGENOLYTIC HORMONES 0,0011 H04AA Glycogenolytic hormones 0,0011 H04AA01 Glucagon(P) 0,54 g 0,001 g 0,0011 H05 CALCIUM HOMEOSTASIS 0,0393 H05B ANTI-PARATHYROID AGENTS 0,0393 H05BX Other anti-parathyroid agents 0,0393 H05BX01 Cinacalcet(O) 931,56 g 0,06 g 0,0320 H05BX02 Paricalcitol(O) 0,0071 g 2 mcg 0,0073 J ANTIINFECTIVES FOR SYSTEMIC USE 17,7152 J01 ANTIBACTERIALS FOR SYSTEMIC USE 10,6478 J01A TETRACYCLINES 1,3901 J01AA Tetracyclines 1,3901 J01AA02 Doxycycline(O) 67380,24 g 0,1 g 1,3894 J01AA07 Tetracycline(O) 7 g 1 g <0,0001 J01AA12 Tigecycline(P) 31 g 0,1 g 0,0006 J01C BETA-LACTAM ANTIBACTERIALS, PENICILLINS 3,7574 J01CA Penicillins with extended spectrum 1,3216 J01CA01 Ampicillin(P) 20900 g 6 g 0,0072 J01CA04 Amoxicillin(O) 956108 g 1,5 g 1,3144 J01CA04 Amoxicillin(P) 10 g 3 g <0,0001 J01CE Beta-lactamase sensitive penicillins 0,1220 J01CE01 Benzylpenicillin(P) 27540 g 3,6 g 0,0158 J01CE02 Phenoxymethylpenicillin(O) 102289,2 g 2 g 0,1055 J01CE08 Benzathine benzylpenicillin(P) 1337,4 g 3,6 g 0,0008 J01CE80 Benzathine benzylpenicillin+Procaine benzylpenicillin(P) 15,3 g 3,6 g <0,0001 J01CF Beta-lactamase resistant penicillins 0,0978 J01CF04 Oxacillin(P) 94584 g 2 g 0,0975 J01CF05 Flucloxacillin(O) 240 g 2 g 0,0002 J01CR Combinations of penicillins, incl. beta-lactamase inhibitors 2,2161 J01CR01 Ampicillin+Sulbactam(P) 70434 g 6 g 0,0242 J01CR02 Amoxicillin+Clavulanic acid(O) 1352010,1 g 1,5 g 1,8586 J01CR02 Amoxicillin+Clavulanic acid(P) 306478 g 3 g 0,2107 J01CR04 Sultamicillin(O) 50013 g 1,5 g 0,0688 J01CR05 Piperacillin+Tazobactam(P) 365628 g 14 g 0,0539 J01D OTHER BETA-LACTAM ANTIBACTERIALS 1,5344 J01DB First-generation cephalosporins 0,2135 J01DB01 Cefalexin(O) 96 g 2 g 0,0001 J01DB04 Cefazolin(P) 109130 g 3 g 0,0750 J01DB05 Cefadroxil(O) 134219 g 2 g 0,1384 J01DC Second-generation cephalosporins 1,1693 J01DC01 Cefoxitin(P) 13850 g 6 g 0,0048 J01DC02 Cefuroxime(O) 229047,5 g 0,5 g 0,9446 J01DC02 Cefuroxime(P) 263572,5 g 3 g 0,1812 J01DC10 Cefprozil(O) 18805,5 g 1 g 0,0388 19/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J01DD Third-generation cephalosporins 0,0590 J01DD01 Cefotaxime(P) 50730 g 4 g 0,0262 J01DD02 Ceftazidime(P) 17860 g 4 g 0,0092 J01DD04 Ceftriaxone(P) 21570 g 2 g 0,0222 J01DD81 Ceftazidime+Avibactam(P) 3980 g 6 g 0,0014 J01DE Fourth-generation cephalosporins 0,0143 J01DE01 Cefepime(P) 27710 g 4 g 0,0143 J01DH Carbapenems 0,0782 J01DH02 Meropenem(P) 57741 g 3 g 0,0397 J01DH03 Ertapenem(P) 11652 g 1 g 0,0240 J01DH51 Imipenem+Cilastatin(P) 14055 g 2 g 0,0145 J01DI Other cephalosporins and penems 0,0002 J01DI54 Ceftolozane+Tazobactam(P) 240 g 3 g 0,0002 J01E SULFONAMIDES AND TRIMETHOPRIM 0,3386 J01EA Trimethoprim and derivatives 0,0418 J01EA01 Trimethoprim(O) 8106 g 0,4 g 0,0418 Combinations of sulfonamides and trimethoprim, incl. J01EE 0,2968 derivatives J01EE01 Sulfamethoxazole+Trimethoprim(O) 248400 pieces 2 pieces 0,2561 J01EE01 Sulfamethoxazole+Trimethoprim(O) 674100 ml 40 ml 0,0348 J01EE01 Sulfamethoxazole+Trimethoprim(P) 57530 ml 20 ml 0,0059 J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS 1,9702 J01FA Macrolides 1,8016 J01FA01 Erythromycin(P) 400 g 1 g 0,0008 J01FA09 Clarithromycin(O) 309700 g 0,5 g 1,2772 J01FA09 Clarithromycin(P) 3356 g 1 g 0,0069 J01FA10 Azithromycin(O) 75143,5 g 0,3 g 0,5165 J01FA10 Azithromycin(P) 17,5 g 0,5 g 0,0001 J01FF Lincosamides 0,1686 J01FF01 Clindamycin(O) 90580,8 g 1,2 g 0,1557 J01FF01 Clindamycin(P) 11316 g 1,8 g 0,0130 J01G AMINOGLYCOSIDE ANTIBACTERIALS 0,0240 J01GB Other aminoglycosides 0,0240 J01GB01 Tobramycin(I) 50,176 g 0,112 g 0,0009 J01GB01 Tobramycin(I) 268,8 g 0,3 g 0,0018 J01GB01 Tobramycin(P) 48 g 0,24 g 0,0004 J01GB03 Gentamicin(P) 1439,2 g 0,24 g 0,0124 J01GB04 Kanamycin(P) 500 g 1 g 0,0010 J01GB06 Amikacin(P) 3610 g 1 g 0,0074 J01M QUINOLONE ANTIBACTERIALS 0,8827 J01MA Fluoroquinolones 0,8827 J01MA01 Ofloxacin(O) 3198 g 0,4 g 0,0165 J01MA02 Ciprofloxacin(O) 287275 g 1 g 0,5924 J01MA02 Ciprofloxacin(P) 12342,5 g 0,8 g 0,0318 J01MA06 Norfloxacin(O) 59584 g 0,8 g 0,1536 J01MA12 Levofloxacin(O) 8718,5 g 0,5 g 0,0360 J01MA12 Levofloxacin(P) 475 g 0,5 g 0,0020 J01MA14 Moxifloxacin(O) 9532 g 0,4 g 0,0491 J01MA14 Moxifloxacin(P) 263,6 g 0,4 g 0,0014 J01X OTHER ANTIBACTERIALS 0,7504 J01XA Glycopeptide antibacterials 0,0248 J01XA01 Vancomycin(O) 12 g 2 g <0,0001 J01XA01 Vancomycin(P) 23935 g 2 g 0,0247 J01XA02 Teicoplanin(P) 12 g 0,4 g 0,0001 J01XB Polymyxins 0,0020 J01XB01 Colistin(I, P) 1170000000 U 9000000 U 0,0003 J01XB01 Colistin(P) 7650000000 U 9000000 U 0,0018 J01XD Imidazole derivatives 0,2291 J01XD01 Metronidazole (O) 181715 g 2 g 0,1874 J01XD01 Metronidazole (P) 30350 g 1,5 g 0,0417 20/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J01XE Nitrofuran derivatives 0,4697 J01XE01 Nitrofurantoin(O) 45552,5 g 0,2 g 0,4697 J01XX Other antibacterials 0,0249 J01XX01 Fosfomycin(O) 13338 g 3 g 0,0092 J01XX08 Linezolid(O) 7008 g 1,2 g 0,0120 J01XX08 Linezolid(P) 1404 g 1,2 g 0,0024 J01XX09 Daptomycin(P) 172,4 g 0,28 g 0,0013 J02 ANTIMYCOTICS FOR SYSTEMIC USE 0,3909 J02A ANTIMYCOTICS FOR SYSTEMIC USE 0,3909 J02AA Antibiotics 0,0096 J02AA01 Amphotericin(O) 234 g J02AA01 Amphotericin(P) 162,75 g 0,035 g 0,0096 J02AC Triazole derivatives 0,3704 J02AC01 Fluconazole(O) 13979,95 g 0,2 g 0,1441 J02AC01 Fluconazole(P) 3298,6 g 0,2 g 0,0340 J02AC02 Itraconazole(O) 15481 g 0,2 g 0,1596 J02AC03 Voriconazole(O) 2014,8 g 0,4 g 0,0104 J02AC03 Voriconazole(P) 129 g 0,4 g 0,0007 J02AC04 Posaconazole(O) 3100,8 g 0,3 g 0,0213 J02AC05 Isavuconazole(O) 26,6 g 0,2 g 0,0003 J02AC05 Isavuconazole(P) 3,2 g 0,2 g <0,0001 J02AX Other antimycotics for systemic use 0,0109 J02AX04 Caspofungin(P) 103,27 g 0,05 g 0,0043 J02AX06 Anidulafungin(P) 322,6 g 0,1 g 0,0067 J04 ANTIMYCOBACTERIALS 0,2924 J04A DRUGS FOR TREATMENT OF TUBERCULOSIS 0,2631 J04AA Aminosalicylic acid and derivatives 0,0005 J04AA01 Paraaminosalicylic acid(O) 3000 g 12 g 0,0005 J04AB Antibiotics 0,0569 J04AB01 Cycloserine(O) 6000 g 0,75 g 0,0165 J04AB02 Rifampicin(O) 11685,6 g 0,6 g 0,0402 J04AB02 Rifampicin(P) 60 g 0,6 g 0,0002 J04AK Other drugs for treatment of tuberculosis 0,1665 J04AK01 Pyrazinamide(O) 30000 g 1,5 g 0,0412 J04AK02 Ethambutol(O) 67400 g 1,2 g 0,1158 J04AK05 Bedaquiline(O) 394,8 g 86 mg 0,0095 J04AM Combinations of drugs for treatment of tuberculosis 0,0392 J04AM02 Rifampicin+Isoniazid(O) 8000 pieces 4 pieces 0,0041 J04AM02 Rifampicin+Isoniazid(O) 34000 pieces 2 pieces 0,0351 J04B DRUGS FOR TREATMENT OF LEPRA 0,0293 J04BA Drugs for treatment of lepra 0,0293 J04BA01 Clofazimine(O) 800 g 0,1 g 0,0165 J04BA02 Dapsone(O) 310 g 0,05 g 0,0128 J05 ANTIVIRALS FOR SYSTEMIC USE 6,3840 J05A DIRECT ACTING ANTIVIRALS 6,3840 Nucleosides and nucleotides excl. reverse transcriptase J05AB 0,4043 inhibitors J05AB01 Aciclovir(O) 392911,5 g 4 g 0,2026 J05AB01 Aciclovir(P) 3823,75 g 4 g 0,0020 J05AB06 Ganciclovir(P) 375,5 g 0,5 g 0,0015 J05AB09 Famciclovir(O) 168 g 0,75 g 0,0005 J05AB11 Valaciclovir(O) 268834 g 3 g 0,1848 J05AB12 Cidofovir(P) 1,5 g 0,025 g 0,0001 J05AB14 Valganciclovir(O) 5619 g 0,9 g 0,0129 J05AB80 Remdesivir(P) 163,4 g J05AE Protease inhibitors 0,3255 J05AE03 Ritonavir(O) 21048 g 1,2 g 0,0362 J05AE10 Darunavir(O) 168384 g 1,2 g 0,2893 J05AF Nucleoside and nucleotide reverse transcriptase inhibitors 0,1236 J05AF01 Zidovudine(O) 198 g 0,6 g 0,0007 21/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J05AF01 Zidovudine(P) 39 g 0,6 g 0,0001 J05AF05 Lamivudine(O) 1821 g 0,3 g 0,0125 J05AF06 Abacavir(O) 1755,6 g 0,6 g 0,0060 J05AF07 Tenofovir disoproxil(O) 235,2 g 0,245 g 0,0020 J05AF10 Entecavir(O) 23,805 g 0,5 mg 0,0982 J05AF13 Tenofovir alafenamide(O) 49,5 g 25 mg 0,0041 J05AG Non-nucleoside reverse transcriptase inhibitors 0,8082 J05AG03 Efavirenz(O) 43560 g 0,6 g 0,1497 J05AG05 Rilpivirine(O) 7983,75 g 25 mg 0,6585 J05AH Neuraminidase inhibitors 0,1187 J05AH02 Oseltamivir(O) 8637,75 g 0,15 g 0,1187 J05AJ Integrase inhibitors 0,9169 J05AJ01 Raltegravir(O) 324120 g 0,8 g 0,8354 J05AJ03 Dolutegravir(O) 1974,75 g 50 mg 0,0814 J05AP Antivirals for treatment of HCV infections 0,0955 J05AP01 Ribavirin(O) 392 g 1 g 0,0008 J05AP54 Elbasvir+Grazoprevir(O) 1540 pieces 1 pieces 0,0032 J05AP55 Sofosbuvir+Velpatasvir(O) 5460 pieces 1 pieces 0,0113 J05AP57 Glecaprevir+Pibrentasvir(O) 116760 pieces 3 pieces 0,0803 J05AR Antivirals for treatment of HIV infections, combinations 3,5780 J05AR01 Zidovudine+Lamivudine(O) 40380 pieces 2 pieces 0,0416 J05AR02 Lamivudine+Abacavir(O) 332850 pieces 1 pieces 0,6864 J05AR03 Tenofovir disoproxil+Emtricitabine(O) 841590 pieces 1 pieces 1,7354 J05AR06 Emtricitabine+Tenofovir disoproxil+Efavirenz(O) 33720 pieces 1 pieces 0,0695 J05AR10 Lopinavir+Ritonavir(O) 168 g 0,8 g 0,0004 J05AR13 Lamivudine+Abacavir+Dolutegravir(O) 287040 pieces 1 pieces 0,5919 J05AR14 Darunavir+Cobicistat(O) 219180 pieces 1 pieces 0,4520 Emtricitabine+Tenofovir J05AR18 360 pieces 1 pieces 0,0007 alafenamide+Elvitegravir+Cobicistat(O) J05AX Other antivirals 0,0133 J05AX27 Favipiravir(O) 10296 g 1,6 g 0,0133 J06 IMMUNE SERA AND IMMUNOGLOBULINS J06A IMMUNE SERA J06AA Immune sera J06AA01 Diphtheria antitoxin(P) 200000 U J06AA03 Snake venom antiserum(P) 70 pieces J06B IMMUNOGLOBULINS J06BA Immunoglobulins, normal human J06BA01 Immunoglobulins, normal human, for extravascular a(P) 12919,5 g J06BA02 Immunoglobulins, normal human, for intravascular a(P) 110590 g J06BB Specific immunoglobulins J06BB01 Human Anti-D Immunoglobulin(P) 1947125 U J06BB02 Tetanus immunoglobulin(P) 12000 U J06BB03 Varicella zoster immunoglobulin(P) 2500 U J06BB04 Hepatitis B immunoglobulin(P) 2800 U J06BB05 Rabies immunoglobulin(P) 3000 U J06BB16 Palivizumab(P) 44,1 g J07 VACCINES J07A BACTERIAL VACCINES J07AG Hemophilus influenzae B vaccines J07AG01 Haemophilus influenzae B, purified antigen conjugated(P) 373 doses J07AH Meningococcal vaccines Meningococcus, tetravalent purified polysaccharides antigen J07AH08 507 doses conjugated(P) J07AH09 Meningococcus B, multicomponent vaccine(P) 42 doses J07AL Pneumococcal vaccines J07AL01 Pneumococcus, purified polysaccharides antigen(P) 1110 doses Pneumococcus, purified polysaccharides antigen J07AL02 4838 doses conjugated(P) 22/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day Pneumococcus, purified polysaccharides antigen+Haemophilus J07AL52 228 doses influenzae, conjugated(P) J07AM Tetanus vaccines J07AM51 Tetanus toxoid+Diphtheria toxoid(P) 23175 doses J07AN Tuberculosis vaccines J07AN01 Tuberculosis, live attenuated(P) 23260 doses J07AP Typhoid vaccines J07AP03 Typhoid, purified polysaccharide antigen(P) 825 doses J07AX Other bacterial vaccines J07AX80 Diphtheria-tetanus-pertussis(P) 17482 doses J07B VIRAL VACCINES J07BA Encephalitis vaccines J07BA01 Encephalitis, tick borne, inactivated, whole virus(P) 88374 doses J07BB Influenza vaccines J07BB02 Influenza, inactivated, split virus or surface antigen(P) 153821 doses J07BC Hepatitis vaccines J07BC01 Hepatitis B, purified antigen(P) 3303 doses J07BC02 Hepatitis A, inactivated, whole virus(P) 4308 doses Hepatitis A, inactivated, whole virus+Hepatitis B, purified J07BC80 1625 doses antigen(P) J07BD Measles vaccines Measles, live attunated+Rubella, live attenuated+Mumps, J07BD52 31091 doses live,attenuated(P) J07BF Poliomyelitis vaccines J07BF03 Poliomyelitis, trivalent, inactivated, whole virus(P) 607 doses J07BG Rabies vaccines J07BG01 Rabies, inactivated, whole virus(P) 1774 doses J07BH Rota virus diarrhea vaccines J07BH02 Rota virus, pentavalent, live, reassorted(O) 64411 doses J07BK Varicella zoster vaccines J07BK01 Varicella, live attenuated(P) 2096 doses J07BK02 Zoster, live attenuated(P) 40 doses J07BK03 Zoster, purified antigen(P) 5 doses J07BL Yellow fever vaccines J07BL01 Yellow fever, live attenuated(P) 773 doses J07BM Papillomavirus vaccines J07BM02 Papillomavirus (human types 16, 18)(P) 9 doses Papillomavirus (human types 6, 11, 16, 18, 31, 33, 45, 52, J07BM03 12056 doses 58)(P) J07BX Other viral vaccines J07BX03 Covid-19 vaccine(P) 6099,6 doses J07C BACTERIAL AND VIRAL VACCINES, COMBINED J07CA Bacterial and viral vaccines, combined Diphtheria toxoid+Pertussis, purified antigen+Tetanus J07CA02 15054 doses toxoid+Poliomyelitis, trivalent, inactivated, whole virus(P) Diphtheria toxoid+Tetanus toxoid+Pertussis, purified antigen+Poliomyelitis, trivalent, inactivated, whole J07CA06 1049 doses virus+Haemophilus influenzae B, purified antigen conjugated(P) Diphtheria toxoid+Poliomyelitis, trivalent, inactivated, whole virus+Pertussis, purified antigen+Haemophilus influenzae B, J07CA09 48420 doses purified antigen conjugated+Hepatitis B, purified antigen+Tetanus toxoid(P) L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS 12,4653 L01 ANTINEOPLASTIC AGENTS L01A ALKYLATING AGENTS L01AA Nitrogen mustard analogues L01AA01 Cyclophosphamide(O) 627,5 g L01AA01 Cyclophosphamide(P) 3931 g L01AA02 Chlorambucil(O) 22,9 g L01AA03 Melphalan(O) 4,7 g 23/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L01AA03 Melphalan(P) 26,1 g L01AA06 Ifosfamide(P) 1640 g L01AA09 Bendamustine(P) 121 g L01AB Alkyl sulfonates L01AB01 Busulfan(O) 7 g L01AB01 Busulfan(P) 4,32 g L01AB02 Treosulfan(P) 1375 g L01AC Ethylene imines L01AC01 Thiotepa(P) 6,805 g L01AD Nitrosoureas L01AD01 Carmustine(P) 13,8 g L01AD02 Lomustine(O) 16,4 g L01AX Other alkylating agents L01AX03 Temozolomide(O) 609,35 g L01AX04 Dacarbazine(P) 395 g L01B ANTIMETABOLITES L01BA Folic acid analogues L01BA01 Methotrexate(P) 1624,1 g L01BA04 Pemetrexed(P) 431 g L01BB Purine analogues L01BB02 Mercaptopurine(O) 417,5 g L01BB03 Tioguanine(O) 9 g L01BB04 Cladribine(P) 0,34 g L01BB05 Fludarabine(P) 17,85 g L01BB07 Nelarabine(P) 4,5 g L01BC Pyrimidine analogues L01BC01 Cytarabine(P) 2458 g L01BC02 Fluorouracil(P) 14785 g L01BC05 Gemcitabine(P) 5450,3596 g L01BC06 Capecitabine(O) 252768 g L01BC07 Azacitidine(P) 283,7 g L01BC83 Trifluridine+Tipiracil(O) 17480 pieces L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS L01CA Vinca alkaloids and analogues L01CA01 Vinblastine(P) 5,52 g L01CA02 Vincristine(P) 2,221 g L01CA04 Vinorelbine(O) 2,2 g L01CA04 Vinorelbine(P) 14,6 g L01CB Podophyllotoxin derivatives L01CB01 Etoposide(O) 341 g L01CB01 Etoposide(P) 502,3 g L01CD Taxanes L01CD01 Paclitaxel(P) 777,7 g L01CD02 Docetaxel(P) 412 g L01CD04 Cabazitaxel(P) 5,7 g L01CE Topoisomerase 1 (TOP1) inhibitors L01CE01 Topotecan(P) 3,521 g L01CE02 Irinotecan(P) 681 g L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES L01DA Actinomycines L01DA01 Dactinomycin(P) 0,015 g L01DB Anthracyclines and related substances L01DB01 Doxorubicin(P) 136,39 g L01DB02 Daunorubicin(P) 11,28 g L01DB03 Epirubicin(P) 187,5 g L01DB06 Idarubicin(P) 2,16 g L01DB07 Mitoxantrone(P) 1,88 g L01DB11 Pixantrone(P) 1,015 g L01DC Other cytotoxic antibiotics 24/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L01DC01 Bleomycin(P) 9795000 U L01DC03 Mitomycin(P) 5,76 g L01E PROTEIN KINASE INHIBITORS L01EA BCR-ABL tyrosine kinase inhibitors L01EA01 Imatinib(O) 16512 g L01EA02 Dasatinib(O) 648 g L01EA03 Nilotinib(O) 8624 g L01EA04 Bosutinib(O) 252 g L01EA05 Ponatinib(O) 8,1 g Epidermal growth factor receptor (EGFR) tyrosine kinase L01EB inhibitors L01EB01 Gefitinib(O) 1005 g L01EB02 Erlotinib(O) 117 g L01EB03 Afatinib(O) 129,64 g L01EB04 Osimertinib(O) 210 g L01EC B-Raf serine-threonine kinase (BRAF) inhibitors L01EC02 Dabrafenib(O) 3672 g L01ED Anaplastic lymphoma kinase (ALK) inhibitors L01ED01 Crizotinib(O) 345 g L01ED02 Ceritinib(O) 270 g L01ED04 Brigatinib(O) 90,72 g L01EE Mitogen-activated protein kinase (MEK) inhibitors L01EE01 Trametinib(O) 25,86 g L01EF Cyclin-dependent kinase (CDK) inhibitors L01EF01 Palbociclib(O) 1096,2 g L01EF02 Ribociclib(O) 3376,8 g L01EG Mammalian target of rapamycin (mTOR) kinase inhibitors L01EG01 Temsirolimus(P) 0,81 g L01EG02 Everolimus(O) 43,2 g Human epidermal growth factor receptor 2 (HER2) tyrosine L01EH kinase inhibitors L01EH01 Lapatinib(O) 52,5 g L01EJ Janus-associated kinase (JAK) inhibitors L01EJ01 Ruxolitinib(O) 254,8 g Vascular endothelial growth factor receptor (VEGFR) tyrosine L01EK kinase inhibitors L01EK01 Axitinib(O) 28 g L01EL Bruton's tyrosine kinase (BTK) inhibitors L01EL01 Ibrutinib(O) 9151,8 g L01EX Other protein kinase inhibitors L01EX01 Sunitinib(O) 288,4 g L01EX02 Sorafenib(O) 4368 g L01EX03 Pazopanib(O) 13824 g L01EX05 regorafenib(O) 235,2 g L01EX07 Cabozantinib(O) 442,96 g L01EX08 Lenvatinib(O) 1,74 g L01EX09 Nintedanib(O) 5871 g L01EX10 Midostaurin(O) 60,2 g L01X OTHER ANTINEOPLASTIC AGENTS L01XA Platinum compounds L01XA01 Cisplatin(P) 189,8 g L01XA02 Carboplatin(P) 1883,4 g L01XA03 Oxaliplatin(P) 887,4 g L01XB Methylhydrazines L01XB01 Procarbazine(O) 187,5 g L01XC Monoclonal antibodies L01XC02 Rituximab(P) 2147,96 g L01XC03 Trastuzumab(P) 1734,15 g L01XC06 Cetuximab(P) 109,2 g L01XC07 Bevacizumab(P) 1178,2 g 25/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L01XC08 Panitumumab(P) 108,6 g L01XC11 Ipilimumab(P) 1,95 g L01XC12 Brentuximab vedotin(P) 11,5 g L01XC13 Pertuzumab(P) 308,7 g L01XC14 Trastuzumab emtansine(P) 76,68 g L01XC15 Obinutuzumab(P) 135 g L01XC17 Nivolumab(P) 212,34 g L01XC18 Pembrolizumab(P) 328,6 g L01XC19 Blinatumomab(P) 0,0026 g L01XC21 Ramucirumab(P) 4 g L01XC24 Daratumumab(P) 467,6 g L01XC26 Inotuzumab ozogamicin(P) 0,003 g L01XC28 Durvalumab(P) 364,68 g L01XC32 Atezolizumab(P) 289,2 g L01XC80 Dinutuximab beta(P) 0,405 g L01XD Sensitizers used in photodynamic/radiation therapy L01XD04 Aminolevulinic acid(O) 7,5 g L01XF Retinoids for cancer treatment L01XF01 Tretinoin(O) 42 g L01XG Proteasome inhibitors L01XG01 Bortezomib(P) 8,897 g L01XG02 Carfilzomib(P) 2,64 g L01XG03 Ixazomib(O) 0,18 g L01XK Poly (ADP-ribose) polymerase (PARP) inhibitors L01XK01 Olaparib(O) 9260,8 g L01XX Other antineoplastic agents L01XX02 Asparaginase(P) 1100000 U L01XX05 Hydroxycarbamide(O) 255250 g L01XX11 Estramustine(O) 123,2 g L01XX23 Mitotane(O) 950 g L01XX24 Pegaspargase(P) 390000 U L01XX27 Arsenic trioxide(P) 3,5 g L01XX35 Anagrelide(O) 1,15 g L01XX41 Eribulin(P) 0,095 g L01XX52 Venetoclax(O) 1367,87 g L02 ENDOCRINE THERAPY 4,7298 L02A HORMONES AND RELATED AGENTS 0,6680 L02AB Progestogens 0,0085 L02AB02 Medroxyprogesterone(O) 4110 g 1 g 0,0085 L02AE Gonadotropin releasing hormone analogues 0,6595 L02AE03 Goserelin(P) 9,5832 g 0,129 mg 0,1532 L02AE04 Triptorelin(P) 0,2429 g 0,1 mg 0,0050 L02AE04 Triptorelin(P) 32,5762 g 0,134 mg 0,5013 L02B HORMONE ANTAGONISTS AND RELATED AGENTS 4,0619 L02BA Anti-estrogens 0,8118 L02BA01 Tamoxifen(O) 6229,2 g 0,02 g 0,6423 L02BA03 Fulvestrant(P) 682,5 g 8,3 mg 0,1696 L02BB Anti-androgens 1,2948 L02BB03 Bicalutamide(O) 30907,8 g 0,05 g 1,2747 enzalutamide L02BB04 1379,84 g 0,16 g 0,0178 (O) L02BB05 Apalutamide(O) 273,6 g 0,24 g 0,0024 L02BG Aromatase inhibitors 1,8432 L02BG03 Anastrozole(O) 334,908 g 1 mg 0,6906 L02BG04 Letrozole(O) 1252,95 g 2,5 mg 1,0335 L02BG06 Exemestane(O) 1443,75 g 0,025 g 0,1191 L02BX Other hormone antagonists and related agents 0,1121 L02BX03 Abiraterone(O) 54360 g 1 g 0,1121 L03 IMMUNOSTIMULANTS 0,6028 L03A IMMUNOSTIMULANTS 0,6028 L03AA Colony stimulating factors 0,0904 26/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L03AA02 Filgrastim(P) 9,5856 g 0,35 mg 0,0565 L03AA13 Pegfilgrastim(P) 4,932 g 0,3 mg 0,0339 L03AB Interferons 0,3958 L03AB04 Interferon alfa-2a(P) 19131000000 U 2000000 U 0,0197 L03AB07 Interferon beta-1a(P) 0,5849 g 0,0043 mg 0,2805 L03AB08 Interferon beta-1b(P) 99720000000 U 4000000 U 0,0514 L03AB11 Peginterferon alfa-2a(P) 0,0111 g 0,026 mg 0,0009 L03AB13 Peginterferon beta-1a(P) 0,1868 g 8,9 mcg 0,0433 L03AX Other immunostimulants 0,1166 L03AX03 BCG bacteria(P) 2,8375 g 1,8 mg 0,0033 L03AX13 Glatiramer acetate(P) 1099,12 g 0,02 g 0,1133 L03AX16 Plerixafor(P) 0,528 g 16,8 mg 0,0001 L03AX80 Methyluracil(R) 240 g L04 IMMUNOSUPPRESSANTS 7,1326 L04A IMMUNOSUPPRESSANTS 7,1326 L04AA Selective immunosuppressants 1,1772 L04AA03 Antilymphocyte immunoglobulin (horse)(P) 35 g L04AA04 Rabbit anti-T-lymphocyte immunoglobulin(P) 19,525 g 0,1 g 0,0004 L04AA06 Mycophenolic acid(O) 309567,4 g 2 g 0,3192 L04AA06 Mycophenolic acid(P) 324 g 2 g 0,0003 L04AA10 Sirolimus(O) 22,56 g 0,003 g 0,0155 L04AA13 Leflunomide(O) 5352,9 g 0,02 g 0,5519 L04AA18 Everolimus(O) 0,36 g 1,5 mg 0,0005 L04AA23 Natalizumab(P) 47,4 g 0,01 g 0,0098 L04AA24 Abatacept(P) 174 g 0,027 g 0,0133 L04AA25 Eculizumab(P) 84,3 g 0,064 g 0,0027 L04AA26 Belimumab(P) 9,2 g 25 mg 0,0008 L04AA27 Fingolimod(O) 5,11 g 0,5 mg 0,0211 Tofacitinib L04AA29 98 g 10 mg 0,0202 (O) L04AA31 Teriflunomide(O) 685,608 g 14 mg 0,1010 L04AA32 Apremilast(O) 4,05 g 60 mg 0,0001 L04AA33 Vedolizumab(P) 103,5 g 5,4 mg 0,0395 L04AA34 Alemtuzumab(P) 0,252 g 0,13 mg 0,0040 L04AA36 Ocrelizumab(P) 104,1 g 3,29 mg 0,0652 L04AA40 Cladribine(O) 1,92 g 0,34 mg 0,0116 L04AA42 Siponimod(O) 0,56 g L04AA44 Upadacitinib(O) 63,84 g L04AB Tumor necrosis factor alpha (TNF-alpha) inhibitors 1,3593 L04AB01 Etanercept(P) 896,88 g 0,007 g 0,2642 L04AB02 Infliximab(P) 984 g 3,75 mg 0,5411 L04AB04 Adalimumab(P) 642,8 g 2,9 mg 0,4571 L04AB05 Certolizumab pegol(P) 28,8 g 14 mg 0,0042 L04AB06 Golimumab(P) 74,6 g 1,66 mg 0,0927 L04AC Interleukin inhibitors 0,4357 L04AC02 Basiliximab(P) 1,42 g 0,04 g 0,0001 L04AC03 Anakinra(P) 176,5785 g 0,1 g 0,0036 L04AC05 Ustekinumab(P) 54,515 g 0,54 mg 0,2082 L04AC07 Tocilizumab(P) 927,776 g 0,02 g 0,0957 L04AC10 Secukinumab(P) 439,2 g 10 mg 0,0906 L04AC13 Ixekizumab(P) 17,52 g 2,9 mg 0,0125 L04AC14 Sarilumab(P) 103,4 g 14,3 mg 0,0149 L04AC16 Guselkumab(P) 4,2 g 1,79 mg 0,0048 L04AC18 Risankizumab(P) 4,35 g 1,67 mg 0,0054 L04AD Calcineurin inhibitors 0,5308 L04AD01 Ciclosporin(O) 26086,25 g 0,25 g 0,2152 L04AD01 Ciclosporin(P) 85 g 0,25 g 0,0007 L04AD02 Tacrolimus(O) 763,5125 g 5 mg 0,3149 L04AD02 Tacrolimus(P) 0,2 g 5 mg 0,0001 L04AX Other immunosuppressants 3,6297 L04AX01 Azathioprine(O) 29045 g 0,15 g 0,3993 27/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L04AX02 Thalidomide(O) 434 g 0,1 g 0,0089 L04AX03 Methotrexate(O) 3437,5 g 2,5 mg 2,8353 L04AX03 Methotrexate(P) 129,835 g 2,5 mg 0,1071 L04AX04 Lenalidomide(O) 380,205 g 0,01 g 0,0784 L04AX05 Pirfenidone(O) 25837,056 g 2,4 g 0,0222 Pomalidomide L04AX06 17,556 g 3 mg 0,0121 (O) L04AX07 Dimethyl fumarate(O) 38718,96 g 0,48 g 0,1663 M MUSCULO-SKELETAL SYSTEM 84,4914 M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS 69,3257 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, M01A 69,3145 NON-STEROIDS M01AB Acetic acid derivatives and related substances 8,9249 M01AB01 Indometacin(O) 3565,5 g 0,1 g 0,0735 M01AB05 Diclofenac(O) 326928,5 g 0,1 g 6,7415 M01AB05 Diclofenac(P) 8213,625 g 0,1 g 0,1694 M01AB05 Diclofenac(R) 13236,875 g 0,1 g 0,2730 M01AB16 Aceclofenac(O) 41698 g 0,2 g 0,4299 M01AB82 Diclofenac+Omeprazole(O) 60018,75 g 0,1 g 1,2376 M01AC Oxicams 3,7597 M01AC01 Piroxicam(O) 1258,4 g 0,02 g 0,1297 M01AC05 Lornoxicam(O) 1246,24 g 0,012 g 0,2142 M01AC05 Lornoxicam(P) 4,08 g 0,012 g 0,0007 M01AC06 Meloxicam(O) 24630,525 g 0,015 g 3,3860 M01AC06 Meloxicam(P) 211,825 g 0,015 g 0,0291 M01AE Propionic acid derivatives 39,5921 M01AE01 Ibuprofen(O) 14565502 g 1,2 g 25,0292 M01AE01 Ibuprofen(P) 6586 g 1,2 g 0,0113 M01AE02 Naproxen(O) 738728,65 g 0,5 g 3,0466 M01AE03 Ketoprofen(O) 123315,625 g 0,15 g 1,6952 M01AE03 Ketoprofen(P) 13023 g 0,15 g 0,1790 M01AE03 Ketoprofen(R) 1,2 g 0,15 g <0,0001 M01AE17 Dexketoprofen(O) 75805,25 g 0,075 g 2,0842 M01AE17 Dexketoprofen(P) 3606,5 g 0,075 g 0,0992 M01AE52 Naproxen+Esomeprazole(O) 1803045 g 0,5 g 7,4360 M01AE82 Ibuprofen+Phenylephrine(O) 6561,6 g 1,2 g 0,0113 M01AG Fenamates 0,0044 M01AG02 Tolfenamic acid(O) 636 g 0,3 g 0,0044 M01AH Coxibs 9,2549 M01AH01 Celecoxib(O) 80092 g 0,2 g 0,8258 M01AH05 Etoricoxib(O) 245263,41 g 60 mg 8,4292 M01AX Other antiinflammatory and antirheumatic agents, non-steroids 7,7785 M01AX01 Nabumetone(O) 146460 g 1 g 0,3020 M01AX05 Glucosamine(O) 5438609,76 g 1,5 g 7,4765 M01C SPECIFIC ANTIRHEUMATIC AGENTS 0,0112 M01CC Penicillamine and similar agents 0,0112 M01CC01 Penicillamine(O) 2712,5 g 0,5 g 0,0112 M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN M02AA Antiinflammatory preparations, non-steroids for topical use M02AA10 Ketoprofen(C) 1158850 g M02AA12 Naproxen(C) 994675 g M02AA13 Ibuprofen(C) 13002 pieces M02AA13 Ibuprofen(C) 902450 g M02AA15 Diclofenac(C) 450690 pieces M02AA15 Diclofenac(C) 32066799,7 g M02AA81 Ibuprofen+Levomenthol(C) 1700900 g 28/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day M02AC Preparations with salicylic acid derivatives Methyl salicylate+Levomenthol+Eucalyptus oil+Turpentine M02AC80 93867 g oil(C) M02AX Other topical products for joint and muscular pain M02AX80 Nicoboxil+Nonivamide(C) 186240 g Camphor+Salicylic acid+Turpentine oil+Venenum Viperae M02AX90 747000 g berus(C) Benzyl nicotinate+Nonivamide+Camphor+Turpentine M02AX92 747800 g oil+Dimethyl sulfoxide(C) M03 MUSCLE RELAXANTS 0,9980 M03A MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS M03AB Choline derivatives M03AB01 Suxamethonium chloride(P) 3593 g M03AC Other quaternary ammonium compounds M03AC04 Atracurium besilate(P) 1583,75 g M03AC06 Pipecuronium bromide(P) 35 g M03AC09 Rocuronium bromide(P) 1090,25 g M03AX Other muscle relaxants, peripherally acting agents M03AX01 Botulinum toxin(P) 1477150 U M03B MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS 0,9980 M03BX Other centrally acting agents 0,9980 M03BX01 Baclofen(O) 4939,25 g 0,05 g 0,2037 M03BX01 Baclofen(P) 2,6215 g 0,55 mg 0,0098 M03BX02 Tizanidine(O) 4565,04 g 0,012 g 0,7845 M04 ANTIGOUT PREPARATIONS 9,5556 M04A ANTIGOUT PREPARATIONS 9,5556 M04AA Preparations inhibiting uric acid production 9,5445 M04AA01 Allopurinol(O) 1269495,8 g 0,4 g 6,5445 M04AA03 Febuxostat(O) 116389,28 g 0,08 g 3,0000 M04AB Preparations increasing uric acid excretion 0,0032 M04AB01 Probenecid(O) 50 g 1 g 0,0001 M04AB03 Benzbromarone(O) 149 g 0,1 g 0,0031 M04AC Preparations with no effect on uric acid metabolism 0,0079 M04AC01 Colchicine(O) 3,835 g 1 mg 0,0079 M05 DRUGS FOR TREATMENT OF BONE DISEASES 4,6122 DRUGS AFFECTING BONE STRUCTURE AND M05B 4,6122 MINERALIZATION M05BA Bisphosphonates 0,7983 M05BA03 Pamidronic acid(P) 13,89 g 0,06 g 0,0005 M05BA04 Alendronic acid(O) 223,72 g 0,01 g 0,0461 M05BA06 Ibandronic acid(O) 1364,7 g 0,005 g 0,5628 M05BA06 Ibandronic acid(P) 0,12 g 0,006 g <0,0001 M05BA07 Risedronic acid(O) 437,36 g 0,005 g 0,1804 M05BA08 Zoledronic acid(P) 16,365 g 0,004 g 0,0084 M05BB Bisphosphonates, combinations 2,6506 M05BB03 Alendronic acid+Colecalciferol(O) 12854,24 g 10 mg 2,6506 M05BX Other drugs affecting bone structure and mineralization 1,1633 M05BX04 Denosumab(P) 186,16 g 0,33 mg 1,1633 M05BX05 Burosumab(P) 1,35 g N NERVOUS SYSTEM 142,3143 N01 ANESTHETICS N01A ANESTHETICS, GENERAL N01AB Halogenated hydrocarbons N01AB06 Isoflurane(I) 15000 ml N01AB07 Desflurane(I) 72960 ml N01AB08 Sevoflurane(I) 821750 ml N01AF Barbiturates, plain N01AF03 Thiopental(P) 1790 g N01AH Opioid anesthetics N01AH01 Fentanyl(I) 30,7205 g 29/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N01AH06 Remifentanil(P) 18,37 g N01AX Other general anesthetics N01AX03 Ketamine(P) 551 g N01AX07 Etomidate(P) 57,2 g N01AX10 Propofol(P) 70630 g N01AX11 Sodium oxybate(P) 120 g N01AX13 Nitrous oxide(I) 10162000 ml N01AX14 Esketamine(P) 226,5 g N01B ANESTHETICS, LOCAL N01BA Esters of aminobenzoic acid N01BA02 Procaine(P) 40 g N01BB Amides N01BB01 Bupivacaine(Infilt, P) 2841 g N01BB01 Bupivacaine(P) 238,25 g N01BB02 Lidocaine(C) 2050 ml N01BB02 Lidocaine(C) 2357,5 g N01BB02 Lidocaine(NA) 2400 ml N01BB02 Lidocaine(NA) 5719 g N01BB02 Lidocaine(O) 72240 g N01BB02 Lidocaine(P) 27198,6 g N01BB03 Mepivacaine(dental) 1443,3 g N01BB08 Articaine(P) 0,8 g N01BB09 Ropivacaine(P) 745,9 g N01BB80 Articaine+Epinephrine(dental) 841840 ml N01BB80 Articaine+Epinephrine(O) 438660 ml N01BB81 Bupivacaine+Epinephrine(P) 250000 ml N01BB82 Lidocaine+Epinephrine(dental) 67900 ml N01BB83 Lidocaine+Prilocaine(C) 53945,25 g N01BB86 Lidocaine+Chlorhexidine(urethral) 930312,5 g N01BC Esters of benzoic acid N01BC01 Cocaine(NA) 310 g N01BX Other local anesthetics N01BX04 Capsaicin(C) 75,0904 g N02 ANALGESICS 26,7993 N02A OPIOIDS 8,8276 N02AA Natural opium alkaloids 0,8756 N02AA01 Morphine(O) 5806,8 g 0,1 g 0,1197 N02AA01 Morphine(P) 809,8 g 0,03 g 0,0557 N02AA05 Oxycodone(O) 20429,1 g 0,075 g 0,5617 N02AA05 Oxycodone(P) 228,6 g 0,03 g 0,0157 N02AA08 Dihydrocodeine(O) 8413,2 g 0,15 g 0,1157 N02AA55 Oxycodone+Naloxone(O) 260,55 g 75 mg 0,0072 N02AB Phenylpiperidine derivatives 0,1430 N02AB02 Pethidine(P) 33 g 0,4 g 0,0002 N02AB02 Pethidine(P, V) 1922,5 g 0,4 g 0,0099 N02AB03 Fentanyl(O) 3,4736 g N02AB03 Fentanyl(SL) 3,243 g 0,6 mg 0,0111 N02AB03 Fentanyl(TD) 70,8412 g 1,2 mg 0,1217 N02AE Oripavine derivatives 0,0163 N02AE01 Buprenorphine(TD) 9,5088 g 1,2 mg 0,0163 N02AJ Opioids in combination with non-opioid analgesics 5,8990 N02AJ06 Codeine+Paracetamol(O) 6878930 pieces 3 pieces 4,7283 N02AJ13 Tramadol+Paracetamol(O) 1992 g 150 mg 0,0274 N02AJ14 Tramadol+Dexketoprofen(O) 83172,375 g 150 mg 1,1434 N02AX Other opioids 1,8936 N02AX02 Tramadol(O) 271498 g 0,3 g 1,8662 N02AX02 Tramadol(P) 3992 g 0,3 g 0,0274 N02B OTHER ANALGESICS AND ANTIPYRETICS 16,8943 N02BA Salicylic acid and derivatives 0,9381 N02BA01 Acetylsalicylic acid (O) 1178865,56 g 3 g 0,8103 N02BA01 Acetylsalicylic acid (P) 31 g 30/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N02BA80 Acetylsalicylic acid +Ascorbic acid(O) 185862,4 g 3 g 0,1278 N02BB Pyrazolones 0,0015 N02BB02 Metamizole sodium(O) 240 g 3 g 0,0002 N02BB02 Metamizole sodium(P) 1970 g 3 g 0,0014 N02BB02 Metamizole sodium(P, V) 30 g 3 g <0,0001 N02BE Anilides 15,9547 N02BE01 Paracetamol(O) 17012588,8 g 3 g 11,6937 N02BE01 Paracetamol(P) 324282 g 3 g 0,2229 N02BE01 Paracetamol(R) 58933,7 g 3 g 0,0405 N02BE52 Paracetamol+Pseudoephedrine+Diphenhydramine(O) 73336 g 3 g 0,0504 N02BE75 Paracetamol+Guaifenesin+Phenylephrine(O) 199881,5 g 3 g 0,1374 Paracetamol+Chlorphenamine+Pseudoephedrine+Dextrometh N02BE81 412106 g 3 g 0,2833 orphan(O) N02BE83 Paracetamol+Caffeine(O) 245446 g 3 g 0,1687 N02BE84 Paracetamol+Phenylephrine+Ascorbic acid(O) 934201,25 g 3 g 0,6421 N02BE85 Paracetamol+Pheniramine+Ascorbic acid(O) 86508,32 g 3 g 0,0595 Paracetamol+Phenylephrine+Terpin hydrate+Ascorbic N02BE86 327030 g 3 g 0,2248 acid+Caffeine(O) N02BE87 Paracetamol+Pseudoephedrine(O) 62200 g 3 g 0,0428 N02BE91 Paracetamol+Ascorbic acid(O) 9510,6 g 3 g 0,0065 N02BE92 Paracetamol+Codeine(O) 1050760 g 3 g 0,7222 N02BE94 Paracetamol+Codeine+Caffeine(O) 1879902 g 3 g 1,2922 N02BE95 Paracetamol+Phenylephrine(O) 69645 g 3 g 0,0479 N02BE97 Paracetamol+Pseudoephedrine+Dextromethorphan(O) 465414 g 3 g 0,3199 N02C ANTIMIGRAINE PREPARATIONS 1,0774 N02CC Selective serotonin (5HT1) agonists 1,0565 N02CC01 Sumatriptan(N) 1,2 g 0,02 g 0,0001 N02CC01 Sumatriptan(O) 21927,6 g 0,05 g 0,9043 N02CC03 Zolmitriptan(O) 66,59 g 2,5 mg 0,0549 N02CC04 Rizatriptan(O) 61,89 g 0,01 g 0,0128 N02CC07 Frovatriptan(O) 102,26 g 2,5 mg 0,0843 N02CD Calcitonin gene-related peptide (CGRP) antagonists 0,0210 N02CD01 Erenumab(P) 22,4 g 2,5 mg 0,0185 N02CD03 fremanezumab(P) 9 g 7,5 mg 0,0025 N03 ANTIEPILEPTICS 11,9146 N03A ANTIEPILEPTICS 11,9146 N03AA Barbiturates and derivatives 0,4563 N03AA02 Phenobarbital(O) 19800 g 0,1 g 0,4083 N03AA02 Phenobarbital(P) 140 g 0,1 g 0,0029 N03AA03 Primidone(O) 27350 g 1,25 g 0,0451 N03AA80 Benzobarbital(O) 150 g N03AB Hydantoin derivatives 0,0419 N03AB02 Phenytoin(O) 5890 g 0,3 g 0,0405 N03AB02 Phenytoin(P) 200 g 0,3 g 0,0014 N03AD Succinimide derivatives 0,0134 N03AD01 Ethosuximide(O) 8150 g 1,25 g 0,0134 N03AE Benzodiazepine derivatives 0,5825 N03AE01 Clonazepam(O) 2260,02 g 0,008 g 0,5825 N03AF Carboxamide derivatives 2,7683 N03AF01 Carbamazepine(O) 944646 g 1 g 1,9479 N03AF02 Oxcarbazepine(O) 397845 g 1 g 0,8204 N03AG Fatty acid derivatives 1,7071 N03AG01 Valproic acid(O) 1227965 g 1,5 g 1,6881 N03AG01 Valproic acid(P) 1671,3 g 1,5 g 0,0023 N03AG04 Vigabatrin(O) 16200 g 2 g 0,0167 N03AX Other antiepileptics 6,3451 N03AX03 Sultiame(O) 5300 g 0,4 g 0,0273 N03AX09 Lamotrigine(O) 108935,26 g 0,3 g 0,7488 N03AX11 Topiramate(O) 39232,5 g 0,3 g 0,2697 N03AX12 Gabapentin(O) 1639378 g 1,8 g 1,8781 N03AX14 Levetiracetam(O) 582090 g 1,5 g 0,8002 31/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N03AX14 Levetiracetam(P) 690 g 1,5 g 0,0009 N03AX15 Zonisamide(O) 14 g 0,2 g 0,0001 N03AX16 Pregabalin(O) 380276,4 g 0,3 g 2,6139 N03AX17 Stiripentol(O) 1320 g 1 g 0,0027 N03AX18 Lacosamide(O) 39,9 g 0,3 g 0,0003 N03AX22 perampanel(O) 2,016 g 8 mg 0,0005 N03AX23 Brivaracetam(O) 124,6 g 0,1 g 0,0026 N03AX24 Cannabidiol(O) 120 g N04 ANTI-PARKINSON DRUGS 3,7745 N04A ANTICHOLINERGIC AGENTS 0,5833 N04AA Tertiary amines 0,5833 N04AA01 Trihexyphenidyl(O) 2828,8 g 0,01 g 0,5833 N04B DOPAMINERGIC AGENTS 3,1911 N04BA Dopa and dopa derivatives 1,4809 N04BA03 Levodopa +Carbidopa+Entacapone(O) 72982,5 g 0,45 g 0,3344 N04BA80 Levodopa +Benserazide(O) 324140 g 0,6 g 1,1140 N04BA81 Levodopa +Carbidopa(intestin) 20132 g N04BA81 Levodopa +Carbidopa(O) 9446 g 0,6 g 0,0325 N04BB Adamantane derivatives 0,3144 N04BB01 Amantadine(O) 30490 g 0,2 g 0,3144 N04BB01 Amantadine(P) 26 g N04BC Dopamine agonists 0,7696 N04BC04 Ropinirole(O) 1080,996 g 0,006 g 0,3715 N04BC05 Pramipexole(O) 445,4819 g 2,5 mg 0,3674 N04BC07 Apomorphine(P) 297,05 g 20 mg 0,0306 N04BD Monoamine oxidase type B inhibitors 0,6263 N04BD02 Rasagiline(O) 303,726 g 0,001 g 0,6263 N05 PSYCHOLEPTICS 45,4010 N05A ANTIPSYCHOTICS 10,0797 N05AA Phenothiazines with aliphatic side-chain 0,1472 N05AA01 Chlorpromazine(O) 10418,5 g 0,3 g 0,0716 N05AA01 Chlorpromazine(P) 37,5 g 0,1 g 0,0008 N05AA02 Levomepromazine(O) 10852,5 g 0,3 g 0,0746 N05AA02 Levomepromazine(P, V) 12,5 g 0,1 g 0,0003 N05AB Phenothiazines with piperazine structure 0,0866 N05AB02 Fluphenazine(P) 8,625 g 0,001 g 0,0178 N05AB03 Perphenazine(O) 436,4 g 0,03 g 0,0300 N05AB03 Perphenazine(P) 188,268 g 0,01 g 0,0388 N05AB04 Prochlorperazine(O) 0,82 g 0,1 g <0,0001 N05AC Phenothiazines with piperidine structure 0,0009 N05AC01 Periciazine(O) 21,6 g 0,05 g 0,0009 N05AD Butyrophenone derivatives 1,0486 N05AD01 Haloperidol(O) 1988,735 g 0,008 g 0,5126 N05AD01 Haloperidol(P) 1014,575 g 0,008 g 0,2615 N05AD03 Melperone(O) 37695 g 0,3 g 0,2591 N05AD08 Droperidol(P) 18,675 g 2,5 mg 0,0154 N05AE Indole derivatives 0,0824 N05AE03 Sertindole(O) 621,664 g 0,016 g 0,0801 N05AE04 Ziprasidone(O) 89,36 g 0,08 g 0,0023 N05AF Thioxanthene derivatives 0,8488 N05AF01 Flupentixol(O) 363,75 g 0,006 g 0,1250 N05AF01 Flupentixol(P) 124 g 0,004 g 0,0639 N05AF03 Chlorprothixene(O) 29357,5 g 0,3 g 0,2018 N05AF05 Zuclopenthixol(O) 1340,5 g 0,03 g 0,0921 N05AF05 Zuclopenthixol(P) 49,5 g 0,03 g 0,0034 N05AF05 Zuclopenthixol(P) 2637,2 g 0,015 g 0,3625 N05AH Diazepines, oxazepines and thiazepines 5,7949 N05AH02 Clozapine(O) 99170,5 g 0,3 g 0,6817 N05AH03 Olanzapine(O) 11305,56 g 0,01 g 2,3313 N05AH03 Olanzapine(P) 195,16 g 0,01 g 0,0402 N05AH04 Quetiapine(O) 531841 g 0,4 g 2,7417 32/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N05AL Benzamides 0,1349 N05AL01 Sulpiride(O) 20110,5 g 0,8 g 0,0518 N05AL05 Amisulpride(O) 16122 g 0,4 g 0,0831 N05AN Lithium 0,2947 N05AN01 Lithium(O) 128610 g 0,9 g 0,2947 N05AX Other antipsychotics 1,6406 N05AX08 Risperidone(O) 1662,3 g 0,005 g 0,6856 N05AX08 Risperidone(P) 21,7625 g 2,7 mg 0,0166 N05AX12 Aripiprazole(O) 5597,22 g 0,015 g 0,7695 N05AX12 Aripiprazole(P) 9,5842 g 0,015 g 0,0013 N05AX12 Aripiprazole(P) 542,8 g 0,0133 g 0,0842 N05AX13 Paliperidone(P) 98,05 g 2,5 mg 0,0809 N05AX15 Cariprazine(O) 3,738 g 3 mg 0,0026 N05B ANXIOLYTICS 13,1656 N05BA Benzodiazepine derivatives 13,1650 N05BA01 Diazepam(O) 27486,95 g 0,01 g 5,6680 N05BA01 Diazepam(P) 467,3 g 0,01 g 0,0964 N05BA01 Diazepam(R) 63,075 g 0,01 g 0,0130 N05BA04 Oxazepam(O) 1 g 0,05 g <0,0001 N05BA06 Lorazepam(O) 871,71 g 2,5 mg 0,7190 N05BA06 Lorazepam(P) 10,22 g 2,5 mg 0,0084 N05BA08 Bromazepam(O) 5899,53 g 0,01 g 1,2165 N05BA09 Clobazam(O) 326 g 0,02 g 0,0336 N05BA12 Alprazolam(O) 2615,3425 g 0,001 g 5,3930 N05BA80 Phenazepam(O) 8,25 g 0,001 g 0,0170 N05BB Diphenylmethane derivatives 0,0001 N05BB01 Hydroxyzine(O) 3,6 g 0,075 g 0,0001 N05BE Azaspirodecanedione derivatives 0,0005 N05BE01 Buspirone(O) 7,2 g 0,03 g 0,0005 N05C HYPNOTICS AND SEDATIVES 22,1557 N05CD Benzodiazepine derivatives 0,1658 N05CD02 Nitrazepam(O) 209,35 g 0,005 g 0,0863 N05CD05 Triazolam(O) 0,0075 g 0,25 mg 0,0001 N05CD08 Midazolam(O) 0,04 g 0,01 g <0,0001 N05CD08 Midazolam(O) 80,9507 g 0,015 g 0,0111 N05CD08 Midazolam(P) 491,0807 g 0,015 g 0,0675 N05CD08 Midazolam(P, R) 5,25 g 0,015 g 0,0007 N05CF Benzodiazepine related drugs 21,3986 N05CF01 Zopiclone(O) 61256,925 g 7,5 mg 16,8421 N05CF02 Zolpidem(O) 22096,6 g 0,01 g 4,5565 N05CH Melatonin receptor agonists 0,2853 N05CH01 Melatonin(O) 276,71 g 2 mg 0,2853 N05CM Other hypnotics and sedatives 0,3061 N05CM09 Valerianae radix(O) 421890 pieces 3 pieces 0,2900 N05CM18 Dexmedetomidine(P) 7,8008 g 1 mg 0,0161 N06 PSYCHOANALEPTICS 42,2154 N06A ANTIDEPRESSANTS 37,1049 N06AA Non-selective monoamine reuptake inhibitors 1,9309 N06AA02 Imipramine(O) 6,25 g 0,1 g 0,0001 N06AA04 Clomipramine(O) 4758,45 g 0,1 g 0,0981 N06AA04 Clomipramine(P) 2,5 g 0,1 g 0,0001 N06AA09 Amitriptyline(O) 54730,5 g 0,075 g 1,5048 N06AA10 Nortriptyline(O) 11922,5 g 0,075 g 0,3278 N06AB Selective serotonin reuptake inhibitors 21,7827 N06AB03 Fluoxetine(O) 31871,4 g 0,02 g 3,2861 N06AB04 Citalopram(O) 13786,54 g 0,02 g 1,4214 N06AB05 Paroxetine(O) 22537,8 g 0,02 g 2,3237 N06AB06 Sertraline(O) 146511,2 g 0,05 g 6,0423 N06AB08 Fluvoxamine(O) 432 g 0,1 g 0,0089 N06AB10 Escitalopram(O) 42191,8 g 0,01 g 8,7002 N06AF Monoamine oxidase inhibitors, non-selective 0,0091 33/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N06AF04 Tranylcypromine(O) 44 g 0,01 g 0,0091 N06AG Monoamine oxidase type A inhibitors 0,0001 N06AG02 Moclobemide(O) 18 g 0,3 g 0,0001 N06AX Other antidepressants 13,3822 N06AX03 Mianserin(O) 31,8 g 0,06 g 0,0011 N06AX05 Trazodone(O) 15279 g 0,3 g 0,1050 N06AX11 Mirtazapine(O) 38672,46 g 0,03 g 2,6582 N06AX12 Bupropione(O) 128682 g 0,3 g 0,8845 N06AX14 Tianeptine(O) 22753,5 g 0,0375 g 1,2512 N06AX16 Venlafaxine(O) 190464,75 g 0,1 g 3,9275 N06AX18 Reboxetine(O) 0,72 g 0,008 g 0,0002 N06AX21 Duloxetine(O) 74708,04 g 0,06 g 2,5676 N06AX22 Agomelatine(O) 15207,5 g 0,025 g 1,2544 N06AX26 Vortioxetine(O) 3552,64 g 10 mg 0,7326 PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND N06B 1,5304 NOOTROPICS N06BA Centrally acting sympathomimetics 1,2658 N06BA04 Methylphenidate(O) 17228,1 g 0,03 g 1,1842 N06BA07 Modafinil(O) 1179 g 0,3 g 0,0081 N06BA09 Atomoxetine(O) 2853,62 g 0,08 g 0,0736 N06BA12 Lisdexamfetamine dimesylate(O) 7,2 g N06BC Xanthine derivatives N06BC81 Caffeine citrate(O, P) 63,6 g N06BX Other psychostimulants and nootropics 0,2646 N06BX03 Piracetam (O) 295680 g 2,4 g 0,2540 N06BX13 Idebenone(O) 243 g 0,9 g 0,0006 N06BX18 Vinpocetine(O) 72,75 g 15 mg 0,0100 N06BX83 Aminobutyric acid(O) 33115 g N06D ANTI-DEMENTIA DRUGS 3,5801 N06DA Anticholinesterases 1,1041 N06DA02 Donepezil(O) 4015,76 g 7,5 mg 1,1041 N06DX Other anti-dementia drugs 2,4760 N06DX01 Memantine(O) 4535,52 g 0,02 g 0,4676 N06DX02 Ginkgo folium(O) 116874 g 0,12 g 2,0084 N06DX80 cerebrolysine(P) 4,304 g N07 OTHER NERVOUS SYSTEM DRUGS 12,2094 N07A PARASYMPATHOMIMETICS 0,3739 N07AA Anticholinesterases 0,3739 N07AA01 neostigmine(O) 1,8 g 0,06 g 0,0001 N07AA01 neostigmine(P) 33,545 g 0,002 g 0,0346 N07AA02 Pyridostigmine bromide(O) 27189 g 0,18 g 0,3115 N07AA03 Distigmine bromide(O) 3,1 g 0,005 g 0,0013 N07AA80 Neostigmine+Glycopyrronium(P) 12850 ml 1 ml 0,0265 N07AX Other parasympathomimetics N07AX01 Pilocarpine(O) 1,68 g N07B DRUGS USED IN ADDICTIVE DISORDERS 3,3984 N07BA Drugs used in nicotine dependence 1,8655 N07BA01 Nicotine(O) 17003,7 g 0,03 g 1,1688 N07BA01 Nicotine(TD) 4441,738 g 0,014 g 0,6542 N07BA03 Varenicline(O) 41,222 g 2 mg 0,0425 N07BB Drugs used in alcohol dependence 0,3664 N07BB01 Disulfiram(O) 28410 g 0,2 g 0,2929 N07BB01 Disulfiram(P) 106 g N07BB03 Acamprosate(O) 447,552 g 2 g 0,0005 N07BB04 Naltrexone(O) 1549,8 g 50 mg 0,0639 N07BB05 nalmefene(O) 79,632 g 18 mg 0,0091 N07BC Drugs used in opioid dependence 1,1665 N07BC02 Methadone(O) 13520 g 0,025 g 1,1152 N07BC51 Buprenorphine+Naloxone(SL) 199,234 g 8 mg 0,0514 N07C ANTIVERTIGO PREPARATIONS 8,4046 N07CA Antivertigo preparations 8,4046 34/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N07CA01 Betahistine(O) 83376,48 g 0,024 g 7,1637 N07CA02 Cinnarizine(O) 51360 g 0,09 g 1,1768 N07CA03 Flunarizine(O) 4,5 g 0,01 g 0,0009 N07CA80 Cinnarizine+Dimenhydrinate(O) 2762 g 90 mg 0,0633 N07X OTHER NERVOUS SYSTEM DRUGS 0,0324 N07XX Other nervous system drugs 0,0324 N07XX02 Riluzole(O) 1352,4 g 0,1 g 0,0279 N07XX06 Tetrabenazine(O) 168 g 0,1 g 0,0035 N07XX07 Fampridine(O) 10,64 g 20 mg 0,0011 N07XX14 Edaravone(P) 8,1 g ANTIPARASITIC PRODUCTS, INSECTICIDES AND P 1,0260 REPELLENTS P01 ANTIPROTOZOALS 0,8172 AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL P01A DISEASES P01AB Nitroimidazole derivatives P01AB01 Metronidazole (O, V) 1062 g P01B ANTIMALARIALS 0,8172 P01BA Aminoquinolines 0,7762 P01BA02 Hydroxychloroquine(O) 194124 g 0,516 g 0,7758 P01BA03 Primaquine(O) 3 g 0,015 g 0,0004 P01BB Biguanides 0,0407 P01BB51 Proguanil+Atovaquone(O) 648 pieces 16 pieces 0,0001 P01BB51 Proguanil+Atovaquone(O) 78852 pieces 4 pieces 0,0406 P01BD Diaminopyrimidines 0,0003 P01BD01 Pyrimethamine(O) 10,5 g 0,075 g 0,0003 P01BE Artemisinin and derivatives, plain <0,0001 P01BE03 Artesunate(P) 0,6 g 0,28 g <0,0001 P02 ANTHELMINTICS 0,2088 P02B ANTITREMATODALS 0,0002 P02BA Quinoline derivatives and related substances 0,0002 P02BA01 Praziquantel(O) 313,2 g 3 g 0,0002 P02C ANTINEMATODAL AGENTS 0,2086 P02CA Benzimidazole derivatives 0,2083 P02CA01 Mebendazole(O) 18001 g 0,2 g 0,1856 P02CA03 Albendazole(O) 4400 g 0,4 g 0,0227 P02CF Avermectines 0,0003 P02CF01 Ivermectin(O) 1,746 g 12 mg 0,0003 ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES P03 AND REPELLENTS P03A ECTOPARASITICIDES, INCL. SCABICIDES P03AC Pyrethrines, incl. synthetic compounds P03AC04 Permethrin(C) 74760 g P03AX Other ectoparasiticides, incl. scabicides P03AX01 Benzyl benzoate(C) 351330 g R RESPIRATORY SYSTEM 91,8504 R01 NASAL PREPARATIONS 36,2791 DECONGESTANTS AND OTHER NASAL PREPARATIONS R01A 34,1838 FOR TOPICAL USE R01AA Sympathomimetics, plain 22,0028 R01AA05 Oxymetazoline(N) 281,8575 g 0,4 mg 1,4530 R01AA07 Xylometazoline(N) 7972,5 g 0,8 mg 20,5498 R01AB Sympathomimetics, combinations excl. corticosteroids 3,0514 R01AB83 Xylometazoline+Ipratropium bromide(N) 193840 ml 0,8 ml 0,4996 R01AB85 Xylometazoline+Dexpanthenol(N) 989980 ml 0,8 ml 2,5518 R01AC Antiallergic agents, excl. corticosteroids 0,3533 R01AC03 Azelastine(N) 95,94 g 0,56 mg 0,3533 R01AD Corticosteroids 8,7763 R01AD01 Beclometasone(N) 6,31 g 0,4 mg 0,0325 R01AD05 Budesonide(N) 37,4907 g 0,2 mg 0,3865 R01AD08 Fluticasone(N) 84,759 g 0,2 mg 0,8739 35/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day R01AD09 Mometasone(N) 370,468 g 0,2 mg 3,8197 R01AD12 Fluticasone furoate(N) 168,9567 g 0,11 mg 3,1673 R01AD81 Fluticasone+Azelastine(N) 963000 doses 4 doses 0,4964 R01AX Other nasal preparations R01AX06 Mupirocin(N) 120 g R01AX83 Retinol+Tocopherol(N) 142880 ml R01B NASAL DECONGESTANTS FOR SYSTEMIC USE 2,0952 R01BA Sympathomimetics 2,0952 R01BA02 Pseudoephedrine(O) 140291,52 g 0,24 g 1,2054 R01BA81 Pseudoephedrine+Triprolidine(O) 28360,68 g 0,24 g 0,2437 R01BA84 Pseudoephedrine+Guaifenesin(O) 9138,6 g 0,24 g 0,0785 R01BA89 Pseudoephedrine+Loratadine(O) 10970,4 g 0,24 g 0,0943 R01BA93 Pseudoephedrine+Cetirizine(O) 55100,64 g 0,24 g 0,4734 R02 THROAT PREPARATIONS 2,7242 R02A THROAT PREPARATIONS 2,7242 R02AA Antiseptics 2,2405 R02AA06 Cetylpyridinium chloride(O) 18324 pieces R02AA82 Benzydamine+Cetylpyridinium chloride(O) 852720 ml R02AA82 Benzydamine+Cetylpyridinium chloride(O) 2008368 pieces 6 pieces 0,6902 R02AA89 Povidone, iodinated+Allantoin(O) 327330 ml R02AA92 Dequalinium+Cinchocaine(O) 1115720 pieces 6 pieces 0,3834 R02AA94 Amylmetacresol+Dichlorobenzyl alcohol(O) 961920 pieces 6 pieces 0,3306 R02AA95 Amylmetacresol+Dichlorobenzyl alcohol+Levomenthol(O) 1664472 pieces 6 pieces 0,5720 R02AA96 Amylmetacresol+Dichlorobenzyl alcohol+Ascorbic acid(O) 641376 pieces 6 pieces 0,2204 R02AA98 Cetylpyridinium chloride+Benzocaine(O) 127458 pieces 6 pieces 0,0438 R02AD Anesthetics, local 0,1260 R02AD80 Lidocaine+Propyl parahydroxybenzoate(O) 366660 pieces 6 pieces 0,1260 R02AX Other throat preparations 0,3577 R02AX01 Flurbiprofen(O) 7631,89 g 44 mg 0,3577 R02AX80 Thyme herb+Sage leaf(O) 30150 ml R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES 28,0422 R03A ADRENERGICS, INHALANTS 20,4007 R03AC Selective beta-2-adrenoceptor agonists 3,9206 R03AC02 Salbutamol(I) 984,42 g 0,8 mg 2,5374 R03AC02 Salbutamol(I) 1286 g 0,01 g 0,2652 R03AC04 Fenoterol(I) 62,38 g 0,6 mg 0,2144 R03AC12 Salmeterol(I) 4,638 g 0,1 mg 0,0956 R03AC13 Formoterol(I) 5,7728 g 0,024 mg 0,4960 R03AC18 Indacaterol(I) 22,6935 g 0,15 mg 0,3120 Adrenergics in combination with corticosteroids or other drugs, R03AK 12,6544 excl. anticholinergics R03AK06 Salmeterol+Fluticasone(I) 576480 doses 4 doses 0,2972 R03AK06 Salmeterol+Fluticasone(I) 2395860 doses 2 doses 2,4702 R03AK07 Formoterol+Budesonide(I) 1105440 doses 2 doses 1,1397 R03AK07 Formoterol+Budesonide(I) 6400680 doses 4 doses 3,2997 R03AK08 Formoterol+Beclometasone(I) 3452760 doses 4 doses 1,7800 R03AK10 Vilanterol+Fluticasone furoate(I) 1739040 doses 1 doses 3,5860 R03AK13 Salbutamol+Beclometasone(I) 158400 doses 4 doses 0,0817 Adrenergics in combinations with anticholinergics incl. triple R03AL 3,8256 combinations with corticosteroids R03AL01 Fenoterol+Ipratropium bromide(I) 205720 ml 16 ml 0,0265 R03AL01 Fenoterol+Ipratropium bromide(I) 2713600 doses 6 doses 0,9326 R03AL03 Vilanterol+Umeclidinium(I) 355590 doses 1 doses 0,7333 R03AL04 Indacaterol+Glycopyrronium(I) 191370 doses 1 doses 0,3946 R03AL05 Formoterol+Aclidinium(I) 369240 doses 2 doses 0,3807 R03AL06 Olodaterol+Tiotropium(I) 699120 doses 2 doses 0,7208 R03AL07 Formoterol+Glycopyrronium(I) 195120 doses 4 doses 0,1006 R03AL08 Vilanterol+Umeclidinium+Fluticasone furoate(I) 72990 doses 1 doses 0,1505 R03AL09 Formoterol+Glycopyrronium+Beclometasone(I) 748800 doses 4 doses 0,3860 36/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, R03B 4,7057 INHALANTS R03BA Glucocorticoids 1,5566 R03BA02 Budesonide(I) 149,2 g 1,5 mg 0,2051 R03BA02 Budesonide(I) 305,864 g 0,8 mg 0,7884 R03BA05 Fluticasone(I) 163,857 g 0,6 mg 0,5631 R03BB Anticholinergics 3,1491 R03BB01 Ipratropium bromide(I) 21,108 g 0,12 mg 0,3627 R03BB01 Ipratropium bromide(I) 21,625 g 0,3 mg 0,1486 R03BB04 Tiotropium(I) 3,4729 g 0,005 mg 1,4323 R03BB05 Aclidinium(I) 136,8242 g 0,644 mg 0,4381 R03BB06 Glycopyrronium(I) 7,4712 g 44 mcg 0,3501 R03BB07 Umeclidinium(I) 11,1276 g 55 mcg 0,4172 R03C ADRENERGICS FOR SYSTEMIC USE 0,0872 R03CC Selective beta-2-adrenoceptor agonists 0,0872 R03CC02 Salbutamol(O) 507,06 g 0,012 g 0,0871 R03CC02 Salbutamol(P) 0,327 g 0,012 g 0,0001 OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY R03D 2,8486 DISEASES R03DA Xanthines 1,1525 R03DA04 Theophylline(O) 219340 g 0,4 g 1,1307 R03DA05 Aminophylline(O) 22,5 g 0,1 g 0,0005 R03DA05 Aminophylline(O) 36 g 0,6 g 0,0001 R03DA05 Aminophylline(P) 6174,8 g 0,6 g 0,0212 R03DC Leukotriene receptor antagonists 1,6247 R03DC03 Montelukast(O) 7878,808 g 0,01 g 1,6247 R03DX Other systemic drugs for obstructive airway diseases 0,0714 R03DX05 Omalizumab(P) 224,1 g 0,016 g 0,0289 R03DX07 Roflumilast(O) 0,18 g 0,5 mg 0,0007 R03DX09 Mepolizumab(P) 40,5 g 3,6 mg 0,0232 R03DX10 Benralizumab(P) 4,86 g 0,54 mg 0,0186 R05 COUGH AND COLD PREPARATIONS 6,8646 EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH R05C 6,7464 SUPPRESSANTS R05CA Expectorants 0,0644 R05CA03 Guaifenesin(O) 28116 g 0,9 g 0,0644 R05CA12 Hederae helicis folium(O) 216938 pieces R05CA12 Hederae helicis folium(O) 5806120 ml R05CA86 Iceland moss(O) 6406500 ml Distillate of rectified essential oils of eucalyptus, sweet orange, R05CA87 1122820 pieces myrtle and lemon(O) R05CA88 Thyme herb+Wild thyme+Plantain(O) 320800 ml R05CA89 Thyme herb+Hederae helicis folium(O) 248400 ml R05CA91 Thyme herb+Marshmallow root(O) 183940 pieces R05CA91 Thyme herb+Marshmallow root(O) 3851760 ml R05CA92 Thyme herb(O) 162660 pieces R05CB Mucolytics 6,6820 R05CB01 Acetylcysteine(I, P) 225 g R05CB01 Acetylcysteine(O) 985524,8 g 0,5 g 4,0644 R05CB01 Acetylcysteine(P) 7968 g R05CB02 Bromhexine(O) 7499,12 g 0,024 g 0,6443 R05CB03 Carbocisteine(O) 136752,5 g 1,5 g 0,1880 R05CB06 Ambroxol(O) 102684,75 g 0,12 g 1,7645 R05CB13 Dornase alfa(I) 25,14 g 2,5 mg 0,0207 COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH R05D 0,0759 EXPECTORANTS R05DB Other cough suppressants 0,0759 R05DB09 Oxeladin(O) 2945,75 g 0,08 g 0,0759 COUGH SUPPRESSANTS AND EXPECTORANTS, R05F 0,0422 COMBINATIONS R05FA Opium derivatives and expectorants 0,0422 37/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day R05FA80 Codeine+Guaifenesin(O) 614250 ml 30 ml 0,0422 R05X OTHER COLDPREPARATIONS R05XA Other cold combination preparations Gentian root+Primula flower+Common sorrel+Elder R05XA80 3102,4 g flower+Verbena herb(O) Gentian root+Primula flower+Common sorrel+Elder R05XA80 1401770 pieces flower+Verbena herb(O) R05XA82 Ibuprofen+Pseudoephedrine(O) 5733,6 g R06 ANTIHISTAMINES FOR SYSTEMIC USE 17,9399 R06A ANTIHISTAMINES FOR SYSTEMIC USE 17,9399 R06AA Aminoalkyl ethers 0,4810 R06AA02 Diphenhydramine(O) 19 g 0,2 g 0,0002 R06AA02 Diphenhydramine(P) 30,1 g R06AA04 Clemastine(O) 425,96 g 0,002 g 0,4392 R06AA04 Clemastine(P) 40,4 g 0,002 g 0,0417 R06AE Piperazine derivatives 8,9059 R06AE07 Cetirizine(O) 40804,27 g 0,01 g 8,4141 R06AE09 Levocetirizine(O) 1192,55 g 0,005 g 0,4918 R06AX Other antihistamines for systemic use 8,5530 R06AX02 Cyproheptadine(O) 0,12 g 0,012 g <0,0001 R06AX13 Loratadine(O) 18549,3 g 0,01 g 3,8250 R06AX15 Mebhydrolin(O) 10 g 0,2 g 0,0001 R06AX17 Ketotifen(O) 1,32 g 0,002 g 0,0014 R06AX22 Ebastine(O) 7202,1 g 0,01 g 1,4851 R06AX27 Desloratadine(O) 2485,37 g 0,005 g 1,0250 R06AX28 Rupatadine(O) 941,12 g 0,01 g 0,1941 R06AX29 Bilastine(O) 19614,2 g 20 mg 2,0223 R07 OTHER RESPIRATORY SYSTEM PRODUCTS 0,0004 R07A OTHER RESPIRATORY SYSTEM PRODUCTS 0,0004 R07AA Lung surfactants 0,0004 R07AA81 Porcine lung phospholipids(endotrach) 33,48 g 0,16 g 0,0004 S SENSORY ORGANS 32,8766 S01 OPHTHALMOLOGICALS 32,8766 S01A ANTIINFECTIVES S01AA Antibiotics S01AA01 Chloramphenicol(S) 168710 ml S01AA02 Chlortetracycline(S) 0,75 g S01AA12 Tobramycin(S) 34485 ml S01AA12 Tobramycin(S) 47820,5 g S01AA13 Fusidic acid(S) 35950 g S01AD Antivirals S01AD02 Trifluridine(S) 5 ml S01AD03 Aciclovir(S) 3159 g S01AE Fluoroquinolones S01AE03 Ciprofloxacin(S) 12430 ml S01AE05 Levofloxacin(S) 25485 ml S01AE07 Moxifloxacin(S) 15465 ml S01AX Other antiinfectives S01AX15 Propamidine(S) 130 ml S01AX18 Povidone, iodinated(S) 472 ml S01B ANTIINFLAMMATORY AGENTS S01BA Corticosteroids, plain S01BA01 Dexamethasone(S) 162 pieces S01BA01 Dexamethasone(S) 15035,6 g S01BA01 Dexamethasone(S) 142710 ml S01BA02 Hydrocortisone(S) 4206 g S01BA09 Clobetasone(S) 12500 ml S01BA14 Loteprednol(S) 1305 ml S01BC Antiinflammatory agents, non-steroids S01BC03 Diclofenac(S) 30 ml S01BC05 Ketorolac(S) 11500 ml 38/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day S01BC10 Nepafenac(S) 19645 ml S01BC11 Bromfenac(S) 12760 ml ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN S01C COMBINATION S01CA Corticosteroids and antiinfectives in combination S01CA80 Dexamethasone+Neomycin+Polymyxin B(S) 43670 ml S01CA81 Dexamethasone+Tobramycin(S) 13639,5 g S01CA81 Dexamethasone+Tobramycin(S) 37545 ml S01CA82 Dexamethasone+Chloramphenicol(S) 47792,5 g S01CA82 Dexamethasone+Chloramphenicol(S) 434070 ml S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS 32,8766 S01EA Sympathomimetics in glaucoma therapy 0,0516 S01EA05 Brimonidine(S) 5000 ml 0,2 ml 0,0516 S01EB Parasympathomimetics 0,0150 S01EB01 Pilocarpine(S) 2225 ml 0,4 ml 0,0115 S01EB02 Carbachol(S) 690 ml 0,4 ml 0,0036 S01EB09 Acetylcholine chloride(S) 0,2 g S01EC Carbonic anhydrase inhibitors 3,7275 S01EC01 Acetazolamide(O) 26335 g 0,75 g 0,0724 S01EC01 Acetazolamide(P) 97 g 0,75 g 0,0003 S01EC03 Dorzolamide(S) 140115 ml 0,3 ml 0,9631 S01EC04 Brinzolamide(S) 163050 ml 0,2 ml 1,6811 S01EC80 Brinzolamide+Brimonidine(S) 98025 ml 0,2 ml 1,0107 S01ED Beta blocking agents 20,5307 S01ED01 Timolol(S) 20510 ml 0,2 ml 0,2115 S01ED01 Timolol(S) 226900 g 40 mg 11,6971 S01ED02 Betaxolol(S) 83585 ml 0,2 ml 0,8618 S01ED80 Timolol+Dorzolamide(S) 295210 ml 0,2 ml 3,0437 S01ED81 Timolol+Travoprost(S) 41442,5 ml 0,2 ml 0,4273 S01ED82 Timolol+Bimatoprost(S) 110142 ml 0,2 ml 1,1356 S01ED83 Timolol+Brinzolamide(S) 224240 ml 0,2 ml 2,3120 S01ED84 Timolol+Latanoprost(S) 73267,5 ml 0,2 ml 0,7554 S01ED85 Timolol+Tafluprost(S) 8377,8 ml 0,2 ml 0,0864 S01EE Prostaglandin analogues 8,5518 S01EE01 Latanoprost(S) 269522,5 ml 0,1 ml 5,5577 S01EE03 Bimatoprost(S) 276 ml 0,1 ml 0,0057 S01EE04 Travoprost(S) 64497,5 ml 0,1 ml 1,3300 S01EE05 Tafluprost(S) 241272 ml 0,3 ml 1,6584 S01F MYDRIATICS AND CYCLOPLEGICS S01FA Anticholinergics S01FA01 Atropine(S) 640 ml S01FA04 Cyclopentolate(S) 26520 ml S01FA06 Tropicamide(S) 13150 ml S01FB Sympathomimetics excl. antiglaucoma preparations S01FB01 Phenylephrine(S) 6270 ml S01G DECONGESTANTS AND ANTIALLERGICS S01GA Sympathomimetics used as decongestants S01GA02 Tetryzoline(S) 260730 ml S01GX Other antiallergics S01GX01 Cromoglicic acid(S) 103170 ml S01GX07 Azelastine(S) 39960 ml S01GX09 Olopatadine(S) 22255 ml S01H LOCAL ANESTHETICS S01HA Local anesthetics S01HA03 Tetracaine(S) 25390 ml S01HA04 Proxymetacaine(S) 33285 ml S01J DIAGNOSTIC AGENTS S01JA Colouring agents S01JA01 Fluorescein(P) 4500 ml S01JA81 Fluorescein+Oxybuprocaine+Chlorobutanol(S) 2650 ml S01K SURGICAL AIDS 39/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day S01KA Viscoelastic substances S01KA02 Hypromellose(S) 5250 g S01L OCULAR VASCULAR DISORDER AGENTS S01LA Antineovascularisation agents S01LA01 Verteporfin(P) 2 pieces S01LA04 Ranibizumab(S) 1 pieces S01LA05 aflibercept(S) 191 pieces S01X OTHER OPHTHALMOLOGICALS S01XA Other ophthalmologicals S01XA03 Sodium chloride(S) 227,5 g S01XA18 Ciclosporin(S) 4671 ml S01XA80 Retinol+Dexpanthenol(S) 8172,5 g S01XA81 Carbomer(S) 196380 g S01XA82 Hypromellose(S) 169750 ml S01XA85 Hypromellose+Dextran(S) 353100 ml S02 OTOLOGICALS CORTICOSTEROIDS AND ANTIINFECTIVES IN S02C COMBINATION S02CA Corticosteroids and antiinfectives in combination S02CA81 Dexamethasone+Neomycin+Acetic acid, glacial(A) 3770 ml S02CA82 Hydrocortisone+Ciprofloxacin(A) 131210 ml S02D OTHER OTOLOGICALS S02DA Analgesics and anesthetics S02DA81 Phenazone+Lidocaine(A) 1530 ml T HERBAL MEDICINAL PRODUCTS T01 HERBAL MEDICINAL PRODUCTS T01R HERBAL MEDICINAL PRODUCTS T01RS Herbal medicinal products T01RS01 herbal preparation(O) 676890 pieces T01RS01 herbal preparation(O) 7993240 ml T01RS02 homeopathic preparations(A) 5470 ml T01RS02 homeopathic preparations(C) 549650 g T01RS02 homeopathic preparations(O) 1680 g T01RS02 homeopathic preparations(O) 1124710 ml T01RS02 homeopathic preparations(O) 1270430 pieces T01RS02 homeopathic preparations(R) 12 pieces V VARIOUS 0,2149 V01 ALLERGENS V01A ALLERGENS V01AA Allergen extracts V01AA02 Grass pollen(O) 151 pieces V01AA02 Grass pollen(P) 165 pieces V01AA03 House dust mites(O) 264 pieces V01AA03 House dust mites(P) 12 ml V01AA03 House dust mites(P) 285 pieces V01AA05 Tree pollen(P) 495 pieces V01AA05 Tree pollen(SL) 642 pieces V01AA07 Allergen products (insects)(P) 534 pieces V01AA11 Animals(O) 39 pieces V01AA80 Tree and grass pollen(O) 111 pieces V01AA80 Tree and grass pollen(P) 99 pieces V01AA83 Grass pollen+Flowers(O) 5 pieces V01AA84 Tree and flower pollen(O) 12 pieces V03 ALL OTHER THERAPEUTIC PRODUCTS 0,2149 V03A ALL OTHER THERAPEUTIC PRODUCTS 0,2149 V03AB Antidotes V03AB06 Sodium thiosulphate(P) 450 g V03AB09 Dimercaprol(P) 4,8 g V03AB14 Protamine sulfate(P) 285 g V03AB15 Naloxone(N) 3,6 g V03AB15 Naloxone(P) 2,272 g 40/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day V03AB16 Ethanol(P) 10900 ml V03AB17 Methylthioninium chloride(P) 173 g V03AB19 Physostigmine(P) 0,06 g V03AB21 Potassium iodide(O) 13 g V03AB24 Digitalis antitoxin(P) 3,44 g V03AB25 Flumazenil(P) 0,29 g V03AB33 Hydroxocobalamin(P) 80 g V03AB34 Fomepizole(P) 20 g V03AB35 Sugammadex(P) 104 g V03AB37 Idarucizumab(P) 270 g V03AB80 Sodium calcium edetate(P) 40 g V03AC Iron chelating agents V03AC01 Deferoxamine(P) 50 g V03AC03 Deferasirox(O) 7695 g V03AE Drugs for treatment of hyperkalemia and hyperphosphatemia 0,1501 V03AE01 Polystyrene sulfonate(O, R) 1826350,5 g 45 g 0,0837 V03AE02 Sevelamer(O) 155664 g 6,4 g 0,0502 V03AE03 Lanthan(O) 17752,5 g 2,25 g 0,0163 V03AF Detoxifying agents for antineoplastic treatment 0,0647 V03AF01 Mesna(P) 4188 g V03AF03 Calcium folinate(O) 30,6 g 0,06 g 0,0011 V03AF07 Rasburicase(P) 0,738 g 0,014 g 0,0001 V03AF09 Glucarpidase(P) 19000 U V03AF10 Sodium levofolinate(P) 925 g 0,03 g 0,0636 V03AH Drugs for treatment of hypoglycemia V03AH01 Diazoxide(O) 60 g V03AN Medical gases V03AN01 Oxygen(I) 486681000 ml V03AN05 Air, medicinal(I) 2840000 ml V04 DIAGNOSTIC AGENTS V04C OTHER DIAGNOSTIC AGENTS V04CD Tests for pituitary function V04CD04 Corticorelin(P) 0,0004 g V04CF Tuberculosis diagnostics V04CF01 Tuberculin(P) 9630 U V04CJ Tests for thyreoidea function V04CJ02 Protirelin(P) 0,004 g V04CX Other diagnostic agents V04CX01 Indocyanine green(P) 1,15 g V04CX03 Methacholine(I) 51,708 g V04CX04 Mannitol(I) 14,605 g V04CX04 Mannitol(I) 80 pieces V04CX06 Hexaminolevulinate(P) 20,145 g V04CX09 Patent blue(P) 5 g V04CX87 Carbon monoxide+Helium(I) 20000 ml V07 ALL OTHER NON-THERAPEUTIC PRODUCTS V07A ALL OTHER NON-THERAPEUTIC PRODUCTS V07AB Solvents and diluting agents, incl. irrigating solutions V07AB80 Sodium chloride(P) 7065500 ml V07AB83 Water for injection(NA) 16928200 ml V08 CONTRAST MEDIA V08A X-RAY CONTRAST MEDIA, IODINATED V08AA Watersoluble, nephrotropic, high osmolar X-ray contrast media V08AA01 Sodium amidotrizoate+Meglumine Amidotrizoate(P) 6000 ml V08AB Watersoluble, nephrotropic, low osmolar X-ray contrast media V08AB02 Iohexol(P) 1657574,5 g V08AB05 Iopromide(P) 1186640 g V08AB09 Iodixanol(P) 2849386 g 41/42  Estonian Statistics on Medicines 2020 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day V08AD Non-watersoluble X-ray contrast media V08AD01 Ethyl esters of iodised fatty acids(P) 96 g V08B X-RAY CONTRAST MEDIA, NON-IODINATED V08BA Barium sulfate containing X-ray contrast media V08BA01 Barium sulfate(O) 192520,72 g V08C MAGNETIC RESONANCE IMAGING CONTRAST MEDIA V08CA Paramagnetic contrast media V08CA01 Gadopentetic acid(P) 4460 ml V08CA02 Gadoteric acid(P) 54450 ml V08CA09 Gadobutrol(P) 85447,5 ml V08CA10 Gadoxetic acid(P) 5670 ml V08D ULTRASOUND CONTRAST MEDIA V08DA Ultrasound contrast media V08DA05 Sulfur hexafluoride, phospholipid microspheres(P) 100 ml V09 DIAGNOSTIC RADIOPHARMACEUTICALS V09A CENTRAL NERVOUS SYSTEM V09AB Iodine (123I) compounds V09AB03 Ioflupane (123I)(P) 430 ml V09F THYROID V09FX Various thyroid diagnostic radiopharmaceuticals V09FX01 Technetium (99mTc) pertechnetate(S) 30 pieces V10 THERAPEUTIC RADIOPHARMACEUTICALS V10X OTHER THERAPEUTIC RADIOPHARMACEUTICALS V10XA Iodine (131I) compounds V10XA01 Sodium iodide (131I)(O) 65 pieces 42/42 Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A ALIMENTARY TRACT AND METABOLISM 188,4400 A01 STOMATOLOGICAL PREPARATIONS 0,0703 A01A STOMATOLOGICAL PREPARATIONS 0,0703 A01AB Antiinfectives and antiseptics for local oral treatment 0,0703 A01AB09 Miconazole (O) 6820,8 g 0,2 g 0,0703 A01AB12 Hexetidine (O) 1321280 ml A01AB82 Demeclocycline+Triamcinolone (dental) 465 g A01AD Other agents for local oral treatment A01AD80 Lidocaine+Cetylpyridinium chloride (gingival) 221300 g A01AD81 Lidocaine+Cetrimide (O) 64265 g A01AD82 Choline salicylate (O) 403808 pieces A01AD83 Lidocaine+Chamomille extract (O) 347870 g A02 DRUGS FOR ACID RELATED DISORDERS 62,6277 A02A ANTACIDS 1,1306 Combinations and complexes of aluminium, calcium and A02AD 1,1306 magnesium compounds A02AD81 Aluminium hydroxide+Magnesium hydroxide (O) 1227440 pieces 10 pieces 0,2528 A02AD81 Aluminium hydroxide+Magnesium hydroxide (O) 5263316 ml 50 ml 0,2168 A02AD83 Calcium carbonate+Magnesium carbonate (O) 3208344 pieces 10 pieces 0,6609 DRUGS FOR PEPTIC ULCER AND GASTRO- A02B 61,4971 OESOPHAGEAL REFLUX DISEASE (GORD) A02BA H2-receptor antagonists 0,0430 A02BA02 Ranitidine (P) 2757 g 0,3 g 0,0189 A02BA03 Famotidine (O) 468 g 0,04 g 0,0241 A02BC Proton pump inhibitors 61,4401 A02BC01 Omeprazole (O) 300792,74 g 0,02 g 30,9808 A02BC02 Pantoprazole (O) 320357,94 g 0,04 g 16,4980 A02BC02 Pantoprazole (P) 19,6 g 0,04 g 0,0010 A02BC03 Lansoprazole (O) 7,98 g 0,03 g 0,0005 A02BC04 Rabeprazole (O) 15,68 g 0,02 g 0,0016 A02BC05 Esomeprazole (O) 198885,96 g 0,03 g 13,6565 A02BC05 Esomeprazole (P) 4393,6 g 0,03 g 0,3017 A02BC08 Vonoprazan (O) 8 g A02BD Combinations for eradication of Helicobacter pylori 0,0019 A02BD08 Bismuth subcitrate+Tetracycline+Metronidazole (O) 11160 pieces 12 pieces 0,0019 Other drugs for peptic ulcer and gastro-oesophageal reflux A02BX 0,0120 disease (GORD) A02BX02 Sucralfate (O) 23340 g 4 g 0,0120 DRUGS FOR FUNCTIONAL GASTROINTESTINAL A03 8,8152 DISORDERS DRUGS FOR FUNCTIONAL GASTROINTESTINAL A03A 7,8830 DISORDERS A03AA Synthetic anticholinergics, esters with tertiary amino group 1,4006 A03AA04 Mebeverine (O) 203982 g 0,3 g 1,4006 A03AB Synthetic anticholinergics, quaternary ammonium compounds 0,0002 A03AB02 Glycopyrronium (P) 0,027 g 0,3 mg 0,0002 A03AD Papaverine and derivatives 4,8961 A03AD01 Papaverine hydrochloride (P) 20 g 0,1 g 0,0004 A03AD02 Drotaverine (O) 234638,08 g 0,1 g 4,8334 A03AD02 Drotaverine (P) 3022 g 0,1 g 0,0623 A03AX Other drugs for functional gastrointestinal disorders 1,5861 A03AX13 Simeticone (O) 384996,15 g 0,5 g 1,5861 A03B BELLADONNA AND DERIVATIVES, PLAIN 0,0744 A03BA Belladonna alkaloids, tertiary amines 0,0647 A03BA01 Atropine (O, P) 18,25 g 0,0015 g 0,0251 A03BA01 Atropine (P) 28,88 g 0,0015 g 0,0397 Belladonna alkaloids, semisynthetic, quaternary ammonium A03BB 0,0096 compounds A03BB01 Hyoscine butylbromide (O) 1,8 g 0,06 g 0,0001 A03BB01 Hyoscine butylbromide (P) 278,8 g 0,06 g 0,0096 A03F PROPULSIVES 0,8578 1/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A03FA Propulsives 0,8578 A03FA01 Metoclopramide (O) 10650,5 g 0,03 g 0,7313 A03FA01 Metoclopramide (P) 1601,3 g 0,03 g 0,1100 A03FA03 Domperidone (O) 240,6 g 0,03 g 0,0165 A04 ANTIEMETICS AND ANTINAUSEANTS 0,1251 A04A ANTIEMETICS AND ANTINAUSEANTS 0,1251 A04AA Serotonin (5-HT3) antagonists 0,1169 A04AA01 Ondansetron (P) 192,36 g 0,016 g 0,0248 A04AA02 Granisetron (O) 63,73 g 0,002 g 0,0656 A04AA02 Granisetron (P) 35,5 g 0,003 g 0,0244 A04AA05 Palonosetron (P) 0,0025 g 0,25 mg <0,0001 A04AA80 Palonosetron+Netupitant (O) 1020 pieces 1 pieces 0,0021 A04AD Other antiemetics 0,0082 A04AD01 Scopolamine (TD) 5 pieces 1 pieces <0,0001 A04AD12 Aprepitant (O) 219,735 g 0,165 g 0,0027 A04AD81 Fosaprepitant (P) 251,7 g 0,095 g 0,0055 A05 BILE AND LIVER THERAPY 1,9950 A05A BILE THERAPY 0,5801 A05AA Bile acids and derivatives 0,5801 A05AA02 Ursodeoxycholic acid (O) 211225 g 0,75 g 0,5801 A05B LIVER THERAPY, LIPOTROPICS 1,4149 A05BA Liver therapy 1,4149 A05BA03 Silymarin (O) 1955410 pieces A05BA03 Silymarin (P) 56 g A05BA80 Phospholipids from Soya Beans (O) 1368450 pieces 3 pieces 0,9396 A05BA80 Phospholipids from Soya Beans (O) 1384250 pieces 6 pieces 0,4752 A05BA80 Phospholipids from Soya Beans (P) 605 pieces A06 DRUGS FOR CONSTIPATION 17,4337 A06A DRUGS FOR CONSTIPATION 17,4337 A06AB Contact laxatives 7,6130 A06AB02 Bisacodyl (O) 14106,4 g 0,01 g 2,9058 A06AB02 Bisacodyl (R) 160,82 g 0,01 g 0,0331 A06AB06 Senna glycosides (O) 2480 pieces 1 pieces 0,0051 A06AB08 Sodium picosulfate (O) 11324,937 g 0,005 g 4,6657 A06AB80 Sodium picosulfate+Magnesium oxide+Citric acid (O) 3080 pieces 2 pieces 0,0032 A06AD Osmotically acting laxatives 8,7400 A06AD11 Lactulose (O) 26717524,2 g 6,7 g 8,2144 A06AD15 Macrogol (O) 2551560 g 10 g 0,5256 Macrogol+Sodium citrate+Citric acid+Sodium A06AD80 17000 ml chloride+Potassium chloride (O) Sodium sulphate, anhydrous+Potassium chloride+Sodium A06AD81 32936 pieces chloride+Macrogol+Sodium hydrogen carbonate (O) Macrogol+Sodium sulphate, anhydrous+Sodium A06AD83 chloride+Potassium chloride+Ascorbic acid+Sodium ascorbate 6412 pieces (O) Sodium sulphate, anhydrous+magnesium sulfate A06AD85 720896 ml heptahydrate+Potassium sulphate (O) A06AG Enemas 1,0292 A06AG11 Laurilsulfate, incl. combinations+Sorbitol+Sodium citrate (R) 499608 pieces 1 pieces 1,0292 A06AH Peripheral opioid receptor antagonists 0,0515 A06AH03 Naloxegol (O) 624,75 g 25 mg 0,0515 A06AX Other drugs for constipation A06AX81 Sodium hydrogen carbonate+Potassium hydrogentartrate (R) 120 pieces ANTIDIARRHEALS, INTESTINAL A07 4,3086 ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS A07A INTESTINAL ANTIINFECTIVES 0,0054 A07AA Antibiotics 0,0054 A07AA02 Nystatin (O) 100000000 U 1500000 U 0,0001 A07AA11 Rifaximin (O) 1536 g 0,6 g 0,0053 A07B INTESTINAL ADSORBENTS 0,3805 A07BC Other intestinal adsorbents 0,3805 A07BC05 Diosmectidum (O) 1662420 g 9 g 0,3805 2/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A07C ELECTROLYTES WITH CARBOHYDRATES A07CA Oral rehydration salt formulations Sodium chloride+Potassium chloride+Sodium citrate+Glucose A07CA80 86920 pieces (O) A07D ANTIPROPULSIVES 0,9125 A07DA Antipropulsives 0,9125 A07DA03 Loperamide (O) 4429,652 g 0,01 g 0,9125 A07E INTESTINAL ANTIINFLAMMATORY AGENTS 2,4140 A07EA Corticosteroids acting locally 0,0271 A07EA06 Budesonide (O) 118,29 g 0,009 g 0,0271 A07EA06 Budesonide (R) 1,5694 g A07EC Aminosalicylic acid and similar agents 2,3869 A07EC01 Sulfasalazine (O) 757500 g 2 g 0,7802 A07EC02 Mesalazine (O) 1072408 g 1,5 g 1,4727 A07EC02 Mesalazine (R) 97544 g 1,5 g 0,1340 A07F ANTIDIARRHEAL MICROORGANISMS 0,5962 A07FA Antidiarrheal microorganisms 0,5962 A07FA02 Saccharomyces boulardii (O) 289442,5 g 1 g 0,5962 A07X OTHER ANTIDIARRHEALS A07XA Other antidiarrheals A07XA04 Racecadotril (O) 2869,44 g A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS 0,0503 A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS 0,0503 A08AA Centrally acting antiobesity products 0,0503 A08AA62 Bupropione+Naltrexone (O) 97664 pieces 4 pieces 0,0503 A09 DIGESTIVES, INCL. ENZYMES 1,8176 A09A DIGESTIVES, INCL. ENZYMES 1,8176 A09AA Enzyme preparations 1,8176 A09AA02 Lipase+Amylase+Protease (O) 3529492 pieces 4 pieces 1,8176 A10 DRUGS USED IN DIABETES 67,4826 A10A INSULINS AND ANALOGUES 15,3462 A10AB Insulins and analogues for injection, fast-acting 5,8915 A10AB01 Insulin (human) (P) 1339500 U 40 U 0,0690 A10AB04 Insulin lispro (P) 19329000 U 40 U 0,9954 A10AB05 Insulin aspart (P) 82717500 U 40 U 4,2598 A10AB06 Insulin glulisine (P) 11014500 U 40 U 0,5672 A10AC Insulins and analogues for injection, intermediate-acting 0,0485 A10AC01 Insulin (human) (P) 942000 U 40 U 0,0485 Insulins and analogues for injection, intermediate- or long- A10AD 0,6543 acting combined with fast-acting A10AD04 Insulin lispro (P) 3465000 U 40 U 0,1784 A10AD05 Insulin aspart (P) 8764500 U 40 U 0,4514 A10AD06 Insulin degludec+Insulin aspart (P) 476000 U 40 U 0,0245 A10AE Insulins and analogues for injection, long-acting 8,7519 A10AE04 Insulin glargine (P) 91207500 U 40 U 4,6971 A10AE05 Insulin detemir (P) 33979500 U 40 U 1,7499 A10AE06 Insulin degludec (P) 41344200 U 40 U 2,1292 A10AE54 Insulin glargine+Lixisenatide (P) 3412500 U 40 U 0,1757 A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS 52,1365 A10BA Biguanides 20,9501 A10BA02 Metformin (O) 20340486 g 2 g 20,9501 A10BB Sulfonylureas 11,2810 A10BB07 Glipizide (O) 767,1 g 0,01 g 0,1580 A10BB09 Gliclazide (O) 187531,8 g 0,06 g 6,4384 A10BB12 Glimepiride (O) 4548,27 g 0,002 g 4,6846 A10BD Combinations of oral blood glucose lowering drugs 7,9925 A10BD07 Metformin+Sitagliptin (O) 1512000 pieces 2 pieces 1,5573 A10BD08 Metformin+Vildagliptin (O) 1347660 pieces 2 pieces 1,3881 A10BD10 Metformin+Saxagliptin (O) 291720 pieces 2 pieces 0,3005 A10BD11 Metformin+Linagliptin (O) 1280520 pieces 2 pieces 1,3189 A10BD15 Metformin+Dapagliflozin (O) 1014944 pieces 2 pieces 1,0454 3/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A10BD19 Linagliptin+Empagliflozin (O) 217080 pieces 1 pieces 0,4472 A10BD20 Metformin+Empagliflozin (O) 1681260 pieces 2 pieces 1,7317 A10BD21 Saxagliptin+Dapagliflozin (O) 97944 pieces 1 pieces 0,2018 A10BD23 Metformin+Ertugliflozin (O) 896 pieces 1 pieces 0,0018 A10BF Alpha glucosidase inhibitors 0,0006 A10BF01 Acarbose (O) 89,25 g 0,3 g 0,0006 A10BG Thiazolidinediones 0,1295 A10BG03 Pioglitazone (O) 1886,22 g 0,03 g 0,1295 A10BH Dipeptyl peptidase 4 (DPP-4) inhibitors 4,1812 A10BH01 Sitagliptin (O) 39196,5 g 0,1 g 0,8074 A10BH02 Vildagliptin (O) 7593 g 0,1 g 0,1564 A10BH03 Saxagliptin (O) 504,9 g 5 mg 0,2080 A10BH05 Linagliptin (O) 7304,55 g 5 mg 3,0094 A10BJ Glucagon-like peptide-1 (GLP-1) analogues 4,1123 A10BJ01 Exenatide (P) 4,368 g 0,286 mg 0,0315 A10BJ02 Liraglutide (P) 482,796 g 1,5 mg 0,6630 A10BJ03 Lixisenatide (P) 0,3993 g 20 mcg 0,0411 A10BJ05 Dulaglutide (P) 34,104 g 0,16 mg 0,4391 A10BJ06 Semaglutide (O) 576,63 g 10,5 mg 0,1131 A10BJ06 Semaglutide (P) 150,827 g 0,11 mg 2,8245 A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors 3,4891 A10BK01 Dapagliflozin (O) 7520,4 g 10 mg 1,5492 A10BK03 empagliflozin (O) 16477,05 g 17,5 mg 1,9395 A10BK04 Ertugliflozin (O) 1,96 g 10 mg 0,0004 A11 VITAMINS 14,0734 A11A MULTIVITAMINS, COMBINATIONS 1,3133 A11AA Multivitamins with minerals 1,3133 A11AA03 Multivitamins+Mineral elements (O) 637560 pieces 1 pieces 1,3133 A11C VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO 5,3526 A11CA Vitamin A, plain <0,0001 A11CA01 Retinol (P) 600000 U 50000 U <0,0001 A11CC Vitamin D and analogues 5,3526 A11CC04 Calcitriol (O) 0,1299 g 0,001 mg 0,2676 A11CC05 Colecalciferol (O) 987400000 U 400 U 5,0850 A11CC05 Colecalciferol (P) 31000000 U VITAMIN B1, PLAIN AND IN COMBINATION WITH VITAMIN A11D 1,5294 B6 AND B12 A11DA Vitamin B1, plain 0,4082 A11DA01 Thiamine (P) 9908,5 g 0,05 g 0,4082 A11DA03 Benfotiamine (O) 1689370 pieces A11DB Vitamin B1 in combination with vitamin B6 and/or vitamin B12 1,1212 A11DB80 Thiamine+Pyridoxine (P) 3750 pieces 1 pieces 0,0077 A11DB81 Benfotiamine+Pyridoxine (O) 227520 pieces 3 pieces 0,1562 A11DB84 Thiamine+Pyridoxine+Cyanocobalamin (O) 401120 pieces 1 pieces 0,8263 A11DB85 Thiamine+Pyridoxine+Cyanocobalamin+Lidocaine (P) 63590 pieces 1 pieces 0,1310 A11E VITAMIN B-COMPLEX, INCL. COMBINATIONS 0,4707 A11EA Vitamin B-complex, plain 0,4707 Thiamine+Nicotinamide+Riboflavin+Calcium A11EA80 228500 pieces 1 pieces 0,4707 pantothenate+Pyridoxine (O) Thiamine+Nicotinamide+Riboflavin+Calcium A11EA80 1032 pieces pantothenate+Pyridoxine (P) A11G ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS 0,1610 A11GA Ascorbic acid (vitamin C), plain 0,1610 A11GA01 Ascorbic acid (P) 15630 g 0,2 g 0,1610 A11H OTHER PLAIN VITAMIN PREPARATIONS 0,0511 A11HA Other plain vitamin preparations 0,0511 A11HA02 Pyridoxine (O) 150 g 0,16 g 0,0019 A11HA02 Pyridoxine (P) 3630,5 g 0,16 g 0,0467 A11HA03 Tocopherol (P) 4,5 g 0,2 g <0,0001 A11HA08 Tocofersolan (O) 234 g 0,2 g 0,0024 A11J OTHER VITAMIN PRODUCTS, COMBINATIONS 5,1952 A11JA Combinations of vitamins 4/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A11JA80 Combinations of vitamins (O) 700 ml A11JB Vitamins with minerals 5,1952 A11JB81 Pyridoxine+Magnesium (O) 7469180 pieces 4 pieces 3,8465 Thiamine+Riboflavin+Pyridoxine+Cyanocobalamin+Ascorbic A11JB82 acid+Biotin+Nicotinamide+Calcium 654735 pieces 1 pieces 1,3487 pantothenate+Calcium+Magnesium+Folic acid+Zinc (O) A12 MINERAL SUPPLEMENTS 8,9740 A12A CALCIUM 5,4367 A12AA Calcium 0,9393 A12AA03 Calcium gluconate (P) 60410 g 3 g 0,0415 A12AA04 Calcium carbonate (O) 1307550 g 3 g 0,8978 A12AX Calcium, combinations with vitamin D and/or other drugs 4,4974 A12AX80 Calcium+Colecalciferol (O) 611880 pieces 1 pieces 1,2604 A12AX80 Calcium+Colecalciferol (O) 3142740 pieces 2 pieces 3,2369 A12B POTASSIUM 3,0981 A12BA Potassium 3,0981 A12BA01 Potassium chloride (O) 380400 g 3 g 0,2612 A12BA80 Potassium chloride+Potassium hydrogen carbonate (O) 10600 pieces A12BA81 Potassium aspartate+Magnesium aspartate (O) 4094050 pieces 3 pieces 2,8112 A12BA81 Potassium aspartate+Magnesium aspartate (P) 12490 pieces 1 pieces 0,0257 A12C OTHER MINERAL SUPPLEMENTS 0,4392 A12CC Magnesium 0,4392 A12CC04 Magnesium citrate (O) 426425,192 g 2 g 0,4392 A12CX Other mineral products A12CX83 Phosphate (O) 12200 pieces A14 ANABOLIC AGENTS FOR SYSTEMIC USE 0,0025 A14A ANABOLIC STEROIDS 0,0025 A14AB Estren derivatives 0,0025 A14AB01 Nandrolone (P) 2,4 g 0,002 g 0,0025 OTHER ALIMENTARY TRACT AND METABOLISM A16 0,6640 PRODUCTS OTHER ALIMENTARY TRACT AND METABOLISM A16A 0,6640 PRODUCTS A16AA Amino acids and derivatives 0,0021 A16AA01 Levocarnitine (O) 2070 g 2 g 0,0021 A16AA02 Ademetionine (O) 900 g A16AA02 Ademetionine (P) 50 g A16AA81 Glycine (O) 390 g A16AB Enzymes 0,0046 A16AB03 Agalsidase alfa (P) 1,337 g 0,001 g 0,0028 A16AB04 Agalsidase beta (P) 1,625 g 0,005 g 0,0007 A16AB07 Alglucosidase alfa (P) 57,5 g 0,1 g 0,0012 A16AB09 Idursulfase (P) 1,344 g A16AX Various alimentary tract and metabolism products 0,6573 A16AX01 Thioctic acid (O) 187506 g 0,6 g 0,6438 A16AX01 Thioctic acid (P) 342 g 0,6 g 0,0012 A16AX03 Sodium phenylbutyrate (O) 1250 g 20 g 0,0001 A16AX05 Zinc (O) 700 g 0,15 g 0,0096 A16AX07 Sapropterin (O) 876 g A16AX10 Eliglustat (O) 211,68 g 0,168 g 0,0026 A16AX80 Creatine (O) 450 g A16AX81 Copper histidine (P) 0,2 g B BLOOD AND BLOOD FORMING ORGANS 112,5103 B01 ANTITHROMBOTIC AGENTS 83,6039 B01A ANTITHROMBOTIC AGENTS 83,6039 B01AA Vitamin K antagonists 1,5288 B01AA03 Warfarin (O) 5566,1 g 0,0075 g 1,5288 B01AB Heparin group 3,4423 B01AB01 Heparin sodium (P) 591625000 U 10000 U 0,1219 B01AB05 Enoxaparin sodium (hem, P) 1151800000 U 2000 U 1,1863 B01AB05 Enoxaparin sodium (P) 1746104000 U 2000 U 1,7984 B01AB06 Nadroparin calcium (P) 2413000 U 2850 U 0,0017 5/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day B01AB12 Bemiparin sodium (P) 405245000 U 2500 U 0,3339 B01AC Platelet aggregation inhibitors, excl. heparin 54,5428 B01AC04 Clopidogrel (O) 146263,8 g 0,075 g 4,0173 B01AC06 Acetylsalicylic acid (O) 4712830 pieces 1 pieces 9,7082 B01AC09 Epoprostenol (P) 0,001 g B01AC11 Iloprost (I) 0,0437 g 0,15 mg 0,0006 B01AC11 Iloprost (P) 0,0045 g 50 mcg 0,0002 B01AC16 Eptifibatide (P) 64,365 g 0,2 g 0,0007 B01AC21 Treprostinil (P) 1,88 g 0,0043 g 0,0009 B01AC24 Ticagrelor (O) 102275,04 g 0,18 g 1,1704 Selexipag B01AC27 3,672 g 1,8 mg 0,0042 (O) B01AC80 Acetylsalicylic acid +Magnesium oxide (O) 19243400 pieces 1 pieces 39,6403 B01AD Enzymes 0,0023 B01AD02 Alteplase (P) 97,47 g 0,1 g 0,0020 B01AD11 Tenecteplase (P) 6,25 g 0,04 g 0,0003 B01AE Direct thrombin inhibitors 2,6545 B01AE03 Argatroban (P) 1,5 g 0,2 g <0,0001 B01AE06 Bivalirudine (P) 2,5 g 0,25 g <0,0001 B01AE07 Dabigatran etexilate (O) 386586,75 g 0,3 g 2,6545 B01AF Direct factor Xa inhibitors 21,4316 B01AF01 Rivaroxaban (O) 103850,7934 g 0,02 g 10,6963 B01AF02 Apixaban (O) 47447,55 g 10 mg 9,7739 B01AF03 Edoxaban (O) 28000,8 g 60 mg 0,9613 B01AX Other antithrombotic agents 0,0016 B01AX05 Fondaparinux sodium (P) 1,95 g 0,0025 g 0,0016 B02 ANTIHEMORRHAGICS 0,1892 B02A ANTIFIBRINOLYTICS 0,1625 B02AA Amino acids 0,1625 B02AA01 Aminocaproic acid (P) 6175 g 16 g 0,0008 B02AA02 Tranexamic acid (O) 120180 g 2 g 0,1238 B02AA02 Tranexamic acid (P) 36867,5 g 2 g 0,0380 B02B VITAMIN K AND OTHER HEMOSTATICS 0,0266 B02BA Vitamin K 0,0042 B02BA01 Phytomenadione (O) 7,5 g 0,02 g 0,0008 B02BA01 Phytomenadione (O, P) 8,03 g 0,02 g 0,0008 B02BA01 Phytomenadione (P) 25,35 g 0,02 g 0,0026 B02BB Fibrinogen 0,0001 B02BB01 Fibrinogen human (P) 345 g 5 g 0,0001 B02BC Local hemostatics B02BC81 Fibrinogen human+Human thrombin (epil) 631 pieces B02BD Blood coagulation factors B02BD01 Human prothrombin complex (P) 251200 U B02BD02 Human coagulation factor VIII (P) 3024500 U B02BD04 Human coagulation factor IX (P) 685600 U B02BD05 Human coagulation factor VII (P) 180000 U Von Willebrand factor, human+Human coagulation factor VIII B02BD06 1625250 U (P) B02BD08 Coagulation factor VIIa (P) 14150000 U B02BD80 Turoctocog alfa (P) 4000 U B02BD81 Simoctocog alfa (P) 143000 U B02BD83 Efmoroctocog alfa (P) 3837000 U B02BX Other systemic hemostatics 0,0223 B02BX01 Etamsylate (P) 567,5 g B02BX04 Romiplostim (P) 0,0735 g 30 mcg 0,0050 B02BX05 Eltrombopag (O) 310,1 g 50 mg 0,0128 B02BX06 Emicizumab (P) 32,46 g 15 mg 0,0045 B03 ANTIANEMIC PREPARATIONS 28,7143 B03A IRON PREPARATIONS 4,3963 B03AA Iron bivalent, oral preparations 2,4065 B03AA07 Ferrous sulphate (O) 233643 g 0,2 g 2,4065 B03AB Iron trivalent, oral preparations 6/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day B03AB80 Iron (III)-hydroxide polymaltose complex (O) 81936 g B03AC Iron, parenteral preparations 0,1149 B03AC01 Dextriferron (P) 2053,5 g 0,1 g 0,0423 B03AC02 Iron (III)-hydroxide sucrose complex (P) 1472 g 0,1 g 0,0303 B03AC06 Iron (III)-hydroxide dextran complex (P) 1000 g 0,1 g 0,0206 B03AC80 Ferric derisomaltose (P) 1054,5 g 0,1 g 0,0217 B03AD Iron in combination with folic acid 1,8749 B03AD02 Ferrous fumarate+Folic acid (O) 509090 pieces 1 pieces 1,0487 B03AD03 Ferrous sulphate+Folic acid (O) 401100 pieces 1 pieces 0,8262 B03AE Iron in other combinations Ferrous gluconate+Manganese gluconate+Copper gluconate B03AE81 1653600 ml (O) B03AE82 Ferrous fumarate+Folic acid+Ascorbic acid (O) 35690 pieces B03B VITAMIN B12 AND FOLIC ACID 23,3333 B03BA Vitamin B12 (cyanocobalamin and analogues) 6,5782 B03BA01 Cyanocobalamin (O) 10,3 g 1 mg 0,0212 B03BA01 Cyanocobalamin (P) 62,86 g 0,02 mg 6,4744 B03BA03 Hydroxocobalamin (P) 0,802 g 0,02 mg 0,0826 B03BB Folic acid and derivatives 16,7551 B03BB01 Folic acid (O) 3253,5 g 0,4 mg 16,7551 B03X OTHER ANTIANEMIC PREPARATIONS 0,9847 B03XA Other antianemic preparations 0,9847 B03XA02 Darbepoetin alfa (P) 1,5333 g 0,0045 mg 0,7019 B03XA03 Methoxy polyethylene glycol-epoetin beta (P) 0,3039 g 4 mcg 0,1565 B03XA80 Epoetin beta (P) 61302000 U 1000 U 0,1263 B05 BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS B05A BLOOD AND RELATED PRODUCTS B05AA Blood substitutes and plasma protein fractions B05AA01 Albumin (P) 913255 g B05AA06 Gelatin agents (P) 6045000 ml Gelatine+Sodium chloride+Potassium chloride+Magnesium B05AA83 550000 ml chloride+Sodium lactate (P) B05AA86 human plasma proteins (P) 537800 ml B05B I.V. SOLUTIONS B05BA Solutions for parenteral nutrition B05BA01 Amino acids (P) 1084000 ml B05BA02 Fat emulsions (P) 107000 ml B05BA03 Carbohydrates (P) 61720 g B05BA03 Carbohydrates (P) 68538600 ml B05BA10 Combinations (P) 17379915 ml B05BB Solutions affecting the electrolyte balance B05BB01 Electrolytes (P) 289763500 ml B05BC Solutions producing osmotic diuresis B05BC01 Mannitol (P) 1056000 ml B05C IRRIGATING SOLUTIONS B05CX Other irrigating solutions B05CX10 Combinations (NA) 100000 ml B05D PERITONEAL DIALYTICS B05DA Isotonic solutions B05DA80 Isotonic solutions (P) 10400000 ml B05DB Hypertonic solutions B05DB80 hypertonic solutions (P) 156132000 ml Amino acids+Sodium chloride+Calcium chloride B05DB81 dihydrate+Magnesium chloride hexahydrate+Sodium lactate 850000 ml (P) B05Z HEMODIALYTICS AND HEMOFILTRATES B05ZB Hemofiltrates Sodium chloride+Potassium chloride+Calcium chloride B05ZB80 dihydrate+Magnesium chloride+Glucose+Sodium hydrogen 33840000 ml carbonate (P) 7/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day Calcium chloride dihydrate+Magnesium chloride hexahydrate+Sodium chloride+Sodium hydrogen B05ZB82 10010000 ml carbonate+Potassium chloride+Disodium phosphate dihydrate (P) Calcium chloride dihydrate+Magnesium chloride B05ZB83 hexahydrate+Glucose+Lactic acid+Sodium chloride+Sodium 200000 ml hydrogen carbonate+Potassium chloride (P) Calcium chloride dihydrate+Magnesium chloride B05ZB84 hexahydrate+Lactic acid+Sodium hydrogen 950000 ml carbonate+Sodium chloride (P) B05ZB85 Sodium citrate+Sodium chloride (P) 28460000 ml Magnesium chloride hexahydrate+Sodium chloride+Potassium B05ZB86 chloride+Disodium phosphate dihydrate+Sodium hydrogen 12950000 ml carbonate (P) B05X I.V. SOLUTION ADDITIVES B05XA Electrolyte solutions B05XA01 Potassium chloride (P) 750 g B05XA01 Potassium chloride (P) 3453200 ml B05XA02 Sodium hydrogen carbonate (P) 1476500 ml B05XA03 Sodium chloride (P) 9 g B05XA03 Sodium chloride (P) 361069780 ml B05XA05 Magnesium sulphate (P) 425000 ml B05XA07 Calcium chloride (P) 418700 ml B05XA14 Sodium glycerophosphate, hydrated (P) 133000 ml B05XA80 Electrolytes (P) 147600 ml B05XB Amino acids B05XB01 Arginine (P) 4500 ml B05XB02 Alanyl glutamine (P) 62000 ml B05XC Vitamins B05XC80 Vitamins (P) 8220,24 g B05XC80 Vitamins (P) 125400 ml B06 OTHER HEMATOLOGICAL AGENTS 0,0029 B06A OTHER HEMATOLOGICAL AGENTS 0,0029 B06AA Enzymes B06AA03 Hyaluronidase (P) 90000 U B06AB Heme products B06AB81 Hemin (P) 40 ml B06AC Drugs usedin hereditary angioedema 0,0029 B06AC01 C1-inhibitor, plasma derived (P) 315000 U 1400 U 0,0005 B06AC02 Icatibant (P) 6,15 g 0,03 g 0,0004 B06AC05 Lanadelumab (P) 20,7 g 21,4 mg 0,0020 C CARDIOVASCULAR SYSTEM 449,7935 C01 CARDIAC THERAPY 20,7126 C01A CARDIAC GLYCOSIDES 2,0111 C01AA Digitalis glycosides 2,0111 C01AA05 Digoxin (O) 242,1925 g 0,25 mg 1,9956 C01AA05 Digoxin (P) 1,85 g 0,25 mg 0,0152 C01AA06 Lanatoside C (O) 0,105 g 0,001 g 0,0002 C01B ANTIARRHYTHMICS, CLASS I AND III 4,9697 C01BA Antiarrhythmics, class Ia C01BA13 Hydroquinidine (O) 324 g C01BB Antiarrhythmics, class Ib 0,0192 C01BB02 Mexiletine (O) 160 g 0,8 g 0,0004 C01BB80 Aethacizin (O) 1822,5 g 0,2 g 0,0188 C01BC Antiarrhythmics, class Ic 3,3101 C01BC03 Propafenone (O) 458685 g 0,3 g 3,1496 C01BC03 Propafenone (P) 359,1 g 0,3 g 0,0025 C01BC04 Flecainide (O) 15326 g 0,2 g 0,1579 C01BC04 Flecainide (P) 18,75 g 0,2 g 0,0002 C01BD Antiarrhythmics, class III 1,6405 C01BD01 Amiodarone (O) 152766 g 0,2 g 1,5734 C01BD01 Amiodarone (P) 5427 g 0,2 g 0,0559 8/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C01BD07 Dronedarone (O) 4320 g 0,8 g 0,0111 C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES 0,6722 C01CA Adrenergic and dopaminergic agents 0,6705 C01CA01 Etilefrine (O) 2,0625 g 0,05 g 0,0001 C01CA02 Isoprenaline (P) 0,657 g 0,09 g <0,0001 C01CA03 Norepinephrine (P) 396,04 g 0,006 g 0,1360 C01CA04 Dopamine (P) 622 g 0,5 g 0,0026 C01CA06 Phenylephrine (P) 118 g 0,004 g 0,0608 C01CA07 Dobutamine (P) 837,5 g 0,5 g 0,0035 C01CA17 Midodrine (O) 10,95 g 0,03 g 0,0008 C01CA24 Epinephrine (intraoss, P) 44,56 g 0,5 mg 0,1836 C01CA24 Epinephrine (P) 57,694 g 0,5 mg 0,2377 C01CA26 Ephedrine (P) 1108,25 g 0,05 g 0,0457 C01CE Phosphodiesterase inhibitors 0,0012 C01CE02 Milrinone (P) 28,06 g 0,05 g 0,0012 C01CX Other cardiac stimulants 0,0005 C01CX08 Levosimendan (P) 2,9 g 11 mg 0,0005 C01CX80 Ammonia (I) 1450280 ml C01D VASODILATORS USED IN CARDIAC DISEASES 5,3544 C01DA Organic nitrates 5,3527 C01DA02 Glyceryl trinitrate (P) 172,1 g C01DA02 Glyceryl trinitrate (SL) 496,752 g 0,0025 g 0,4093 C01DA05 Pentaerithrityl tetranitrate (O) 3 g 0,12 g 0,0001 C01DA08 Isosorbide dinitrate (O) 22,5 g 0,06 g 0,0008 C01DA08 Isosorbide dinitrate (SL) 261,975 g 0,02 g 0,0270 C01DA14 Isosorbide mononitrate (O) 95450,2 g 0,04 g 4,9156 C01DX Other vasodilatators used in cardiac diseases 0,0018 C01DX80 Meldonium (O) 615 g 0,75 g 0,0017 C01DX80 Meldonium (P) 25 g 0,75 g 0,0001 C01E OTHER CARDIAC PREPARATIONS 7,7052 C01EA Prostaglandins 0,0002 C01EA01 Alprostadil (P) 0,0448 g 0,5 mg 0,0002 C01EB Other cardiac preparations 7,7050 C01EB10 Adenosine (P) 119,192 g 0,015 g 0,0164 C01EB15 Trimetazidine (O) 140036,4 g 0,04 g 7,2117 C01EB16 Ibuprofen (P) 0,4 g 0,03 g <0,0001 C01EB17 Ivabradine (O) 1847,58 g 0,01 g 0,3806 C01EB18 Ranolazine (O) 69427,5 g 1,5 g 0,0953 C01EB21 Regadenoson (P) 0,188 g 0,4 mg 0,0010 C01EB80 Hawthorn berry (O) 31040 ml C02 ANTIHYPERTENSIVES 3,7403 C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING 2,3417 C02AC Imidazoline receptor agonists 2,3417 C02AC01 Clonidine (O) 5,025 g 0,45 mg 0,0230 C02AC01 Clonidine (P) 2,829 g 0,45 mg 0,0130 C02AC02 Guanfacine (O) 0,196 g 3 mg 0,0001 C02AC05 Moxonidine (O) 335,783 g 0,3 mg 2,3056 C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING 1,3603 C02CA Alpha-adrenoreceptor antagonists 1,3603 C02CA01 Prazosin (O) 1,62 g 0,005 g 0,0007 C02CA04 Doxazosin (O) 2640,116 g 0,004 g 1,3596 C02D ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON 0,0006 C02DD Nitroferricyanide derivatives 0,0006 C02DD01 Sodium nitroprusside (P) 14,25 g 0,05 g 0,0006 C02K OTHER ANTIHYPERTENSIVES 0,0377 C02KX Antihypertensives for pulmonary arterial hypertension 0,0377 C02KX01 Bosentan (O) 1368,5 g 0,25 g 0,0113 C02KX02 Ambrisentan (O) 49,95 g 7,5 mg 0,0137 C02KX04 Macitentan (O) 4,8 g 10 mg 0,0010 C02KX05 Riociguat (O) 25,494 g 4,5 mg 0,0117 C03 DIURETICS 26,3879 C03A LOW-CEILING DIURETICS, THIAZIDES 1,2035 9/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C03AA Thiazides, plain 1,2035 C03AA03 Hydrochlorothiazide (O) 14605,5 g 0,025 g 1,2035 C03B LOW-CEILING DIURETICS, EXCL. THIAZIDES 2,1909 C03BA Sulfonamides, plain 2,1909 C03BA11 Indapamide (O) 2658,9 g 2,5 mg 2,1909 C03C HIGH-CEILING DIURETICS 19,5433 C03CA Sulfonamides, plain 19,5433 C03CA01 Furosemide (O) 62122,6 g 0,04 g 3,1992 C03CA01 Furosemide (P) 4993 g 0,04 g 0,2571 C03CA04 Torasemide (O) 116733 g 0,015 g 16,0309 C03CA04 Torasemide (P) 407,8 g 0,015 g 0,0560 ALDOSTERONE ANTAGONISTS AND OTHER POTASSIUM- C03D 3,4324 SPARING AGENTS C03DA Aldosterone antagonists 3,4324 C03DA01 Spironolactone (O) 124934,25 g 0,075 g 3,4314 C03DA04 Eplerenone (O) 23,25 g 0,05 g 0,0010 DIURETICS AND POTASSIUM-SPARING AGENTS IN C03E 0,0179 COMBINATION C03EA Low-ceiling diuretics and potassium-sparing agents 0,0179 C03EA81 Hydrochlorothiazide+Amiloride (O) 8700 pieces 1 pieces 0,0179 C04 PERIPHERAL VASODILATORS 2,5427 C04A PERIPHERAL VASODILATORS 2,5427 C04AC Nicotinic acid and derivatives 0,0004 C04AC01 Nicotinic acid (P) 38 g 0,2 g 0,0004 C04AD Purine derivatives 1,4605 C04AD02 Xantinol nicotinate (O) 54 g 0,9 g 0,0001 C04AD03 Pentoxifylline (O) 707552 g 1 g 1,4575 C04AD03 Pentoxifylline (P) 418 g 0,3 g 0,0029 C04AX Other peripheral vasodilators 1,0818 C04AX21 Naftidrofuryl (O) 315090 g 0,6 g 1,0818 C05 VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL C05A FISSURES FOR TOPICAL USE C05AA Corticosteroids C05AA82 Hydrocortisone+Cinchocaine (R) 13788 pieces C05AA84 Fluocortolone+Lidocaine (R) 215700 g C05AA84 Fluocortolone+Lidocaine (R) 272520 pieces Other agents for treatment of hemorrhoids and anal fissures C05AX for topical use C05AX81 Xeroformium+Zinc sulphate+Extract of Belladonna (R) 2880 pieces C05AX83 Yeast cell extract+Shark liver oil (R) 265440 pieces C05B ANTIVARICOSE THERAPY C05BA Heparins or heparinoids for topical use C05BA03 Heparin sodium (C) 7546000 g C05BB Sclerosing agents for local injection C05BB02 Lauromacrogol 400 (P) 81,375 g C05C CAPILLARY STABILIZING AGENTS C05CA Bioflavonoids C05CA01 Rutoside (O) 216750 pieces C05CA03 Diosmin (O) 510690 g C05CA04 Troxerutin (C) 3559740 g C05CA04 Troxerutin (O) 202395 g C05CA53 Diosmin+Hesperidine (O) 2220 pieces C05CA53 Diosmin+Hesperidine (O) 42619,5 g C07 BETA BLOCKING AGENTS 57,0059 C07A BETA BLOCKING AGENTS 57,0054 C07AA Beta blocking agents, non-selective 1,5725 C07AA05 Propranolol (O) 50817,5 g 0,16 g 0,6543 C07AA07 Sotalol (O) 71325,6 g 0,16 g 0,9183 C07AB Beta blocking agents, selective 54,8343 C07AB02 Metoprolol (O) 1975176,05 g 0,15 g 27,1250 C07AB02 Metoprolol (P) 111,725 g 0,15 g 0,0015 10/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C07AB03 Atenolol (O) 16983,75 g 0,075 g 0,4665 C07AB07 Bisoprolol (O) 18936,45 g 0,01 g 3,9008 C07AB12 Nebivolol (O) 56653,14 g 0,005 g 23,3405 C07AG Alpha and beta blocking agents 0,5985 C07AG01 Labetalol (O) 31350 g 0,6 g 0,1076 C07AG01 Labetalol (P) 1484 g 0,6 g 0,0051 C07AG02 Carvedilol (O) 8843,8125 g 0,0375 g 0,4858 C07B BETA BLOCKING AGENTS AND THIAZIDES 0,0005 C07BB Beta blocking agents, selective, and thiazides 0,0005 C07BB07 Bisoprolol+Hydrochlorothiazide (O) 240 pieces 1 pieces 0,0005 C08 CALCIUM CHANNEL BLOCKERS 44,0099 SELECTIVE CALCIUM CHANNEL BLOCKERS WITH C08C 42,6730 MAINLY VASCULAR EFFECTS C08CA Dihydropyridine derivatives 42,6730 C08CA01 Amlodipine (O) 62464,8 g 0,005 g 25,7348 C08CA02 Felodipine (O) 5197,275 g 0,005 g 2,1412 C08CA05 Nifedipine (O) 13717,76 g 0,03 g 0,9419 C08CA06 Nimodipine (O) 351 g 0,3 g 0,0024 C08CA06 Nimodipine (P) 3,42 g 0,05 g 0,0001 C08CA08 Nitrendipine (O) 38023,12 g 0,02 g 3,9163 C08CA09 Lacidipine (O) 5458,544 g 0,004 g 2,8111 C08CA13 Lercanidipine (O) 34588,8 g 0,01 g 7,1251 SELECTIVE CALCIUM CHANNEL BLOCKERS WITH C08D 1,3369 DIRECT CARDIAC EFFECTS C08DA Phenylalkylamine derivatives 1,2170 C08DA01 Verapamil (O) 141780 g 0,24 g 1,2169 C08DA01 Verapamil (P) 10,525 g 0,24 g 0,0001 C08DB Benzothiazepine derivatives 0,1199 C08DB01 Diltiazem (O) 13971,6 g 0,24 g 0,1199 C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM 207,0866 C09A ACE INHIBITORS, PLAIN 72,7975 C09AA ACE inhibitors, plain 72,7975 C09AA01 Captopril (O) 359 g 0,05 g 0,0148 C09AA02 Enalapril (O) 34805,66 g 0,01 g 7,1698 C09AA02 Enalapril (P) 10,1875 g 0,01 g 0,0021 C09AA04 Perindopril (O) 16900,14 g 0,004 g 8,7033 C09AA05 Ramipril (O) 64093,595 g 2,5 mg 52,8117 C09AA09 Fosinopril (O) 29211,56 g 0,015 g 4,0116 C09AA10 Trandolapril (O) 81,704 g 0,002 g 0,0842 C09B ACE INHIBITORS, COMBINATIONS 57,2270 C09BA ACE inhibitors and diuretics 28,6124 C09BA02 Enalapril+Hydrochlorothiazide (O) 2418812 pieces 1 pieces 4,9826 C09BA04 Perindopril+Indapamide (O) 9832740 pieces 1 pieces 20,2549 C09BA05 Ramipril+Hydrochlorothiazide (O) 1121282 pieces 1 pieces 2,3098 C09BA06 Quinapril+Hydrochlorothiazide (O) 150 pieces 1 pieces 0,0003 C09BA09 Fosinopril+Hydrochlorothiazide (O) 516888 pieces 1 pieces 1,0648 C09BB ACE inhibitors and calcium channel blockers 12,7735 C09BB03 Lisinopril+Amlodipine (O) 734790 pieces 1 pieces 1,5136 C09BB04 Perindopril+Amlodipine (O) 4482630 pieces 1 pieces 9,2340 C09BB07 Ramipril+Amlodipine (O) 746490 pieces 1 pieces 1,5377 C09BB10 Trandolapril+Verapamil (O) 236992 pieces 1 pieces 0,4882 C09BX ACE inhibitors, other combinations 15,8411 C09BX01 Perindopril+Amlodipine+Indapamide (O) 7690080 pieces 1 pieces 15,8411 C09C ANGIOTENSIN II RECEPTOR BLOCKERS (ARBS), PLAIN 43,1342 C09CA Angiotensin II receptor blockers (ARBs), plain 43,1342 C09CA01 Losartan (O) 79278,3 g 0,05 g 3,2662 C09CA02 Eprosartan (O) 823,2 g 0,6 g 0,0028 C09CA03 Valsartan (O) 160637,12 g 0,08 g 4,1363 C09CA06 Candesartan (O) 42075,84 g 0,008 g 10,8342 C09CA07 Telmisartan (O) 419850,96 g 0,04 g 21,6217 C09CA08 Olmesartan medoxomil (O) 31776,92 g 0,02 g 3,2729 11/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day ANGIOTENSIN II RECEPTOR BLOCKERS (ARBS), C09D 33,9279 COMBINATIONS C09DA Angiotensin II receptor blockers (ARBs) and diuretics 14,6674 C09DA01 Losartan+Hydrochlorothiazide (O) 815330 pieces 1 pieces 1,6795 C09DA03 Valsartan+Hydrochlorothiazide (O) 831712 pieces 1 pieces 1,7133 C09DA06 Candesartan+Hydrochlorothiazide (O) 1099280 pieces 1 pieces 2,2645 C09DA07 Telmisartan+Hydrochlorothiazide (O) 4109742 pieces 1 pieces 8,4658 C09DA08 Olmesartan medoxomil+Hydrochlorothiazide (O) 264240 pieces 1 pieces 0,5443 Angiotensin II receptor blockers (ARBs) and calcium channel C09DB 13,5183 blockers C09DB01 Valsartan+Amlodipine (O) 230026 pieces 1 pieces 0,4738 C09DB02 Olmesartan medoxomil+Amlodipine (O) 3086804 pieces 1 pieces 6,3586 C09DB04 Telmisartan+Amlodipine (O) 3179484 pieces 1 pieces 6,5496 C09DB07 Candesartan+Amlodipine (O) 66164 pieces 1 pieces 0,1363 C09DX Angiotensin II receptor blockers (ARBs), other combinations 5,7422 C09DX01 Valsartan+Amlodipine+Hydrochlorothiazide (O) 3696 pieces 1 pieces 0,0076 C09DX03 Olmesartan medoxomil+Amlodipine+Hydrochlorothiazide (O) 2415476 pieces 1 pieces 4,9757 C09DX04 Valsartan+Sacubitril (O) 368368 pieces 1 pieces 0,7588 C10 LIPID MODIFYING AGENTS 88,3076 C10A LIPID MODIFYING AGENTS, PLAIN 84,9056 C10AA HMG CoA reductase inhibitors 83,6112 C10AA01 Simvastatin (O) 60920,2 g 0,03 g 4,1831 C10AA03 Pravastatin (O) 3834,6 g 0,03 g 0,2633 C10AA04 Fluvastatin (O) 14976,64 g 0,06 g 0,5142 C10AA05 Atorvastatin (O) 330680,4 g 0,02 g 34,0592 C10AA07 Rosuvastatin (O) 216469,24 g 0,01 g 44,5915 C10AB Fibrates 0,6805 C10AB05 Fenofibrate (O) 66072 g 0,2 g 0,6805 C10AC Bile acid sequestrants 0,0015 C10AC01 Colestyramine (O) 9800 g 14 g 0,0014 C10AC02 Colestipol (O) 250 g 20 g <0,0001 C10AX Other lipid modifying agents 0,6125 C10AX09 Ezetimibe (O) 2834,8 g 0,01 g 0,5840 C10AX13 Evolocumab (P) 86,52 g 10 mg 0,0178 C10AX14 Alirocumab (P) 28,05 g 5,4 mg 0,0107 C10AX80 Omega-3-acid ethyl esters 90 (O) 40740 g C10AX80 Omega-3-acid ethyl esters 90 (O) 168336 pieces C10B LIPID MODIFYING AGENTS, COMBINATIONS 3,4020 C10BA Combinations of various lipid modifying agents 2,7743 C10BA05 Atorvastatin+Ezetimibe (O) 142860 pieces 1 pieces 0,2943 C10BA06 Rosuvastatin+Ezetimibe (O) 1203900 pieces 1 pieces 2,4800 C10BX Lipid modifying agents in combination with other drugs 0,6277 C10BX11 Atorvastatin+Amlodipine+Perindopril (O) 204180 pieces 1 pieces 0,4206 C10BX13 Rosuvastatin+Perindopril+Indapamide (O) 83820 pieces 1 pieces 0,1727 C10BX15 Atorvastatin+Perindopril (O) 16740 pieces 1 pieces 0,0345 D DERMATOLOGICALS 1,8152 D01 ANTIFUNGALS FOR DERMATOLOGICAL USE 0,9776 D01A ANTIFUNGALS FOR TOPICAL USE D01AC Imidazole and triazole derivatives D01AC01 Clotrimazole (C) 502455,4 g D01AC05 Isoconazole (C) 253810 g D01AC08 Ketoconazole (C) 80500 ml D01AC08 Ketoconazole (C) 1123900,2 g D01AC80 Isoconazole+Diflucortolone (C) 923940 g D01AC81 Clotrimazole+Hexamidine (C) 120360 g D01AE Other antifungals for topical use D01AE14 Ciclopirox (C) 48,312 g D01AE15 Terbinafine (C) 520571 g D01AE16 Amorolfine (C) 27837,5 ml D01AE22 Naftifine (C) 158750 ml D01AE22 Naftifine (C) 204045 g D01B ANTIFUNGALS FOR SYSTEMIC USE 0,9776 12/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day D01BA Antifungals for systemic use 0,9776 D01BA01 Griseofulvin (O) 612,5 g 0,5 g 0,0025 D01BA02 Terbinafine (O) 118336,5 g 0,25 g 0,9751 D02 EMOLLIENTS AND PROTECTIVES D02A EMOLLIENTS AND PROTECTIVES D02AB Zinc products D02AB80 Zinc oxide (C) 337980 g D02AE Carbamide products D02AE01 Urea (C) 42550 g D02B PROTECTIVES AGAINST UV-RADIATION D02BA Protectives against UV-radiation for topical use D02BA01 4-Aminobenzoic acid (O) 720 g PREPARATIONS FOR TREATMENT OF WOUNDS AND D03 ULCERS D03A CICATRIZANTS D03AX Other cicatrizants D03AX03 Dexpanthenol (C) 3965440 g D03AX81 Heparin sodium+Allantoin+Extract of Cepae (C) 121020 g D03AX83 Dexpanthenol+Chlorhexidine (C) 2171040 g D03B ENZYMES D03BA Proteolytic enzymes D03BA80 Collagenase+Chloramphenicol (C) 90 g ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, D04 ETC. ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, D04A ETC. D04AA Antihistamines for topical use D04AA09 Chloropyramine (P) 1 g D05 ANTIPSORIATICS 0,0510 D05A ANTIPSORIATICS FOR TOPICAL USE D05AA Tars D05AA85 Coal tar+Salicylic acid (C) 675400 ml D05AX Other antipsoriatics for topical use D05AX80 Calcipotriol+Betamethasone (C) 969120 g D05B ANTIPSORIATICS FOR SYSTEMIC USE 0,0510 D05BB Retinoids for treatment of psoriasis 0,0510 D05BB02 Acitretin (O) 866,4 g 0,035 g 0,0510 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR D06 DERMATOLOGICAL USE D06A ANTIBIOTICS FOR TOPICAL USE D06AX Other antibiotics for topical use D06AX01 Fusidic acid (C) 199785 g D06AX02 Chloramphenicol (C) 500 g D06AX09 Mupirocin (C) 1125 g D06AX80 Bacitracin+Neomycin (C) 50550 g D06AX84 Chloramphenicol+Methyluracil (C) 4800 g D06B CHEMOTHERAPEUTICS FOR TOPICAL USE D06BA Sulfonamides D06BA01 Silver sulfadiazine (C) 1596065 g D06BB Antivirals D06BB03 Aciclovir (C) 198966 g D06BB04 Podophyllotoxin (C) 1564,5 ml D06BB10 Imiquimod (C) 5442 g D06BB81 Aciclovir+Hydrocortisone (C) 27100 g D06BX Other chemotherapeutics D06BX01 Metronidazole (C) 85026,975 g D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS D07A CORTICOSTEROIDS, PLAIN D07AA Corticosteroids, weak (group I) D07AA02 Hydrocortisone (C) 609050 g 13/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day D07AB Corticosteroids, moderately potent (group II) D07AB09 Triamcinolone (C) 260,0045 g D07AC Corticosteroids, potent (group III) D07AC01 Betamethasone (C) 140415 g D07AC04 Fluocinolone acetonide (C) 345 g D07AC13 Mometasone (C) 341080 ml D07AC13 Mometasone (C) 1177992,465 g D07AC14 Methylprednisolone aceponate (C) 617415 g D07AC17 Fluticasone (C) 46080 g D07AD Corticosteroids, very potent (group IV) D07AD01 Clobetasol (C) 82025 ml D07AD01 Clobetasol (C) 938206,9625 g D07B CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS D07BA Corticosteroids, weak, combinations with antiseptics D07BA80 Hydrocortisone+Chlorhexidine (C) 337140 g D07BC Corticosteroids, potent, combinations with antiseptics D07BC80 Betamethasone+Salicylic acid (C) 21030 g D07BC80 Betamethasone+Salicylic acid (C) 945250 ml D07C CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS D07CA Corticosteroids, weak, combinations with antibiotics D07CA83 Hydrocortisone+Fusidic acid (C) 78090 g D07CC Corticosteroids, potent, combinations with antibiotics D07CC80 Betamethasone+Fusidic acid (C) 601440 g D07CC83 Betamethasone+Gentamicin (C) 120 g D07X CORTICOSTEROIDS, OTHER COMBINATIONS D07XA Corticosteroids, weak, other combinations D07XA81 Prednisolone+Salicylic acid (C) 232700 ml D07XC Corticosteroids, potent, other combinations D07XC03 Mometasone+Salicylic acid (C) 400 g D08 ANTISEPTICS AND DISINFECTANTS D08A ANTISEPTICS AND DISINFECTANTS D08AG Iodine products D08AG02 Povidone, iodinated (C) 1134220 ml D08AG02 Povidone, iodinated (C) 3790020 g D08AG03 Iodine (C) 893960 ml D08AJ Quaternary ammonium compounds D08AJ81 Octenidine+Phenoxyethanol (C) 11159000 ml D08AX Other antiseptics and disinfectants D08AX82 Tar+Castor oil+Xeroformium (C) 6150 g D08AX83 Brilliant Green (C) 241620 ml D10 ANTI-ACNE PREPARATIONS 0,6570 D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE D10AD Retinoids for topical use in acne D10AD01 Tretinoin (C) 41970 g D10AD03 Adapalene (C) 51480 g D10AD80 Adapalene+Benzoyl peroxide (C) 114300 g D10AD81 Tretinoin+Erythromycin (C) 24030 g D10AF Antiinfectives for treatment of acne D10AF01 Clindamycin (C) 2250 ml D10AF02 Erythromycin (C) 348600 ml D10AF81 Clindamycin+Benzoyl peroxide (C) 297975 g D10AF82 Clindamycin+Tretinoin (C) 147360 g D10AX Other anti-acne preparations for topical use D10AX03 Azelaic acid (C) 314574 g D10B ANTI-ACNE PREPARATIONS FOR SYSTEMIC USE 0,6570 D10BA Retinoids for treatment of acne 0,6570 D10BA01 Isotretinoin (O) 9567,6 g 0,03 g 0,6570 D11 OTHER DERMATOLOGICAL PREPARATIONS 0,1296 D11A OTHER DERMATOLOGICAL PREPARATIONS 0,1296 D11AF Wart and anti-corn preparations D11AF80 Salicylic acid+Lactic acid (C) 78075 ml 14/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day D11AH Agents for dermatitis, excluding corticosteroids 0,0484 D11AH01 Tacrolimus (C) 108540 g D11AH02 Pimecrolimus (C) 226350 g D11AH05 Dupilumab (P) 502,4 g 21,4 mg 0,0484 D11AX Other dermatologicals 0,0813 D11AX01 Minoxidil (C) 207300 ml D11AX10 Finasteride (O) 39,452 g 0,001 g 0,0813 D11AX16 Eflornithine (C) 480 g D11AX21 Brimonidine (C) 90 g D11AX22 Ivermectin (C) 67860 g D11AX82 Hydroquinone+Fluocinolone acetonide+Tretinoin (C) 30 g G GENITO URINARY SYSTEM AND SEX HORMONES 56,4804 G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS 0,7699 ANTIINFECTIVES AND ANTISEPTICS, EXCL. G01A 0,7699 COMBINATIONS WITH CORTICOSTEROIDS G01AA Antibiotics 0,0420 G01AA01 Nystatin (O) 1200000 U G01AA10 Clindamycin (V) 2041,1 g 0,1 g 0,0420 G01AC Quinoline derivatives 0,0434 G01AC05 Dequalinium (V) 421,14 g 20 mg 0,0434 G01AF Imidazole derivatives 0,6845 G01AF01 Metronidazole (V) 9998 g 0,5 g 0,0412 G01AF02 Clotrimazole (V) 26696 g 0,1 g 0,5499 G01AF05 Econazole (V) 4533,3 g 0,1 g 0,0934 G02 OTHER GYNECOLOGICALS 4,0514 G02A UTEROTONICS 0,1418 G02AB Ergot alkaloids 0,0022 G02AB01 Methylergometrine (P) 0,2168 g 0,2 mg 0,0022 G02AD Prostaglandins 0,1395 G02AD02 Dinoprostone (P) 0,42 g G02AD02 Dinoprostone (V) 1,8739 g 0,5 mg 0,0077 G02AD06 Misoprostol (O) 12,799 g 0,2 mg 0,1318 G02B CONTRACEPTIVES FOR TOPICAL USE 2,3182 G02BA Intrauterine contraceptives 0,0177 G02BA03 Levonorgestrel (V) 8595 pieces 1 pieces 0,0177 G02BB Intravaginal contraceptives 2,3005 G02BB01 Etonogestrel+Ethinylestradiol (V) 39021 pieces 0,036 pieces 2,2328 G02BB81 Benzalkonium chloride (V) 32880 pieces 1 pieces 0,0677 G02BB81 Benzalkonium chloride (V) 37656 g G02C OTHER GYNECOLOGICALS 1,5914 G02CA Sympathomimetics, labour repressants G02CA80 Hexoprenaline (P) 0,0103 g G02CB Prolactine inhibitors 0,1391 G02CB01 Bromocriptine (O) 271,425 g 0,005 g 0,1118 G02CB03 Cabergoline (O) 6,62 g 0,5 mg 0,0273 G02CX Other gynecologicals 1,4523 G02CX01 Atosiban (P) 1,0388 g 0,165 g <0,0001 G02CX03 Agni casti fructus (O) 386280 pieces 1 pieces 0,7957 G02CX04 Cimicifugae rhizoma (O) 637440 pieces 2 pieces 0,6565 SEX HORMONES AND MODULATORS OF THE GENITAL G03 30,3378 SYSTEM G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE 23,3445 G03AA Progestogens and estrogens, fixed combinations 18,3957 G03AA07 Levonorgestrel+Ethinylestradiol (O) 220724 pieces 1 pieces 0,4547 G03AA09 Desogestrel+Ethinylestradiol (O) 360612 pieces 0,75 pieces 0,9905 G03AA10 Gestodene+Ethinylestradiol (O) 2008944 pieces 0,75 pieces 5,5178 G03AA12 Drospirenone+Ethinylestradiol (O) 1102500 pieces 1 pieces 2,2711 G03AA12 Drospirenone+Ethinylestradiol (O) 1553874 pieces 0,75 pieces 4,2679 G03AA13 Norelgestromin+Ethinylestradiol (TD) 89901 pieces 0,107 pieces 1,7308 G03AA14 Nomegestrol+Estradiol (O) 1512 pieces 1 pieces 0,0031 G03AA15 Chlormadinone+Ethinylestradiol (O) 137592 pieces 0,75 pieces 0,3779 G03AA16 Dienogest+Ethinylestradiol (O) 1012907 pieces 0,75 pieces 2,7820 15/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day G03AB Progestogens and estrogens, sequential preparations 0,1666 G03AB05 Desogestrel+Ethinylestradiol (O) 1650 pieces 0,75 pieces 0,0045 G03AB08 Dienogest+Estradiol valerate (O) 78680 pieces 1 pieces 0,1621 G03AC Progestogens 4,7022 G03AC08 Etonogestrel (P) 63,512 g 68 mcg 1,9240 G03AC09 Desogestrel (O) 1326724 pieces 1 pieces 2,7330 G03AC10 Drospirenone (O) 21952 pieces 1 pieces 0,0452 G03AD Emergency contraceptives 0,0800 G03AD01 Levonorgestrel (O) 56,8935 g 1,5 mg 0,0781 G03AD02 Ulipristal (O) 27,27 g 0,03 g 0,0019 G03B ANDROGENS 0,2711 G03BA 3-oxoandrosten (4) derivatives 0,2711 G03BA03 Testosterone (O) 14,4 g 0,12 g 0,0002 G03BA03 Testosterone (P) 2357,75 g 0,018 g 0,2698 G03BA03 Testosterone (TD) 25,76 g 0,05 g 0,0011 G03C ESTROGENS 1,5141 G03CA Natural and semisynthetic estrogens, plain 1,5000 G03CA03 Estradiol (C, V) 60875 g G03CA03 Estradiol (O) 834,232 g 2 mg 0,8592 G03CA03 Estradiol (TD) 53,1216 g 1,53 mg 0,0715 G03CA03 Estradiol (TD) 77,7 g 1 mg 0,1601 G03CA03 Estradiol (V) 2,8688 g 0,025 mg 0,2364 G03CA04 Estriol (V) 16,7775 g 0,2 mg 0,1728 G03CA80 Estradiol+Prednisolone (C) 61150 g G03CX Other estrogens 0,0141 G03CX01 Tibolone (O) 17,15 g 2,5 mg 0,0141 G03D PROGESTOGENS 2,2967 G03DA Pregnen (4) derivatives 1,5341 G03DA02 Medroxyprogesterone (O) 74,55 g 0,005 g 0,0307 G03DA02 Medroxyprogesterone (P) 291,465 g 0,007 g 0,0858 G03DA04 Progesterone (O) 9426 g 0,3 g 0,0647 G03DA04 Progesterone (P) 314,9915 g 0,005 g 0,1298 G03DA04 Progesterone (V) 53438,1 g 0,09 g 1,2231 G03DB Pregnadien derivatives 0,7619 G03DB01 Dydrogesterone (O) 2673,4 g 0,01 g 0,5507 G03DB08 Dienogest (O) 205,016 g 2 mg 0,2112 G03DC Estren derivatives 0,0007 G03DC02 Norethisterone (O) 1,8 g 0,005 g 0,0007 G03F PROGESTOGENS AND ESTROGENS IN COMBINATION 2,0851 G03FA Progestogens and estrogens, fixed combinations 1,6641 G03FA01 Norethisterone+Estradiol (O) 493276 pieces 1 pieces 1,0161 G03FA14 Dydrogesterone+Estradiol (O) 139468 pieces 1 pieces 0,2873 G03FA17 Drospirenone+Estradiol (O) 175112 pieces 1 pieces 0,3607 G03FB Progestogens and estrogens, sequential preparations 0,4210 G03FB05 Norethisterone+Estradiol (O) 147168 pieces 1 pieces 0,3032 G03FB08 Dydrogesterone+Estradiol (O) 57204 pieces 1 pieces 0,1178 G03G GONADOTROPINS AND OTHER OVULATION STIMULANTS 0,4704 G03GA Gonadotropins 0,1804 G03GA05 Follitropin alfa (P) 5525175 U 75 U 0,1518 G03GA07 Lutropin alfa (P) 679650 U 75 U 0,0187 G03GA08 Choriogonadotropin alfa (P) 0,859 g 0,25 mg 0,0071 G03GA30 Follitropin alfa+Lutropin alfa (P) 1427 doses 1 doses 0,0029 G03GB Ovulation stimulants, synthetic 0,2899 G03GB02 Clomifene (O) 1266,7 g 0,009 g 0,2899 G03H ANTIANDROGENS 0,3519 G03HA Antiandrogens, plain 0,0739 G03HA01 Cyproterone (O) 3587,5 g 0,1 g 0,0739 G03HB Antiandrogens and estrogens 0,2780 G03HB01 Cyproterone+Estrogen (O) 101220 pieces 0,75 pieces 0,2780 OTHER SEX HORMONES AND MODULATORS OF THE G03X 0,0040 GENITAL SYSTEM 16/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day G03XB Progesterone receptor modulators 0,0038 G03XB01 Mifepristone (O) 840 g 0,6 g 0,0029 G03XB02 Ulipristal (O) 2,24 g 5 mg 0,0009 G03XC Selective estrogen receptor modulators 0,0002 G03XC01 Raloxifene (O) 5,04 g 0,06 g 0,0002 G04 UROLOGICALS 21,3212 G04B UROLOGICALS 3,8300 G04BD Drugs for urinary frequency and incontinence 2,2222 G04BD04 Oxybutynin (O) 4560,6 g 0,015 g 0,6263 G04BD06 Propiverine (O) 14,7 g 0,03 g 0,0010 G04BD07 Tolterodine (O) 640,416 g 0,004 g 0,3298 G04BD08 Solifenacin (O) 945,45 g 0,005 g 0,3895 G04BD09 Trospium chloride (O) 3707,55 g 0,04 g 0,1909 G04BD12 Mirabegron (O) 16617 g 50 mg 0,6846 G04BE Drugs used in erectile dysfunction 1,5962 G04BE01 Alprostadil (P) 0,0461 g 0,02 mg 0,0047 G04BE03 Sildenafil (O) 26924,2 g 0,05 g 1,1092 G04BE08 Tadalafil (O) 2035,76 g 0,01 g 0,4194 G04BE09 Vardenafil (O) 55,12 g 0,01 g 0,0114 G04BE10 Avanafil (O) 2498,8 g 0,1 g 0,0515 G04BX Other urologicals 0,0116 G04BX14 Dapoxetin (O) 169,29 g 0,03 g 0,0116 G04BX80 Centaury+Lovage root+Rosemary leaf (O) 1137060 pieces G04BX90 Extr. prostatae (P) 1000 pieces G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY 17,4913 G04CA Alpha-adrenoreceptor antagonists 14,4261 G04CA01 Alfuzosin (O) 8334,6 g 7,5 mg 2,2892 G04CA02 Tamsulosin (O) 1603,536 g 0,4 mg 8,2580 G04CA04 Silodosin (O) 789,36 g 8 mg 0,2033 G04CA52 Tamsulosin+Dutasteride (O) 1784340 pieces 1 pieces 3,6756 G04CB Testosterone-5-alpha reductase inhibitors 0,5665 G04CB01 Finasteride (O) 451,67 g 0,005 g 0,1861 G04CB02 Dutasteride (O) 92,325 g 0,5 mg 0,3804 G04CX Other drugs used in benign prostatic hypertrophy 2,4988 G04CX02 Sabalis serrulatae fructus (O) 388166,4 g 0,32 g 2,4988 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX H 31,2564 HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND H01 0,4655 ANALOGUES ANTERIOR PITUITARY LOBE HORMONES AND H01A 0,1784 ANALOGUES H01AA ACTH 0,0002 H01AA02 Tetracosactide (P) 0,02 g 0,25 mg 0,0002 H01AB Thyrotropin 0,0003 H01AB01 Thyrotropin alfa (P) 0,1368 g 0,9 mg 0,0003 H01AC Somatropin and somatropin agonists 0,1604 H01AC01 Somatropin (P) 155737,6372 U 2 U 0,1604 H01AX Other anterior pituitary lobe hormones and analogues 0,0175 H01AX01 Pegvisomant (P) 84,9 g 0,01 g 0,0175 H01B POSTERIOR PITUITARY LOBE HORMONES 0,1513 H01BA Vasopressin and analogues 0,1037 H01BA01 Argipressin (P) 44400 U 40 U 0,0023 H01BA02 Desmopressin (N) 0,015 g 0,025 mg 0,0012 H01BA02 Desmopressin (P) 0,0201 g 0,004 mg 0,0104 H01BA02 Desmopressin (SL) 10,4688 g 0,24 mg 0,0899 H01BB Oxytocin and analogues 0,0476 H01BB01 Demoxytocin (O) 850000 U 100 U 0,0175 H01BB02 Oxytocin (P) 195900 U 15 U 0,0269 H01BB03 Carbetocin (P) 0,1556 g 0,1 mg 0,0032 H01C HYPOTHALAMIC HORMONES 0,1358 H01CA Gonadotropin-releasing hormones H01CA01 Gonadorelin (P) 0,0037 g 17/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day H01CB Somatostatin and analogues 0,1137 H01CB02 Octreotide (P) 9,043 g 0,7 mg 0,0266 H01CB03 Lanreotide (P) 112,05 g 3 mg 0,0769 H01CB05 Pasireotide (P) 5,94 g 1,2 mg 0,0102 H01CC Anti-gonadotropin-releasing hormones 0,0220 H01CC02 Cetrorelix (P) 2,6718 g 0,25 mg 0,0220 H02 CORTICOSTEROIDS FOR SYSTEMIC USE 9,8660 H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN 9,8617 H02AA Mineralocorticoids 0,1765 H02AA02 Fludrocortisone (O) 8,57 g 0,1 mg 0,1765 H02AB Glucocorticoids 9,6852 H02AB01 Betamethasone (P) 15,1965 g 1,5 mg 0,0209 H02AB02 Dexamethasone (O) 1398,13 g 1,5 mg 1,9200 H02AB02 Dexamethasone (P) 950,2 g 1,5 mg 1,3049 H02AB04 Methylprednisolone (O) 7474 g 7,5 mg 2,0528 H02AB04 Methylprednisolone (P) 4749,35 g 0,02 g 0,4892 H02AB06 Prednisolone (O) 13905 g 0,01 g 2,8644 H02AB06 Prednisolone (P) 1270,85 g 0,01 g 0,2618 H02AB08 Triamcinolone (O) 11,2 g 7,5 mg 0,0031 H02AB08 Triamcinolone (P) 1562,4 g 7,5 mg 0,4291 H02AB09 Hydrocortisone (O) 4251,65 g 0,03 g 0,2919 H02AB09 Hydrocortisone (P) 680,4 g 0,03 g 0,0467 H02AB13 Deflazacort (O) 3 g 15 mg 0,0004 CORTICOSTEROIDS FOR SYSTEMIC USE, H02B 0,0043 COMBINATIONS H02BX Corticosteroids for systemic use, combinations 0,0043 H02BX80 Hydrocortisone+Lidocaine (P) 56,625 g 0,03 g 0,0039 H02BX81 Methylprednisolone+Bupivacaine (P) 4 g 20 mg 0,0004 H03 THYROID THERAPY 20,8799 H03A THYROID PREPARATIONS 19,6724 H03AA Thyroid hormones 19,6724 H03AA01 Levothyroxine sodium (O) 1432,35 g 0,15 mg 19,6704 H03AA02 Liothyronine (O) 0,058 g 0,06 mg 0,0020 H03AA03 Levothyroxine sodium+Liothyronine (O) 300 pieces H03AA04 Tiratricol (O) 0,189 g H03B ANTITHYROID PREPARATIONS 1,2075 H03BA Thiouracils 0,1443 H03BA02 Propylthiouracil (O) 7004,5 g 0,1 g 0,1443 H03BB Sulfur-containing imidazole derivatives 1,0632 H03BB02 Thiamazole (O) 5161,5 g 0,01 g 1,0632 H03BC Perchlorates H03BC01 Sodium perchlorate (O) 72 g H04 PANCREATIC HORMONES 0,0010 H04A GLYCOGENOLYTIC HORMONES 0,0010 H04AA Glycogenolytic hormones 0,0010 H04AA01 Glucagon (P) 0,47 g 0,001 g 0,0010 H05 CALCIUM HOMEOSTASIS 0,0440 H05B ANTI-PARATHYROID AGENTS 0,0440 H05BX Other anti-parathyroid agents 0,0440 H05BX01 Cinacalcet (O) 1276,8 g 0,06 g 0,0438 H05BX02 Paricalcitol (O) 0,0001 g 2 mcg 0,0001 J ANTIINFECTIVES FOR SYSTEMIC USE 17,7055 J01 ANTIBACTERIALS FOR SYSTEMIC USE 10,0665 J01A TETRACYCLINES 1,3317 J01AA Tetracyclines 1,3317 J01AA02 Doxycycline (O) 64635 g 0,1 g 1,3314 J01AA02 Doxycycline (P) 3,5 g 0,1 g 0,0001 J01AA07 Tetracycline (O) 5 g 1 g <0,0001 J01AA12 Tigecycline (P) 8 g 0,1 g 0,0002 J01C BETA-LACTAM ANTIBACTERIALS, PENICILLINS 3,7400 J01CA Penicillins with extended spectrum 1,2931 J01CA01 Ampicillin (P) 18100 g 6 g 0,0062 18/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J01CA04 Amoxicillin (O) 937090,5 g 1,5 g 1,2869 J01CE Beta-lactamase sensitive penicillins 0,0914 J01CE01 Benzylpenicillin (P) 29160 g 3,6 g 0,0167 J01CE02 Phenoxymethylpenicillin (O) 71629,8 g 2 g 0,0738 J01CE08 Benzathine benzylpenicillin (P) 1638 g 3,6 g 0,0009 J01CE80 Benzathine benzylpenicillin+Procaine benzylpenicillin (P) 17,1 g 3,6 g <0,0001 J01CF Beta-lactamase resistant penicillins 0,0814 J01CF04 Oxacillin (P) 78940 g 2 g 0,0813 J01CF05 Flucloxacillin (O) 120 g 2 g 0,0001 J01CR Combinations of penicillins, incl. beta-lactamase inhibitors 2,2741 J01CR01 Ampicillin+Sulbactam (P) 53366 g 6 g 0,0183 J01CR02 Amoxicillin+Clavulanic acid (O) 1415868,3 g 1,5 g 1,9444 J01CR02 Amoxicillin+Clavulanic acid (P) 300895 g 3 g 0,2066 J01CR04 Sultamicillin (O) 40374 g 1,5 g 0,0554 J01CR05 Piperacillin+Tazobactam (P) 334928 g 14 g 0,0493 J01D OTHER BETA-LACTAM ANTIBACTERIALS 1,3922 J01DB First-generation cephalosporins 0,1960 J01DB01 Cefalexin (O) 30 g 2 g <0,0001 J01DB04 Cefazolin (P) 94420 g 3 g 0,0648 J01DB05 Cefadroxil (O) 127335 g 2 g 0,1312 J01DC Second-generation cephalosporins 1,0486 J01DC01 Cefoxitin (P) 12305 g 6 g 0,0042 J01DC02 Cefuroxime (O) 206940,25 g 0,5 g 0,8526 J01DC02 Cefuroxime (P) 227040 g 3 g 0,1559 J01DC10 Cefprozil (O) 17427,5 g 1 g 0,0359 J01DD Third-generation cephalosporins 0,0559 J01DD01 Cefotaxime (P) 51070 g 4 g 0,0263 J01DD02 Ceftazidime (P) 11703 g 4 g 0,0060 J01DD04 Ceftriaxone (P) 19970 g 2 g 0,0206 J01DD81 Ceftazidime+Avibactam (P) 8700 g 6 g 0,0030 J01DE Fourth-generation cephalosporins 0,0109 J01DE01 Cefepime (P) 21210 g 4 g 0,0109 J01DH Carbapenems 0,0808 J01DH02 Meropenem (P) 68314 g 3 g 0,0469 J01DH03 Ertapenem (P) 10650 g 1 g 0,0219 J01DH51 Imipenem+Cilastatin (P) 11600 g 2 g 0,0119 J01E SULFONAMIDES AND TRIMETHOPRIM 0,3656 J01EA Trimethoprim and derivatives 0,0295 J01EA01 Trimethoprim (O) 5730 g 0,4 g 0,0295 Combinations of sulfonamides and trimethoprim, incl. J01EE 0,3361 derivatives J01EE01 Sulfamethoxazole+Trimethoprim (O) 2544 pieces 4 pieces 0,0013 J01EE01 Sulfamethoxazole+Trimethoprim (O) 286130 pieces 2 pieces 0,2947 J01EE01 Sulfamethoxazole+Trimethoprim (O) 623500 ml 40 ml 0,0321 J01EE01 Sulfamethoxazole+Trimethoprim (P) 77445 ml 20 ml 0,0080 J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS 1,8609 J01FA Macrolides 1,6962 J01FA01 Erythromycin (O) 135 g 1 g 0,0003 J01FA01 Erythromycin (P) 80 g 1 g 0,0002 J01FA09 Clarithromycin (O) 281758,5 g 0,5 g 1,1608 J01FA09 Clarithromycin (P) 2873,5 g 1 g 0,0059 J01FA10 Azithromycin (O) 77038,5 g 0,3 g 0,5290 J01FF Lincosamides 0,1648 J01FF01 Clindamycin (O) 89815,2 g 1,2 g 0,1542 J01FF01 Clindamycin (P) 9249 g 1,8 g 0,0106 J01G AMINOGLYCOSIDE ANTIBACTERIALS 0,0218 J01GB Other aminoglycosides 0,0218 J01GB01 Tobramycin (I) 150,528 g 0,112 g 0,0028 J01GB01 Tobramycin (I) 604,8 g 0,3 g 0,0042 J01GB01 Tobramycin (P) 80 g 0,24 g 0,0007 J01GB03 Gentamicin (P) 1217,2 g 0,24 g 0,0104 J01GB06 Amikacin (P) 1825 g 1 g 0,0038 19/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J01M QUINOLONE ANTIBACTERIALS 0,7032 J01MA Fluoroquinolones 0,7032 J01MA01 Ofloxacin (O) 3210 g 0,4 g 0,0165 J01MA02 Ciprofloxacin (O) 249480 g 1 g 0,5139 J01MA02 Ciprofloxacin (P) 10306 g 0,8 g 0,0265 J01MA06 Norfloxacin (O) 36384 g 0,8 g 0,0937 J01MA12 Levofloxacin (O) 6210,75 g 0,5 g 0,0256 J01MA12 Levofloxacin (P) 569,5 g 0,5 g 0,0023 J01MA14 Moxifloxacin (O) 4492 g 0,4 g 0,0231 J01MA14 Moxifloxacin (P) 288 g 0,4 g 0,0015 J01X OTHER ANTIBACTERIALS 0,6510 J01XA Glycopeptide antibacterials 0,0281 J01XA01 Vancomycin (P) 27165 g 2 g 0,0280 J01XA02 Teicoplanin (P) 28 g 0,4 g 0,0001 J01XB Polymyxins 0,0023 J01XB01 Colistin (I) 1800000000 U 9000000 U 0,0004 J01XB01 Colistin (I, P) 1590000000 U 9000000 U 0,0004 J01XB01 Colistin (P) 6560000000 U 9000000 U 0,0015 J01XD Imidazole derivatives 0,0284 J01XD01 Metronidazole (P) 20710 g 1,5 g 0,0284 J01XE Nitrofuran derivatives 0,5708 J01XE01 Nitrofurantoin (O) 55422 g 0,2 g 0,5708 J01XX Other antibacterials 0,0213 J01XX01 Fosfomycin (O) 7854 g 3 g 0,0054 J01XX08 Linezolid (O) 5796 g 1,2 g 0,0099 J01XX08 Linezolid (P) 2760 g 1,2 g 0,0047 J01XX09 Daptomycin (P) 169,65 g 0,28 g 0,0012 J02 ANTIMYCOTICS FOR SYSTEMIC USE 0,4090 J02A ANTIMYCOTICS FOR SYSTEMIC USE 0,4090 J02AA Antibiotics 0,0150 J02AA01 Amphotericin (O) 205 g J02AA01 Amphotericin (P) 255,05 g 0,035 g 0,0150 J02AB Imidazole derivatives 0,0012 J02AB02 Ketoconazole (O) 120 g 0,2 g 0,0012 J02AC Triazole and tetrazole derivatives 0,3822 J02AC01 Fluconazole (O) 15340,3 g 0,2 g 0,1580 J02AC01 Fluconazole (P) 3956 g 0,2 g 0,0407 J02AC02 Itraconazole (O) 13460,2 g 0,2 g 0,1386 J02AC03 Voriconazole (O) 2920,4 g 0,4 g 0,0150 J02AC03 Voriconazole (P) 616,6 g 0,4 g 0,0032 J02AC04 Posaconazole (O) 2764,2 g 0,3 g 0,0190 J02AC04 Posaconazole (P) 688,8 g 0,3 g 0,0047 J02AC05 Isavuconazole (O) 168 g 0,2 g 0,0017 J02AC05 Isavuconazole (P) 110,8 g 0,2 g 0,0011 J02AX Other antimycotics for systemic use 0,0105 J02AX04 Caspofungin (P) 63,61 g 0,05 g 0,0026 J02AX06 Anidulafungin (P) 383,8 g 0,1 g 0,0079 J04 ANTIMYCOBACTERIALS 0,0664 J04A DRUGS FOR TREATMENT OF TUBERCULOSIS 0,0516 J04AB Antibiotics 0,0154 J04AB02 Rifampicin (O) 4429,2 g 0,6 g 0,0152 J04AB02 Rifampicin (P) 63 g 0,6 g 0,0002 J04AC Hydrazides 0,0154 J04AC01 Isoniazid (O) 2250 g 0,3 g 0,0154 J04AD Thiocarbamide derivatives 0,0055 J04AD01 Protionamide (O) 2000 g 0,75 g 0,0055 J04AK Other drugs for treatment of tuberculosis 0,0115 J04AK05 Bedaquiline (O) 376 g 86 mg 0,0090 J04AK06 Delamanid (O) 240 g 0,2 g 0,0025 J04AK08 Pretomanid (O) 291,2 g J04AM Combinations of drugs for treatment of tuberculosis 0,0037 J04AM02 Rifampicin+Isoniazid (O) 7200 pieces 4 pieces 0,0037 20/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J04B DRUGS FOR TREATMENT OF LEPRA 0,0148 J04BA Drugs for treatment of lepra 0,0148 J04BA02 Dapsone (O) 360 g 0,05 g 0,0148 J05 ANTIVIRALS FOR SYSTEMIC USE 7,1637 J05A DIRECT ACTING ANTIVIRALS 7,1637 Nucleosides and nucleotides excl. reverse transcriptase J05AB 0,4540 inhibitors J05AB01 Aciclovir (O) 388037 g 4 g 0,1998 J05AB01 Aciclovir (P) 2876,25 g 4 g 0,0015 J05AB06 Ganciclovir (P) 419,5 g 0,5 g 0,0017 J05AB09 Famciclovir (O) 189 g 0,75 g 0,0005 J05AB11 Valaciclovir (O) 280250 g 3 g 0,1924 J05AB12 Cidofovir (P) 1,125 g 0,025 g 0,0001 J05AB14 Valganciclovir (O) 6355 g 0,9 g 0,0145 J05AB16 Remdesivir (P) 2105 g 0,1 g 0,0434 J05AD Phosphonic acid derivatives 0,0001 J05AD01 Foscarnet sodium (P) 360 g 6,5 g 0,0001 J05AE Protease inhibitors 1,0143 J05AE03 Ritonavir (O) 94131 g 1,2 g 0,1616 J05AE10 Darunavir (O) 496728 g 1,2 g 0,8527 J05AF Nucleoside and nucleotide reverse transcriptase inhibitors 0,1327 J05AF01 Zidovudine (O) 292 g 0,6 g 0,0010 J05AF01 Zidovudine (P) 93 g 0,6 g 0,0003 J05AF05 Lamivudine (O) 575,4 g 0,3 g 0,0040 J05AF06 Abacavir (O) 2582,4 g 0,6 g 0,0089 J05AF07 Tenofovir disoproxil (O) 499,8 g 0,245 g 0,0042 J05AF10 Entecavir (O) 26,19 g 0,5 mg 0,1079 J05AF13 Tenofovir alafenamide (O) 78 g 25 mg 0,0064 J05AG Non-nucleoside reverse transcriptase inhibitors 0,8506 J05AG05 Rilpivirine (O) 10323 g 25 mg 0,8506 J05AH Neuraminidase inhibitors 0,0134 J05AH02 Oseltamivir (O) 974,25 g 0,15 g 0,0134 J05AJ Integrase inhibitors 1,2941 J05AJ01 Raltegravir (O) 473544 g 0,8 g 1,2193 J05AJ03 Dolutegravir (O) 1813,5 g 50 mg 0,0747 J05AP Antivirals for treatment of HCV infections 0,1925 J05AP54 Elbasvir+Grazoprevir (O) 43092 pieces 1 pieces 0,0888 J05AP55 Sofosbuvir+Velpatasvir (O) 2856 pieces 1 pieces 0,0059 J05AP57 Glecaprevir+Pibrentasvir (O) 142464 pieces 3 pieces 0,0978 J05AR Antivirals for treatment of HIV infections, combinations 3,2121 J05AR02 Lamivudine+Abacavir (O) 335190 pieces 1 pieces 0,6905 J05AR03 Tenofovir disoproxil+Emtricitabine (O) 825960 pieces 1 pieces 1,7014 J05AR06 Emtricitabine+Tenofovir disoproxil+Efavirenz (O) 134910 pieces 1 pieces 0,2779 J05AR13 Lamivudine+Abacavir+Dolutegravir (O) 262650 pieces 1 pieces 0,5410 Emtricitabine+Tenofovir alafenamide+Elvitegravir+Cobicistat J05AR18 600 pieces 1 pieces 0,0012 (O) J06 IMMUNE SERA AND IMMUNOGLOBULINS J06A IMMUNE SERA J06AA Immune sera J06AA04 Botulinum antitoxin (P) 35 pieces J06B IMMUNOGLOBULINS J06BA Immunoglobulins, normal human J06BA01 Immunoglobulins, normal human, for extravascular a (P) 11217,9 g J06BA02 Immunoglobulins, normal human, for intravascular a (P) 106802,5 g J06BB Specific immunoglobulins J06BB01 Human Anti-D Immunoglobulin (P) 1866375 U J06BB02 Tetanus immunoglobulin (P) 43000 U J06BB03 Varicella zoster immunoglobulin (P) 6250 U J06BB04 Hepatitis B immunoglobulin (P) 6800 U J06BB05 Rabies immunoglobulin (P) 3000 U J06BB09 Cytomegalovirus immunoglobulin (P) 70000 U J06BB82 Regdanvimab (P) 192 g 21/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J06BD Antiviral monoclonal antibodies J06BD01 Palivizumab (P) 42,45 g J07 VACCINES J07A BACTERIAL VACCINES J07AE Cholera vaccines J07AE01 Cholera, inactivated, whole cell (O) 84 doses J07AG Hemophilus influenzae B vaccines J07AG01 Haemophilus influenzae B, purified antigen conjugated (P) 229 doses J07AH Meningococcal vaccines Meningococcus, tetravalent purified polysaccharides antigen J07AH08 453 doses conjugated (P) J07AH09 Meningococcus B, multicomponent vaccine (P) 46 doses J07AL Pneumococcal vaccines J07AL01 Pneumococcus, purified polysaccharides antigen (P) 553 doses Pneumococcus, purified polysaccharides antigen conjugated J07AL02 2391 doses (P) Pneumococcus, purified polysaccharides J07AL52 209 doses antigen+Haemophilus influenzae, conjugated (P) J07AM Tetanus vaccines J07AM51 Tetanus toxoid+Diphtheria toxoid (P) 48673 doses J07AN Tuberculosis vaccines J07AN01 Tuberculosis, live attenuated (P) 2622 pieces J07AP Typhoid vaccines J07AP03 Typhoid, purified polysaccharide antigen (P) 737 doses J07AX Other bacterial vaccines J07AX80 Diphtheria-tetanus-pertussis (P) 10784 doses J07B VIRAL VACCINES J07BA Encephalitis vaccines J07BA01 Encephalitis, tick borne, inactivated, whole virus (P) 72311 doses J07BB Influenza vaccines J07BB02 Influenza, inactivated, split virus or surface antigen (P) 201317 doses J07BB03 Influenza, live attenuated (N) 2830 doses J07BC Hepatitis vaccines J07BC01 Hepatitis B, purified antigen (P) 2316 doses J07BC02 Hepatitis A, inactivated, whole virus (P) 1490 doses Hepatitis A, inactivated, whole virus+Hepatitis B, purified J07BC80 1037 doses antigen (P) J07BD Measles vaccines Measles, live attunated+Rubella, live attenuated+Mumps, J07BD52 23986 doses live,attenuated (P) J07BF Poliomyelitis vaccines J07BF03 Poliomyelitis, trivalent, inactivated, whole virus (P) 533 doses J07BG Rabies vaccines J07BG01 Rabies, inactivated, whole virus (P) 1377 doses J07BH Rota virus diarrhea vaccines J07BH02 Rota virus, pentavalent, live, reassorted (O) 79845 doses J07BK Varicella zoster vaccines J07BK01 Varicella, live attenuated (P) 1838 doses J07BK02 Zoster, live attenuated (P) 44 doses J07BK03 Zoster, purified antigen (P) 4 doses J07BL Yellow fever vaccines J07BL01 Yellow fever, live attenuated (P) 711 doses J07BM Papillomavirus vaccines J07BM02 Papillomavirus (human types 16, 18) (P) 1 doses Papillomavirus (human types 6, 11, 16, 18, 31, 33, 45, 52, 58) J07BM03 15319 doses (P) J07BX Other viral vaccines J07BX03 Covid-19 vaccine (P) 2115397,2 doses J07C BACTERIAL AND VIRAL VACCINES, COMBINED J07CA Bacterial and viral vaccines, combined Diphtheria toxoid+Pertussis, purified antigen+Tetanus J07CA02 16332 doses toxoid+Poliomyelitis, trivalent, inactivated, whole virus (P) 22/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day Diphtheria toxoid+Tetanus toxoid+Pertussis, purified antigen+Poliomyelitis, trivalent, inactivated, whole J07CA06 455 doses virus+Haemophilus influenzae B, purified antigen conjugated (P) Diphtheria toxoid+Poliomyelitis, trivalent, inactivated, whole virus+Pertussis, purified antigen+Haemophilus influenzae B, J07CA09 47370 doses purified antigen conjugated+Hepatitis B, purified antigen+Tetanus toxoid (P) L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS 13,0308 L01 ANTINEOPLASTIC AGENTS 0,4860 L01A ALKYLATING AGENTS L01AA Nitrogen mustard analogues L01AA01 Cyclophosphamide (O) 660 g L01AA01 Cyclophosphamide (P) 3690 g L01AA02 Chlorambucil (O) 18,85 g L01AA03 Melphalan (O) 4,5 g L01AA03 Melphalan (P) 21,75 g L01AA06 Ifosfamide (P) 1995 g L01AA09 Bendamustine (P) 150,4 g L01AB Alkyl sulfonates L01AB01 Busulfan (O) 4 g L01AB01 Busulfan (P) 1,92 g L01AB02 Treosulfan (P) 1530 g L01AC Ethylene imines L01AC01 Thiotepa (P) 1,965 g L01AD Nitrosoureas L01AD01 Carmustine (P) 6,3 g L01AD02 Lomustine (O) 22,4 g L01AD04 Streptozocin (P) 16 g L01AX Other alkylating agents L01AX03 Temozolomide (O) 668,8 g L01AX04 Dacarbazine (P) 415 g L01B ANTIMETABOLITES L01BA Folic acid analogues L01BA01 Methotrexate (P) 1165,2 g L01BA04 Pemetrexed (P) 365 g L01BB Purine analogues L01BB02 Mercaptopurine (O) 448,75 g L01BB03 Tioguanine (O) 6 g L01BB04 Cladribine (P) 0,42 g L01BB05 Fludarabine (P) 19,5 g L01BB06 Clofarabine (P) 1,1 g L01BC Pyrimidine analogues L01BC01 Cytarabine (P) 2136 g L01BC02 Fluorouracil (C) 80 g L01BC02 Fluorouracil (P) 13025 g L01BC05 Gemcitabine (P) 5081,4348 g L01BC06 Capecitabine (O) 256872 g L01BC07 Azacitidine (P) 315 g L01BC82 Fluorouracil+Salicylic acid (C) 150 ml L01BC83 Trifluridine+Tipiracil (O) 16380 pieces L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS L01CA Vinca alkaloids and analogues L01CA01 Vinblastine (P) 2,91 g L01CA02 Vincristine (P) 2,233 g L01CA03 Vindesine (P) 0,005 g L01CA04 Vinorelbine (O) 6,38 g L01CA04 Vinorelbine (P) 19,55 g L01CB Podophyllotoxin derivatives L01CB01 Etoposide (O) 275 g L01CB01 Etoposide (P) 461,2 g 23/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L01CD Taxanes L01CD01 Paclitaxel (P) 813,2 g L01CD02 Docetaxel (P) 469,12 g L01CD04 Cabazitaxel (P) 1,32 g L01CE Topoisomerase 1 (TOP1) inhibitors L01CE01 Topotecan (P) 2,12 g L01CE02 Irinotecan (P) 630 g L01CX Other plant alkaloids and natural products L01CX01 Trabectedin (P) 0,009 g L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES L01DA Actinomycines L01DA01 Dactinomycin (P) 0,052 g L01DB Anthracyclines and related substances L01DB01 Doxorubicin (P) 148,84 g L01DB02 Daunorubicin (P) 8,12 g L01DB03 Epirubicin (P) 188,8 g L01DB06 Idarubicin (P) 1,4 g L01DB07 Mitoxantrone (P) 0,82 g L01DC Other cytotoxic antibiotics L01DC01 Bleomycin (P) 6960000 U L01DC03 Mitomycin (P) 4,22 g L01E PROTEIN KINASE INHIBITORS 0,4860 L01EA BCR-ABL tyrosine kinase inhibitors 0,1211 L01EA01 Imatinib (O) 14400 g 0,4 g 0,0742 L01EA02 Dasatinib (O) 663 g 0,1 g 0,0137 L01EA03 Nilotinib (O) 8534,4 g 0,6 g 0,0293 L01EA04 Bosutinib (O) 551,6 g 0,4 g 0,0028 L01EA05 Ponatinib (O) 24,3 g 45 mg 0,0011 Epidermal growth factor receptor (EGFR) tyrosine kinase L01EB 0,0258 inhibitors L01EB01 Gefitinib (O) 1665 g 0,25 g 0,0137 L01EB02 Erlotinib (O) 48 g 0,15 g 0,0007 L01EB03 Afatinib (O) 73,36 g 40 mg 0,0038 L01EB04 Osimertinib (O) 295,2 g 80 mg 0,0076 L01EC B-Raf serine-threonine kinase (BRAF) inhibitors 0,0205 L01EC02 Dabrafenib (O) 2979 g 0,3 g 0,0205 L01ED Anaplastic lymphoma kinase (ALK) inhibitors 0,0055 L01ED01 Crizotinib (O) 315 g 0,5 g 0,0013 L01ED02 Ceritinib (O) 315 g 0,45 g 0,0014 L01ED03 Alectinib (O) 974,4 g 1,2 g 0,0017 L01ED04 Brigatinib (O) 93,24 g 0,18 g 0,0011 L01EE Mitogen-activated protein kinase (MEK) inhibitors 0,0220 L01EE01 Trametinib (O) 21,36 g 2 mg 0,0220 L01EE04 selumetinib (O) 2,1 g L01EF Cyclin-dependent kinase (CDK) inhibitors 0,0711 L01EF01 Palbociclib (O) 2657,025 g 94 mg 0,0582 L01EF02 Ribociclib (O) 2809,8 g 0,45 g 0,0129 L01EG Mammalian target of rapamycin (mTOR) kinase inhibitors 0,0101 L01EG01 Temsirolimus (P) 0,36 g 3,57 mg 0,0002 L01EG02 Everolimus (O) 48 g 10 mg 0,0099 Human epidermal growth factor receptor 2 (HER2) tyrosine L01EH 0,0009 kinase inhibitors L01EH01 Lapatinib (O) 420 g 1,25 g 0,0007 L01EH03 Tucatinib (O) 54 g 0,6 g 0,0002 L01EJ Janus-associated kinase (JAK) inhibitors 0,0175 L01EJ01 Ruxolitinib (O) 254,8 g 30 mg 0,0175 Vascular endothelial growth factor receptor (VEGFR) tyrosine L01EK 0,0050 kinase inhibitors L01EK01 Axitinib (O) 24,304 g 10 mg 0,0050 L01EL Bruton's tyrosine kinase (BTK) inhibitors 0,0521 L01EL01 Ibrutinib (O) 10617,6 g 0,42 g 0,0521 L01EX Other protein kinase inhibitors 0,1346 24/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L01EX01 Sunitinib (O) 325,5 g 33 mg 0,0203 L01EX02 Sorafenib (O) 3718,4 g 0,8 g 0,0096 L01EX03 Pazopanib (O) 15234 g 0,8 g 0,0392 L01EX05 regorafenib (O) 201,6 g 0,12 g 0,0035 L01EX07 Cabozantinib (O) 477,72 g 60 mg 0,0164 L01EX08 Lenvatinib (O) 87,06 g 18 mg 0,0100 L01EX09 Nintedanib (O) 6126 g 0,38 g 0,0332 L01EX10 Midostaurin (O) 119 g 0,1 g 0,0025 MONOCLONAL ANTIBODIES AND ANTIBODY DRUG L01F CONJUGATES L01FA CD20 (Clusters of Differentiation 20) inhibitors L01FA01 Rituximab (P) 2036,856 g L01FA03 Obinutuzumab (P) 50 g L01FB CD22 (Clusters of Differentiation 22) inhibitors L01FB01 Inotuzumab ozogamicin (P) 0,016 g L01FC CD38 (Clusters of Differentiation 38) inhibitors L01FC01 Daratumumab (P) 760,6 g HER2 (Human Epidermal Growth Factor Receptor 2) L01FD inhibitors L01FD01 Trastuzumab (P) 1632,15 g L01FD02 Pertuzumab (P) 255,78 g L01FD03 Trastuzumab emtansine (P) 124,72 g L01FE EGFR (Epidermal Growth Factor Receptor) inhibitors L01FE01 Cetuximab (P) 19,6 g L01FE02 Panitumumab (P) 109,3 g PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) L01FF inhibitors L01FF01 Nivolumab (P) 294,72 g L01FF02 Pembrolizumab (P) 438 g L01FF03 Durvalumab (P) 318,5 g L01FF05 Atezolizumab (P) 524,4 g L01FG VEGF/VEGFR (Vascular Endothelial Growth Factor) inhibitors L01FG01 Bevacizumab (P) 1214,5 g L01FG02 Ramucirumab (P) 2,8 g L01FX Other monoclonal antibodies and antibody drug conjugates L01FX04 Ipilimumab (P) 2,7 g L01FX05 Brentuximab vedotin (P) 13,1 g L01FX07 Blinatumomab (P) 0,004 g L01FX14 polatuzumab vedotin (P) 0,51 g L01FX18 Amivantamab (P) 6,3 g L01X OTHER ANTINEOPLASTIC AGENTS L01XA Platinum compounds L01XA01 Cisplatin (P) 174 g L01XA02 Carboplatin (P) 2049 g L01XA03 Oxaliplatin (P) 860 g L01XB Methylhydrazines L01XB01 Procarbazine (O) 262,5 g L01XD Sensitizers used in photodynamic/radiation therapy L01XD04 Aminolevulinic acid (O) 18 g L01XF Retinoids for cancer treatment L01XF01 Tretinoin (O) 9 g L01XG Proteasome inhibitors L01XG01 Bortezomib (P) 8,7465 g L01XG02 Carfilzomib (P) 10,26 g L01XK Poly (ADP-ribose) polymerase (PARP) inhibitors L01XK01 Olaparib (O) 10761,6 g L01XX Other antineoplastic agents L01XX02 Asparaginase (P) 2550000 U L01XX05 Hydroxycarbamide (O) 254750 g L01XX11 Estramustine (O) 72,8 g L01XX23 Mitotane (O) 3600 g 25/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L01XX24 Pegaspargase (P) 281250 U L01XX27 Arsenic trioxide (P) 0,3 g L01XX35 Anagrelide (O) 1,65 g L01XX41 Eribulin (P) 0,3687 g L01XX52 Venetoclax (O) 3938,48 g L01XX73 Sotorasib (O) 172,8 g L01XY Combinations of antineoplastic agents L01XY02 Pertuzumab+Trastuzumab (P) 3445 ml L02 ENDOCRINE THERAPY 4,7394 L02A HORMONES AND RELATED AGENTS 0,7576 L02AB Progestogens 0,0118 L02AB02 Medroxyprogesterone (O) 5745 g 1 g 0,0118 L02AE Gonadotropin releasing hormone analogues 0,7458 L02AE03 Goserelin (P) 9,2952 g 0,129 mg 0,1484 L02AE04 Triptorelin (P) 0,3108 g 0,1 mg 0,0064 L02AE04 Triptorelin (P) 38,4412 g 0,134 mg 0,5909 L02B HORMONE ANTAGONISTS AND RELATED AGENTS 3,9817 L02BA Anti-estrogens 0,8024 L02BA01 Tamoxifen (O) 6112,2 g 0,02 g 0,6295 L02BA03 Fulvestrant (P) 696,5 g 8,3 mg 0,1729 L02BB Anti-androgens 1,1581 L02BB03 Bicalutamide (O) 27742,4 g 0,05 g 1,1430 enzalutamide L02BB04 1061,76 g 0,16 g 0,0137 (O) L02BB05 Apalutamide (O) 172,8 g 0,24 g 0,0015 L02BG Aromatase inhibitors 1,9004 L02BG03 Anastrozole (O) 340,944 g 1 mg 0,7023 L02BG04 Letrozole (O) 1312,95 g 2,5 mg 1,0818 L02BG06 Exemestane (O) 1410,75 g 0,025 g 0,1162 L02BX Other hormone antagonists and related agents 0,1208 L02BX03 Abiraterone (O) 58650 g 1 g 0,1208 L03 IMMUNOSTIMULANTS 0,5084 L03A IMMUNOSTIMULANTS 0,5084 L03AA Colony stimulating factors 0,0976 L03AA02 Filgrastim (P) 9,7851 g 0,35 mg 0,0576 L03AA13 Pegfilgrastim (P) 5,826 g 0,3 mg 0,0400 L03AB Interferons 0,2994 L03AB04 Interferon alfa-2a (P) 1230000000 U 2000000 U 0,0013 L03AB07 Interferon beta-1a (P) 0,4547 g 0,0043 mg 0,2178 L03AB08 Interferon beta-1b (P) 72960000000 U 4000000 U 0,0376 L03AB11 Peginterferon alfa-2a (P) 0,035 g 0,026 mg 0,0028 L03AB13 Peginterferon beta-1a (P) 0,1726 g 8,9 mcg 0,0400 L03AX Other immunostimulants 0,1114 L03AX03 BCG bacteria (P) 4,175 g 1,8 mg 0,0048 L03AX13 Glatiramer acetate (P) 1029,6 g 0,02 g 0,1060 L03AX15 Mifamurtide (P) 0,192 g 0,7 mg 0,0006 L03AX16 Plerixafor (P) 0,456 g 16,8 mg 0,0001 L03AX80 Methyluracil (R) 300 g L04 IMMUNOSUPPRESSANTS 7,2970 L04A IMMUNOSUPPRESSANTS 7,2970 L04AA Selective immunosuppressants 1,2287 L04AA03 Antilymphocyte immunoglobulin (horse) (P) 10 g L04AA04 Rabbit anti-T-lymphocyte immunoglobulin (P) 20,65 g 0,1 g 0,0004 L04AA06 Mycophenolic acid (O) 290647,6 g 2 g 0,2994 L04AA06 Mycophenolic acid (P) 146 g 2 g 0,0002 L04AA10 Sirolimus (O) 23,67 g 0,003 g 0,0163 L04AA13 Leflunomide (O) 5487,3 g 0,02 g 0,5652 L04AA18 Everolimus (O) 0,36 g 1,5 mg 0,0005 L04AA23 Natalizumab (P) 45,9 g 0,01 g 0,0095 L04AA24 Abatacept (P) 202,25 g 0,027 g 0,0154 L04AA25 Eculizumab (P) 79,8 g 0,064 g 0,0026 L04AA26 Belimumab (P) 5,6 g 25 mg 0,0005 26/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L04AA27 Fingolimod (O) 3,99 g 0,5 mg 0,0164 Tofacitinib L04AA29 124,992 g 10 mg 0,0257 (O) L04AA31 Teriflunomide (O) 700,504 g 14 mg 0,1031 L04AA33 Vedolizumab (P) 96,612 g 5,4 mg 0,0369 L04AA34 Alemtuzumab (P) 0,84 g 0,13 mg 0,0133 L04AA36 Ocrelizumab (P) 130,5 g 3,29 mg 0,0817 Baricitinib L04AA37 3,92 g 4 mg 0,0020 (O) L04AA40 Cladribine (O) 1,81 g 0,34 mg 0,0110 L04AA42 Siponimod (O) 15,354 g L04AA44 Upadacitinib (O) 209,58 g 15 mg 0,0288 L04AA47 Inebilizumab (P) 1,2 g L04AB Tumor necrosis factor alpha (TNF-alpha) inhibitors 1,4872 L04AB01 Etanercept (P) 1009 g 0,007 g 0,2969 L04AB02 Infliximab (P) 1013,3 g 3,75 mg 0,5566 L04AB04 Adalimumab (P) 757,4 g 2,9 mg 0,5380 L04AB05 Certolizumab pegol (P) 28,8 g 14 mg 0,0042 L04AB06 Golimumab (P) 73,65 g 1,66 mg 0,0914 L04AC Interleukin inhibitors 0,5350 L04AC02 Basiliximab (P) 1,44 g 0,04 g 0,0001 L04AC03 Anakinra (P) 59,7975 g 0,1 g 0,0012 L04AC05 Ustekinumab (P) 59,43 g 0,54 mg 0,2267 L04AC07 Tocilizumab (P) 1524,376 g 0,02 g 0,1570 L04AC10 Secukinumab (P) 451,05 g 10 mg 0,0929 L04AC13 Ixekizumab (P) 21,12 g 2,9 mg 0,0150 L04AC14 Sarilumab (P) 131,1 g 14,3 mg 0,0189 L04AC16 Guselkumab (P) 7,9 g 1,79 mg 0,0091 L04AC18 Risankizumab (P) 11,4 g 1,67 mg 0,0141 L04AD Calcineurin inhibitors 0,4489 L04AD01 Ciclosporin (O) 26942,5 g 0,25 g 0,2220 L04AD01 Ciclosporin (P) 95 g 0,25 g 0,0008 L04AD02 Tacrolimus (O) 548,6025 g 5 mg 0,2260 L04AD02 Tacrolimus (P) 0,3 g 5 mg 0,0001 L04AX Other immunosuppressants 3,5973 L04AX01 Azathioprine (O) 29980 g 0,15 g 0,4117 L04AX02 Thalidomide (O) 313,6 g 0,1 g 0,0065 L04AX03 Methotrexate (O) 3341,8 g 2,5 mg 2,7536 L04AX03 Methotrexate (P) 139,95 g 2,5 mg 0,1153 L04AX04 Lenalidomide (O) 427,77 g 0,01 g 0,0881 L04AX05 Pirfenidone (O) 19512,36 g 2,4 g 0,0167 Pomalidomide L04AX06 18,144 g 3 mg 0,0125 (O) L04AX07 Dimethyl fumarate (O) 44943,36 g 0,48 g 0,1929 M MUSCULO-SKELETAL SYSTEM 84,8775 M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS 68,4088 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, M01A 68,3974 NON-STEROIDS M01AB Acetic acid derivatives and related substances 8,5761 M01AB01 Indometacin (O) 2065,2 g 0,1 g 0,0425 M01AB05 Diclofenac (O) 294447 g 0,1 g 6,0654 M01AB05 Diclofenac (P) 7798,5 g 0,1 g 0,1606 M01AB05 Diclofenac (R) 12623,375 g 0,1 g 0,2600 M01AB15 Ketorolac (P) 1,8 g 30 mg 0,0001 M01AB16 Aceclofenac (O) 42012 g 0,2 g 0,4327 M01AB82 Diclofenac+Omeprazole (O) 78381 g 0,1 g 1,6146 M01AC Oxicams 3,6044 M01AC01 Piroxicam (O) 939,6 g 0,02 g 0,0968 M01AC05 Lornoxicam (O) 1962,96 g 0,012 g 0,3370 M01AC06 Meloxicam (O) 22912,2 g 0,015 g 3,1465 M01AC06 Meloxicam (P) 175,725 g 0,015 g 0,0241 27/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day M01AE Propionic acid derivatives 39,5075 M01AE01 Ibuprofen (O) 14553081,2 g 1,2 g 24,9821 M01AE01 Ibuprofen (P) 7830 g 1,2 g 0,0134 M01AE02 Naproxen (O) 697334 g 0,5 g 2,8729 M01AE03 Ketoprofen (O) 123697,375 g 0,15 g 1,6987 M01AE03 Ketoprofen (P) 12086 g 0,15 g 0,1660 M01AE03 Ketoprofen (R) 1,2 g 0,15 g <0,0001 M01AE17 Dexketoprofen (O) 81245,75 g 0,075 g 2,2315 M01AE17 Dexketoprofen (P) 3681,25 g 0,075 g 0,1011 M01AE52 Naproxen+Esomeprazole (O) 1802955 g 0,5 g 7,4280 M01AE82 Ibuprofen+Phenylephrine (O) 7982,4 g 1,2 g 0,0137 M01AG Fenamates 0,0050 M01AG02 Tolfenamic acid (O) 732 g 0,3 g 0,0050 M01AH Coxibs 9,4846 M01AH01 Celecoxib (O) 79634 g 0,2 g 0,8202 M01AH05 Etoricoxib (O) 252367,29 g 60 mg 8,6644 M01AX Other antiinflammatory and antirheumatic agents, non-steroids 7,2198 M01AX01 Nabumetone (O) 153000 g 1 g 0,3152 M01AX05 Glucosamine (O) 5027748,69 g 1,5 g 6,9046 M01C SPECIFIC ANTIRHEUMATIC AGENTS 0,0114 M01CC Penicillamine and similar agents 0,0114 M01CC01 Penicillamine (O) 2775 g 0,5 g 0,0114 M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN M02AA Antiinflammatory preparations, non-steroids for topical use M02AA10 Ketoprofen (C) 1330650 g M02AA12 Naproxen (C) 1004135 g M02AA13 Ibuprofen (C) 26462 pieces M02AA13 Ibuprofen (C) 810500 g M02AA15 Diclofenac (C) 482007 pieces M02AA15 Diclofenac (C) 30657500 g M02AA81 Ibuprofen+Levomenthol (C) 1867700 g M02AC Preparations with salicylic acid derivatives Methyl salicylate+Levomenthol+Eucalyptus oil+Turpentine oil M02AC80 93063 g (C) M02AX Other topical products for joint and muscular pain M02AX80 Nicoboxil+Nonivamide (C) 101340 g Camphor+Salicylic acid+Turpentine oil+Venenum Viperae M02AX90 836050 g berus (C) Benzyl nicotinate+Nonivamide+Camphor+Turpentine M02AX92 737300 g oil+Dimethyl sulfoxide (C) M03 MUSCLE RELAXANTS 1,0042 M03A MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS M03AB Choline derivatives M03AB01 Suxamethonium chloride (P) 2881 g M03AC Other quaternary ammonium compounds M03AC04 Atracurium besilate (P) 3034,75 g M03AC06 Pipecuronium bromide (P) 17,5 g M03AC09 Rocuronium bromide (P) 1072 g M03AX Other muscle relaxants, peripherally acting agents M03AX01 Botulinum toxin (P) 1922300 U M03B MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS 1,0042 M03BX Other centrally acting agents 1,0042 M03BX01 Baclofen (O) 4710,75 g 0,05 g 0,1941 M03BX01 Baclofen (P) 3,9608 g 0,55 mg 0,0148 M03BX02 Tizanidine (O) 4632,9 g 0,012 g 0,7953 M03C MUSCLE RELAXANTS, DIRECTLY ACTING AGENTS M03CA Dantrolene and derivatives M03CA01 Dantrolene (P) 3,12 g M04 ANTIGOUT PREPARATIONS 10,6963 28/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day M04A ANTIGOUT PREPARATIONS 10,6963 M04AA Preparations inhibiting uric acid production 10,6778 M04AA01 Allopurinol (O) 1504129 g 0,4 g 7,7461 M04AA03 Febuxostat (O) 113856,96 g 0,08 g 2,9317 M04AB Preparations increasing uric acid excretion 0,0038 M04AB01 Probenecid (O) 50 g 1 g 0,0001 M04AB03 Benzbromarone (O) 180 g 0,1 g 0,0037 M04AC Preparations with no effect on uric acid metabolism 0,0147 M04AC01 Colchicine (O) 7,15 g 1 mg 0,0147 M05 DRUGS FOR TREATMENT OF BONE DISEASES 4,7681 DRUGS AFFECTING BONE STRUCTURE AND M05B 4,7681 MINERALIZATION M05BA Bisphosphonates 0,7069 M05BA03 Pamidronic acid (P) 8,13 g 0,06 g 0,0003 M05BA04 Alendronic acid (O) 252 g 0,01 g 0,0519 M05BA06 Ibandronic acid (O) 1212,6 g 0,005 g 0,4996 M05BA06 Ibandronic acid (P) 0,006 g 0,006 g <0,0001 M05BA07 Risedronic acid (O) 357,14 g 0,005 g 0,1471 M05BA08 Zoledronic acid (P) 15,566 g 0,004 g 0,0080 M05BB Bisphosphonates, combinations 2,6112 M05BB03 Alendronic acid+Colecalciferol (O) 12675,88 g 10 mg 2,6112 M05BX Other drugs affecting bone structure and mineralization 1,4500 M05BX04 Denosumab (P) 232,294 g 0,33 mg 1,4500 M05BX05 Burosumab (P) 2,53 g OTHER DRUGS FOR DISORDERS OF THE MUSCULO- M09 SKELETAL SYSTEM OTHER DRUGS FOR DISORDERS OF THE MUSCULO- M09A SKELETAL SYSTEM M09AX Other drugs for disorders of the musculo-skeletal system M09AX10 Risdiplam (O) 0,6 g N NERVOUS SYSTEM 148,2854 N01 ANESTHETICS N01A ANESTHETICS, GENERAL N01AB Halogenated hydrocarbons N01AB06 Isoflurane (I) 7500 ml N01AB07 Desflurane (I) 63360 ml N01AB08 Sevoflurane (I) 745250 ml N01AF Barbiturates, plain N01AF03 Thiopental (P) 2160 g N01AH Opioid anesthetics N01AH01 Fentanyl (I) 18,182 g N01AH01 Fentanyl (P) 34,298 g N01AH06 Remifentanil (P) 22,235 g N01AX Other general anesthetics N01AX03 Ketamine (P) 2107 g N01AX07 Etomidate (P) 40,8 g N01AX10 Propofol (P) 89540,5 g N01AX13 Nitrous oxide (I) 11170000 ml N01AX14 Esketamine (P) 1089 g N01B ANESTHETICS, LOCAL N01BB Amides N01BB01 Bupivacaine (Infilt, P) 3211,2 g N01BB01 Bupivacaine (P) 219,8 g N01BB02 Lidocaine (endocerv, P) 200 g N01BB02 Lidocaine (C) 2097 g N01BB02 Lidocaine (C) 5650 ml N01BB02 Lidocaine (NA) 20100 ml N01BB02 Lidocaine (NA) 68722 g N01BB02 Lidocaine (O) 79772 g N01BB02 Lidocaine (P) 23476,15 g N01BB03 Mepivacaine (dental) 1514,7 g N01BB08 Articaine (P) 0,8 g 29/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N01BB09 Ropivacaine (P) 725,9 g N01BB80 Articaine+Epinephrine (dental) 943160 ml N01BB80 Articaine+Epinephrine (O) 602280 ml N01BB81 Bupivacaine+Epinephrine (P) 82 g N01BB81 Bupivacaine+Epinephrine (P) 248200 ml N01BB82 Lidocaine+Epinephrine (dental) 51800 ml N01BB83 Lidocaine+Prilocaine (C) 72046,5 g N01BB86 Lidocaine+Chlorhexidine (urethral) 1410375 g N01BC Esters of benzoic acid N01BC01 Cocaine (NA) 30 g N01BX Other local anesthetics N01BX04 Capsaicin (C) 67,8718 g N02 ANALGESICS 27,8706 N02A OPIOIDS 9,3531 N02AA Natural opium alkaloids 0,9453 N02AA01 Morphine (O) 5757,9 g 0,1 g 0,1186 N02AA01 Morphine (P) 758 g 0,03 g 0,0520 N02AA05 Oxycodone (O) 23151,3 g 0,075 g 0,6359 N02AA05 Oxycodone (P) 272,6 g 0,03 g 0,0187 N02AA08 Dihydrocodeine (O) 7836,6 g 0,15 g 0,1076 N02AA55 Oxycodone+Naloxone (O) 453,45 g 75 mg 0,0125 N02AB Phenylpiperidine derivatives 0,1259 N02AB02 Pethidine (P) 140,5 g 0,4 g 0,0007 N02AB02 Pethidine (P, V) 1408 g 0,4 g 0,0073 N02AB03 Fentanyl (O) 2,9652 g N02AB03 Fentanyl (SL) 2,949 g 0,6 mg 0,0101 N02AB03 Fentanyl (TD) 62,8196 g 1,2 mg 0,1078 N02AE Oripavine derivatives 0,0183 N02AE01 Buprenorphine (TD) 10,6814 g 1,2 mg 0,0183 N02AJ Opioids in combination with non-opioid analgesics 6,4965 N02AJ06 Codeine+Paracetamol (O) 7516390 pieces 3 pieces 5,1611 N02AJ13 Tramadol+Paracetamol (O) 2164,5 g 150 mg 0,0297 N02AJ14 Tramadol+Dexketoprofen (O) 95073,75 g 150 mg 1,3056 N02AX Other opioids 1,7670 N02AX02 Tramadol (O) 254279 g 0,3 g 1,7460 N02AX02 Tramadol (P) 3055,25 g 0,3 g 0,0210 N02B OTHER ANALGESICS AND ANTIPYRETICS 17,3768 N02BA Salicylic acid and derivatives 0,9327 N02BA01 Acetylsalicylic acid (O) 1156337,76 g 3 g 0,7940 N02BA01 Acetylsalicylic acid (P) 27 g N02BA80 Acetylsalicylic acid +Ascorbic acid (O) 201991,2 g 3 g 0,1387 N02BB Pyrazolones 0,0020 N02BB02 Metamizole sodium (O) 50 g 3 g <0,0001 N02BB02 Metamizole sodium (P) 1680 g 3 g 0,0012 N02BB02 Metamizole sodium (P, V) 1190 g 3 g 0,0008 N02BE Anilides 16,4421 N02BE01 Paracetamol (O) 18053987,2 g 3 g 12,3967 N02BE01 Paracetamol (P) 316560 g 3 g 0,2174 N02BE01 Paracetamol (R) 56152,15 g 3 g 0,0386 N02BE52 Paracetamol+Pseudoephedrine+Diphenhydramine (O) 32896 g 3 g 0,0226 N02BE75 Paracetamol+Guaifenesin+Phenylephrine (O) 158191 g 3 g 0,1086 Paracetamol+Chlorphenamine+Pseudoephedrine+Dextrometh N02BE81 416918 g 3 g 0,2863 orphan (O) N02BE83 Paracetamol+Caffeine (O) 235272 g 3 g 0,1615 N02BE84 Paracetamol+Phenylephrine+Ascorbic acid (O) 815071,25 g 3 g 0,5597 N02BE85 Paracetamol+Pheniramine+Ascorbic acid (O) 71018,24 g 3 g 0,0488 Paracetamol+Phenylephrine+Terpin hydrate+Ascorbic N02BE86 268788 g 3 g 0,1846 acid+Caffeine (O) N02BE87 Paracetamol+Pseudoephedrine (O) 60265 g 3 g 0,0414 N02BE91 Paracetamol+Ascorbic acid (O) 9688,8 g 3 g 0,0067 N02BE92 Paracetamol+Codeine (O) 1253650 g 3 g 0,8608 N02BE94 Paracetamol+Codeine+Caffeine (O) 1786764 g 3 g 1,2269 30/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N02BE95 Paracetamol+Phenylephrine (O) 27820 g 3 g 0,0191 N02BE97 Paracetamol+Pseudoephedrine+Dextromethorphan (O) 382394 g 3 g 0,2626 N02C ANTIMIGRAINE PREPARATIONS 1,1407 N02CC Selective serotonin (5HT1) agonists 1,1117 N02CC01 Sumatriptan (N) 1 g 0,02 g 0,0001 N02CC01 Sumatriptan (O) 23223 g 0,05 g 0,9568 N02CC03 Zolmitriptan (O) 76,47 g 2,5 mg 0,0630 N02CC04 Rizatriptan (O) 56,25 g 0,01 g 0,0116 N02CC07 Frovatriptan (O) 97,325 g 2,5 mg 0,0802 N02CD Calcitonin gene-related peptide (CGRP) antagonists 0,0291 N02CD01 Erenumab (P) 18,55 g 2,5 mg 0,0153 N02CD03 fremanezumab (P) 50,175 g 7,5 mg 0,0138 N03 ANTIEPILEPTICS 12,3166 N03A ANTIEPILEPTICS 12,3166 N03AA Barbiturates and derivatives 0,3440 N03AA02 Phenobarbital (O) 14485 g 0,1 g 0,2984 N03AA02 Phenobarbital (P) 120 g 0,1 g 0,0025 N03AA03 Primidone (O) 26200 g 1,25 g 0,0432 N03AA80 Benzobarbital (O) 90 g N03AB Hydantoin derivatives 0,0387 N03AB02 Phenytoin (O) 5490 g 0,3 g 0,0377 N03AB02 Phenytoin (P) 147,5 g 0,3 g 0,0010 N03AD Succinimide derivatives 0,0172 N03AD01 Ethosuximide (O) 10425 g 1,25 g 0,0172 N03AE Benzodiazepine derivatives 0,5495 N03AE01 Clonazepam (O) 2133,96 g 0,008 g 0,5495 N03AF Carboxamide derivatives 2,6382 N03AF01 Carbamazepine (O) 878151 g 1 g 1,8089 N03AF02 Oxcarbazepine (O) 401505 g 1 g 0,8271 N03AF03 Rufinamide (O) 1480 g 1,4 g 0,0022 N03AG Fatty acid derivatives 1,6288 N03AG01 Valproic acid (O) 1171350 g 1,5 g 1,6086 N03AG01 Valproic acid (P) 2051,3 g 1,5 g 0,0028 N03AG04 Vigabatrin (O) 16850 g 2 g 0,0174 N03AX Other antiepileptics 7,1003 N03AX03 Sultiame (O) 4770 g 0,4 g 0,0246 N03AX09 Lamotrigine (O) 122867,8 g 0,3 g 0,8437 N03AX11 Topiramate (O) 40113 g 0,3 g 0,2754 N03AX12 Gabapentin (O) 1842411 g 1,8 g 2,1085 N03AX14 Levetiracetam (O) 615172,5 g 1,5 g 0,8448 N03AX14 Levetiracetam (P) 575 g 1,5 g 0,0008 N03AX15 Zonisamide (O) 43,4 g 0,2 g 0,0004 N03AX16 Pregabalin (O) 436014,25 g 0,3 g 2,9939 N03AX17 Stiripentol (O) 1815 g 1 g 0,0037 N03AX18 Lacosamide (O) 68,6 g 0,3 g 0,0005 N03AX22 perampanel (O) 2,016 g 8 mg 0,0005 N03AX23 Brivaracetam (O) 121,8 g 0,1 g 0,0025 N03AX24 Cannabidiol (O) 320 g 0,7 g 0,0009 N04 ANTI-PARKINSON DRUGS 3,6332 N04A ANTICHOLINERGIC AGENTS 0,5502 N04AA Tertiary amines 0,5502 N04AA01 Trihexyphenidyl (O) 2670,9 g 0,01 g 0,5502 N04B DOPAMINERGIC AGENTS 3,0830 N04BA Dopa and dopa derivatives 1,4234 N04BA03 Levodopa +Carbidopa+Entacapone (O) 66452,5 g 0,45 g 0,3042 N04BA80 Levodopa +Benserazide (O) 310370 g 0,6 g 1,0656 N04BA81 Levodopa +Carbidopa (intestin) 22316 g N04BA81 Levodopa +Carbidopa (O) 15629 g 0,6 g 0,0537 N04BB Adamantane derivatives 0,2933 N04BB01 Amantadine (O) 28480 g 0,2 g 0,2933 N04BB01 Amantadine (P) 16 g N04BC Dopamine agonists 0,7800 31/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N04BC04 Ropinirole (O) 1097,824 g 0,006 g 0,3769 N04BC05 Pramipexole (O) 462,1697 g 2,5 mg 0,3808 N04BC07 Apomorphine (P) 215,8 g 20 mg 0,0222 N04BD Monoamine oxidase type B inhibitors 0,5863 N04BD02 Rasagiline (O) 284,63 g 0,001 g 0,5863 N05 PSYCHOLEPTICS 45,7687 N05A ANTIPSYCHOTICS 10,1784 N05AA Phenothiazines with aliphatic side-chain 0,1470 N05AA01 Chlorpromazine (O) 10095,5 g 0,3 g 0,0693 N05AA01 Chlorpromazine (P) 33,5 g 0,1 g 0,0007 N05AA02 Levomepromazine (O) 11188 g 0,3 g 0,0768 N05AA02 Levomepromazine (P, V) 8 g 0,1 g 0,0002 N05AB Phenothiazines with piperazine structure 0,0786 N05AB02 Fluphenazine (P) 5,125 g 0,001 g 0,0106 N05AB03 Perphenazine (O) 397,2 g 0,03 g 0,0273 N05AB03 Perphenazine (P) 198,006 g 0,01 g 0,0408 N05AC Phenothiazines with piperidine structure 0,0009 N05AC01 Periciazine (O) 21,6 g 0,05 g 0,0009 N05AD Butyrophenone derivatives 0,8906 N05AD01 Haloperidol (O) 1803,485 g 0,008 g 0,4644 N05AD01 Haloperidol (P) 25 g 0,0033 g 0,0156 N05AD01 Haloperidol (P) 644,25 g 0,008 g 0,1659 N05AD03 Melperone (O) 34075 g 0,3 g 0,2340 N05AD08 Droperidol (P) 13,1 g 2,5 mg 0,0108 N05AE Indole derivatives 0,0804 N05AE03 Sertindole (O) 607,792 g 0,016 g 0,0783 N05AE04 Ziprasidone (O) 81,6 g 0,08 g 0,0021 N05AE05 Lurasidone (O) 1,0416 g 60 mg <0,0001 N05AF Thioxanthene derivatives 0,8348 N05AF01 Flupentixol (O) 347,9 g 0,006 g 0,1194 N05AF01 Flupentixol (P) 116,84 g 0,004 g 0,0602 N05AF03 Chlorprothixene (O) 27282,5 g 0,3 g 0,1873 N05AF05 Zuclopenthixol (O) 1310,5 g 0,03 g 0,0900 N05AF05 Zuclopenthixol (P) 42,5 g 0,03 g 0,0029 N05AF05 Zuclopenthixol (P) 2730 g 0,015 g 0,3749 N05AH Diazepines, oxazepines, thiazepines and oxepines 5,9685 N05AH02 Clozapine (O) 98186,75 g 0,3 g 0,6742 N05AH03 Olanzapine (O) 11638,9 g 0,01 g 2,3975 N05AH03 Olanzapine (P) 213,45 g 0,01 g 0,0440 N05AH04 Quetiapine (O) 553954,25 g 0,4 g 2,8528 N05AL Benzamides 0,1239 N05AL01 Sulpiride (O) 18312 g 0,8 g 0,0472 N05AL05 Amisulpride (O) 14910 g 0,4 g 0,0768 N05AN Lithium 0,3380 N05AN01 Lithium (O) 147660 g 0,9 g 0,3380 N05AX Other antipsychotics 1,7156 N05AX08 Risperidone (O) 1661,6 g 0,005 g 0,6846 N05AX08 Risperidone (P) 20,95 g 2,7 mg 0,0160 N05AX12 Aripiprazole (O) 6028,23 g 0,015 g 0,8279 N05AX12 Aripiprazole (P) 9,0675 g 0,015 g 0,0012 N05AX12 Aripiprazole (P) 663,6 g 0,0133 g 0,1028 N05AX13 Paliperidone (P) 96,825 g 2,5 mg 0,0798 N05AX15 Cariprazine (O) 4,998 g 3 mg 0,0034 N05B ANXIOLYTICS 12,9529 N05BA Benzodiazepine derivatives 12,9523 N05BA01 Diazepam (O) 27207,35 g 0,01 g 5,6046 N05BA01 Diazepam (P) 460,4 g 0,01 g 0,0948 N05BA01 Diazepam (R) 64,825 g 0,01 g 0,0134 N05BA06 Lorazepam (O) 1034,82 g 2,5 mg 0,8527 N05BA06 Lorazepam (P) 15,78 g 2,5 mg 0,0130 N05BA08 Bromazepam (O) 5379,42 g 0,01 g 1,1081 N05BA09 Clobazam (O) 368 g 0,02 g 0,0379 32/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N05BA12 Alprazolam (O) 2529,0875 g 0,001 g 5,2098 N05BA80 Phenazepam (O) 8,75 g 0,001 g 0,0180 N05BB Diphenylmethane derivatives <0,0001 N05BB01 Hydroxyzine (O) 0,4 g 0,075 g <0,0001 N05BE Azaspirodecanedione derivatives 0,0006 N05BE01 Buspirone (O) 9 g 0,03 g 0,0006 N05C HYPNOTICS AND SEDATIVES 22,6375 N05CD Benzodiazepine derivatives 0,2051 N05CD02 Nitrazepam (O) 222,3 g 0,005 g 0,0916 N05CD05 Triazolam (O) 0,015 g 0,25 mg 0,0001 N05CD08 Midazolam (O) 75,375 g 0,015 g 0,0104 N05CD08 Midazolam (P) 712,3 g 0,015 g 0,0978 N05CD08 Midazolam (P, R) 37,65 g 0,015 g 0,0052 N05CF Benzodiazepine related drugs 21,3026 N05CF01 Zopiclone (O) 60598,95 g 7,5 mg 16,6441 N05CF02 Zolpidem (O) 22234,52 g 0,01 g 4,5802 N05CF04 Eszopiclone (O) 76,104 g 2 mg 0,0784 N05CH Melatonin receptor agonists 0,6816 N05CH01 Melatonin (O) 661,81 g 2 mg 0,6816 N05CM Other hypnotics and sedatives 0,4481 N05CM09 Valerianae radix (O) 599130 pieces 3 pieces 0,4114 N05CM18 Dexmedetomidine (P) 17,8332 g 1 mg 0,0367 N06 PSYCHOANALEPTICS 46,5395 N06A ANTIDEPRESSANTS 40,7262 N06AA Non-selective monoamine reuptake inhibitors 1,9370 N06AA02 Imipramine (O) 45 g 0,1 g 0,0009 N06AA04 Clomipramine (O) 4425 g 0,1 g 0,0912 N06AA09 Amitriptyline (O) 56274,25 g 0,075 g 1,5456 N06AA10 Nortriptyline (O) 10897,5 g 0,075 g 0,2993 N06AB Selective serotonin reuptake inhibitors 24,0617 N06AB03 Fluoxetine (O) 39099,48 g 0,02 g 4,0271 N06AB04 Citalopram (O) 13565,14 g 0,02 g 1,3972 N06AB05 Paroxetine (O) 22728,6 g 0,02 g 2,3410 N06AB06 Sertraline (O) 173843,1 g 0,05 g 7,1621 N06AB08 Fluvoxamine (O) 980 g 0,1 g 0,0202 N06AB10 Escitalopram (O) 44244,28 g 0,01 g 9,1141 N06AF Monoamine oxidase inhibitors, non-selective 0,0115 N06AF04 Tranylcypromine (O) 56 g 0,01 g 0,0115 N06AG Monoamine oxidase type A inhibitors 0,0008 N06AG02 Moclobemide (O) 120 g 0,3 g 0,0008 N06AX Other antidepressants 14,7151 N06AX03 Mianserin (O) 50,4 g 0,06 g 0,0017 N06AX05 Trazodone (O) 21087 g 0,3 g 0,1448 N06AX11 Mirtazapine (O) 39220,65 g 0,03 g 2,6931 N06AX12 Bupropione (O) 159853,5 g 0,3 g 1,0976 N06AX14 Tianeptine (O) 25356,75 g 0,0375 g 1,3929 N06AX16 Venlafaxine (O) 212042,1 g 0,1 g 4,3679 N06AX17 Milnacipran (O) 8,4 g 0,1 g 0,0002 N06AX18 Reboxetine (O) 1,44 g 0,008 g 0,0004 N06AX21 Duloxetine (O) 82083,24 g 0,06 g 2,8181 N06AX22 Agomelatine (O) 14884,1 g 0,025 g 1,2264 N06AX26 Vortioxetine (O) 4718,42 g 10 mg 0,9720 PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND N06B 2,1640 NOOTROPICS N06BA Centrally acting sympathomimetics 1,7780 N06BA04 Methylphenidate (O) 24284,16 g 0,03 g 1,6675 N06BA07 Modafinil (O) 864 g 0,3 g 0,0059 N06BA09 Atomoxetine (O) 4061,12 g 0,08 g 0,1046 N06BA12 Lisdexamfetamine dimesylate (O) 31,5 g N06BC Xanthine derivatives N06BC81 Caffeine citrate (O, P) 42 g N06BX Other psychostimulants and nootropics 0,3860 33/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N06BX03 Piracetam (O) 433464 g 2,4 g 0,3720 N06BX18 Vinpocetine (O) 101,5 g 15 mg 0,0139 N06BX83 Aminobutyric acid (O) 33485 g N06D ANTI-DEMENTIA DRUGS 3,6493 N06DA Anticholinesterases 1,1914 N06DA02 Donepezil (O) 4337,76 g 7,5 mg 1,1914 N06DX Other anti-dementia drugs 2,4579 N06DX01 Memantine (O) 5960,68 g 0,02 g 0,6139 N06DX02 Ginkgo folium (O) 107419,8 g 0,12 g 1,8440 N06DX80 cerebrolysine (P) 360,46 g N07 OTHER NERVOUS SYSTEM DRUGS 12,1568 N07A PARASYMPATHOMIMETICS 0,3566 N07AA Anticholinesterases 0,3566 N07AA01 neostigmine (P) 26,75 g 0,002 g 0,0276 N07AA02 Pyridostigmine bromide (O) 26892 g 0,18 g 0,3078 N07AA80 Neostigmine+Glycopyrronium (P) 10350 ml 1 ml 0,0213 N07AX Other parasympathomimetics N07AX01 Pilocarpine (O) 1,26 g N07B DRUGS USED IN ADDICTIVE DISORDERS 3,3302 N07BA Drugs used in nicotine dependence 1,7231 N07BA01 Nicotine (O) 16377,04 g 0,03 g 1,1245 N07BA01 Nicotine (TD) 3898,874 g 0,014 g 0,5737 N07BA03 Varenicline (O) 24,154 g 2 mg 0,0249 N07BB Drugs used in alcohol dependence 0,4209 N07BB01 Disulfiram (O) 33820 g 0,2 g 0,3483 N07BB01 Disulfiram (P) 80 g N07BB03 Acamprosate (O) 347,652 g 2 g 0,0004 N07BB04 Naltrexone (O) 1598,8 g 50 mg 0,0659 N07BB05 nalmefene (O) 55,188 g 18 mg 0,0063 N07BC Drugs used in opioid dependence 1,1862 N07BC02 Methadone (O) 13848 g 0,025 g 1,1410 N07BC51 Buprenorphine+Naloxone (SL) 175,504 g 8 mg 0,0452 N07C ANTIVERTIGO PREPARATIONS 8,4395 N07CA Antivertigo preparations 8,4395 N07CA01 Betahistine (O) 84223,92 g 0,024 g 7,2290 N07CA02 Cinnarizine (O) 49865 g 0,09 g 1,1413 N07CA03 Flunarizine (O) 3,3 g 0,01 g 0,0007 N07CA80 Cinnarizine+Dimenhydrinate (O) 2990 g 90 mg 0,0684 N07X OTHER NERVOUS SYSTEM DRUGS 0,0305 N07XX Other nervous system drugs 0,0305 N07XX02 Riluzole (O) 1310,4 g 0,1 g 0,0270 N07XX06 Tetrabenazine (O) 120,4 g 0,1 g 0,0025 N07XX07 Fampridine (O) 10,08 g 20 mg 0,0010 N07XX14 Edaravone (P) 4,5 g ANTIPARASITIC PRODUCTS, INSECTICIDES AND P 1,0909 REPELLENTS P01 ANTIPROTOZOALS 0,8872 AGENTS AGAINST AMOEBIASIS AND OTHER P01A 0,1744 PROTOZOAL DISEASES P01AB Nitroimidazole derivatives 0,1744 P01AB01 Metronidazole (O) 169330 g 2 g 0,1744 P01AB01 Metronidazole (O, V) 831 g P01B ANTIMALARIALS 0,7128 P01BA Aminoquinolines 0,6861 P01BA02 Hydroxychloroquine (O) 171702 g 0,516 g 0,6855 P01BA03 Primaquine (O) 4,5 g 0,015 g 0,0006 P01BB Biguanides 0,0264 P01BB51 Proguanil+Atovaquone (O) 792 pieces 16 pieces 0,0001 P01BB51 Proguanil+Atovaquone (O) 51048 pieces 4 pieces 0,0263 P01BC Methanolquinolines 0,0001 P01BC01 Quinine (P) 60 g 1,5 g 0,0001 P01BD Diaminopyrimidines 0,0003 34/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day P01BD01 Pyrimethamine (O) 9,75 g 0,075 g 0,0003 P02 ANTHELMINTICS 0,2037 P02B ANTITREMATODALS 0,0001 P02BA Quinoline derivatives and related substances 0,0001 P02BA01 Praziquantel (O) 198 g 3 g 0,0001 P02C ANTINEMATODAL AGENTS 0,2036 P02CA Benzimidazole derivatives 0,2029 P02CA01 Mebendazole (O) 17140,6 g 0,2 g 0,1765 P02CA03 Albendazole (O) 5112 g 0,4 g 0,0263 P02CF Avermectines 0,0007 P02CF01 Ivermectin (O) 4,14 g 12 mg 0,0007 ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES P03 AND REPELLENTS P03A ECTOPARASITICIDES, INCL. SCABICIDES P03AC Pyrethrines, incl. synthetic compounds P03AC04 Permethrin (C) 160090 g P03AX Other ectoparasiticides, incl. scabicides P03AX01 Benzyl benzoate (C) 284790 g R RESPIRATORY SYSTEM 96,3499 R01 NASAL PREPARATIONS 39,0823 DECONGESTANTS AND OTHER NASAL PREPARATIONS R01A 36,7791 FOR TOPICAL USE R01AA Sympathomimetics, plain 23,3489 R01AA05 Oxymetazoline (N) 265,2525 g 0,4 mg 1,3660 R01AA07 Xylometazoline (N) 8537,2875 g 0,8 mg 21,9829 R01AB Sympathomimetics, combinations excl. corticosteroids 3,6750 R01AB83 Xylometazoline+Ipratropium bromide (N) 223180 ml 0,8 ml 0,5747 R01AB85 Xylometazoline+Dexpanthenol (N) 1204030 ml 0,8 ml 3,1003 R01AC Antiallergic agents, excl. corticosteroids 0,3890 R01AC03 Azelastine (N) 105,76 g 0,56 mg 0,3890 R01AD Corticosteroids 9,3661 R01AD01 Beclometasone (N) 5,21 g 0,4 mg 0,0268 R01AD05 Budesonide (N) 34,2561 g 0,2 mg 0,3528 R01AD08 Fluticasone (N) 89,718 g 0,2 mg 0,9241 R01AD09 Mometasone (N) 407,652 g 0,2 mg 4,1987 R01AD12 Fluticasone furoate (N) 177,1605 g 0,11 mg 3,3176 R01AD81 Fluticasone+Azelastine (N) 1060320 doses 4 doses 0,5461 R01AX Other nasal preparations R01AX06 Mupirocin (N) 24 g R01AX83 Retinol+Tocopherol (N) 146040 ml R01B NASAL DECONGESTANTS FOR SYSTEMIC USE 2,3033 R01BA Sympathomimetics 2,3033 R01BA02 Pseudoephedrine (O) 156945,12 g 0,24 g 1,3471 R01BA81 Pseudoephedrine+Triprolidine (O) 29880,12 g 0,24 g 0,2565 R01BA84 Pseudoephedrine+Guaifenesin (O) 9267,6 g 0,24 g 0,0795 R01BA89 Pseudoephedrine+Loratadine (O) 11276,16 g 0,24 g 0,0968 R01BA93 Pseudoephedrine+Cetirizine (O) 60980,64 g 0,24 g 0,5234 R02 THROAT PREPARATIONS 2,6112 R02A THROAT PREPARATIONS 2,6112 R02AA Antiseptics 2,1806 R02AA06 Cetylpyridinium chloride (O) 1386 pieces R02AA82 Benzydamine+Cetylpyridinium chloride (O) 818940 ml R02AA82 Benzydamine+Cetylpyridinium chloride (O) 2041936 pieces 6 pieces 0,7010 R02AA89 Povidone, iodinated+Allantoin (O) 328650 ml R02AA92 Dequalinium+Cinchocaine (O) 1075380 pieces 6 pieces 0,3692 R02AA94 Amylmetacresol+Dichlorobenzyl alcohol (O) 1252416 pieces 6 pieces 0,4300 R02AA95 Amylmetacresol+Dichlorobenzyl alcohol+Levomenthol (O) 1153632 pieces 6 pieces 0,3961 R02AA96 Amylmetacresol+Dichlorobenzyl alcohol+Ascorbic acid (O) 828120 pieces 6 pieces 0,2843 R02AA98 Cetylpyridinium chloride+Benzocaine (O) 18 pieces 6 pieces <0,0001 R02AD Anesthetics, local 0,0227 R02AD80 Lidocaine+Propyl parahydroxybenzoate (O) 65980 pieces 6 pieces 0,0227 R02AX Other throat preparations 0,4080 35/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day R02AX01 Flurbiprofen (O) 8713,74 g 44 mg 0,4080 R02AX80 Thyme herb+Sage leaf (O) 23880 ml R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES 27,5760 R03A ADRENERGICS, INHALANTS 20,0939 R03AC Selective beta-2-adrenoceptor agonists 3,5904 R03AC02 Salbutamol (I) 935,452 g 0,8 mg 2,4087 R03AC02 Salbutamol (I) 1367,6 g 0,01 g 0,2817 R03AC04 Fenoterol (I) 56,8 g 0,6 mg 0,1950 R03AC12 Salmeterol (I) 3,717 g 0,1 mg 0,0766 R03AC13 Formoterol (I) 4,3448 g 0,024 mg 0,3729 R03AC18 Indacaterol (I) 18,5985 g 0,15 mg 0,2554 Adrenergics in combination with corticosteroids or other drugs, R03AK 12,5187 excl. anticholinergics R03AK06 Salmeterol+Fluticasone (I) 518280 doses 4 doses 0,2669 R03AK06 Salmeterol+Fluticasone (I) 2082420 doses 2 doses 2,1448 R03AK07 Formoterol+Budesonide (I) 1066080 doses 2 doses 1,0980 R03AK07 Formoterol+Budesonide (I) 6442020 doses 4 doses 3,3176 R03AK08 Formoterol+Beclometasone (I) 3817980 doses 4 doses 1,9662 R03AK10 Vilanterol+Fluticasone furoate (I) 1758090 doses 1 doses 3,6216 R03AK13 Salbutamol+Beclometasone (I) 201200 doses 4 doses 0,1036 Adrenergics in combinations with anticholinergics incl. triple R03AL 3,9848 combinations with corticosteroids R03AL01 Fenoterol+Ipratropium bromide (I) 221780 ml 16 ml 0,0286 R03AL01 Fenoterol+Ipratropium bromide (I) 2585200 doses 6 doses 0,8876 R03AL03 Vilanterol+Umeclidinium (I) 402690 doses 1 doses 0,8295 R03AL04 Indacaterol+Glycopyrronium (I) 160260 doses 1 doses 0,3301 R03AL05 Formoterol+Aclidinium (I) 366540 doses 2 doses 0,3775 R03AL06 Olodaterol+Tiotropium (I) 646380 doses 2 doses 0,6658 R03AL07 Formoterol+Glycopyrronium (I) 279960 doses 4 doses 0,1442 R03AL08 Vilanterol+Umeclidinium+Fluticasone furoate (I) 103800 doses 1 doses 0,2138 R03AL09 Formoterol+Glycopyrronium+Beclometasone (I) 912720 doses 4 doses 0,4700 R03AL11 Formoterol+Glycopyrronium+Budesonide (I) 73320 doses 4 doses 0,0378 OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, R03B 4,6161 INHALANTS R03BA Glucocorticoids 1,5513 R03BA01 Beclometasone (I) 0,1 g 1,5 mg 0,0001 R03BA02 Budesonide (I) 210,3 g 1,5 mg 0,2888 R03BA02 Budesonide (I) 278,972 g 0,8 mg 0,7183 R03BA05 Fluticasone (I) 158,457 g 0,6 mg 0,5440 R03BB Anticholinergics 3,0648 R03BB01 Ipratropium bromide (I) 19,66 g 0,12 mg 0,3375 R03BB01 Ipratropium bromide (I) 33,105 g 0,3 mg 0,2273 R03BB04 Tiotropium (I) 3,2122 g 0,005 mg 1,3234 R03BB05 Aclidinium (I) 126,5074 g 0,644 mg 0,4047 R03BB06 Glycopyrronium (I) 7,2362 g 44 mcg 0,3388 R03BB07 Umeclidinium (I) 11,5649 g 55 mcg 0,4331 R03C ADRENERGICS FOR SYSTEMIC USE 0,0980 R03CC Selective beta-2-adrenoceptor agonists 0,0980 R03CC02 Salbutamol (O) 570,96 g 0,012 g 0,0980 R03CC02 Salbutamol (P) 0,095 g 0,012 g <0,0001 OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY R03D 2,7680 DISEASES R03DA Xanthines 1,0798 R03DA04 Theophylline (O) 206480 g 0,4 g 1,0633 R03DA05 Aminophylline (P) 4796,7 g 0,6 g 0,0165 R03DC Leukotriene receptor antagonists 1,5992 R03DC03 Montelukast (O) 7763,308 g 0,01 g 1,5992 R03DX Other systemic drugs for obstructive airway diseases 0,0890 R03DX05 Omalizumab (P) 209,7 g 0,016 g 0,0270 R03DX07 Roflumilast (O) 0,095 g 0,5 mg 0,0004 R03DX09 Mepolizumab (P) 68 g 3,6 mg 0,0389 R03DX10 Benralizumab (P) 5,94 g 0,54 mg 0,0227 36/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day R05 COUGH AND COLD PREPARATIONS 7,4035 EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH R05C 7,2390 SUPPRESSANTS R05CA Expectorants 0,0077 R05CA03 Guaifenesin (O) 3360 g 0,9 g 0,0077 R05CA12 Hederae helicis folium (O) 166632 pieces R05CA12 Hederae helicis folium (O) 7406965 ml R05CA86 Iceland moss (O) 6530550 ml Distillate of rectified essential oils of eucalyptus, sweet orange, R05CA87 2019220 pieces myrtle and lemon (O) R05CA88 Thyme herb+Wild thyme+Plantain (O) 525900 ml R05CA89 Thyme herb+Hederae helicis folium (O) 387600 ml R05CA91 Thyme herb+Marshmallow root (O) 210420 pieces R05CA91 Thyme herb+Marshmallow root (O) 4960050 ml R05CA92 Thyme herb (O) 138520 pieces R05CB Mucolytics 7,2313 R05CB01 Acetylcysteine (I, P) 1077 g R05CB01 Acetylcysteine (O) 1107653,2 g 0,5 g 4,5634 R05CB01 Acetylcysteine (P) 5892 g R05CB02 Bromhexine (O) 6919,84 g 0,024 g 0,5939 R05CB03 Carbocisteine (O) 176156,25 g 1,5 g 0,2419 R05CB06 Ambroxol (O) 105584,85 g 0,12 g 1,8125 R05CB13 Dornase alfa (I) 23,715 g 2,5 mg 0,0195 COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH R05D 0,0901 EXPECTORANTS R05DB Other cough suppressants 0,0901 R05DB09 Oxeladin (O) 3498,25 g 0,08 g 0,0901 COUGH SUPPRESSANTS AND EXPECTORANTS, R05F 0,0744 COMBINATIONS R05FA Opium derivatives and expectorants 0,0744 R05FA80 Codeine+Guaifenesin (O) 1083750 ml 30 ml 0,0744 R05X OTHER COLDPREPARATIONS R05XA Other cold combination preparations Gentian root+Primula flower+Common sorrel+Elder R05XA80 1700780 pieces flower+Verbena herb (O) Gentian root+Primula flower+Common sorrel+Elder R05XA80 2129200 ml flower+Verbena herb (O) R05XA82 Ibuprofen+Pseudoephedrine (O) 5508 g R06 ANTIHISTAMINES FOR SYSTEMIC USE 19,6762 R06A ANTIHISTAMINES FOR SYSTEMIC USE 19,6762 R06AA Aminoalkyl ethers 0,4448 R06AA02 Diphenhydramine (O) 10 g 0,2 g 0,0001 R06AA02 Diphenhydramine (P) 12 g R06AA04 Clemastine (O) 387,38 g 0,002 g 0,3990 R06AA04 Clemastine (P) 44,34 g 0,002 g 0,0457 R06AD Phenothiazine derivatives 0,0002 R06AD02 Promethazine (O) 2 g 0,025 g 0,0002 R06AE Piperazine derivatives 9,8576 R06AE07 Cetirizine (O) 45436,995 g 0,01 g 9,3598 R06AE09 Levocetirizine (O) 1208,33 g 0,005 g 0,4978 R06AX Other antihistamines for systemic use 9,3737 R06AX13 Loratadine (O) 19838,1 g 0,01 g 4,0865 R06AX15 Mebhydrolin (O) 29 g 0,2 g 0,0003 R06AX17 Ketotifen (O) 3,69 g 0,002 g 0,0038 R06AX22 Ebastine (O) 7135 g 0,01 g 1,4698 R06AX27 Desloratadine (O) 2682,32 g 0,005 g 1,1051 R06AX28 Rupatadine (O) 890,48 g 0,01 g 0,1834 R06AX29 Bilastine (O) 24513,2 g 20 mg 2,5248 R07 OTHER RESPIRATORY SYSTEM PRODUCTS 0,0006 R07A OTHER RESPIRATORY SYSTEM PRODUCTS 0,0006 R07AA Lung surfactants 0,0005 R07AA81 Porcine lung phospholipids (endotrach) 39,84 g 0,16 g 0,0005 37/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day R07AX Other respiratory system products 0,0001 R07AX02 ivacaftor (O) 16,8 g 0,3 g 0,0001 R07AX32 Ivacaftor+Tezacaftor+Elexacaftor (O) 42 g S SENSORY ORGANS 36,0108 S01 OPHTHALMOLOGICALS 36,0108 S01A ANTIINFECTIVES S01AA Antibiotics S01AA01 Chloramphenicol (S) 138030 ml S01AA12 Tobramycin (S) 30315 ml S01AA12 Tobramycin (S) 51618 g S01AA13 Fusidic acid (S) 32070 g S01AD Antivirals S01AD03 Aciclovir (S) 3514,5 g S01AE Fluoroquinolones S01AE03 Ciprofloxacin (S) 8,07 g S01AE03 Ciprofloxacin (S) 10885 ml S01AE05 Levofloxacin (S) 32000 ml S01AE07 Moxifloxacin (S) 13950 ml S01AX Other antiinfectives S01AX18 Povidone, iodinated (S) 280 ml S01B ANTIINFLAMMATORY AGENTS S01BA Corticosteroids, plain S01BA01 Dexamethasone (S) 220 pieces S01BA01 Dexamethasone (S) 16254,7 g S01BA01 Dexamethasone (S) 148315 ml S01BA02 Hydrocortisone (S) 3978 g S01BA09 Clobetasone (S) 30820 ml S01BA14 Loteprednol (S) 9785 ml S01BC Antiinflammatory agents, non-steroids S01BC03 Diclofenac (S) 15 ml S01BC05 Ketorolac (S) 5000 ml S01BC10 Nepafenac (S) 21955 ml S01BC11 Bromfenac (S) 12375 ml ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN S01C COMBINATION S01CA Corticosteroids and antiinfectives in combination S01CA80 Dexamethasone+Neomycin+Polymyxin B (S) 49635 ml S01CA81 Dexamethasone+Tobramycin (S) 16030 g S01CA81 Dexamethasone+Tobramycin (S) 41225 ml S01CA82 Dexamethasone+Chloramphenicol (S) 51642,5 g S01CA82 Dexamethasone+Chloramphenicol (S) 447920 ml S01CA84 Dexamethasone+Levofloxacin (S) 865 ml S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS 36,0108 S01EA Sympathomimetics in glaucoma therapy 0,0261 S01EA05 Brimonidine (S) 2530 ml 0,2 ml 0,0261 S01EB Parasympathomimetics 0,0177 S01EB01 Pilocarpine (S) 2670 ml 0,4 ml 0,0138 S01EB02 Carbachol (S) 768 ml 0,4 ml 0,0040 S01EB09 Acetylcholine chloride (S) 0,2 g S01EC Carbonic anhydrase inhibitors 3,7834 S01EC01 Acetazolamide (O) 25870 g 0,75 g 0,0711 S01EC01 Acetazolamide (P) 25 g 0,75 g 0,0001 S01EC03 Dorzolamide (S) 154225 ml 0,3 ml 1,0590 S01EC04 Brinzolamide (S) 152685 ml 0,2 ml 1,5726 S01EC80 Brinzolamide+Brimonidine (S) 104925 ml 0,2 ml 1,0807 S01ED Beta blocking agents 24,3791 S01ED01 Timolol (S) 24270 ml 0,2 ml 0,2500 S01ED01 Timolol (S) 245445 g 40 mg 12,6401 S01ED02 Betaxolol (S) 76575 ml 0,2 ml 0,7887 S01ED80 Timolol+Dorzolamide (S) 301550 ml 0,2 ml 3,1059 S01ED81 Timolol+Travoprost (S) 39262,5 ml 0,2 ml 0,4044 S01ED82 Timolol+Bimatoprost (S) 107109 ml 0,2 ml 1,1032 38/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day S01ED83 Timolol+Brinzolamide (S) 227515 ml 0,2 ml 2,3433 S01ED84 Timolol+Latanoprost (S) 73820 ml 0,2 ml 0,7603 S01ED85 Timolol+Tafluprost (S) 289638 ml 0,2 ml 2,9832 S01EE Prostaglandin analogues 7,8045 S01EE01 Latanoprost (S) 263740 ml 0,1 ml 5,4329 S01EE03 Bimatoprost (S) 261 ml 0,1 ml 0,0054 S01EE04 Travoprost (S) 56862,5 ml 0,1 ml 1,1713 S01EE05 Tafluprost (S) 174024 ml 0,3 ml 1,1949 S01F MYDRIATICS AND CYCLOPLEGICS S01FA Anticholinergics S01FA01 Atropine (S) 615 ml S01FA04 Cyclopentolate (S) 30800 ml S01FA06 Tropicamide (S) 16630 ml S01FA80 Tropicamide+Phenylephrine+Lidocaine (int.cam) 1480 pieces S01FB Sympathomimetics excl. antiglaucoma preparations S01FB01 Phenylephrine (S) 7735 ml S01G DECONGESTANTS AND ANTIALLERGICS S01GA Sympathomimetics used as decongestants S01GA02 Tetryzoline (S) 276225 ml S01GX Other antiallergics S01GX01 Cromoglicic acid (S) 110210 ml S01GX07 Azelastine (S) 49782 ml S01GX09 Olopatadine (S) 49955 ml S01H LOCAL ANESTHETICS S01HA Local anesthetics S01HA03 Tetracaine (S) 24780 ml S01HA04 Proxymetacaine (S) 37875 ml S01J DIAGNOSTIC AGENTS S01JA Colouring agents S01JA01 Fluorescein (P) 362 g S01JA01 Fluorescein (P) 2820 ml S01JA81 Fluorescein+Oxybuprocaine+Chlorobutanol (S) 2525 ml S01K SURGICAL AIDS S01KA Viscoelastic substances S01KA02 Hypromellose (S) 5940 ml S01L OCULAR VASCULAR DISORDER AGENTS S01LA Antineovascularisation agents S01LA01 Verteporfin (P) 3 pieces S01LA05 aflibercept (S) 205 pieces S01LA06 Brolucizumab (S) 0,516 g S01X OTHER OPHTHALMOLOGICALS S01XA Other ophthalmologicals S01XA03 Sodium chloride (S) 1151,5 g S01XA18 Ciclosporin (S) 14535 ml S01XA80 Retinol+Dexpanthenol (S) 6041 g S01XA81 Carbomer (S) 188900 g S01XA82 Hypromellose (S) 223620 ml S01XA85 Hypromellose+Dextran (S) 410355 ml S01XA86 cytochrome C+Adenosine+Nicotinamide (S) 90 ml S02 OTOLOGICALS CORTICOSTEROIDS AND ANTIINFECTIVES IN S02C COMBINATION S02CA Corticosteroids and antiinfectives in combination S02CA81 Dexamethasone+Neomycin+Acetic acid, glacial (A) 4210 ml S02CA82 Hydrocortisone+Ciprofloxacin (A) 143170 ml S02D OTHER OTOLOGICALS S02DA Analgesics and anesthetics S02DA81 Phenazone+Lidocaine (A) 1875 ml T HERBAL MEDICINAL PRODUCTS T01 HERBAL MEDICINAL PRODUCTS T01R HERBAL MEDICINAL PRODUCTS T01RS Herbal medicinal products 39/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day T01RS01 herbal preparation (O) 505900 pieces T01RS01 herbal preparation (O) 8862890 ml T01RS02 homeopathic preparations (A) 5420 ml T01RS02 homeopathic preparations (C) 617000 g T01RS02 homeopathic preparations (O) 1940 g T01RS02 homeopathic preparations (O) 1326010 pieces T01RS02 homeopathic preparations (O) 1683700 ml V VARIOUS 0,2127 V01 ALLERGENS V01A ALLERGENS V01AA Allergen extracts V01AA02 Grass pollen (O) 226 pieces V01AA02 Grass pollen (P) 225 pieces V01AA03 House dust mites (O) 253 pieces V01AA03 House dust mites (P) 30 ml V01AA03 House dust mites (P) 268 pieces V01AA05 Tree pollen (P) 482 pieces V01AA05 Tree pollen (SL) 463 pieces V01AA07 Allergen products (insects) (P) 330 pieces V01AA11 Animals (O) 34 pieces V01AA80 Tree and grass pollen (O) 159 pieces V01AA80 Tree and grass pollen (P) 40 pieces V01AA83 Grass pollen+Flowers (O) 18 pieces V01AA84 Tree and flower pollen (O) 18 pieces V03 ALL OTHER THERAPEUTIC PRODUCTS 0,2127 V03A ALL OTHER THERAPEUTIC PRODUCTS 0,2127 V03AB Antidotes V03AB04 Pralidoxime (O, P) 120 g V03AB06 Sodium thiosulphate (P) 1200 g V03AB09 Dimercaprol (P) 4,8 g V03AB14 Protamine sulfate (P) 214,5 g V03AB15 Naloxone (N) 3,6 g V03AB15 Naloxone (P) 1,172 g V03AB16 Ethanol (P) 23400 ml V03AB17 Methylthioninium chloride (P) 193,6 g V03AB19 Physostigmine (P) 0,15 g V03AB21 Potassium iodide (O) 78 g V03AB25 Flumazenil (P) 0,3 g V03AB32 Glutathione (P) 630 g V03AB33 Hydroxocobalamin (P) 110 g V03AB34 Fomepizole (P) 20,5 g V03AB35 Sugammadex (P) 102 g V03AB37 Idarucizumab (P) 115 g V03AB81 Obidoxime chloride+Atropine (P) 100 pieces V03AC Iron chelating agents V03AC01 Deferoxamine (P) 60 g V03AC02 Deferiprone (O) 900 g V03AC03 Deferasirox (O) 6285,6 g V03AE Drugs for treatment of hyperkalemia and hyperphosphatemia 0,1558 V03AE01 Polystyrene sulfonate (O, R) 1774155,5 g 45 g 0,0812 V03AE02 Sevelamer (O) 185904 g 6,4 g 0,0598 V03AE03 Lanthan (O) 16132,5 g 2,25 g 0,0148 V03AF Detoxifying agents for antineoplastic treatment 0,0569 V03AF01 Mesna (P) 5268 g V03AF03 Calcium folinate (O) 38,25 g 0,06 g 0,0013 V03AF07 Rasburicase (P) 0,585 g 0,014 g 0,0001 V03AF09 Glucarpidase (P) 8000 U V03AF10 Sodium levofolinate (P) 808,5 g 0,03 g 0,0555 V03AH Drugs for treatment of hypoglycemia V03AH01 Diazoxide (O) 10 g V03AN Medical gases V03AN01 Oxygen (I) 756792000 ml 40/41  Estonian Statistics on Medicines 2021 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day V03AN05 Air, medicinal (I) 4830000 ml V04 DIAGNOSTIC AGENTS V04C OTHER DIAGNOSTIC AGENTS V04CD Tests for pituitary function V04CD04 Corticorelin (P) 0,0014 g V04CF Tuberculosis diagnostics V04CF01 Tuberculin (P) 4800 U V04CJ Tests for thyreoidea function V04CJ02 Protirelin (P) 0,001 g V04CX Other diagnostic agents V04CX01 Indocyanine green (P) 8,4 g V04CX03 Methacholine (I) 37,53 g V04CX04 Mannitol (I) 72,39 g V04CX06 Hexaminolevulinate (P) 20,06 g V04CX87 Carbon monoxide+Helium (I) 20000 ml V07 ALL OTHER NON-THERAPEUTIC PRODUCTS V07A ALL OTHER NON-THERAPEUTIC PRODUCTS V07AB Solvents and diluting agents, incl. irrigating solutions V07AB80 Sodium chloride (P) 9680052 ml V07AB83 Water for injection (NA) 38910000 ml V07AB83 Water for injection (P) 2400000 ml V08 CONTRAST MEDIA V08A X-RAY CONTRAST MEDIA, IODINATED V08AA Watersoluble, nephrotropic, high osmolar X-ray contrast media V08AA01 Sodium amidotrizoate+Meglumine Amidotrizoate (P) 4000 ml V08AB Watersoluble, nephrotropic, low osmolar X-ray contrast media V08AB02 Iohexol (P) 1907365,5 g V08AB05 Iopromide (P) 1133405 g V08AB09 Iodixanol (P) 2838794 g V08AD Non-watersoluble X-ray contrast media V08AD01 Ethyl esters of iodised fatty acids (P) 72 g V08B X-RAY CONTRAST MEDIA, NON-IODINATED V08BA Barium sulfate containing X-ray contrast media V08BA01 Barium sulfate (O) 134091,92 g V08C MAGNETIC RESONANCE IMAGING CONTRAST MEDIA V08CA Paramagnetic contrast media V08CA01 Gadopentetic acid (P) 3120 ml V08CA02 Gadoteric acid (P) 61550 ml V08CA09 Gadobutrol (P) 90085 ml V08CA10 Gadoxetic acid (P) 5800 ml V08D ULTRASOUND CONTRAST MEDIA V08DA Ultrasound contrast media V08DA05 Sulfur hexafluoride, phospholipid microspheres (P) 150 ml V09 DIAGNOSTIC RADIOPHARMACEUTICALS V09A CENTRAL NERVOUS SYSTEM V09AB Iodine (123I) compounds V09AB03 Ioflupane (123I) (P) 480 ml V09F THYROID V09FX Various thyroid diagnostic radiopharmaceuticals V09FX01 Technetium (99mTc) pertechnetate (S) 80 pieces V10 THERAPEUTIC RADIOPHARMACEUTICALS V10X OTHER THERAPEUTIC RADIOPHARMACEUTICALS V10XA Iodine (131I) compounds V10XA01 Sodium iodide (131I) (O) 86 pieces 41/41 Saatja: "Janne Sepp" <[email protected]> Saaja: [email protected] Teema: Vs: OECD Health Statistic Inquiry Kuupäev: 2025-01-14 10:08 Dear Sophie, Thank you for the feedback. Please find attached the files for 2019-2022, but please be informed that these are compiled using the ATC codes that were valid at that time. We can provide this data to you also in one dataset and using the currently valid ATC codes (2025). 2024 data will be available by the end of February. Kind regards, Janne Sepp State Agency of Medicines Department of Post-Authorisation Safety Bureau of Drug Statistics Specialist Phone: +372 737 4140 <mailto:[email protected]> [email protected] Nooruse 1, 50411 Tartu, Estonia www.ravimiamet.ee This e-mail and any attachments transmitted may contain confidential and privileged information. If you are not the intended recipient, please notify the sender immediately by returning the e-mail and permanently deleting what you have recieved. Any dissemination or use of this information by a third person without permission is prohibited and may be illegaal. Saatja: [email protected] <[email protected]> Saatmisaeg: esmaspäev, 6. jaanuar 2025 13:24 Adressaat: Janne Sepp <[email protected]> Teema: RE: OECD Health Statistic Inquiry Tähelepanu! Tegemist on väljastpoolt asutust saabunud kirjaga. Tundmatu saatja korral palume linke ja faile mitte avada. Hi Janne, Hope you had a wonderful holiday season! Many thanks for your guidance on this matter, it is very helpful. I was wondering if it would be possible to receive similar reports to “DDD 2023 ENG.pdf” for previous years so we are able to create a time series? I wish you a wonderful start to the new year! Best, Sophie Restricted Use - À usage restreint From: Janne Sepp <[email protected] <mailto:[email protected]> > Sent: Monday, December 9, 2024 9:54 AM To: WANG Sophie, ELS/HD <[email protected] <mailto:[email protected]> > Subject: Vs: OECD Health Statistic Inquiry Dear Sophie, Thank you for your e-mail and apologizes for the delay in answering. In Estonia the consumption of ATC N01 group (anesthetics) is collected at the national level (wholesale data). You can find a more detailed information on our website: https://ravimiamet.ee/en/statistics/statistics-medicines On the same page there is a data table (named “DDD 2023 ENG.pdf”) on active substance level, covering also N01 units: https://ravimiamet.ee/sites/default/files/documents/2024-04/DDD%202023%20E NG.pdf Kind regards, Janne Sepp State Agency of Medicines Department of Post-Authorisation Safety Bureau of Drug Statistics Specialist Phone: +372 737 4140 <mailto:[email protected]> [email protected] Nooruse 1, 50411 Tartu, Estonia <http://www.ravimiamet.ee/> www.ravimiamet.ee This e-mail and any attachments transmitted may contain confidential and privileged information. If you are not the intended recipient, please notify the sender immediately by returning the e-mail and permanently deleting what you have recieved. Any dissemination or use of this information by a third person without permission is prohibited and may be illegaal. Restricted Use - À usage restreint From: [email protected] <mailto:[email protected]> <[email protected] <mailto:[email protected]> > Sent: esmaspäev, 25. november 2024 10:59 To: Ravimiamet <[email protected] <mailto:[email protected]> > Subject: OECD Health Statistic Inquiry Tähelepanu! Tegemist on väljastpoolt asutust saabunud kirjaga. Tundmatu saatja korral palume linke ja faile mitte avada. Hello, Pleased to e-meet you. I am from OECD Health working on climate and health issues. I am quite interested in the database of medicine statistics provided here: PxWeb - Select table <https://statistika.tai.ee/pxweb/en/Andmebaas/Andmebaas__06Ravimistatistik a__01Ravimistatistika/?tablelist=true> . We are currently in the process of looking at anesthetic gas volumes consumed in countries and wanted to inquire about whether if consumption of ATC N01 group (anesthetics) is collected at the national level? And if so, at what unit is this data collected? Many thanks, Sophie Sophie Wang, PhD Health Policy Researcher, Health Division Directorate for Employment, Labour, and Social Affairs 2, rue André Pascal – 75775 Paris Cedex 16 [email protected] <mailto:[email protected]> | Tel: +33 1 85 55 49 44 This communication is intended only for the use of the individual or entity to whom it is addressed and others authorised by the sender to receive it. Any unauthorised disclosure, use, or publication of this information is not allowed. If you have received this communication in error, please notify the sender immediately and delete it from your system. Cette communication est uniquement destinée à la personne ou à l’entité à laquelle elle est adressée et à d’autres autorisées par l’émetteur à la recevoir. Aucune divulgation, utilisation ou publication de ces informations n’est autorisée. Si vous avez reçu cette communication par erreur, veuillez en notifier l’émetteur immédiatement et la détruire de votre système. Restricted Use - À usage restreint This communication is intended only for the use of the individual or entity to whom it is addressed and others authorised by the sender to receive it. Any unauthorised disclosure, use, or publication of this information is not allowed. If you have received this communication in error, please notify the sender immediately and delete it from your system. Cette communication est uniquement destinée à la personne ou à l’entité à laquelle elle est adressée et à d’autres autorisées par l’émetteur à la recevoir. Aucune divulgation, utilisation ou publication de ces informations n’est autorisée. Si vous avez reçu cette communication par erreur, veuillez en notifier l’émetteur immédiatement et la détruire de votre système. Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A ALIMENTARY TRACT AND METABOLISM 195,7240 A01 STOMATOLOGICAL PREPARATIONS 0,0712 A01A STOMATOLOGICAL PREPARATIONS 0,0712 A01AA Caries prophylactic agents A01AA01 Sodium fluoride (dental) 1 pieces A01AB Antiinfectives and antiseptics for local oral treatment 0,0712 A01AB09 Miconazole (O) 6921,6 g 0,2 g 0,0712 A01AB12 Hexetidine (O) 631960 ml A01AB82 Demeclocycline+ Triamcinolone (dental) 415 g A01AD Other agents for local oral treatment A01AD80 Lidocaine+ Cetylpyridinium chloride (gingival) 220680 g A01AD81 Lidocaine+ Cetrimide (O) 67725 g A01AD82 Choline salicylate (O) 648896 pieces A01AD83 Lidocaine+ Chamomillae extractum (O) 379450 g A02 DRUGS FOR ACID RELATED DISORDERS 66,8968 A02A ANTACIDS 1,3880 Combinations and complexes of aluminium, calcium and A02AD 1,3880 magnesium compounds A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 2198600 pieces 10 pieces 0,4522 A02AD81 Aluminium hydroxide+ Magnesium hydroxide (O) 5200710 ml 50 ml 0,2139 A02AD83 Calcium carbonate+ Magnesium carbonate (O) 3509592 pieces 10 pieces 0,7219 DRUGS FOR PEPTIC ULCER AND GASTRO- A02B 65,5087 OESOPHAGEAL REFLUX DISEASE (GORD) A02BA H2-receptor antagonists 0,0104 A02BA02 Ranitidine (P) 3,25 g 0,3 g <0,0001 A02BA03 Famotidine (O) 201,6 g 0,04 g 0,0104 A02BC Proton pump inhibitors 65,4802 A02BC01 Omeprazole (O) 313399,56 g 0,02 g 32,2308 A02BC02 Pantoprazole (O) 343352,52 g 0,04 g 17,6556 A02BC02 Pantoprazole (P) 12 g 0,04 g 0,0006 A02BC03 Lansoprazole (O) 15,12 g 0,03 g 0,0010 A02BC05 Esomeprazole (O) 219529,8 g 0,03 g 15,0513 A02BC05 Esomeprazole (P) 7887,6 g 0,03 g 0,5408 A02BC08 Vonoprazan (O) 2 g A02BD Combinations for eradication of Helicobacter pylori 0,0031 A02BD08 Bismuth subcitrate+ Tetracycline+ Metronidazole (O) 18000 pieces 12 pieces 0,0031 Other drugs for peptic ulcer and gastro-oesophageal A02BX 0,0151 reflux disease (GORD) A02BX02 Sucralfate (O) 29220 g 4 g 0,0150 A02BX05 Bismuth subcitrate (O) 6 g 0,48 g <0,0001 DRUGS FOR FUNCTIONAL GASTROINTESTINAL A03 9,1480 DISORDERS DRUGS FOR FUNCTIONAL GASTROINTESTINAL A03A 8,1562 DISORDERS Synthetic anticholinergics, esters with tertiary amino A03AA 1,4403 group A03AA04 Mebeverine (O) 210078 g 0,3 g 1,4403 Synthetic anticholinergics, quaternary ammonium A03AB 0,0002 compounds A03AB02 Glycopyrronium (P) 0,028 g 0,3 mg 0,0002 A03AD Papaverine and derivatives 5,0731 A03AD01 Papaverine hydrochloride (P) 66,4 g 0,1 g 0,0014 A03AD02 Drotaverine (O) 243003,84 g 0,1 g 4,9982 A03AD02 Drotaverine (P) 3575 g 0,1 g 0,0735 A03AX Other drugs for functional gastrointestinal disorders 1,6426 A03AX13 Simeticone (O) 399293,125 g 0,5 g 1,6426 A03B BELLADONNA AND DERIVATIVES, PLAIN 0,0856 A03BA Belladonna alkaloids, tertiary amines 0,0739 1/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A03BA01 Atropine (O, P) 9,76 g 0,0015 g 0,0134 A03BA01 Atropine (P) 44,11 g 0,0015 g 0,0605 Belladonna alkaloids, semisynthetic, quaternary A03BB 0,0118 ammonium compounds A03BB01 Hyoscine butylbromide (O) 8,4 g 0,06 g 0,0003 A03BB01 Hyoscine butylbromide (P) 335 g 0,06 g 0,0115 A03F PROPULSIVES 0,9061 A03FA Propulsives 0,9061 A03FA01 Metoclopramide (O) 11435 g 0,03 g 0,7840 A03FA01 Metoclopramide (P) 1568,4 g 0,03 g 0,1075 A03FA03 Domperidone (O) 212,4 g 0,03 g 0,0146 A04 ANTIEMETICS AND ANTINAUSEANTS 0,1376 A04A ANTIEMETICS AND ANTINAUSEANTS 0,1376 A04AA Serotonin (5-HT3) antagonists 0,1284 A04AA01 Ondansetron (P) 233,36 g 0,016 g 0,0300 A04AA02 Granisetron (O) 67 g 0,002 g 0,0689 A04AA02 Granisetron (P) 39,265 g 0,003 g 0,0269 A04AA80 Palonosetron+ Netupitant (O) 1235 pieces 1 pieces 0,0025 A04AD Other antiemetics 0,0092 A04AD01 Scopolamine (TD) 10 pieces 1 pieces <0,0001 A04AD12 Aprepitant (O) 190,095 g 0,165 g 0,0024 A04AD81 Fosaprepitant (P) 316,65 g 0,095 g 0,0069 A05 BILE AND LIVER THERAPY 1,8146 A05A BILE THERAPY 0,6209 A05AA Bile acids and derivatives 0,6209 A05AA02 Ursodeoxycholic acid (O) 226387,5 g 0,75 g 0,6209 A05B LIVER THERAPY, LIPOTROPICS 1,1937 A05BA Liver therapy 1,1937 A05BA03 Silymarin (O) 1886850 pieces A05BA03 Silymarin (P) 28 g A05BA80 Phospholipids from Soya Beans (O) 1017710 pieces 6 pieces 0,3489 A05BA80 Phospholipids from Soya Beans (O) 1232250 pieces 3 pieces 0,8449 A06 DRUGS FOR CONSTIPATION 17,9700 A06A DRUGS FOR CONSTIPATION 17,9700 A06AB Contact laxatives 7,5544 A06AB02 Bisacodyl (O) 14349,8 g 0,01 g 2,9515 A06AB02 Bisacodyl (R) 166,08 g 0,01 g 0,0342 A06AB06 Sennoside A (O) 460 pieces 1 pieces 0,0009 A06AB08 Sodium picosulfate (O) 11091,3849 g 0,005 g 4,5627 A06AB80 Sodium picosulfate+ Magnesium oxide+ Citric acid (O) 4922 pieces 2 pieces 0,0051 A06AD Osmotically acting laxatives 9,3124 A06AD11 Lactulose (O) 28355286 g 6,7 g 8,7049 A06AD15 Macrogol (O) 2953920 g 10 g 0,6076 Macrogol+ Sodium citrate+ Citric acid+ Sodium chloride+ A06AD80 2400 ml Potassium chloride (O) Sodium sulfate anhydrous+ Potassium chloride+ Sodium A06AD81 35656 pieces chloride+ Macrogol+ Sodium hydrogen carbonate (O) Macrogol+ Sodium sulfate anhydrous+ Sodium chloride+ A06AD83 Potassium chloride+ Ascorbic acid+ Sodium ascorbate 7855 pieces (O) Sodium sulfate anhydrous+ magnesium sulfate A06AD85 790944 ml heptahydrate+ Potassium sulphate (O) A06AG Enemas 1,0533 A06AG11 Sodium lauryl sulfoacetate+ Sorbitol+ Sodium citrate (R) 512116 pieces 1 pieces 1,0533 A06AH Peripheral opioid receptor antagonists 0,0497 A06AH03 Naloxegol (O) 603,75 g 25 mg 0,0497 A06AX Other drugs for constipation 0,0002 A06AX06 Tegaserod (O) 1,08 g 12 mg 0,0002 2/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day ANTIDIARRHEALS, INTESTINAL A07 4,9266 ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS A07A INTESTINAL ANTIINFECTIVES 0,0082 A07AA Antibiotics 0,0082 A07AA02 Nystatin (O) 90000000 U 1500000 U 0,0001 A07AA11 Rifaximin (O) 2200,8 g 0,6 g 0,0075 A07AA12 Fidaxomicin (O) 108 g 0,4 g 0,0006 A07B INTESTINAL ADSORBENTS 0,5120 A07BC Other intestinal adsorbents 0,5120 A07BC05 Diosmectite (O) 2240220 g 9 g 0,5120 A07C ELECTROLYTES WITH CARBOHYDRATES A07CA Oral rehydration salt formulations Sodium chloride+ Potassium chloride+ Sodium citrate+ A07CA80 107820 pieces Glucose (O) A07D ANTIPROPULSIVES 1,0396 A07DA Antipropulsives 1,0396 A07DA03 Loperamide (O) 5054,564 g 0,01 g 1,0396 A07E INTESTINAL ANTIINFLAMMATORY AGENTS 2,5534 A07EA Corticosteroids acting locally 0,0319 A07EA06 Budesonide (O) 139,62 g 0,009 g 0,0319 A07EA06 Budesonide (R) 1,0619 g A07EC Aminosalicylic acid and similar agents 2,5215 A07EC01 Sulfasalazine (O) 749300 g 2 g 0,7706 A07EC02 Mesalazine (O) 1167564 g 1,5 g 1,6010 A07EC02 Mesalazine (R) 109310 g 1,5 g 0,1499 A07F ANTIDIARRHEAL MICROORGANISMS 0,8134 A07FA Antidiarrheal microorganisms 0,8134 A07FA02 Saccharomyces boulardii (O) 395457,5 g 1 g 0,8134 A07X OTHER ANTIDIARRHEALS A07XA Other antidiarrheals A07XA04 Racecadotril (O) 2626 g ANTIOBESITY PREPARATIONS, EXCL. DIET A08 0,0035 PRODUCTS ANTIOBESITY PREPARATIONS, EXCL. DIET A08A 0,0035 PRODUCTS A08AA Centrally acting antiobesity products 0,0031 A08AA62 Bupropion+ Naltrexone (O) 6048 pieces 4 pieces 0,0031 A08AB Peripherally acting antiobesity products 0,0003 A08AB01 Orlistat (O) 60,48 g 0,36 g 0,0003 A09 DIGESTIVES, INCL. ENZYMES 1,8593 A09A DIGESTIVES, INCL. ENZYMES 1,8593 A09AA Enzyme preparations 1,8593 A09AA02 Lipase+ Amylase+ Protease (O) 3615886 pieces 4 pieces 1,8593 A10 DRUGS USED IN DIABETES 73,7920 A10A INSULINS AND ANALOGUES 15,9233 A10AB Insulins and analogues for injection, fast-acting 6,1766 A10AB01 Insulin human rapid-acting (P) 1054500 U 40 U 0,0542 A10AB04 Insulin lispro (P) 18876000 U 40 U 0,9706 A10AB05 Insulin aspart (P) 88759500 U 40 U 4,5641 A10AB06 Insulin glulisine (P) 11427000 U 40 U 0,5876 A10AC Insulins and analogues for injection, intermediate-acting 0,0421 A10AC01 Insulin human intermediate-acting (P) 819000 U 40 U 0,0421 Insulins and analogues for injection, intermediate- or long- A10AD 0,7257 acting combined with fast-acting A10AD04 Insulin lispro (P) 2949000 U 40 U 0,1516 A10AD05 Insulin aspart (P) 7050000 U 40 U 0,3625 A10AD06 Insulin degludec+ Insulin aspart (P) 4114500 U 40 U 0,2116 A10AE Insulins and analogues for injection, long-acting 8,9789 A10AE04 Insulin glargine (P) 89067750 U 40 U 4,5800 A10AE05 Insulin detemir (P) 29962500 U 40 U 1,5407 3/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A10AE06 Insulin degludec (P) 52365300 U 40 U 2,6927 A10AE54 Insulin glargine+ Lixisenatide (P) 3219000 U 40 U 0,1655 BLOOD GLUCOSE LOWERING DRUGS, EXCL. A10B 57,8687 INSULINS A10BA Biguanides 21,2384 A10BA02 Metformin (O) 20651358 g 2 g 21,2384 A10BB Sulfonylureas 10,7837 A10BB01 Glibenclamide (O) 0,054 g 0,01 g <0,0001 A10BB07 Glipizide (O) 650,85 g 0,01 g 0,1339 A10BB08 Gliquidone (O) 16,2 g 0,06 g 0,0006 A10BB09 Gliclazide (O) 179014,2 g 0,06 g 6,1368 A10BB12 Glimepiride (O) 4387,77 g 0,002 g 4,5125 A10BD Combinations of oral blood glucose lowering drugs 8,8691 A10BD07 Metformin+ Sitagliptin (O) 1368640 pieces 2 pieces 1,4075 A10BD08 Metformin+ Vildagliptin (O) 1349640 pieces 2 pieces 1,3880 A10BD10 Metformin+ Saxagliptin (O) 265920 pieces 2 pieces 0,2735 A10BD11 Metformin+ Linagliptin (O) 1351920 pieces 2 pieces 1,3903 A10BD15 Metformin+ Dapagliflozin (O) 1222648 pieces 2 pieces 1,2574 A10BD19 Linagliptin+ Empagliflozin (O) 292170 pieces 1 pieces 0,6010 A10BD20 Metformin+ Empagliflozin (O) 2272560 pieces 2 pieces 2,3372 A10BD21 Saxagliptin+ Dapagliflozin (O) 102928 pieces 1 pieces 0,2117 A10BD23 Metformin+ Ertugliflozin (O) 1232 pieces 1 pieces 0,0025 A10BF Alpha glucosidase inhibitors 0,0001 A10BF01 Acarbose (O) 21 g 0,3 g 0,0001 A10BG Thiazolidinediones 0,1191 A10BG03 Pioglitazone (O) 1737,54 g 0,03 g 0,1191 A10BH Dipeptyl peptidase 4 (DPP-4) inhibitors 4,2405 A10BH01 Sitagliptin (O) 35821,1 g 0,1 g 0,7368 A10BH02 Vildagliptin (O) 7689 g 0,1 g 0,1582 A10BH03 Saxagliptin (O) 448,65 g 5 mg 0,1846 A10BH05 Linagliptin (O) 7684,05 g 5 mg 3,1610 A10BJ Glucagon-like peptide-1 (GLP-1) analogues 7,1421 A10BJ01 Exenatide (P) 2,608 g 0,286 mg 0,0188 A10BJ02 Liraglutide (P) 350,892 g 1,5 mg 0,4812 A10BJ03 Lixisenatide (P) 0,3252 g 20 mcg 0,0334 A10BJ05 Dulaglutide (P) 50,31 g 0,16 mg 0,6468 A10BJ06 Semaglutide (O) 2953,74 g 10,5 mg 0,5786 A10BJ06 Semaglutide (P) 287,9 g 0,11 mg 5,3833 A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors 5,4757 A10BK01 Dapagliflozin (O) 12969,45 g 10 mg 2,6676 A10BK03 empagliflozin (O) 23887,8 g 17,5 mg 2,8076 A10BK04 Ertugliflozin (O) 1,96 g 10 mg 0,0004 A11 VITAMINS 9,3214 A11A MULTIVITAMINS, COMBINATIONS 1,1303 A11AA Multivitamins with minerals 1,1303 A11AA03 Multivitamins+ Mineral elements (O) 549540 pieces 1 pieces 1,1303 VITAMIN A AND D, INCL. COMBINATIONS OF THE A11C 2,1840 TWO A11CA Vitamin A, plain <0,0001 A11CA01 Retinol (P) 1200000 U 50000 U <0,0001 A11CC Vitamin D and analogues 2,1839 A11CC03 Alfacalcidol (O) 0,0003 g 0,001 mg 0,0007 A11CC04 Calcitriol (O) 0,0976 g 0,001 mg 0,2007 A11CC05 Colecalciferol (O) 771100000 U 800 U 1,9825 A11CC05 Colecalciferol (P) 65000000 U VITAMIN B1, PLAIN AND IN COMBINATION WITH A11D 1,5661 VITAMIN B6 AND B12 A11DA Vitamin B1, plain 0,4634 A11DA01 Thiamine (P) 11264 g 0,05 g 0,4634 4/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day A11DA03 Benfotiamine (O) 1759570 pieces Vitamin B1 in combination with vitamin B6 and/or vitamin A11DB 1,1027 B12 A11DB80 Thiamine+ Pyridoxine (P) 5610 pieces 1 pieces 0,0115 A11DB81 Benfotiamine+ Pyridoxine (O) 216930 pieces 3 pieces 0,1487 A11DB84 Thiamine+ Pyridoxine+ Cyanocobalamin (O) 394660 pieces 1 pieces 0,8118 A11DB85 Thiamine+ Pyridoxine+ Cyanocobalamin+ Lidocaine (P) 63530 pieces 1 pieces 0,1307 A11E VITAMIN B-COMPLEX, INCL. COMBINATIONS 0,4422 A11EA Vitamin B-complex, plain 0,4422 Thiamine+ Nicotinamide+ Riboflavin+ Calcium A11EA80 215000 pieces 1 pieces 0,4422 pantothenate+ Pyridoxine (O) Thiamine+ Nicotinamide+ Riboflavin+ Calcium A11EA80 552 pieces pantothenate+ Pyridoxine (P) A11G ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS 0,1701 A11GA Ascorbic acid (vitamin C), plain 0,1701 A11GA01 Ascorbic acid (P) 16535 g 0,2 g 0,1701 A11H OTHER PLAIN VITAMIN PREPARATIONS 0,0554 A11HA Other plain vitamin preparations 0,0554 A11HA02 Pyridoxine (O) 240 g 0,16 g 0,0031 A11HA02 Pyridoxine (P) 3829,5 g 0,16 g 0,0492 A11HA03 Tocopherol (P) 4,5 g 0,2 g <0,0001 A11HA05 Biotin (P) 12 ml A11HA08 Tocofersolan (O) 294 g 0,2 g 0,0030 A11J OTHER VITAMIN PRODUCTS, COMBINATIONS 3,7734 A11JA Combinations of vitamins A11JA80 Combinations of vitamins (O) 600 ml A11JB Vitamins with minerals 3,7734 A11JB81 Pyridoxine+ Magnesium (O) 7338180 pieces 4 pieces 3,7734 A12 MINERAL SUPPLEMENTS 9,0667 A12A CALCIUM 5,4290 A12AA Calcium 0,9629 A12AA03 Calcium gluconate (P) 41340 g 3 g 0,0283 A12AA04 Calcium carbonate (O) 1363050 g 3 g 0,9345 A12AX Calcium, combinations with vitamin D and/or other drugs 4,4661 A12AX80 Calcium+ Colecalciferol (O) 577320 pieces 1 pieces 1,1875 A12AX80 Calcium+ Colecalciferol (O) 3188040 pieces 2 pieces 3,2787 A12B POTASSIUM 3,2030 A12BA Potassium 3,2030 A12BA01 Potassium chloride (O) 405066 g 3 g 0,2777 A12BA02 Potassium citrate (O) 1080 g 4 g 0,0006 A12BA80 Potassium chloride+ Potassium hydrogen carbonate (O) 4500 pieces A12BA81 Potassium aspartate+ Magnesium aspartate (O) 4228100 pieces 3 pieces 2,8989 A12BA81 Potassium aspartate+ Magnesium aspartate (P) 12600 pieces 1 pieces 0,0259 A12C OTHER MINERAL SUPPLEMENTS 0,4346 A12CB Zinc A12CB02 Zinc gluconate (P) 9,061 g A12CC Magnesium 0,4345 A12CC04 Magnesium citrate (O) 422494 g 2 g 0,4345 A12CE Selenium 0,0001 A12CE02 Sodium selenite (P) 0,01 g 0,2 mg 0,0001 A12CX Other mineral products A12CX83 Phosphate (O) 13500 pieces A14 ANABOLIC AGENTS FOR SYSTEMIC USE 0,0044 A14A ANABOLIC STEROIDS 0,0044 A14AB Estren derivatives 0,0044 A14AB01 Nandrolone (P) 4,25 g 0,002 g 0,0044 5/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day OTHER ALIMENTARY TRACT AND METABOLISM A16 0,7120 PRODUCTS OTHER ALIMENTARY TRACT AND METABOLISM A16A 0,7120 PRODUCTS A16AA Amino acids and derivatives 0,0028 A16AA01 Levocarnitine (O) 1800 g 2 g 0,0019 A16AA02 Ademetionine (O) 810 g A16AA05 Carglumic acid (O) 12 g 0,2 g 0,0001 A16AA06 Betaine (O) 2520 g 6 g 0,0009 A16AA81 Glycine (O) 480 g A16AB Enzymes 0,0046 A16AB03 Agalsidase alfa (P) 1,316 g 0,001 g 0,0027 A16AB04 Agalsidase beta (P) 1,755 g 0,005 g 0,0007 A16AB07 Alglucosidase alfa (P) 54,7 g 0,1 g 0,0011 A16AB09 Idursulfase (P) 1,344 g A16AX Various alimentary tract and metabolism products 0,7046 A16AX01 Thioctic acid (O) 201384 g 0,6 g 0,6904 A16AX01 Thioctic acid (P) 375 g 0,6 g 0,0013 A16AX05 Zinc (O) 650 g 0,15 g 0,0089 A16AX06 Miglustat (O) 218,4 g 0,3 g 0,0015 A16AX07 Sapropterin (O) 888 g A16AX10 Eliglustat (O) 206,976 g 0,168 g 0,0025 A16AX80 Creatine (O) 6750 g A16AX81 Copper histidinate (P) 0,19 g B BLOOD AND BLOOD FORMING ORGANS 116,1519 B01 ANTITHROMBOTIC AGENTS 82,2564 B01A ANTITHROMBOTIC AGENTS 82,2564 B01AA Vitamin K antagonists 1,2187 B01AA03 Warfarin (O) 4443,8 g 0,0075 g 1,2187 B01AB Heparin group 3,1306 B01AB01 Heparin sodium (P) 567000000 U 10000 U 0,1166 B01AB05 Enoxaparin sodium (hem, P) 973076000 U 2000 U 1,0007 B01AB05 Enoxaparin sodium (P) 1896468000 U 2000 U 1,9504 B01AB12 Bemiparin sodium (P) 76365000 U 2500 U 0,0628 B01AC Platelet aggregation inhibitors, excl. heparin 51,8484 B01AC04 Clopidogrel (O) 146181,3 g 0,075 g 4,0090 B01AC06 Acetylsalicylic acid (O) 4753972 pieces 1 pieces 9,7782 B01AC09 Epoprostenol (P) 0,005 g B01AC11 Iloprost (I) 0,0084 g 0,15 mg 0,0001 B01AC11 Iloprost (P) 0,0057 g 50 mcg 0,0002 B01AC16 Eptifibatide (P) 68,69 g 0,2 g 0,0007 B01AC21 Treprostinil (P) 7,82 g 0,0043 g 0,0037 B01AC23 Cilostazol (O) 84 g 0,2 g 0,0009 B01AC24 Ticagrelor (O) 102105,36 g 0,18 g 1,1668 Selexipag B01AC27 1,932 g 1,8 mg 0,0022 (O) B01AC80 Acetylsalicylic acid + Magnesium oxide (O) 17933500 pieces 1 pieces 36,8865 B01AD Enzymes 0,0030 B01AD01 Streptokinase (P) 135000000 U 1500000 U 0,0002 B01AD02 Alteplase (P) 116,4 g 0,1 g 0,0024 B01AD11 Tenecteplase (P) 8,11 g 0,04 g 0,0004 B01AE Direct thrombin inhibitors 2,5655 B01AE07 Dabigatran etexilate (O) 374190,6 g 0,3 g 2,5655 B01AF Direct factor Xa inhibitors 23,4886 B01AF01 Rivaroxaban (O) 108453,9088 g 0,02 g 11,1537 B01AF02 Apixaban (O) 51183,75 g 10 mg 10,5277 B01AF03 Edoxaban (O) 52718,4 g 60 mg 1,8072 B01AX Other antithrombotic agents 0,0016 B01AX01 Defibrotide (P) 8 g 1,75 g <0,0001 B01AX05 Fondaparinux sodium (P) 1,925 g 0,0025 g 0,0016 B02 ANTIHEMORRHAGICS 0,2310 6/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day B02A ANTIFIBRINOLYTICS 0,2000 B02AA Amino acids 0,2000 B02AA01 Aminocaproic acid (P) 3430 g 16 g 0,0004 B02AA02 Tranexamic acid (O) 147200 g 2 g 0,1514 B02AA02 Tranexamic acid (P) 46800 g 2 g 0,0481 B02B VITAMIN K AND OTHER HEMOSTATICS 0,0310 B02BA Vitamin K 0,0032 B02BA01 Phytomenadione (O) 0,9 g 0,02 g 0,0001 B02BA01 Phytomenadione (O, P) 3,77 g 0,02 g 0,0004 B02BA01 Phytomenadione (P) 26,51 g 0,02 g 0,0027 B02BB Fibrinogen 0,0002 B02BB01 Fibrinogen human (P) 510 g 5 g 0,0002 B02BC Local hemostatics B02BC81 Fibrinogen human+ Human thrombin (epil) 663 pieces B02BD Blood coagulation factors B02BD01 Human prothrombin complex (P) 247800 U B02BD02 Human coagulation factor VIII (P) 7476000 U B02BD03 Factor VIII inhibitor bypassing fraction (P) 45000 U B02BD04 Human coagulation factor IX (P) 391200 U B02BD05 Human coagulation factor VII (P) 370800 U B02BD06 Von Willebrand factor+ Human coagulation factor VIII (P) 1516000 U B02BD08 Coagulation factor VIIa (P) 77500000 U B02BX Other systemic hemostatics 0,0276 B02BX01 Etamsylate (P) 382,5 g B02BX04 Romiplostim (P) 0,089 g 30 mcg 0,0061 B02BX05 Eltrombopag (O) 394,1 g 50 mg 0,0162 B02BX06 Emicizumab (P) 38,685 g 15 mg 0,0053 B03 ANTIANEMIC PREPARATIONS 33,6611 B03A IRON PREPARATIONS 4,2823 B03AA Iron bivalent, oral preparations 1,9675 B03AA07 Ferrous sulfate (O) 191316 g 0,2 g 1,9675 B03AB Iron trivalent, oral preparations B03AB80 Ferric hydroxide polymaltose complex (O) 86055 g B03AC Iron, parenteral preparations 0,1386 B03AC01 Dextriferron (P) 2845,5 g 0,1 g 0,0585 B03AC02 Iron sucrose (P) 1587,5 g 0,1 g 0,0327 B03AC06 Iron (III)-hydroxide dextran complex (P) 1070,5 g 0,1 g 0,0220 B03AC80 Ferric derisomaltose (P) 1234 g 0,1 g 0,0254 B03AD Iron in combination with folic acid 2,1762 B03AD02 Ferrous fumarate+ Folic acid (O) 580380 pieces 1 pieces 1,1938 B03AD03 Ferrous sulfate+ Folic acid (O) 477650 pieces 1 pieces 0,9825 B03AE Iron in other combinations Ferrous gluconate+ Manganese gluconate+ Copper B03AE81 1510400 ml gluconate (O) B03AE82 Ferrous fumarate+ Folic acid+ Ascorbic acid (O) 75940 pieces B03B VITAMIN B12 AND FOLIC ACID 28,4241 B03BA Vitamin B12 (cyanocobalamin and analogues) 8,2948 B03BA01 Cyanocobalamin (O) 17,15 g 1 mg 0,0353 B03BA01 Cyanocobalamin (P) 78,325 g 0,02 mg 8,0551 B03BA03 Hydroxocobalamin (P) 1,987 g 0,02 mg 0,2043 B03BB Folic acid and derivatives 20,1294 B03BB01 Folic acid (O) 3914,6 g 0,4 mg 20,1294 B03X OTHER ANTIANEMIC PREPARATIONS 0,9546 B03XA Other antianemic preparations 0,9546 B03XA01 Erythropoietin (P) 63663000 U 1000 U 0,1309 B03XA02 Darbepoetin alfa (P) 1,4903 g 0,0045 mg 0,6812 B03XA03 Methoxy polyethylene glycol-epoetin beta (P) 0,2772 g 4 mcg 0,1425 B05 BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS B05A BLOOD AND RELATED PRODUCTS 7/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day B05AA Blood substitutes and plasma protein fractions B05AA01 Albumin (P) 950202,5 g B05AA06 Gelatin (P) 4030000 ml Gelatin (anhydrous)+ Sodium chloride+ Potassium B05AA83 380000 ml chloride+ Magnesium chloride+ Sodium lactate (P) B05AA86 human plasma protein (P) 491600 ml B05B I.V. SOLUTIONS B05BA Solutions for parenteral nutrition B05BA01 Amino acids (P) 761000 ml B05BA02 Fat emulsions (P) 144300 ml B05BA03 Carbohydrates (P) 56765300 ml B05BA10 Combinations (P) 17935741 ml B05BB Solutions affecting the electrolyte balance B05BB01 Electrolytes (P) 301979000 ml B05BB02 Electrolytes+ Carbohydrates (P) 960000 ml B05BB81 Sodium chloride+ Glucose (P) 290000 ml B05BC Solutions producing osmotic diuresis B05BC01 Mannitol (P) 846000 ml B05C IRRIGATING SOLUTIONS B05CX Other irrigating solutions B05CX10 Combinations (NA) 16000 ml B05D PERITONEAL DIALYTICS B05DA Isotonic solutions B05DA80 Isotonic solutions (P) 6080000 ml B05DB Hypertonic solutions B05DB80 hypertonic solutions (P) 127754000 ml Amino acids+ Sodium chloride+ Calcium chloride B05DB81 dihydrate+ Magnesium chloride hexahydrate+ Sodium 370000 ml lactate (P) B05Z HEMODIALYTICS AND HEMOFILTRATES B05ZB Hemofiltrates Sodium chloride+ Potassium chloride+ Calcium chloride B05ZB80 dihydrate+ Magnesium chloride+ Glucose+ Sodium 27530000 ml hydrogen carbonate (P) Calcium chloride dihydrate+ Magnesium chloride hexahydrate+ Sodium chloride+ Sodium hydrogen B05ZB82 8990000 ml carbonate+ Potassium chloride+ Disodium phosphate dihydrate (P) Calcium chloride dihydrate+ Magnesium chloride B05ZB83 hexahydrate+ Glucose+ Lactic acid+ Sodium chloride+ 200000 ml Sodium hydrogen carbonate+ Potassium chloride (P) Calcium chloride dihydrate+ Magnesium chloride B05ZB84 hexahydrate+ Lactic acid+ Sodium hydrogen carbonate+ 150000 ml Sodium chloride (P) B05ZB85 Sodium citrate+ Sodium chloride (P) 25000000 ml Magnesium chloride hexahydrate+ Sodium chloride+ B05ZB86 Potassium chloride+ Disodium phosphate dihydrate+ 12120000 ml Sodium hydrogen carbonate (P) B05X I.V. SOLUTION ADDITIVES B05XA Electrolyte solutions B05XA01 Potassium chloride (P) 750 g B05XA01 Potassium chloride (P) 3346400 ml B05XA02 Sodium hydrogen carbonate (P) 1627500 ml B05XA03 Sodium chloride (P) 333459600 ml B05XA05 Magnesium sulfate (P) 417900 ml B05XA07 Calcium chloride (P) 515600 ml B05XA14 Sodium glycerophosphate hydrate (P) 146000 ml B05XA80 Electrolytes (P) 124800 ml 8/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day B05XB Amino acids B05XB01 Arginine (P) 3600 ml B05XB02 Alanyl glutamine (P) 67000 ml B05XC Vitamins B05XC80 Vitamins (P) 8164,32 g B05XC80 Vitamins (P) 109600 ml B06 OTHER HEMATOLOGICAL AGENTS 0,0034 B06A OTHER HEMATOLOGICAL AGENTS 0,0034 B06AA Enzymes B06AA03 Hyaluronidase (P) 135000 U B06AB Heme products B06AB01 Hemin (P) 120 ml B06AC Drugs usedin hereditary angioedema 0,0034 B06AC01 C1-inhibitor, plasma derived (P) 137000 U 1400 U 0,0002 B06AC02 Icatibant (P) 5,34 g 0,03 g 0,0004 B06AC05 Lanadelumab (P) 29,4 g 21,4 mg 0,0028 C CARDIOVASCULAR SYSTEM 471,4739 C01 CARDIAC THERAPY 20,4066 C01A CARDIAC GLYCOSIDES 1,8085 C01AA Digitalis glycosides 1,8085 C01AA05 Digoxin (O) 217,98 g 0,25 mg 1,7934 C01AA05 Digoxin (P) 1,8325 g 0,25 mg 0,0151 C01B ANTIARRHYTHMICS, CLASS I AND III 4,9656 C01BA Antiarrhythmics, class Ia C01BA13 Hydroquinidine (O) 162 g C01BB Antiarrhythmics, class Ib 0,0211 C01BB02 Mexiletine (O) 198 g 0,8 g 0,0005 C01BB80 Ethacizine (O) 2000 g 0,2 g 0,0206 C01BC Antiarrhythmics, class Ic 3,3044 C01BC03 Propafenone (O) 446476,5 g 0,3 g 3,0611 C01BC03 Propafenone (P) 548,45 g 0,3 g 0,0038 C01BC04 Flecainide (O) 23248 g 0,2 g 0,2391 C01BC04 Flecainide (P) 41,25 g 0,2 g 0,0004 C01BD Antiarrhythmics, class III 1,6402 C01BD01 Amiodarone (O) 153240 g 0,2 g 1,5760 C01BD01 Amiodarone (P) 5013,75 g 0,2 g 0,0516 C01BD07 Dronedarone (O) 4920 g 0,8 g 0,0126 CARDIAC STIMULANTS EXCL. CARDIAC C01C 0,6961 GLYCOSIDES C01CA Adrenergic and dopaminergic agents 0,6936 C01CA01 Etilefrine (O) 1,6875 g 0,05 g 0,0001 C01CA02 Isoprenaline (P) 0,732 g 0,09 g <0,0001 C01CA03 Norepinephrine (P) 352,6 g 0,006 g 0,1209 C01CA04 Dopamine (P) 1086 g 0,5 g 0,0045 C01CA06 Phenylephrine (P) 137,7 g 0,004 g 0,0708 C01CA07 Dobutamine (P) 1205 g 0,5 g 0,0050 C01CA17 Midodrine (O) 23,65 g 0,03 g 0,0016 C01CA24 Epinephrine (intraoss, P) 85,58 g 0,5 mg 0,3521 C01CA24 Epinephrine (P) 23,067 g 0,5 mg 0,0949 C01CA26 Ephedrine (P) 1066,5 g 0,05 g 0,0439 C01CE Phosphodiesterase inhibitors 0,0018 C01CE02 Milrinone (P) 43,08 g 0,05 g 0,0018 C01CX Other cardiac stimulants 0,0007 C01CX08 Levosimendan (P) 3,725 g 11 mg 0,0007 C01CX80 Ammonia (I) 1467400 ml C01D VASODILATORS USED IN CARDIAC DISEASES 5,1316 C01DA Organic nitrates 5,1266 C01DA02 Glyceryl trinitrate (P) 183,8 g C01DA02 Glyceryl trinitrate (SL) 443,552 g 0,0025 g 0,3649 C01DA08 Isosorbide dinitrate (O) 16 g 0,06 g 0,0005 C01DA08 Isosorbide dinitrate (SL) 186,9625 g 0,02 g 0,0192 9/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C01DA14 Isosorbide mononitrate (O) 92217 g 0,04 g 4,7419 C01DX Other vasodilatators used in cardiac diseases 0,0050 C01DX22 Vericiguat (O) 9,275 g 10 mg 0,0019 C01DX80 Meldonium (O) 1080 g 0,75 g 0,0030 C01DX80 Meldonium (P) 45 g 0,75 g 0,0001 C01E OTHER CARDIAC PREPARATIONS 7,8048 C01EA Prostaglandins 0,0002 C01EA01 Alprostadil (P) 0,0528 g 0,5 mg 0,0002 C01EB Other cardiac preparations 7,8045 C01EB10 Adenosine (P) 134,236 g 0,015 g 0,0184 C01EB15 Trimetazidine (O) 141180,9 g 0,04 g 7,2597 C01EB16 Ibuprofen (P) 0,84 g 0,03 g 0,0001 C01EB17 Ivabradine (O) 1973,72 g 0,01 g 0,4060 C01EB18 Ranolazine (O) 87022,5 g 1,5 g 0,1193 C01EB21 Regadenoson (P) 0,21 g 0,4 mg 0,0011 C01EB80 Hawthorn berries (O) 57600 ml C02 ANTIHYPERTENSIVES 3,7688 C02A ANTIADRENERGIC AGENTS, CENTRALLY ACTING 2,3610 C02AC Imidazoline receptor agonists 2,3610 C02AC01 Clonidine (O) 5,19 g 0,45 mg 0,0237 C02AC01 Clonidine (P) 2,191 g 0,45 mg 0,0100 C02AC02 Guanfacine (O) 10,892 g 3 mg 0,0075 C02AC05 Moxonidine (O) 338,3454 g 0,3 mg 2,3198 ANTIADRENERGIC AGENTS, PERIPHERALLY C02C 1,3641 ACTING C02CA Alpha-adrenoreceptor antagonists 1,3641 C02CA01 Prazosin (O) 0,48 g 0,005 g 0,0002 C02CA04 Doxazosin (O) 2652,492 g 0,004 g 1,3639 ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING C02D 0,0013 ON C02DD Nitroferricyanide derivatives 0,0013 C02DD01 Sodium nitroprusside (P) 32 g 0,05 g 0,0013 C02K OTHER ANTIHYPERTENSIVES 0,0424 C02KX Antihypertensives for pulmonary arterial hypertension 0,0424 C02KX01 Bosentan (O) 1617 g 0,25 g 0,0133 C02KX02 Ambrisentan (O) 45,45 g 7,5 mg 0,0125 C02KX04 Macitentan (O) 17,1 g 10 mg 0,0035 C02KX05 Riociguat (O) 28,686 g 4,5 mg 0,0131 C03 DIURETICS 26,7824 C03A LOW-CEILING DIURETICS, THIAZIDES 1,0887 C03AA Thiazides, plain 1,0887 C03AA03 Hydrochlorothiazide (O) 13232 g 0,025 g 1,0887 C03B LOW-CEILING DIURETICS, EXCL. THIAZIDES 2,0716 C03BA Sulfonamides, plain 2,0716 C03BA11 Indapamide (O) 2517,87 g 2,5 mg 2,0716 C03C HIGH-CEILING DIURETICS 19,7813 C03CA Sulfonamides, plain 19,7813 C03CA01 Furosemide (O) 57214,6 g 0,04 g 2,9420 C03CA01 Furosemide (P) 5362,6 g 0,04 g 0,2758 C03CA04 Torasemide (O) 120451,65 g 0,015 g 16,5167 C03CA04 Torasemide (P) 341 g 0,015 g 0,0468 ALDOSTERONE ANTAGONISTS AND OTHER C03D 3,8316 POTASSIUM-SPARING AGENTS C03DA Aldosterone antagonists 3,8300 C03DA01 Spironolactone (O) 139332,75 g 0,075 g 3,8212 C03DA04 Eplerenone (O) 214,5 g 0,05 g 0,0088 C03DB Other potassium-sparing agents 0,0016 C03DB01 Amiloride (O) 7,96 g 10 mg 0,0016 DIURETICS AND POTASSIUM-SPARING AGENTS IN C03E 0,0093 COMBINATION 10/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C03EA Low-ceiling diuretics and potassium-sparing agents 0,0093 C03EA81 Hydrochlorothiazide+ Amiloride (O) 4530 pieces 1 pieces 0,0093 C04 PERIPHERAL VASODILATORS 2,5208 C04A PERIPHERAL VASODILATORS 2,5208 C04AC Nicotinic acid and derivatives 0,0001 C04AC01 Nicotinic acid (P) 5 g 0,2 g 0,0001 C04AD Purine derivatives 1,3867 C04AD02 Xantinol nicotinate (O) 18 g 0,9 g <0,0001 C04AD03 Pentoxifylline (O) 673088 g 1 g 1,3844 C04AD03 Pentoxifylline (P) 320,5 g 0,3 g 0,0022 C04AX Other peripheral vasodilators 1,1341 C04AX21 Naftidrofuryl (O) 330830 g 0,6 g 1,1341 C05 VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND C05A ANAL FISSURES FOR TOPICAL USE C05AA Corticosteroids C05AA82 Hydrocortisone+ Cinchocaine (R) 11940 pieces C05AA84 Fluocortolone+ Lidocaine (R) 197175 g C05AA84 Fluocortolone+ Lidocaine (R) 241850 pieces C05AE Muscle relaxants C05AE01 Glyceryl trinitrate (R) 150 g Other agents for treatment of hemorrhoids and anal C05AX fissures for topical use C05AX81 Xeroformium+ Zinc sulphate+ Belladonna extract (R) 1930 pieces C05AX83 Yeast extract+ Shark-liver oil (R) 279504 pieces C05B ANTIVARICOSE THERAPY C05BA Heparins or heparinoids for topical use C05BA03 Heparin sodium (C) 7213550 g C05BB Sclerosing agents for local injection C05BB02 Lauromacrogol 400 (P) 91,8 g C05C CAPILLARY STABILIZING AGENTS C05CA Bioflavonoids C05CA01 Rutoside (O) 272115 pieces C05CA03 Diosmin (O) 475890 g C05CA04 Troxerutin (C) 3637200 g C05CA04 Troxerutin (O) 198885 g C05CA53 Diosmin+ Hesperidin (O) 618930 pieces C07 BETA BLOCKING AGENTS 58,5134 C07A BETA BLOCKING AGENTS 58,5127 C07AA Beta blocking agents, non-selective 1,5825 C07AA05 Propranolol (O) 56299 g 0,16 g 0,7237 C07AA07 Sotalol (O) 66800 g 0,16 g 0,8587 C07AB Beta blocking agents, selective 56,3160 C07AB02 Metoprolol (O) 2046374,6 g 0,15 g 28,0606 C07AB02 Metoprolol (P) 113,05 g 0,15 g 0,0016 C07AB03 Atenolol (O) 14983,5 g 0,075 g 0,4109 C07AB07 Bisoprolol (O) 21413,65 g 0,01 g 4,4045 C07AB09 Esmolol (P) 10 g 2,5 g <0,0001 C07AB12 Nebivolol (O) 56976,51 g 0,005 g 23,4384 C07AG Alpha and beta blocking agents 0,6142 C07AG01 Labetalol (O) 32105 g 0,6 g 0,1101 C07AG01 Labetalol (P) 1364,5 g 0,6 g 0,0047 C07AG02 Carvedilol (O) 9106,6875 g 0,0375 g 0,4995 C07B BETA BLOCKING AGENTS AND THIAZIDES 0,0007 C07BB Beta blocking agents, selective, and thiazides 0,0007 C07BB81 Bisoprolol+ Hydrochlorothiazide (O) 360 pieces 1 pieces 0,0007 C08 CALCIUM CHANNEL BLOCKERS 43,0355 SELECTIVE CALCIUM CHANNEL BLOCKERS WITH C08C 41,6952 MAINLY VASCULAR EFFECTS 11/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day C08CA Dihydropyridine derivatives 41,6952 C08CA01 Amlodipine (O) 62736,3 g 0,005 g 25,8078 C08CA02 Felodipine (O) 4549,725 g 0,005 g 1,8716 C08CA05 Nifedipine (O) 11833 g 0,03 g 0,8113 C08CA06 Nimodipine (O) 450 g 0,3 g 0,0031 C08CA06 Nimodipine (P) 0,98 g 0,05 g <0,0001 C08CA08 Nitrendipine (O) 36134,3 g 0,02 g 3,7161 C08CA09 Lacidipine (O) 4599,392 g 0,004 g 2,3651 C08CA13 Lercanidipine (O) 34616,7 g 0,01 g 7,1201 SELECTIVE CALCIUM CHANNEL BLOCKERS WITH C08D 1,3402 DIRECT CARDIAC EFFECTS C08DA Phenylalkylamine derivatives 1,2019 C08DA01 Verapamil (O) 140242 g 0,24 g 1,2019 C08DA01 Verapamil (P) 4,775 g 0,24 g <0,0001 C08DB Benzothiazepine derivatives 0,1383 C08DB01 Diltiazem (O) 16137 g 0,24 g 0,1383 AGENTS ACTING ON THE RENIN-ANGIOTENSIN C09 213,9459 SYSTEM C09A ACE INHIBITORS, PLAIN 74,6606 C09AA ACE inhibitors, plain 74,6606 C09AA01 Captopril (O) 2,5 g 0,05 g 0,0001 C09AA02 Enalapril (O) 31966,21 g 0,01 g 6,5750 C09AA02 Enalapril (P) 9,9125 g 0,01 g 0,0020 C09AA03 Lisinopril (O) 2,24 g 0,01 g 0,0005 C09AA04 Perindopril (O) 20142,33 g 0,004 g 10,3574 C09AA05 Ramipril (O) 65743,26 g 2,5 mg 54,0896 C09AA09 Fosinopril (O) 25796,96 g 0,015 g 3,5374 C09AA10 Trandolapril (O) 95,816 g 0,002 g 0,0985 C09B ACE INHIBITORS, COMBINATIONS 59,6075 C09BA ACE inhibitors and diuretics 28,4169 C09BA02 Enalapril+ Hydrochlorothiazide (O) 2273684 pieces 1 pieces 4,6766 C09BA04 Perindopril+ Indapamide (O) 10032510 pieces 1 pieces 20,6354 C09BA05 Ramipril+ Hydrochlorothiazide (O) 1030652 pieces 1 pieces 2,1199 C09BA06 Quinapril+ Hydrochlorothiazide (O) 100 pieces 1 pieces 0,0002 C09BA09 Fosinopril+ Hydrochlorothiazide (O) 478790 pieces 1 pieces 0,9848 C09BB ACE inhibitors and calcium channel blockers 13,5294 C09BB03 Lisinopril+ Amlodipine (O) 738570 pieces 1 pieces 1,5191 C09BB04 Perindopril+ Amlodipine (O) 4938660 pieces 1 pieces 10,1581 C09BB07 Ramipril+ Amlodipine (O) 671520 pieces 1 pieces 1,3812 C09BB10 Trandolapril+ Verapamil (O) 228956 pieces 1 pieces 0,4709 C09BX ACE inhibitors, other combinations 17,6612 C09BX01 Perindopril+ Amlodipine+ Indapamide (O) 8586510 pieces 1 pieces 17,6612 ANGIOTENSIN II RECEPTOR BLOCKERS (ARBS), C09C 44,5999 PLAIN C09CA Angiotensin II receptor blockers (ARBs), plain 44,5999 C09CA01 Losartan (O) 82226 g 0,05 g 3,3825 C09CA02 Eprosartan (O) 428,4 g 0,6 g 0,0015 C09CA03 Valsartan (O) 168660,8 g 0,08 g 4,3364 C09CA06 Candesartan (O) 43007,36 g 0,008 g 11,0575 C09CA07 Telmisartan (O) 430595,2 g 0,04 g 22,1418 C09CA08 Olmesartan medoxomil (O) 35785,96 g 0,02 g 3,6803 ANGIOTENSIN II RECEPTOR BLOCKERS (ARBS), C09D 35,0780 COMBINATIONS C09DA Angiotensin II receptor blockers (ARBs) and diuretics 14,7274 C09DA80 Losartan+ Hydrochlorothiazide (O) 766910 pieces 1 pieces 1,5774 C09DA82 Valsartan+ Hydrochlorothiazide (O) 858256 pieces 1 pieces 1,7653 C09DA84 Candesartan+ Hydrochlorothiazide (O) 1143214 pieces 1 pieces 2,3514 C09DA85 Telmisartan+ Hydrochlorothiazide (O) 4088276 pieces 1 pieces 8,4090 C09DA86 Olmesartan medoxomil+ Hydrochlorothiazide (O) 303510 pieces 1 pieces 0,6243 12/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day Angiotensin II receptor blockers (ARBs) and calcium C09DB 14,3702 channel blockers C09DB01 Valsartan+ Amlodipine (O) 248708 pieces 1 pieces 0,5116 C09DB02 Olmesartan medoxomil+ Amlodipine (O) 3382120 pieces 1 pieces 6,9565 C09DB04 Telmisartan+ Amlodipine (O) 3285912 pieces 1 pieces 6,7586 C09DB07 Candesartan+ Amlodipine (O) 69776 pieces 1 pieces 0,1435 Angiotensin II receptor blockers (ARBs), other C09DX 5,9803 combinations C09DX01 Valsartan+ Amlodipine+ Hydrochlorothiazide (O) 4900 pieces 1 pieces 0,0101 Olmesartan medoxomil+ Amlodipine+ C09DX03 2446584 pieces 1 pieces 5,0323 Hydrochlorothiazide (O) C09DX04 Valsartan+ Sacubitril (O) 456036 pieces 1 pieces 0,9380 C10 LIPID MODIFYING AGENTS 102,5003 C10A LIPID MODIFYING AGENTS, PLAIN 97,8034 C10AA HMG CoA reductase inhibitors 96,0396 C10AA01 Simvastatin (O) 57078,8 g 0,03 g 3,9134 C10AA03 Pravastatin (O) 3542,4 g 0,03 g 0,2429 C10AA04 Fluvastatin (O) 13496 g 0,06 g 0,4627 C10AA05 Atorvastatin (O) 378967,5 g 0,02 g 38,9740 C10AA07 Rosuvastatin (O) 254984,95 g 0,01 g 52,4466 C10AB Fibrates 0,7583 C10AB02 Bezafibrate (O) 20 g 0,6 g 0,0001 C10AB05 Fenofibrate (O) 73728 g 0,2 g 0,7582 C10AC Bile acid sequestrants 0,0029 C10AC01 Colestyramine (O) 19600 g 14 g 0,0029 C10AX Other lipid modifying agents 1,0027 C10AX09 Ezetimibe (O) 4601,04 g 0,01 g 0,9464 C10AX13 Evolocumab (P) 172,2 g 10 mg 0,0354 C10AX14 Alirocumab (P) 17,55 g 5,4 mg 0,0067 C10AX16 Inclisiran (P) 11,076 g 1,6 mg 0,0142 C10AX80 Omega-3-acid ethyl esters 90 (O) 220276 pieces C10B LIPID MODIFYING AGENTS, COMBINATIONS 4,6969 C10BA Combinations of various lipid modifying agents 3,9577 C10BA05 Atorvastatin+ Ezetimibe (O) 198690 pieces 1 pieces 0,4087 C10BA06 Rosuvastatin+ Ezetimibe (O) 1725450 pieces 1 pieces 3,5490 C10BX Lipid modifying agents in combination with other drugs 0,7392 C10BX11 Atorvastatin+ Amlodipine+ Perindopril (O) 203790 pieces 1 pieces 0,4192 C10BX13 Rosuvastatin+ Perindopril+ Indapamide (O) 139170 pieces 1 pieces 0,2863 C10BX15 Atorvastatin+ Perindopril (O) 16440 pieces 1 pieces 0,0338 D DERMATOLOGICALS 1,8433 D01 ANTIFUNGALS FOR DERMATOLOGICAL USE 1,0176 D01A ANTIFUNGALS FOR TOPICAL USE D01AC Imidazole and triazole derivatives D01AC01 Clotrimazole (C) 100 ml D01AC01 Clotrimazole (C) 1021990 g D01AC05 Isoconazole (C) 276240 g D01AC08 Ketoconazole (C) 559545 g D01AC08 Ketoconazole (C) 2699160 ml D01AC80 Isoconazole+ Diflucortolone (C) 793875 g D01AC81 Clotrimazole+ Hexamidine (C) 128790 g D01AE Other antifungals for topical use D01AE14 Ciclopirox (C) 630,3 ml D01AE15 Terbinafine (C) 57849 ml D01AE15 Terbinafine (C) 494104 g D01AE16 Amorolfine (C) 26380 ml D01AE22 Naftifine (C) 141350 ml D01AE22 Naftifine (C) 205380 g D01B ANTIFUNGALS FOR SYSTEMIC USE 1,0176 D01BA Antifungals for systemic use 1,0176 D01BA01 Griseofulvin (O) 372,5 g 0,5 g 0,0015 13/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day D01BA02 Terbinafine (O) 123493 g 0,25 g 1,0160 D02 EMOLLIENTS AND PROTECTIVES D02A EMOLLIENTS AND PROTECTIVES D02AB Zinc products D02AB80 Zinc oxide (C) 240 g D02B PROTECTIVES AGAINST UV-RADIATION D02BA Protectives against UV-radiation for topical use D02BA01 4-aminobenzoic acid (O) 360 g PREPARATIONS FOR TREATMENT OF WOUNDS AND D03 ULCERS D03A CICATRIZANTS D03AX Other cicatrizants D03AX03 Dexpanthenol (C) 4025870 g D03AX81 Heparin sodium+ Allantoin+ Extractum Cepae (C) 130500 g D03AX83 Dexpanthenol+ Chlorhexidine (C) 2213190 g ANTIPRURITICS, INCL. ANTIHISTAMINES, D04 ANESTHETICS, ETC. ANTIPRURITICS, INCL. ANTIHISTAMINES, D04A ANESTHETICS, ETC. D04AA Antihistamines for topical use D04AA13 Dimetindene (C) 37,74 g D05 ANTIPSORIATICS 0,0540 D05A ANTIPSORIATICS FOR TOPICAL USE D05AA Tars D05AA85 Coal tar+ Salicylic acid (C) 794000 ml D05AX Other antipsoriatics for topical use D05AX80 Calcipotriol+ Betamethasone (C) 1064700 g D05B ANTIPSORIATICS FOR SYSTEMIC USE 0,0540 D05BB Retinoids for treatment of psoriasis 0,0540 D05BB02 Acitretin (O) 919,2 g 0,035 g 0,0540 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR D06 DERMATOLOGICAL USE D06A ANTIBIOTICS FOR TOPICAL USE D06AX Other antibiotics for topical use D06AX01 Fusidic acid (C) 243465 g D06AX09 Mupirocin (C) 2520 g D06AX80 Bacitracin+ Neomycin (C) 83970 g D06AX84 Chloramphenicol+ Methyluracil (C) 800 g D06B CHEMOTHERAPEUTICS FOR TOPICAL USE D06BA Sulfonamides D06BA01 Sulfadiazine silver (C) 1466760 g D06BB Antivirals D06BB03 Aciclovir (C) 207002 g D06BB04 Podophyllotoxin (C) 1638 ml D06BB10 Imiquimod (C) 5679 g D06BB81 Aciclovir+ Hydrocortisone (C) 28420 g D06BX Other chemotherapeutics D06BX01 Metronidazole (C) 162010 g CORTICOSTEROIDS, DERMATOLOGICAL D07 PREPARATIONS D07A CORTICOSTEROIDS, PLAIN D07AA Corticosteroids, weak (group I) D07AA02 Hydrocortisone (C) 608910 g D07AB Corticosteroids, moderately potent (group II) D07AB09 Triamcinolone (C) 355 g D07AC Corticosteroids, potent (group III) D07AC01 Betamethasone (C) 114600 g D07AC04 Fluocinolone acetonide (C) 210 g D07AC13 Mometasone (C) 332160 ml D07AC13 Mometasone (C) 1201835 g D07AC14 Methylprednisolone aceponate (C) 594265 g 14/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day D07AC17 Fluticasone (C) 38415 g D07AD Corticosteroids, very potent (group IV) D07AD01 Clobetasol (C) 88400 ml D07AD01 Clobetasol (C) 953175 g CORTICOSTEROIDS, COMBINATIONS WITH D07B ANTISEPTICS D07BA Corticosteroids, weak, combinations with antiseptics D07BA80 Hydrocortisone+ Chlorhexidine (C) 342860 g D07BC Corticosteroids, potent, combinations with antiseptics D07BC80 Betamethasone+ Salicylic acid (C) 26270 g D07BC80 Betamethasone+ Salicylic acid (C) 977530 ml CORTICOSTEROIDS, COMBINATIONS WITH D07C ANTIBIOTICS D07CA Corticosteroids, weak, combinations with antibiotics D07CA83 Hydrocortisone+ Fusidic acid (C) 85050 g D07CC Corticosteroids, potent, combinations with antibiotics D07CC80 Betamethasone+ Fusidic acid (C) 597240 g D07X CORTICOSTEROIDS, OTHER COMBINATIONS D07XA Corticosteroids, weak, other combinations D07XA81 Prednisolone+ Salicylic acid (C) 252700 ml D08 ANTISEPTICS AND DISINFECTANTS D08A ANTISEPTICS AND DISINFECTANTS D08AG Iodine products D08AG02 Povidone, iodinated (C) 1172310 ml D08AG02 Povidone, iodinated (C) 3907170 g D08AG03 Iodine (C) 1166820 ml D08AJ Quaternary ammonium compounds D08AJ81 Octenidine+ Phenoxyethanol (C) 12072850 ml D08AX Other antiseptics and disinfectants D08AX82 Tar blend+ Castor oil+ Xeroformium (C) 9730 g D08AX83 Brilliant Green (C) 289230 ml D10 ANTI-ACNE PREPARATIONS 0,5991 D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE D10AD Retinoids for topical use in acne D10AD01 Tretinoin (C) 55290 g D10AD03 Adapalene (C) 78180 g D10AD80 Adapalene+ Benzoyl peroxide (C) 64170 g D10AD81 Tretinoin+ Erythromycin (C) 42240 g D10AF Antiinfectives for treatment of acne D10AF01 Clindamycin (C) 33300 ml D10AF02 Erythromycin (C) 368000 ml D10AF81 Clindamycin+ Benzoyl peroxide (C) 211215 g D10AF82 Clindamycin+ Tretinoin (C) 139560 g D10AX Other anti-acne preparations for topical use D10AX03 Azelaic acid (C) 340920 g D10B ANTI-ACNE PREPARATIONS FOR SYSTEMIC USE 0,5991 D10BA Retinoids for treatment of acne 0,5991 D10BA01 Isotretinoin (O) 8738,1 g 0,03 g 0,5991 D11 OTHER DERMATOLOGICAL PREPARATIONS 0,1726 D11A OTHER DERMATOLOGICAL PREPARATIONS 0,1726 D11AF Wart and anti-corn preparations D11AF80 Salicylic acid+ Lactic acid (C) 89070 ml D11AH Agents for dermatitis, excluding corticosteroids 0,0720 D11AH01 Tacrolimus (C) 119010 g D11AH02 Pimecrolimus (C) 250275 g D11AH05 Dupilumab (P) 748,6 g 21,4 mg 0,0720 D11AX Other dermatologicals 0,1007 15/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day D11AX01 Minoxidil (C) 158160 ml D11AX10 Finasteride (O) 48,944 g 0,001 g 0,1007 D11AX16 Eflornithine (C) 390 g D11AX21 Brimonidine (C) 30 g D11AX22 Ivermectin (C) 28650 g G GENITO URINARY SYSTEM AND SEX HORMONES 58,2519 GYNECOLOGICAL ANTIINFECTIVES AND G01 0,8455 ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. G01A 0,8455 COMBINATIONS WITH CORTICOSTEROIDS G01AA Antibiotics 0,0231 G01AA10 Clindamycin (V) 1123,5 g 0,1 g 0,0231 G01AA80 Nystatin+ Neomycin+ Polymyxin B (V) 12 pieces G01AC Quinoline derivatives 0,0533 G01AC05 Dequalinium (V) 517,8 g 20 mg 0,0533 G01AF Imidazole derivatives 0,7692 G01AF01 Metronidazole (V) 14338 g 0,5 g 0,0590 G01AF02 Clotrimazole (V) 28079,7 g 0,1 g 0,5776 G01AF05 Econazole (V) 4839,3 g 0,1 g 0,0995 G01AF12 Fenticonazole (V) 1609,8 g 0,1 g 0,0331 G02 OTHER GYNECOLOGICALS 3,9212 G02A UTEROTONICS 0,0925 G02AB Ergot alkaloids 0,0022 G02AB01 Methylergometrine (P) 0,2112 g 0,2 mg 0,0022 G02AD Prostaglandins 0,0903 G02AD02 Dinoprostone (P) 0,08 g G02AD02 Dinoprostone (V) 1,6123 g 0,5 mg 0,0066 G02AD06 Misoprostol (O) 8,1368 g 0,2 mg 0,0837 G02B CONTRACEPTIVES FOR TOPICAL USE 2,2513 G02BA Intrauterine contraceptives G02BA03 Levonorgestrel (V) 8881 pieces G02BB Intravaginal contraceptives 2,2513 G02BB01 Etonogestrel+ Ethinylestradiol (V) 38281 pieces 0,036 pieces 2,1872 G02BB81 Benzalkonium chloride (V) 14688 g G02BB81 Benzalkonium chloride (V) 31170 pieces 1 pieces 0,0641 G02C OTHER GYNECOLOGICALS 1,5775 G02CA Sympathomimetics, labour repressants G02CA80 Hexoprenaline (P) 0,0205 g G02CB Prolactine inhibitors 0,1421 G02CB01 Bromocriptine (O) 264,3 g 0,005 g 0,1087 G02CB03 Cabergoline (O) 8,116 g 0,5 mg 0,0334 G02CX Other gynecologicals 1,4353 G02CX01 Atosiban (P) 1,3125 g 0,165 g <0,0001 G02CX03 Agnus castus fruit (O) 380400 pieces 1 pieces 0,7824 G02CX04 Cimicifugae rhizoma (O) 634860 pieces 2 pieces 0,6529 SEX HORMONES AND MODULATORS OF THE G03 31,0067 GENITAL SYSTEM G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE 23,5400 G03AA Progestogens and estrogens, fixed combinations 18,1700 G03AA07 Levonorgestrel+ Ethinylestradiol (O) 218596 pieces 1 pieces 0,4496 G03AA09 Desogestrel+ Ethinylestradiol (O) 335538 pieces 0,75 pieces 0,9202 G03AA10 Gestodene+ Ethinylestradiol (O) 1933596 pieces 0,75 pieces 5,3028 G03AA12 Drospirenone+ Ethinylestradiol (O) 1162336 pieces 1 pieces 2,3908 G03AA12 Drospirenone+ Ethinylestradiol (O) 1547847 pieces 0,75 pieces 4,2449 G03AA13 Norelgestromin+ Ethinylestradiol (TD) 85920 pieces 0,107 pieces 1,6516 G03AA14 Nomegestrol+ Estradiol (O) 32368 pieces 1 pieces 0,0666 G03AA15 Chlormadinone+ Ethinylestradiol (O) 141876 pieces 0,75 pieces 0,3891 G03AA16 Dienogest+ Ethinylestradiol (O) 1004353 pieces 0,75 pieces 2,7544 G03AB Progestogens and estrogens, sequential preparations 0,1977 16/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day G03AB05 Desogestrel+ Ethinylestradiol (O) 1782 pieces 0,75 pieces 0,0049 G03AB08 Dienogest+ Estradiol valerate (O) 93744 pieces 1 pieces 0,1928 G03AC Progestogens 5,0841 G03AC08 Etonogestrel (P) 63,512 g 68 mcg 1,9211 G03AC09 Desogestrel (O) 1298416 pieces 1 pieces 2,6706 G03AC10 Drospirenone (O) 239372 pieces 1 pieces 0,4924 G03AD Emergency contraceptives 0,0882 G03AD01 Levonorgestrel (O) 62,5815 g 1,5 mg 0,0858 G03AD02 Ulipristal (O) 34,29 g 0,03 g 0,0024 G03B ANDROGENS 0,2661 G03BA 3-oxoandrosten (4) derivatives 0,2661 G03BA03 Testosterone (C) 34,5 g 0,05 g 0,0014 G03BA03 Testosterone (O) 7,2 g 0,12 g 0,0001 G03BA03 Testosterone (P) 2315,25 g 0,018 g 0,2646 G03C ESTROGENS 1,6245 G03CA Natural and semisynthetic estrogens, plain 1,6121 G03CA03 Estradiol (C, V) 6,835 g G03CA03 Estradiol (O) 863,324 g 2 mg 0,8879 G03CA03 Estradiol (TD) 35,3002 g 1,53 mg 0,0475 G03CA03 Estradiol (TD) 126,056 g 1 mg 0,2593 G03CA03 Estradiol (V) 3,0829 g 0,025 mg 0,2536 G03CA04 Estriol (V) 15,9375 g 0,2 mg 0,1639 G03CA80 Estradiol+ Prednisolone (C) 50025 g G03CX Other estrogens 0,0123 G03CX01 Tibolone (O) 14,98 g 2,5 mg 0,0123 G03D PROGESTOGENS 2,4532 G03DA Pregnen (4) derivatives 1,6745 G03DA02 Medroxyprogesterone (O) 119,55 g 0,005 g 0,0492 G03DA02 Medroxyprogesterone (P) 211,65 g 0,007 g 0,0622 G03DA04 Progesterone (O) 6720 g 0,3 g 0,0461 G03DA04 Progesterone (P) 497,525 g 0,005 g 0,2047 G03DA04 Progesterone (V) 57423,9 g 0,09 g 1,3124 G03DB Pregnadien derivatives 0,7788 G03DB01 Dydrogesterone (O) 2326,8 g 0,01 g 0,4786 G03DB08 Dienogest (O) 291,872 g 2 mg 0,3002 PROGESTOGENS AND ESTROGENS IN G03F 2,3092 COMBINATION G03FA Progestogens and estrogens, fixed combinations 1,8060 G03FA01 Norethisterone+ Estradiol (O) 533120 pieces 1 pieces 1,0965 G03FA14 Dydrogesterone+ Estradiol (O) 154784 pieces 1 pieces 0,3184 G03FA17 Drospirenone+ Estradiol (O) 190148 pieces 1 pieces 0,3911 G03FB Progestogens and estrogens, sequential preparations 0,5032 G03FB05 Norethisterone+ Estradiol (O) 171892 pieces 1 pieces 0,3536 G03FB08 Dydrogesterone+ Estradiol (O) 72744 pieces 1 pieces 0,1496 GONADOTROPINS AND OTHER OVULATION G03G 0,4647 STIMULANTS G03GA Gonadotropins 0,2108 G03GA01 Chorionic gonadotrophin (P) 15000 U 250 U 0,0001 G03GA05 Follitropin alfa (P) 6418125 U 75 U 0,1760 G03GA07 Lutropin alfa (P) 691950 U 75 U 0,0190 G03GA08 Choriogonadotropin alfa (P) 0,9168 g 0,25 mg 0,0075 G03GA10 Follitropin delta (P) 0,005 g 12 mcg 0,0009 G03GA30 Follitropin alfa+ Lutropin alfa (P) 3542 dose 1 dose 0,0073 G03GB Ovulation stimulants, synthetic 0,2539 G03GB02 Clomifene (O) 1111 g 0,009 g 0,2539 G03H ANTIANDROGENS 0,3369 G03HA Antiandrogens, plain 0,0672 G03HA01 Cyproterone (O) 3267,5 g 0,1 g 0,0672 G03HB Antiandrogens and estrogens 0,2697 G03HB01 Cyproterone+ Estrogen (O) 98343 pieces 0,75 pieces 0,2697 17/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day OTHER SEX HORMONES AND MODULATORS OF G03X 0,0120 THE GENITAL SYSTEM G03XB Progesterone receptor modulators 0,0120 G03XB01 Mifepristone (O) 826,2 g 0,6 g 0,0028 G03XB02 Ulipristal (O) 22,4 g 5 mg 0,0092 G04 UROLOGICALS 22,4784 G04B UROLOGICALS 4,2142 G04BD Drugs for urinary frequency and incontinence 2,5239 G04BD04 Oxybutynin (O) 4618,5 g 0,015 g 0,6333 G04BD07 Tolterodine (O) 708,904 g 0,004 g 0,3645 G04BD08 Solifenacin (O) 1174,95 g 0,005 g 0,4833 G04BD09 Trospium chloride (O) 3778,65 g 0,04 g 0,1943 G04BD12 Mirabegron (O) 20625 g 50 mg 0,8485 G04BE Drugs used in erectile dysfunction 1,6776 G04BE01 Alprostadil (P) 0,0594 g 0,02 mg 0,0061 G04BE01 Alprostadil (urethral) 0,09 g 0,25 mg 0,0007 G04BE03 Sildenafil (O) 26706,2 g 0,05 g 1,0986 G04BE08 Tadalafil (O) 2460,52 g 0,01 g 0,5061 G04BE09 Vardenafil (O) 75,6 g 0,01 g 0,0155 G04BE10 Avanafil (O) 2452,8 g 0,1 g 0,0505 G04BX Other urologicals 0,0127 G04BX14 Dapoxetine (O) 185,04 g 0,03 g 0,0127 G04BX15 Pentosan polysulfate sodium (O) 9 g 0,3 g 0,0001 G04BX80 Centaurii herba+ Lovage root+ Rosemary leaf (O) 1221900 pieces DRUGS USED IN BENIGN PROSTATIC G04C 18,2642 HYPERTROPHY G04CA Alpha-adrenoreceptor antagonists 15,6044 G04CA01 Alfuzosin (O) 8485,8 g 7,5 mg 2,3272 G04CA02 Tamsulosin (O) 1738,3 g 0,4 mg 8,9386 G04CA04 Silodosin (O) 919,56 g 8 mg 0,2364 G04CA52 Tamsulosin+ Dutasteride (O) 1994400 pieces 1 pieces 4,1022 G04CB Testosterone-5-alpha reductase inhibitors 0,5603 G04CB01 Finasteride (O) 473,39 g 0,005 g 0,1947 G04CB02 Dutasteride (O) 88,86 g 0,5 mg 0,3655 G04CX Other drugs used in benign prostatic hypertrophy 2,0995 G04CX02 Sabalis serrulatae fructus (O) 326640 g 0,32 g 2,0995 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX H 32,7553 HORMONES AND INSULINS PITUITARY AND HYPOTHALAMIC HORMONES AND H01 0,4774 ANALOGUES ANTERIOR PITUITARY LOBE HORMONES AND H01A 0,1800 ANALOGUES H01AA ACTH 0,0002 H01AA02 Tetracosactide (P) 0,0293 g 0,25 mg 0,0002 H01AB Thyrotropin 0,0004 H01AB01 Thyrotropin alfa (P) 0,1746 g 0,9 mg 0,0004 H01AC Somatropin and somatropin agonists 0,1586 H01AC01 Somatropin (P) 154200 U 2 U 0,1586 H01AX Other anterior pituitary lobe hormones and analogues 0,0208 H01AX01 Pegvisomant (P) 101,1 g 0,01 g 0,0208 H01B POSTERIOR PITUITARY LOBE HORMONES 0,1624 H01BA Vasopressin and analogues 0,1203 H01BA01 Argipressin (P) 46800 U 40 U 0,0024 H01BA02 Desmopressin (N) 0,03 g 0,025 mg 0,0025 H01BA02 Desmopressin (P) 0,0273 g 0,004 mg 0,0140 H01BA02 Desmopressin (SL) 11,835 g 0,24 mg 0,1014 H01BB Oxytocin and analogues 0,0421 H01BB01 Demoxytocin (O) 768500 U 100 U 0,0158 H01BB02 Oxytocin (P) 167600 U 15 U 0,0230 H01BB03 Carbetocin (P) 0,1608 g 0,1 mg 0,0033 18/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day H01C HYPOTHALAMIC HORMONES 0,1350 H01CA Gonadotropin-releasing hormones H01CA01 Gonadorelin (P) 0,0038 g H01CB Somatostatin and analogues 0,1133 H01CB02 Octreotide (P) 7,9285 g 0,7 mg 0,0233 H01CB03 Lanreotide (P) 117,48 g 3 mg 0,0805 H01CB05 Pasireotide (P) 5,5 g 1,2 mg 0,0094 H01CC Anti-gonadotropin-releasing hormones 0,0217 H01CC01 Ganirelix (P) 0,025 g 0,25 mg 0,0002 H01CC02 Cetrorelix (P) 2,615 g 0,25 mg 0,0215 H02 CORTICOSTEROIDS FOR SYSTEMIC USE 8,9653 H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN 8,9616 H02AA Mineralocorticoids 0,1623 H02AA02 Fludrocortisone (O) 7,89 g 0,1 mg 0,1623 H02AB Glucocorticoids 8,7993 H02AB01 Betamethasone (P) 13,698 g 1,5 mg 0,0188 H02AB02 Dexamethasone (Infilt, P) 111 g 1,5 mg 0,1522 H02AB02 Dexamethasone (O) 1073,525 g 1,5 mg 1,4721 H02AB02 Dexamethasone (P) 822,7 g 1,5 mg 1,1281 H02AB04 Methylprednisolone (O) 6894 g 7,5 mg 1,8907 H02AB04 Methylprednisolone (P) 4152,55 g 0,02 g 0,4271 H02AB06 Prednisolone (O) 12558,8 g 0,01 g 2,5832 H02AB06 Prednisolone (P) 1607,725 g 0,01 g 0,3307 H02AB08 Triamcinolone (O) 13,6 g 7,5 mg 0,0037 H02AB08 Triamcinolone (P) 1620,6 g 7,5 mg 0,4444 H02AB09 Hydrocortisone (O) 4279,05 g 0,03 g 0,2934 H02AB09 Hydrocortisone (P) 748,4 g 0,03 g 0,0513 H02AB13 Deflazacort (O) 27 g 15 mg 0,0037 CORTICOSTEROIDS FOR SYSTEMIC USE, H02B 0,0037 COMBINATIONS H02BX Corticosteroids for systemic use, combinations 0,0037 H02BX80 Hydrocortisone+ Lidocaine (P) 53,75 g 0,03 g 0,0037 H03 THYROID THERAPY 23,2668 H03A THYROID PREPARATIONS 22,0325 H03AA Thyroid hormones 22,0325 H03AA01 Levothyroxine sodium (O) 1606,685 g 0,15 mg 22,0314 H03AA02 Liothyronine (O) 0,032 g 0,06 mg 0,0011 H03AA03 Levothyroxine sodium+ Liothyronine (O) 300 pieces H03AA04 Tiratricol (O) 0,378 g H03B ANTITHYROID PREPARATIONS 1,2343 H03BA Thiouracils 0,1081 H03BA02 Propylthiouracil (O) 5255,5 g 0,1 g 0,1081 H03BB Sulfur-containing imidazole derivatives 1,1262 H03BB02 Thiamazole (O) 5475,5 g 0,01 g 1,1262 H03BC Perchlorates H03BC01 Sodium perchlorate (O) 48 g H04 PANCREATIC HORMONES 0,0008 H04A GLYCOGENOLYTIC HORMONES 0,0008 H04AA Glycogenolytic hormones 0,0008 H04AA01 Glucagon (P) 0,392 g 0,001 g 0,0008 H05 CALCIUM HOMEOSTASIS 0,0450 H05A PARATHYROID HORMONES AND ANALOGUES 0,0002 H05AA Parathyroid hormones and analogues 0,0002 H05AA02 Teriparatide (P) 0,0024 g 0,02 mg 0,0002 H05B ANTI-PARATHYROID AGENTS 0,0447 H05BX Other anti-parathyroid agents 0,0447 H05BX01 Cinacalcet (O) 1304,52 g 0,06 g 0,0447 J ANTIINFECTIVES FOR SYSTEMIC USE 20,6664 J01 ANTIBACTERIALS FOR SYSTEMIC USE 12,3842 J01A TETRACYCLINES 1,5468 J01AA Tetracyclines 1,5468 19/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J01AA02 Doxycycline (O) 75149 g 0,1 g 1,5457 J01AA02 Doxycycline (P) 6 g 0,1 g 0,0001 J01AA08 Minocycline (O) 9 g 0,2 g 0,0001 J01AA12 Tigecycline (P) 41 g 0,1 g 0,0008 J01C BETA-LACTAM ANTIBACTERIALS, PENICILLINS 4,8793 J01CA Penicillins with extended spectrum 1,6448 J01CA01 Ampicillin (P) 29800 g 6 g 0,0102 J01CA04 Amoxicillin (O) 1192045 g 1,5 g 1,6346 J01CA04 Amoxicillin (P) 50 g 3 g <0,0001 J01CE Beta-lactamase sensitive penicillins 0,1502 J01CE01 Benzylpenicillin (P) 32280 g 3,6 g 0,0184 J01CE02 Phenoxymethylpenicillin (O) 127347,6 g 2 g 0,1310 J01CE08 Benzathine benzylpenicillin (P) 1360,8 g 3,6 g 0,0008 J01CE80 Benzathine benzylpenicillin+ Benzylpenicillin procaine (P) 25,2 g 3,6 g <0,0001 J01CF Beta-lactamase resistant penicillins 0,0953 J01CF04 Oxacillin (P) 92650 g 2 g 0,0953 Combinations of penicillins, incl. beta-lactamase J01CR 2,9890 inhibitors J01CR01 Ampicillin+ Sulbactam (P) 74251 g 6 g 0,0255 J01CR02 Amoxicillin+ Clavulanic acid (O) 1914772,15 g 1,5 g 2,6256 J01CR02 Amoxicillin+ Clavulanic acid (P) 347910 g 3 g 0,2385 J01CR04 Sultamicillin (O) 30582 g 1,5 g 0,0419 J01CR05 Piperacillin+ Tazobactam (P) 391160 g 14 g 0,0575 J01D OTHER BETA-LACTAM ANTIBACTERIALS 1,6711 J01DB First-generation cephalosporins 0,2261 J01DB04 Cefazolin (P) 116990 g 3 g 0,0802 J01DB05 Cefadroxil (O) 141903 g 2 g 0,1459 J01DC Second-generation cephalosporins 1,2753 J01DC01 Cefoxitin (P) 11686 g 6 g 0,0040 J01DC02 Cefuroxime (O) 262062 g 0,5 g 1,0780 J01DC02 Cefuroxime (P) 201457,5 g 3 g 0,1381 J01DC10 Cefprozil (O) 26781 g 1 g 0,0551 J01DD Third-generation cephalosporins 0,0688 J01DD01 Cefotaxime (P) 59600 g 4 g 0,0306 J01DD02 Ceftazidime (P) 14076 g 4 g 0,0072 J01DD04 Ceftriaxone (P) 27920 g 2 g 0,0287 J01DD81 Ceftazidime+ Avibactam (P) 6400 g 6 g 0,0022 J01DE Fourth-generation cephalosporins 0,0137 J01DE01 Cefepime (P) 26620 g 4 g 0,0137 J01DH Carbapenems 0,0872 J01DH02 Meropenem (P) 70183 g 3 g 0,0481 J01DH03 Ertapenem (P) 11915 g 1 g 0,0245 J01DH51 Imipenem+ Cilastatin (P) 14175 g 2 g 0,0146 J01DI Other cephalosporins and penems <0,0001 J01DI04 Cefiderocol (P) 20 g J01DI54 Ceftolozane+ Tazobactam (P) 50 g 3 g <0,0001 J01E SULFONAMIDES AND TRIMETHOPRIM 0,4248 J01EA Trimethoprim and derivatives 0,0302 J01EA01 Trimethoprim (O) 5865 g 0,4 g 0,0302 Combinations of sulfonamides and trimethoprim, incl. J01EE 0,3946 derivatives J01EE01 Sulfamethoxazole+ Trimethoprim (O) 840 pieces 4 pieces 0,0004 J01EE01 Sulfamethoxazole+ Trimethoprim (O) 342994 pieces 2 pieces 0,3527 J01EE01 Sulfamethoxazole+ Trimethoprim (O) 697000 ml 40 ml 0,0358 J01EE01 Sulfamethoxazole+ Trimethoprim (P) 54480 ml 20 ml 0,0056 MACROLIDES, LINCOSAMIDES AND J01F 2,4338 STREPTOGRAMINS J01FA Macrolides 2,2306 J01FA01 Erythromycin (P) 800 g 1 g 0,0016 J01FA09 Clarithromycin (O) 384798,5 g 0,5 g 1,5829 20/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J01FA09 Clarithromycin (P) 1731 g 1 g 0,0036 J01FA10 Azithromycin (O) 93703,7 g 0,3 g 0,6424 J01FF Lincosamides 0,2032 J01FF01 Clindamycin (O) 111566,4 g 1,2 g 0,1912 J01FF01 Clindamycin (P) 10491 g 1,8 g 0,0120 J01G AMINOGLYCOSIDE ANTIBACTERIALS 0,0240 J01GB Other aminoglycosides 0,0240 J01GB01 Tobramycin (I) 119,168 g 0,112 g 0,0022 J01GB01 Tobramycin (I) 638,4 g 0,3 g 0,0044 J01GB01 Tobramycin (P) 68 g 0,24 g 0,0006 J01GB03 Gentamicin (P) 1254,925 g 0,24 g 0,0108 J01GB06 Amikacin (P) 2940 g 1 g 0,0060 J01M QUINOLONE ANTIBACTERIALS 0,7185 J01MA Fluoroquinolones 0,7185 J01MA01 Ofloxacin (O) 3356 g 0,4 g 0,0173 J01MA02 Ciprofloxacin (O) 255802,5 g 1 g 0,5261 J01MA02 Ciprofloxacin (P) 10582 g 0,8 g 0,0272 J01MA06 Norfloxacin (O) 39080 g 0,8 g 0,1005 J01MA12 Levofloxacin (O) 4620 g 0,5 g 0,0190 J01MA12 Levofloxacin (P) 323 g 0,5 g 0,0013 J01MA14 Moxifloxacin (O) 4998 g 0,4 g 0,0257 J01MA14 Moxifloxacin (P) 266,4 g 0,4 g 0,0014 J01X OTHER ANTIBACTERIALS 0,6859 J01XA Glycopeptide antibacterials 0,0262 J01XA01 Vancomycin (O) 75 g 2 g 0,0001 J01XA01 Vancomycin (P) 25295 g 2 g 0,0260 J01XA02 Teicoplanin (P) 24 g 0,4 g 0,0001 J01XB Polymyxins 0,0034 J01XB01 Colistin (I) 7600000000 U 9000000 U 0,0017 J01XB01 Colistin (P) 7220000000 U 9000000 U 0,0017 J01XD Imidazole derivatives 0,0352 J01XD01 Metronidazole (P) 25670 g 1,5 g 0,0352 J01XE Nitrofuran derivatives 0,5999 J01XE01 Nitrofurantoin (O) 58328 g 0,2 g 0,5999 J01XX Other antibacterials 0,0213 J01XX01 Fosfomycin (O) 8091 g 3 g 0,0055 J01XX05 Methenamine (O) 300 g J01XX08 Linezolid (O) 5898 g 1,2 g 0,0101 J01XX08 Linezolid (P) 2661 g 1,2 g 0,0046 J01XX09 Daptomycin (P) 145,05 g 0,28 g 0,0011 J02 ANTIMYCOTICS FOR SYSTEMIC USE 0,3944 J02A ANTIMYCOTICS FOR SYSTEMIC USE 0,3944 J02AA Antibiotics 0,0119 J02AA01 Amphotericin (O) 285 g J02AA01 Amphotericin (P) 202,4 g 0,035 g 0,0119 J02AB Imidazole derivatives 0,0012 J02AB02 Ketoconazole (O) 120 g 0,2 g 0,0012 J02AC Triazole and tetrazole derivatives 0,3710 J02AC01 Fluconazole (O) 16895,15 g 0,2 g 0,1738 J02AC01 Fluconazole (P) 4049,2 g 0,2 g 0,0416 J02AC02 Itraconazole (O) 11741 g 0,2 g 0,1207 J02AC03 Voriconazole (O) 1873,2 g 0,4 g 0,0096 J02AC03 Voriconazole (P) 343,4 g 0,4 g 0,0018 J02AC04 Posaconazole (O) 3206,4 g 0,3 g 0,0220 J02AC05 Isavuconazole (O) 117,6 g 0,2 g 0,0012 J02AC05 Isavuconazole (P) 29,8 g 0,2 g 0,0003 J02AX Other antimycotics for systemic use 0,0103 J02AX04 Caspofungin (P) 65,18 g 0,05 g 0,0027 J02AX05 Micafungin (P) 1 g 0,1 g <0,0001 J02AX06 Anidulafungin (P) 367,4 g 0,1 g 0,0076 J04 ANTIMYCOBACTERIALS 0,3004 21/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J04A DRUGS FOR TREATMENT OF TUBERCULOSIS 0,2844 J04AB Antibiotics 0,0412 J04AB01 Cycloserine (O) 4500 g 0,75 g 0,0123 J04AB02 Rifampicin (O) 3699,6 g 0,6 g 0,0127 J04AB02 Rifampicin (P) 207 g 0,6 g 0,0007 J04AB05 Rifapentine (O) 828 g 0,11 g 0,0155 J04AC Hydrazides 0,1882 J04AC01 Isoniazid (O) 27450 g 0,3 g 0,1882 J04AD Thiocarbamide derivatives 0,0041 J04AD01 Protionamide (O) 1500 g 0,75 g 0,0041 J04AK Other drugs for treatment of tuberculosis 0,0190 J04AK05 Bedaquiline (O) 639,2 g 86 mg 0,0153 J04AK06 Delamanid (O) 362,4 g 0,2 g 0,0037 J04AK08 Pretomanid (O) 218,4 g J04AM Combinations of drugs for treatment of tuberculosis 0,0319 J04AM02 Rifampicin+ Isoniazid (O) 10000 pieces 4 pieces 0,0051 J04AM02 Rifampicin+ Isoniazid (O) 26000 pieces 2 pieces 0,0267 J04B DRUGS FOR TREATMENT OF LEPRA 0,0159 J04BA Drugs for treatment of lepra 0,0159 J04BA02 Dapsone (O) 387,5 g 0,05 g 0,0159 J05 ANTIVIRALS FOR SYSTEMIC USE 7,5875 J05A DIRECT ACTING ANTIVIRALS 7,5875 Nucleosides and nucleotides excl. reverse transcriptase J05AB 0,4901 inhibitors J05AB01 Aciclovir (O) 455492,5 g 4 g 0,2342 J05AB01 Aciclovir (P) 4171,25 g 4 g 0,0021 J05AB06 Ganciclovir (P) 551 g 0,5 g 0,0023 J05AB09 Famciclovir (O) 84 g 0,75 g 0,0002 J05AB11 Valaciclovir (O) 298088 g 3 g 0,2044 J05AB12 Cidofovir (P) 16,5 g 0,025 g 0,0014 J05AB14 Valganciclovir (O) 6344 g 0,9 g 0,0145 J05AB16 Remdesivir (P) 1509,6 g 0,1 g 0,0311 J05AD Phosphonic acid derivatives 0,0009 J05AD01 Foscarnet sodium (P) 2694 g 6,5 g 0,0009 J05AE Protease inhibitors 0,5651 J05AE03 Ritonavir (O) 35733 g 1,2 g 0,0612 J05AE10 Darunavir (O) 293928 g 1,2 g 0,5038 J05AE30 Nirmatrelvir+ Ritonavir (O) 1080 pieces Nucleoside and nucleotide reverse transcriptase J05AF 0,1463 inhibitors J05AF01 Zidovudine (O) 430 g 0,6 g 0,0015 J05AF01 Zidovudine (P) 6 g 0,6 g <0,0001 J05AF05 Lamivudine (O) 1542 g 0,3 g 0,0106 J05AF06 Abacavir (O) 1963,2 g 0,6 g 0,0067 J05AF07 Tenofovir disoproxil (O) 404,25 g 0,245 g 0,0034 J05AF10 Entecavir (O) 28,455 g 0,5 mg 0,1171 J05AF13 Tenofovir alafenamide (O) 86,25 g 25 mg 0,0071 J05AG Non-nucleoside reverse transcriptase inhibitors 0,7490 J05AG05 Rilpivirine (O) 9104,25 g 25 mg 0,7490 J05AH Neuraminidase inhibitors 0,2602 J05AH01 Zanamivir (P) 12 g 1,2 g <0,0001 J05AH02 Oseltamivir (O) 18970,5 g 0,15 g 0,2601 J05AJ Integrase inhibitors 1,6100 J05AJ01 Raltegravir (O) 586368 g 0,8 g 1,5076 J05AJ03 Dolutegravir (O) 2489,85 g 50 mg 0,1024 J05AP Antivirals for treatment of HCV infections 0,1333 J05AP01 Ribavirin (O) 16,8 g 1 g <0,0001 J05AP54 Elbasvir+ Grazoprevir (O) 10388 pieces 1 pieces 0,0214 J05AP55 Sofosbuvir+ Velpatasvir (O) 6300 pieces 1 pieces 0,0130 J05AP57 Glecaprevir+ Pibrentasvir (O) 144256 pieces 3 pieces 0,0989 22/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J05AR Antivirals for treatment of HIV infections, combinations 3,6326 J05AR02 Lamivudine+ Abacavir (O) 181680 pieces 1 pieces 0,3737 J05AR03 Tenofovir disoproxil+ Emtricitabine (O) 1120410 pieces 1 pieces 2,3045 J05AR06 Emtricitabine+ Tenofovir disoproxil+ Efavirenz (O) 152850 pieces 1 pieces 0,3144 J05AR10 Lopinavir+ Ritonavir (O) 15840 g 0,8 g 0,0407 J05AR13 Lamivudine+ Abacavir+ Dolutegravir (O) 128040 pieces 1 pieces 0,2634 Emtricitabine+ Tenofovir alafenamide+ Elvitegravir+ J05AR18 480 pieces 1 pieces 0,0010 Cobicistat (O) J05AR25 Lamivudine+ Dolutegravir (O) 162840 pieces 1 pieces 0,3349 J05AX Other antivirals J05AX10 Maribavir (O) 48 g J06 IMMUNE SERA AND IMMUNOGLOBULINS J06A IMMUNE SERA J06AA Immune sera J06AA01 Diphtheria antitoxin (P) 20 pieces J06AA03 Snake venom antiserum (P) 76 pieces J06B IMMUNOGLOBULINS J06BA Immunoglobulins, normal human J06BA01 Immunoglobulins, normal human, for extravascular a (P) 12326,1 g J06BA02 Immunoglobulins, normal human, for intravascular a (P) 125407,5 g J06BB Specific immunoglobulins J06BB01 Human Anti-D Immunoglobulin (P) 1791875 U J06BB02 Tetanus immunoglobulins (P) 6000 U J06BB03 Varicella-zoster immune globulin (P) 1250 U J06BB04 Hepatitis B immunoglobulins (P) 1000 U J06BB05 Rabies immunoglobulin (P) 1500 U J06BB09 Cytomegalovirus immunoglobulin (P) 120000 U J06BD Antiviral monoclonal antibodies J06BD01 Palivizumab (P) 32,3 g J06BD03 Tixagevimab+ Cilgavimab (P) 1296 ml J06BD06 Regdanvimab (P) 76,8 g J07 VACCINES J07A BACTERIAL VACCINES J07AG Hemophilus influenzae B vaccines Haemophilus influenzae B, purified antigen conjugated J07AG01 273 dose (P) J07AH Meningococcal vaccines Meningococcus, tetravalent purified polysaccharides J07AH08 203 dose antigen conjugated (P) J07AH09 Meningococcus B, multicomponent vaccine (P) 118 dose J07AL Pneumococcal vaccines J07AL01 Pneumococcus, purified polysaccharides antigen (P) 500 dose Pneumococcus, purified polysaccharides antigen J07AL02 2658 dose conjugated (P) Pneumococcus, purified polysaccharides antigen+ J07AL52 226 dose Haemophilus influenzae, conjugated (P) J07AM Tetanus vaccines J07AM51 Tetanus toxoid+ Diphtheria toxoid (P) 81976 dose J07AN Tuberculosis vaccines J07AN01 Tuberculosis, live attenuated (P) 1771 dose J07AP Typhoid vaccines J07AP03 Typhoid, purified polysaccharide antigen (P) 850 dose J07AX Other bacterial vaccines J07AX80 Diphtheria-tetanus-pertussis (P) 18080 dose J07B VIRAL VACCINES J07BA Encephalitis vaccines J07BA01 Encephalitis, tick borne, inactivated, whole virus (P) 72595 dose 23/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day J07BB Influenza vaccines J07BB02 Influenza, inactivated, split virus or surface antigen (P) 191263 dose J07BB03 Influenza vaccine (live attenuated, nasal) (N) 1890 dose J07BC Hepatitis vaccines J07BC01 Hepatitis B, purified antigen (P) 4851 dose J07BC02 Hepatitis A, inactivated, whole virus (P) 2627 dose Hepatitis A, inactivated, whole virus+ Hepatitis B, purified J07BC80 1294 dose antigen (P) J07BD Measles vaccines Measles virus (live, attenuated)+ Rubella virus (live, J07BD52 35869 dose attenuated)+ Mumps virus (live, attenuated) (P) J07BF Poliomyelitis vaccines J07BF03 Poliomyelitis, trivalent, inactivated, whole virus (P) 712 dose J07BG Rabies vaccines J07BG01 Rabies, inactivated, whole virus (P) 1706 dose J07BH Rota virus diarrhea vaccines J07BH02 Rota virus, pentavalent, live, reassorted (O) 39281 dose J07BK Varicella zoster vaccines J07BK01 Varicella, live attenuated (P) 2283 dose J07BK02 Zoster, live attenuated (P) 88 dose J07BK03 Zoster, purified antigen (P) 8 dose J07BL Yellow fever vaccines J07BL01 Yellow fever virus live, attenuated (P) 1249 dose J07BM Papillomavirus vaccines Human papillomavirus vaccine (types 16, 18) J07BM02 3 dose recombinant, adjuvanted, adsorbed (P) Human papillomavirus vaccine (types 6, 11, 16, 18, 31, J07BM03 13833 dose 33, 45, 52, 58) (P) J07BN Covid-19 vaccines J07BN01 Covid-19, RNA-based vaccine (P) 78980 dose J07BN01 Covid-19, RNA-based vaccine (P) 434224,269 dose J07BN02 Covid-19, viral vector, non-replicating (P) 17600 dose J07BN04 Covid-19, protein subunit (P) 29070 dose J07BX Other viral vaccines J07BX01 Smallpox vaccine (P) 600 dose J07C BACTERIAL AND VIRAL VACCINES, COMBINED J07CA Bacterial and viral vaccines, combined Diphtheria toxoid+ Pertussis, purified antigen+ Tetanus J07CA02 toxoid+ Poliomyelitis, trivalent, inactivated, whole virus 13355 dose (P) Diphtheria toxoid+ Tetanus toxoid+ Pertussis, purified antigen+ Poliomyelitis, trivalent, inactivated, whole virus+ J07CA06 642 dose Haemophilus influenzae B, purified antigen conjugated (P) Diphtheria toxoid+ Poliomyelitis, trivalent, inactivated, whole virus+ Pertussis, purified antigen+ Haemophilus J07CA09 60158 dose influenzae B, purified antigen conjugated+ Hepatitis B, purified antigen+ Tetanus toxoid (P) ANTINEOPLASTIC AND IMMUNOMODULATING L 13,9703 AGENTS L01 ANTINEOPLASTIC AGENTS 0,5300 L01A ALKYLATING AGENTS L01AA Nitrogen mustard analogues L01AA01 Cyclophosphamide (O) 390 g L01AA01 Cyclophosphamide (P) 3315 g L01AA02 Chlorambucil (O) 11,55 g L01AA03 Melphalan (O) 2,45 g L01AA03 Melphalan (P) 15,5 g 24/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L01AA06 Ifosfamide (P) 1984,5 g L01AA07 Trofosfamide (O) 10 g L01AA09 Bendamustine (P) 97,5 g L01AB Alkyl sulfonates L01AB01 Busulfan (O) 5,6 g L01AB01 Busulfan (P) 1,44 g L01AB02 Treosulfan (P) 600 g L01AC Ethylene imines L01AC01 Thiotepa (P) 3,745 g L01AD Nitrosoureas L01AD01 Carmustine (P) 9,2 g L01AD02 Lomustine (O) 22 g L01AD04 Streptozocin (P) 1 g L01AX Other alkylating agents L01AX03 Temozolomide (O) 785,3 g L01AX04 Dacarbazine (P) 206 g L01B ANTIMETABOLITES L01BA Folic acid analogues L01BA01 Methotrexate (P) 639,7 g L01BA04 Pemetrexed (P) 464 g L01BB Purine analogues L01BB02 Mercaptopurine (O) 292,5 g L01BB03 Tioguanine (O) 6 g L01BB04 Cladribine (P) 0,43 g L01BB05 Fludarabine (P) 16,5 g L01BB06 Clofarabine (P) 0,5 g L01BB07 Nelarabine (P) 21 g L01BC Pyrimidine analogues L01BC01 Cytarabine (P) 1609 g L01BC02 Fluorouracil (C) 60 g L01BC02 Fluorouracil (P) 13723 g L01BC05 Gemcitabine (P) 6133,88 g L01BC06 Capecitabine (O) 270435 g L01BC07 Azacitidine (P) 438,1 g L01BC82 Fluorouracil+ Salicylic acid (C) 300 ml L01BC83 Trifluridine+ Tipiracil (O) 19240 pieces PLANT ALKALOIDS AND OTHER NATURAL L01C PRODUCTS L01CA Vinca alkaloids and analogues L01CA01 Vinblastine (P) 1,94 g L01CA02 Vincristine (P) 2,021 g L01CA04 Vinorelbine (O) 0,64 g L01CA04 Vinorelbine (P) 18,45 g L01CB Podophyllotoxin derivatives L01CB01 Etoposide (O) 233 g L01CB01 Etoposide (P) 466 g L01CD Taxanes L01CD01 Paclitaxel (P) 997,4 g L01CD02 Docetaxel (P) 457,28 g L01CD04 Cabazitaxel (P) 2,64 g L01CE Topoisomerase 1 (TOP1) inhibitors L01CE01 Topotecan (P) 2,02 g L01CE02 Irinotecan (P) 700 g L01CX Other plant alkaloids and natural products L01CX01 Trabectedin (P) 0,0125 g CYTOTOXIC ANTIBIOTICS AND RELATED L01D SUBSTANCES L01DA Actinomycines L01DA01 Dactinomycin (P) 0,0665 g L01DB Anthracyclines and related substances L01DB01 Doxorubicin (P) 117,7 g 25/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L01DB02 Daunorubicin (P) 14,38 g L01DB03 Epirubicin (P) 188,5 g L01DB06 Idarubicin (O) 0,08 g L01DB06 Idarubicin (P) 0,35 g L01DB07 Mitoxantrone (P) 1,44 g L01DB11 Pixantrone (P) 1,276 g L01DC Other cytotoxic antibiotics L01DC01 Bleomycin (P) 6000000 U L01DC03 Mitomycin (P) 3,54 g L01E PROTEIN KINASE INHIBITORS 0,5300 L01EA BCR-ABL tyrosine kinase inhibitors 0,1336 L01EA01 Imatinib (O) 15972 g 0,4 g 0,0821 L01EA02 Dasatinib (O) 612 g 0,1 g 0,0126 L01EA03 Nilotinib (O) 10080 g 0,6 g 0,0346 L01EA04 Bosutinib (O) 453,6 g 0,4 g 0,0023 L01EA05 Ponatinib (O) 43,2 g 45 mg 0,0020 Epidermal growth factor receptor (EGFR) tyrosine kinase L01EB 0,0227 inhibitors L01EB01 Gefitinib (O) 1387,5 g 0,25 g 0,0114 L01EB02 Erlotinib (O) 24 g 0,15 g 0,0003 L01EB03 Afatinib (O) 89,04 g 40 mg 0,0046 L01EB04 Osimertinib (O) 249,6 g 80 mg 0,0064 L01EB10 Mobocertinib (O) 14,4 g L01EC B-Raf serine-threonine kinase (BRAF) inhibitors 0,0186 L01EC02 Dabrafenib (O) 2709 g 0,3 g 0,0186 L01ED Anaplastic lymphoma kinase (ALK) inhibitors 0,0120 L01ED01 Crizotinib (O) 30 g 0,5 g 0,0001 L01ED02 Ceritinib (O) 247,5 g 0,45 g 0,0011 L01ED03 Alectinib (O) 2083,2 g 1,2 g 0,0036 L01ED04 Brigatinib (O) 627,48 g 0,18 g 0,0072 L01EE Mitogen-activated protein kinase (MEK) inhibitors 0,0200 L01EE01 Trametinib (O) 19,425 g 2 mg 0,0200 L01EE03 Binimetinib (O) 2,52 g 90 mg 0,0001 L01EE04 selumetinib (O) 19,2 g L01EF Cyclin-dependent kinase (CDK) inhibitors 0,1021 L01EF01 Palbociclib (O) 3719,625 g 94 mg 0,0814 L01EF02 Ribociclib (O) 4536 g 0,45 g 0,0207 Mammalian target of rapamycin (mTOR) kinase L01EG 0,0097 inhibitors L01EG01 Temsirolimus (P) 2,28 g 3,57 mg 0,0013 L01EG02 Everolimus (O) 40,8 g 10 mg 0,0084 L01EJ Janus-associated kinase (JAK) inhibitors 0,0201 L01EJ01 Ruxolitinib (C) 0,9 g L01EJ01 Ruxolitinib (O) 292,6 g 30 mg 0,0201 Vascular endothelial growth factor receptor (VEGFR) L01EK 0,0017 tyrosine kinase inhibitors L01EK01 Axitinib (O) 8,288 g 10 mg 0,0017 L01EL Bruton's tyrosine kinase (BTK) inhibitors 0,0548 L01EL01 Ibrutinib (O) 10122 g 0,42 g 0,0496 L01EL02 Acalabrutinib (O) 510 g 0,2 g 0,0052 L01EX Other protein kinase inhibitors 0,1346 L01EX01 Sunitinib (O) 457,45 g 33 mg 0,0285 L01EX02 Sorafenib (O) 2710,4 g 0,8 g 0,0070 L01EX03 Pazopanib (O) 11658 g 0,8 g 0,0300 L01EX04 Vandetanib (O) 27 g 0,3 g 0,0002 L01EX05 regorafenib (O) 164,64 g 0,12 g 0,0028 L01EX07 Cabozantinib (O) 499,24 g 60 mg 0,0171 L01EX08 Lenvatinib (O) 82,74 g 18 mg 0,0095 L01EX09 Nintedanib (O) 6825 g 0,38 g 0,0369 L01EX10 Midostaurin (O) 114,8 g 0,1 g 0,0024 L01EX14 Entrectinib (O) 90 g 0,6 g 0,0003 26/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day MONOCLONAL ANTIBODIES AND ANTIBODY DRUG L01F CONJUGATES L01FA CD20 (Clusters of Differentiation 20) inhibitors L01FA01 Rituximab (P) 1830,28 g L01FA03 Obinutuzumab (P) 136 g L01FB CD22 (Clusters of Differentiation 22) inhibitors L01FB01 Inotuzumab ozogamicin (P) 0,012 g L01FC CD38 (Clusters of Differentiation 38) inhibitors L01FC01 Daratumumab (P) 1283,4 g HER2 (Human Epidermal Growth Factor Receptor 2) L01FD inhibitors L01FD01 Trastuzumab (P) 1393,95 g L01FD02 Pertuzumab (P) 90,3 g L01FD03 Trastuzumab emtansine (P) 155,32 g L01FD04 Trastuzumab deruxtecan (P) 17,5 g L01FE EGFR (Epidermal Growth Factor Receptor) inhibitors L01FE01 Cetuximab (P) 9,8 g L01FE02 Panitumumab (P) 72,1 g PD-1/PDL-1 (Programmed cell death protein 1/death L01FF ligand 1) inhibitors L01FF01 Nivolumab (P) 408,96 g L01FF02 Pembrolizumab (P) 441 g L01FF03 Durvalumab (P) 381 g L01FF05 Atezolizumab (P) 847,2 g VEGF/VEGFR (Vascular Endothelial Growth Factor) L01FG inhibitors L01FG01 Bevacizumab (P) 1530 g L01FG02 Ramucirumab (P) 4,3 g Other monoclonal antibodies and antibody drug L01FX conjugates L01FX02 Gemtuzumab ozogamicin (P) 0,005 g L01FX04 Ipilimumab (P) 1,75 g L01FX05 Brentuximab vedotin (P) 13,15 g L01FX06 Dinutuximab beta (P) 0,5063 g L01FX07 Blinatumomab (P) 0,0015 g L01FX09 Mogamulizumab (P) 0,32 g L01FX20 Tremelimumab (P) 0,3 g L01X OTHER ANTINEOPLASTIC AGENTS L01XA Platinum compounds L01XA01 Cisplatin (P) 189,4 g L01XA02 Carboplatin (P) 2028 g L01XA03 Oxaliplatin (P) 883,8 g L01XB Methylhydrazines L01XB01 Procarbazine (O) 145 g L01XD Sensitizers used in photodynamic/radiation therapy L01XD04 Aminolevulinic acid (O) 39 g L01XF Retinoids for cancer treatment L01XF01 Tretinoin (O) 101 g L01XG Proteasome inhibitors L01XG01 Bortezomib (P) 9,324 g L01XG02 Carfilzomib (P) 22,51 g L01XG03 Ixazomib (O) 0,6 g L01XJ Hedgehog pathway inhibitors L01XJ01 Vismodegib (O) 25,2 g L01XK Poly (ADP-ribose) polymerase (PARP) inhibitors L01XK01 Olaparib (O) 9116,8 g L01XX Other antineoplastic agents L01XX01 Amsacrine (P) 1,35 g L01XX02 Asparaginase (P) 1950000 U L01XX05 Hydroxycarbamide (O) 265300 g 27/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L01XX11 Estramustine (O) 44,8 g L01XX23 Mitotane (O) 900 g L01XX24 Pegaspargase (P) 168750 U L01XX27 Arsenic trioxide (P) 9,86 g L01XX35 Anagrelide (O) 1,15 g L01XX41 Eribulin (P) 0,3458 g L01XX52 Venetoclax (O) 5611,34 g L01XX73 Sotorasib (O) 172,8 g L01XX75 Tebentafusp (P) 0,0054 g L01XY Combinations of antineoplastic agents L01XY02 Pertuzumab+ Trastuzumab (P) 7330 ml L02 ENDOCRINE THERAPY 5,0127 L02A HORMONES AND RELATED AGENTS 0,9032 L02AB Progestogens 0,0098 L02AB02 Medroxyprogesterone (O) 4770 g 1 g 0,0098 L02AE Gonadotropin releasing hormone analogues 0,8934 L02AE03 Goserelin (P) 10,8216 g 0,129 mg 0,1725 L02AE04 Triptorelin (P) 0,3738 g 0,1 mg 0,0077 L02AE04 Triptorelin (P) 46,4625 g 0,134 mg 0,7132 L02B HORMONE ANTAGONISTS AND RELATED AGENTS 4,1095 L02BA Anti-estrogens 0,8139 L02BA01 Tamoxifen (O) 6365,4 g 0,02 g 0,6546 L02BA03 Fulvestrant (P) 642,5 g 8,3 mg 0,1592 L02BB Anti-androgens 1,0476 L02BB03 Bicalutamide (O) 23994,6 g 0,05 g 0,9871 enzalutamide L02BB04 4341,12 g 0,16 g 0,0558 (O) L02BB05 Apalutamide (O) 144 g 0,24 g 0,0012 L02BB06 Darolutamide (O) 2049,6 g 1,2 g 0,0035 L02BG Aromatase inhibitors 2,1515 L02BG03 Anastrozole (O) 361,92 g 1 mg 0,7444 L02BG04 Letrozole (O) 1558,2 g 2,5 mg 1,2820 L02BG06 Exemestane (O) 1521 g 0,025 g 0,1251 L02BX Other hormone antagonists and related agents 0,0964 L02BX03 Abiraterone (O) 46890 g 1 g 0,0964 L03 IMMUNOSTIMULANTS 0,4213 L03A IMMUNOSTIMULANTS 0,4213 L03AA Colony stimulating factors 0,0884 L03AA02 Filgrastim (P) 10,0323 g 0,35 mg 0,0590 L03AA13 Pegfilgrastim (P) 4,29 g 0,3 mg 0,0294 L03AB Interferons 0,2393 L03AB07 Interferon beta-1a (P) 0,3483 g 0,0043 mg 0,1666 L03AB08 Interferon beta-1b (P) 62760000000 U 4000000 U 0,0323 L03AB11 Peginterferon alfa-2a (P) 0,0567 g 0,026 mg 0,0045 L03AB13 Peginterferon beta-1a (P) 0,1556 g 8,9 mcg 0,0360 L03AX Other immunostimulants 0,0936 L03AX03 BCG bacteria (P) 4,1375 g 1,8 mg 0,0047 L03AX13 Glatiramer acetate (P) 863,52 g 0,02 g 0,0888 L03AX16 Plerixafor (P) 0,432 g 16,8 mg 0,0001 L04 IMMUNOSUPPRESSANTS 8,0064 L04A IMMUNOSUPPRESSANTS 8,0064 L04AA Selective immunosuppressants 1,2610 Anti-T lymphocyte immunoglobulin for human use, horse L04AA03 7,5 g (P) Anti-T lymphocyte immunoglobulin for human use, rabbit L04AA04 12,375 g 0,1 g 0,0003 (P) L04AA06 Mycophenolic acid (O) 307761 g 2 g 0,3165 L04AA06 Mycophenolic acid (P) 234 g 2 g 0,0002 L04AA10 Sirolimus (O) 26,58 g 0,003 g 0,0182 L04AA13 Leflunomide (O) 4878,9 g 0,02 g 0,5018 28/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day L04AA18 Everolimus (O) 0,36 g 1,5 mg 0,0005 L04AA23 Natalizumab (P) 56,1 g 0,01 g 0,0115 L04AA24 Abatacept (P) 238 g 0,027 g 0,0181 L04AA25 Eculizumab (P) 102,3 g 0,064 g 0,0033 L04AA26 Belimumab (P) 4,8 g 25 mg 0,0004 L04AA27 Fingolimod (O) 3,416 g 0,5 mg 0,0141 Tofacitinib L04AA29 143,528 g 10 mg 0,0295 (O) L04AA31 Teriflunomide (O) 747,936 g 14 mg 0,1099 L04AA33 Vedolizumab (P) 93,3 g 5,4 mg 0,0355 L04AA34 Alemtuzumab (P) 0,504 g 0,13 mg 0,0080 L04AA36 Ocrelizumab (P) 130,8 g 3,29 mg 0,0818 Baricitinib L04AA37 3,92 g 3 mg 0,0027 (O) L04AA40 Cladribine (O) 2,5 g 0,34 mg 0,0151 L04AA42 Siponimod (O) 40,462 g L04AA43 ravulizumab (P) 5,2 g 58,9 mg 0,0002 L04AA44 Upadacitinib (O) 447,3 g 15 mg 0,0613 L04AA47 Inebilizumab (P) 1,2 g L04AA50 Ponesimod (O) 32,274 g 20 mg 0,0033 L04AA52 Ofatumumab (P) 9,38 g 0,67 mg 0,0288 L04AB Tumor necrosis factor alpha (TNF-alpha) inhibitors 1,7520 L04AB01 Etanercept (P) 1139,1 g 0,007 g 0,3347 L04AB02 Infliximab (P) 1161,8 g 3,75 mg 0,6372 L04AB04 Adalimumab (P) 965,64 g 2,9 mg 0,6849 L04AB05 Certolizumab pegol (P) 28,8 g 14 mg 0,0042 L04AB06 Golimumab (P) 73,35 g 1,66 mg 0,0909 L04AC Interleukin inhibitors 0,6313 L04AC02 Basiliximab (P) 1,04 g 0,04 g 0,0001 L04AC03 Anakinra (P) 124,5195 g 0,1 g 0,0026 L04AC05 Ustekinumab (P) 85,62 g 0,54 mg 0,3261 L04AC07 Tocilizumab (P) 902,312 g 0,02 g 0,0928 L04AC10 Secukinumab (P) 511,65 g 10 mg 0,1052 L04AC13 Ixekizumab (P) 30,4 g 2,9 mg 0,0216 L04AC14 Sarilumab (P) 136,4 g 14,3 mg 0,0196 L04AC16 Guselkumab (P) 21,2 g 1,79 mg 0,0244 L04AC18 Risankizumab (P) 31,65 g 1,67 mg 0,0390 L04AD Calcineurin inhibitors 0,5096 L04AD01 Ciclosporin (O) 29483,75 g 0,25 g 0,2426 L04AD01 Ciclosporin (P) 57,5 g 0,25 g 0,0005 L04AD02 Tacrolimus (O) 647,6 g 5 mg 0,2664 L04AD02 Tacrolimus (P) 0,3 g 5 mg 0,0001 L04AX Other immunosuppressants 3,8525 L04AX01 Azathioprine (O) 32905 g 0,15 g 0,4512 L04AX02 Thalidomide (O) 177,8 g 0,1 g 0,0037 L04AX03 Methotrexate (O) 3572,95 g 2,5 mg 2,9396 L04AX03 Methotrexate (P) 146,075 g 2,5 mg 0,1202 L04AX04 Lenalidomide (O) 513,66 g 0,01 g 0,1057 L04AX05 Pirfenidone (O) 18570,384 g 2,4 g 0,0159 Pomalidomide L04AX06 12,747 g 3 mg 0,0087 (O) L04AX07 Dimethyl fumarate (O) 40375,44 g 0,48 g 0,1730 L04AX09 Diroximel fumarate (O) 15523,2 g 0,924 g 0,0346 M MUSCULO-SKELETAL SYSTEM 91,7225 ANTIINFLAMMATORY AND ANTIRHEUMATIC M01 73,1429 PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC M01A 73,1321 PRODUCTS, NON-STEROIDS M01AB Acetic acid derivatives and related substances 8,8031 M01AB01 Indometacin (O) 1553,275 g 0,1 g 0,0319 M01AB05 Diclofenac (O) 286682,25 g 0,1 g 5,8966 29/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day M01AB05 Diclofenac (P) 7467,375 g 0,1 g 0,1536 M01AB05 Diclofenac (R) 11719,375 g 0,1 g 0,2411 M01AB15 Ketorolac (P) 0,3 g 30 mg <0,0001 M01AB16 Aceclofenac (O) 44684 g 0,2 g 0,4595 M01AB82 Diclofenac+ Omeprazole (O) 98221,5 g 0,1 g 2,0203 M01AC Oxicams 3,5788 M01AC01 Piroxicam (O) 989,2 g 0,02 g 0,1017 M01AC05 Lornoxicam (O) 2015,36 g 0,012 g 0,3454 M01AC06 Meloxicam (O) 22681,875 g 0,015 g 3,1102 M01AC06 Meloxicam (P) 156 g 0,015 g 0,0214 M01AE Propionic acid derivatives 43,5330 M01AE01 Ibuprofen (O) 16187635,2 g 1,2 g 27,7463 M01AE01 Ibuprofen (P) 10706 g 1,2 g 0,0184 M01AE02 Naproxen (O) 776690,75 g 0,5 g 3,1951 M01AE03 Ketoprofen (O) 149395,5 g 0,15 g 2,0486 M01AE03 Ketoprofen (P) 11820 g 0,15 g 0,1621 M01AE17 Dexketoprofen (O) 90957 g 0,075 g 2,4945 M01AE17 Dexketoprofen (P) 3687,25 g 0,075 g 0,1011 M01AE52 Naproxen+ Esomeprazole (O) 1887150 g 0,5 g 7,7632 M01AE82 Ibuprofen+ Phenylephrine (O) 2275,2 g 1,2 g 0,0039 M01AG Fenamates 0,0037 M01AG02 Tolfenamic acid (O) 540 g 0,3 g 0,0037 M01AH Coxibs 10,1303 M01AH01 Celecoxib (O) 86967 g 0,2 g 0,8944 M01AH05 Etoricoxib (O) 269417,61 g 60 mg 9,2359 Other antiinflammatory and antirheumatic agents, non- M01AX 7,0833 steroids M01AX01 Nabumetone (O) 141280 g 1 g 0,2906 M01AX05 Glucosamine (O) 4953734,04 g 1,5 g 6,7927 M01C SPECIFIC ANTIRHEUMATIC AGENTS 0,0108 M01CC Penicillamine and similar agents 0,0108 M01CC01 Penicillamine (O) 2617,5 g 0,5 g 0,0108 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR M02 PAIN TOPICAL PRODUCTS FOR JOINT AND MUSCULAR M02A PAIN Antiinflammatory preparations, non-steroids for topical M02AA use M02AA10 Ketoprofen (C) 1202850 g M02AA12 Naproxen (C) 1081190 g M02AA13 Ibuprofen (C) 31324 pieces M02AA13 Ibuprofen (C) 890800 g M02AA15 Diclofenac (C) 461939 pieces M02AA15 Diclofenac (C) 32275750 g M02AA81 Ibuprofen+ Levomenthol (C) 1953800 g M02AC Preparations with salicylic acid derivatives Methyl salicylate+ Levomenthol+ Eucalyptus oil+ M02AC80 127635 g Turpentine oil (C) M02AX Other topical products for joint and muscular pain M02AX80 Nicoboxil+ Nonivamide (C) 211100 g Camphor+ Salicylic acid+ Turpentine oil+ Viperae beri M02AX90 996575 g venenum (C) Benzyl nicotinate+ Nonivamide+ Camphor+ Turpentine M02AX92 752880 g oil+ Dimethyl sulfoxide (C) M03 MUSCLE RELAXANTS 0,9974 MUSCLE RELAXANTS, PERIPHERALLY ACTING M03A AGENTS M03AB Choline derivatives M03AB01 Suxamethonium chloride (P) 3050 g M03AC Other quaternary ammonium compounds M03AC03 Vecuronium bromide (P) 0,1 g 30/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day M03AC04 Atracurium besilate (P) 2013,625 g M03AC06 Pipecuronium bromide (P) 8,7 g M03AC09 Rocuronium bromide (P) 1244 g M03AX Other muscle relaxants, peripherally acting agents M03AX01 Botulinum toxin (P) 2404950 U M03B MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS 0,9974 M03BX Other centrally acting agents 0,9974 M03BX01 Baclofen (O) 4550,5 g 0,05 g 0,1872 M03BX01 Baclofen (P) 2,0528 g 0,55 mg 0,0077 M03BX02 Tizanidine (O) 4682,04 g 0,012 g 0,8025 M04 ANTIGOUT PREPARATIONS 12,5230 M04A ANTIGOUT PREPARATIONS 12,5230 M04AA Preparations inhibiting uric acid production 12,5032 M04AA01 Allopurinol (O) 1606220 g 0,4 g 8,2594 M04AA03 Febuxostat (O) 165060 g 0,08 g 4,2438 M04AB Preparations increasing uric acid excretion 0,0023 M04AB01 Probenecid (O) 100 g 1 g 0,0002 M04AB03 Benzbromarone (O) 100 g 0,1 g 0,0021 M04AC Preparations with no effect on uric acid metabolism 0,0176 M04AC01 Colchicine (O) 8,555 g 1 mg 0,0176 M05 DRUGS FOR TREATMENT OF BONE DISEASES 5,0512 DRUGS AFFECTING BONE STRUCTURE AND M05B 5,0512 MINERALIZATION M05BA Bisphosphonates 0,7600 M05BA03 Pamidronic acid (P) 3 g 0,06 g 0,0001 M05BA04 Alendronic acid (O) 259 g 0,01 g 0,0533 M05BA06 Ibandronic acid (O) 1402,2 g 0,005 g 0,5768 M05BA07 Risedronic acid (O) 294,42 g 0,005 g 0,1211 M05BA08 Zoledronic acid (P) 16,978 g 0,004 g 0,0087 M05BB Bisphosphonates, combinations 2,6040 M05BB03 Alendronic acid+ Colecalciferol (O) 12659,92 g 10 mg 2,6040 M05BX Other drugs affecting bone structure and mineralization 1,6872 M05BX04 Denosumab (P) 270,343 g 0,33 mg 1,6850 M05BX05 Burosumab (P) 2,7 g 2,5 mg 0,0022 M05BX07 Vosoritide (P) 0,3472 g OTHER DRUGS FOR DISORDERS OF THE MUSCULO- M09 0,0079 SKELETAL SYSTEM OTHER DRUGS FOR DISORDERS OF THE MUSCULO- M09A 0,0079 SKELETAL SYSTEM M09AX Other drugs for disorders of the musculo-skeletal system 0,0079 M09AX10 Risdiplam (O) 19,32 g 5 mg 0,0079 N NERVOUS SYSTEM 160,8567 N01 ANESTHETICS N01A ANESTHETICS, GENERAL N01AB Halogenated hydrocarbons N01AB06 Isoflurane (I) 5000 ml N01AB07 Desflurane (I) 84960 ml N01AB08 Sevoflurane (I) 823250 ml N01AF Barbiturates, plain N01AF03 Thiopental (P) 2330 g N01AH Opioid anesthetics N01AH01 Fentanyl (I) 0,212 g N01AH01 Fentanyl (P) 37,561 g N01AH06 Remifentanil (P) 23,76 g N01AX Other general anesthetics N01AX03 Ketamine (P) 1317 g N01AX07 Etomidate (P) 39,9 g N01AX10 Propofol (P) 87958,5 g 31/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N01AX13 Nitrous oxide (I) 11696000 ml N01AX14 Esketamine (P) 442 g N01B ANESTHETICS, LOCAL N01BB Amides N01BB01 Bupivacaine (Infilt, P) 3639,75 g N01BB01 Bupivacaine (P) 256,1 g N01BB02 Lidocaine (C) 2730 pieces N01BB02 Lidocaine (C) 5100 ml N01BB02 Lidocaine (NA) 5400 ml N01BB02 Lidocaine (NA) 87026 g N01BB02 Lidocaine (O) 101760 g N01BB02 Lidocaine (P) 26036,3 g N01BB03 Mepivacaine (dental) 1379,55 g N01BB08 Articaine (P) 2,4 g N01BB09 Ropivacaine (P) 897,3 g N01BB80 Articaine+ Epinephrine (dental) 933980 ml N01BB80 Articaine+ Epinephrine (O) 603360 ml N01BB81 Bupivacaine+ Epinephrine (P) 260800 ml N01BB82 Lidocaine+ Epinephrine (dental) 1100 ml N01BB82 Lidocaine+ Epinephrine (dental, P) 86000 ml N01BB83 Lidocaine+ Prilocaine (C) 97920 g N01BB86 Lidocaine+ Chlorhexidine (urethral) 1422562,5 g N01BC Esters of benzoic acid N01BC01 Cocaine (NA) 485 g N01BX Other local anesthetics N01BX04 Capsaicin (C) 154220 g N02 ANALGESICS 39,1300 N02A OPIOIDS 10,5817 N02AA Natural opium alkaloids 0,9972 N02AA01 Morphine (O) 4234,5 g 0,1 g 0,0871 N02AA01 Morphine (P) 552,1 g 0,03 g 0,0379 N02AA05 Oxycodone (O) 26376,15 g 0,075 g 0,7234 N02AA05 Oxycodone (P) 425,8 g 0,03 g 0,0292 N02AA08 Dihydrocodeine (O) 7349,4 g 0,15 g 0,1008 N02AA55 Oxycodone+ Naloxone (O) 691,35 g 75 mg 0,0190 N02AB Phenylpiperidine derivatives 0,1495 N02AB02 Pethidine (P) 469,5 g 0,4 g 0,0024 N02AB02 Pethidine (P, V) 1080 g 0,4 g 0,0056 N02AB03 Fentanyl (O) 2,3068 g N02AB03 Fentanyl (SL) 2,707 g 0,6 mg 0,0093 N02AB03 Fentanyl (TD) 77,1664 g 1,2 mg 0,1323 N02AE Oripavine derivatives 0,0066 N02AE01 Buprenorphine (TD) 3,8674 g 1,2 mg 0,0066 N02AJ Opioids in combination with non-opioid analgesics 7,6803 N02AJ06 Codeine+ Paracetamol (O) 8948960 pieces 3 pieces 6,1356 N02AJ13 Tramadol+ Paracetamol (O) 2101,125 g 150 mg 0,0288 N02AJ14 Tramadol+ Dexketoprofen (O) 110552,625 g 150 mg 1,5159 N02AX Other opioids 1,7480 N02AX02 Tramadol (O) 252166,5 g 0,3 g 1,7289 N02AX02 Tramadol (P) 2784,5 g 0,3 g 0,0191 N02B OTHER ANALGESICS AND ANTIPYRETICS 27,2658 N02BA Salicylic acid and derivatives 0,9654 N02BA01 Acetylsalicylic acid (O) 1179075,84 g 3 g 0,8084 N02BA01 Acetylsalicylic acid (P) 55 g N02BA80 Acetylsalicylic acid + Ascorbic acid (O) 229061,6 g 3 g 0,1570 N02BB Pyrazolones 0,0013 N02BB02 Metamizole sodium (P) 1940 g 3 g 0,0013 N02BB86 Metamizole sodium+ Pitofenone (O) 45 g N02BE Anilides 20,4968 N02BE01 Paracetamol (O) 22407489,7 g 3 g 15,3630 N02BE01 Paracetamol (P) 347624 g 3 g 0,2383 32/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N02BE01 Paracetamol (R) 87891,9 g 3 g 0,0603 N02BE52 Paracetamol+ Pseudoephedrine+ Diphenhydramine (O) 1304 g 3 g 0,0009 N02BE70 Paracetamol+ Ibuprofen (O) 55360 g 3 g 0,0380 N02BE75 Paracetamol+ Guaifenesin+ Phenylephrine (O) 455684 g 3 g 0,3124 Paracetamol+ Chlorphenamine+ Pseudoephedrine+ N02BE81 537804 g 3 g 0,3687 Dextromethorphan (O) N02BE83 Paracetamol+ Caffeine (O) 414744 g 3 g 0,2844 N02BE84 Paracetamol+ Phenylephrine+ Ascorbic acid (O) 1415825 g 3 g 0,9707 N02BE85 Paracetamol+ Pheniramine+ Ascorbic acid (O) 98530,4 g 3 g 0,0676 Paracetamol+ Phenylephrine+ Terpin hydrate+ Ascorbic N02BE86 450402 g 3 g 0,3088 acid+ Caffeine (O) N02BE87 Paracetamol+ Pseudoephedrine (O) 44770 g 3 g 0,0307 N02BE91 Paracetamol+ Ascorbic acid (O) 18044,4 g 3 g 0,0124 N02BE92 Paracetamol+ Codeine (O) 1134150 g 3 g 0,7776 N02BE94 Paracetamol+ Codeine+ Caffeine (O) 1748580 g 3 g 1,1989 N02BE95 Paracetamol+ Phenylephrine (O) 40 g 3 g <0,0001 N02BE97 Paracetamol+ Pseudoephedrine+ Dextromethorphan (O) 677188 g 3 g 0,4643 N02BF Gabapentinoids 5,8021 N02BF01 Gabapentin (O) 2055610 g 1,8 g 2,3489 N02BF02 Pregabalin (O) 503661,2 g 0,3 g 3,4532 N02BG Other analgesics and antipyretics 0,0001 N02BG80 Dronabinol+ Cannabidiol (O) 300 dose 8 dose 0,0001 N02C ANTIMIGRAINE PREPARATIONS 1,2825 N02CC Selective serotonin (5HT1) agonists 1,2494 N02CC01 Sumatriptan (N) 0,84 g 0,02 g 0,0001 N02CC01 Sumatriptan (O) 27151,5 g 0,05 g 1,1169 N02CC03 Zolmitriptan (O) 99,07 g 2,5 mg 0,0815 N02CC04 Rizatriptan (O) 58,44 g 0,01 g 0,0120 N02CC07 Frovatriptan (O) 47,2 g 2,5 mg 0,0388 N02CD Calcitonin gene-related peptide (CGRP) antagonists 0,0332 N02CD01 Erenumab (P) 16,24 g 2,5 mg 0,0134 N02CD03 fremanezumab (P) 72,225 g 7,5 mg 0,0198 N02CD05 Eptinezumab (P) 3,6 g N03 ANTIEPILEPTICS 7,5127 N03A ANTIEPILEPTICS 7,5127 N03AA Barbiturates and derivatives 0,2960 N03AA02 Phenobarbital (O) 12300 g 0,1 g 0,2530 N03AA02 Phenobarbital (P) 30 g 0,1 g 0,0006 N03AA03 Primidone (O) 25750 g 1,25 g 0,0424 N03AB Hydantoin derivatives 0,0350 N03AB02 Phenytoin (O) 4930 g 0,3 g 0,0338 N03AB02 Phenytoin (P) 172,5 g 0,3 g 0,0012 N03AD Succinimide derivatives 0,0212 N03AD01 Ethosuximide (O) 12862,5 g 1,25 g 0,0212 N03AE Benzodiazepine derivatives 0,5550 N03AE01 Clonazepam (O) 2158,8 g 0,008 g 0,5550 N03AF Carboxamide derivatives 2,5368 N03AF01 Carbamazepine (O) 865440 g 1 g 1,7801 N03AF02 Oxcarbazepine (O) 367665 g 1 g 0,7562 N03AF03 Rufinamide (O) 360 g 1,4 g 0,0005 N03AG Fatty acid derivatives 1,7520 N03AG01 Valproic acid (O) 1267405 g 1,5 g 1,7379 N03AG01 Valproic acid (P) 2113,5 g 1,5 g 0,0029 N03AG04 Vigabatrin (O) 10900 g 2 g 0,0112 N03AX Other antiepileptics 2,3167 N03AX03 Sultiame (O) 3680 g 0,4 g 0,0189 N03AX09 Lamotrigine (O) 145105,8 g 0,3 g 0,9949 N03AX11 Topiramate (O) 40999,5 g 0,3 g 0,2811 33/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N03AX14 Levetiracetam (O) 737722,5 g 1,5 g 1,0116 N03AX14 Levetiracetam (P) 1325 g 1,5 g 0,0018 N03AX15 Zonisamide (O) 74,2 g 0,2 g 0,0008 N03AX17 Stiripentol (O) 795 g 1 g 0,0016 N03AX18 Lacosamide (O) 486,5 g 0,3 g 0,0033 N03AX22 perampanel (O) 2,016 g 8 mg 0,0005 N03AX24 Cannabidiol (O) 720 g 0,7 g 0,0021 N04 ANTI-PARKINSON DRUGS 3,7003 N04A ANTICHOLINERGIC AGENTS 0,5605 N04AA Tertiary amines 0,5605 N04AA01 Trihexyphenidyl (O) 2725,2 g 0,01 g 0,5605 N04B DOPAMINERGIC AGENTS 3,1398 N04BA Dopa and dopa derivatives 1,4919 N04BA03 Levodopa + Carbidopa+ Entacapone (O) 69965 g 0,45 g 0,3198 N04BA80 Levodopa + Benserazide (O) 316250 g 0,6 g 1,0841 N04BA81 Levodopa + Carbidopa (intestin) 21462 g N04BA81 Levodopa + Carbidopa (O) 25648 g 0,6 g 0,0879 N04BB Adamantane derivatives 0,3004 N04BB01 Amantadine (O) 29210 g 0,2 g 0,3004 N04BB01 Amantadine (P) 4 g N04BC Dopamine agonists 0,7834 N04BC04 Ropinirole (O) 1082,536 g 0,006 g 0,3711 N04BC05 Pramipexole (O) 487,5675 g 2,5 mg 0,4011 N04BC07 Apomorphine (P) 108,65 g 20 mg 0,0112 N04BD Monoamine oxidase type B inhibitors 0,5641 N04BD02 Rasagiline (O) 274,262 g 0,001 g 0,5641 N05 PSYCHOLEPTICS 46,7668 N05A ANTIPSYCHOTICS 10,7098 N05AA Phenothiazines with aliphatic side-chain 0,1335 N05AA01 Chlorpromazine (O) 8368,125 g 0,3 g 0,0574 N05AA01 Chlorpromazine (P) 26 g 0,1 g 0,0005 N05AA02 Levomepromazine (O) 11017 g 0,3 g 0,0755 N05AA02 Levomepromazine (P) 5 g 0,1 g 0,0001 N05AB Phenothiazines with piperazine structure 0,0825 N05AB02 Fluphenazine (P) 3,125 g 0,001 g 0,0064 N05AB03 Perphenazine (O) 408,4 g 0,03 g 0,0280 N05AB03 Perphenazine (P) 233,712 g 0,01 g 0,0481 N05AC Phenothiazines with piperidine structure 0,0005 N05AC01 Periciazine (O) 12 g 0,05 g 0,0005 N05AD Butyrophenone derivatives 0,9394 N05AD01 Haloperidol (O) 1936,465 g 0,008 g 0,4979 N05AD01 Haloperidol (P) 804,8 g 0,008 g 0,2069 N05AD03 Melperone (O) 32950 g 0,3 g 0,2259 N05AD08 Droperidol (P) 10,525 g 2,5 mg 0,0087 N05AE Indole derivatives 0,0717 N05AE03 Sertindole (O) 551,68 g 0,016 g 0,0709 N05AE04 Ziprasidone (O) 31,2 g 0,08 g 0,0008 N05AF Thioxanthene derivatives 0,8345 N05AF01 Flupentixol (O) 358,65 g 0,006 g 0,1229 N05AF01 Flupentixol (P) 121,88 g 0,004 g 0,0627 N05AF03 Chlorprothixene (O) 28042,5 g 0,3 g 0,1923 N05AF05 Zuclopenthixol (O) 1269 g 0,03 g 0,0870 N05AF05 Zuclopenthixol (P) 41,5 g 0,03 g 0,0028 N05AF05 Zuclopenthixol (P) 2674,6 g 0,015 g 0,3668 N05AH Diazepines, oxazepines, thiazepines and oxepines 6,3317 N05AH02 Clozapine (O) 101269 g 0,3 g 0,6943 N05AH03 Olanzapine (O) 12229,42 g 0,01 g 2,5154 N05AH03 Olanzapine (P) 253,07 g 0,01 g 0,0521 N05AH04 Quetiapine (O) 597006 g 0,4 g 3,0699 N05AL Benzamides 0,1188 N05AL01 Sulpiride (O) 18085,5 g 0,8 g 0,0465 34/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N05AL05 Amisulpride (O) 14052 g 0,4 g 0,0723 N05AN Lithium 0,3573 N05AN01 Lithium (O) 156360 g 0,9 g 0,3573 N05AX Other antipsychotics 1,8399 N05AX08 Risperidone (O) 1751,14 g 0,005 g 0,7204 N05AX08 Risperidone (P) 20,6 g 2,7 mg 0,0157 N05AX12 Aripiprazole (O) 5894,34 g 0,015 g 0,8083 N05AX12 Aripiprazole (P) 5,9377 g 0,015 g 0,0008 N05AX12 Aripiprazole (P) 759,2 g 0,0133 g 0,1174 N05AX13 Paliperidone (P) 104,075 g 2,5 mg 0,0856 N05AX15 Cariprazine (O) 133,77 g 3 mg 0,0917 N05B ANXIOLYTICS 13,3017 N05BA Benzodiazepine derivatives 13,3011 N05BA01 Diazepam (O) 27435,75 g 0,01 g 5,6431 N05BA01 Diazepam (P) 460,1 g 0,01 g 0,0946 N05BA01 Diazepam (R) 58,75 g 0,01 g 0,0121 N05BA06 Lorazepam (O) 1187,55 g 2,5 mg 0,9770 N05BA06 Lorazepam (P) 29 g 2,5 mg 0,0239 N05BA08 Bromazepam (O) 5399,58 g 0,01 g 1,1106 N05BA09 Clobazam (O) 465 g 0,02 g 0,0478 N05BA12 Alprazolam (O) 2613,5325 g 0,001 g 5,3756 N05BA80 Phenazepam (O) 7,9 g 0,001 g 0,0162 N05BB Diphenylmethane derivatives 0,0002 N05BB01 Hydroxyzine (O) 8,25 g 0,075 g 0,0002 N05BE Azaspirodecanedione derivatives 0,0004 N05BE01 Buspirone (O) 5,4 g 0,03 g 0,0004 N05C HYPNOTICS AND SEDATIVES 22,7554 N05CD Benzodiazepine derivatives 0,1578 N05CD02 Nitrazepam (O) 162,3 g 0,005 g 0,0668 N05CD08 Midazolam (O) 69,825 g 0,015 g 0,0096 N05CD08 Midazolam (P) 453,9 g 0,015 g 0,0622 N05CD08 Midazolam (P, R) 140,5 g 0,015 g 0,0193 N05CD14 Remimazolam (P) 0,2 g N05CF Benzodiazepine related drugs 21,3903 N05CF01 Zopiclone (O) 60417,465 g 7,5 mg 16,5693 N05CF02 Zolpidem (O) 23147,87 g 0,01 g 4,7612 N05CF04 Eszopiclone (O) 58,184 g 2 mg 0,0598 N05CH Melatonin receptor agonists 0,7566 N05CH01 Melatonin (O) 735,72 g 2 mg 0,7566 N05CM Other hypnotics and sedatives 0,4506 N05CM09 Valerianae radix (O) 615330 pieces 3 pieces 0,4219 N05CM18 Dexmedetomidine (P) 13,962 g 1 mg 0,0287 N06 PSYCHOANALEPTICS 51,1844 N06A ANTIDEPRESSANTS 44,4687 N06AA Non-selective monoamine reuptake inhibitors 1,9928 N06AA02 Imipramine (O) 18,75 g 0,1 g 0,0004 N06AA04 Clomipramine (O) 4591,65 g 0,1 g 0,0944 N06AA04 Clomipramine (P) 2,5 g 0,1 g 0,0001 N06AA09 Amitriptyline (O) 58676,5 g 0,075 g 1,6092 N06AA10 Nortriptyline (O) 10527,5 g 0,075 g 0,2887 N06AB Selective serotonin reuptake inhibitors 26,2635 N06AB03 Fluoxetine (O) 40737,16 g 0,02 g 4,1895 N06AB04 Citalopram (O) 14242,04 g 0,02 g 1,4647 N06AB05 Paroxetine (O) 23454 g 0,02 g 2,4121 N06AB06 Sertraline (O) 200415,2 g 0,05 g 8,2445 N06AB08 Fluvoxamine (O) 1557,5 g 0,1 g 0,0320 N06AB10 Escitalopram (O) 48232,66 g 0,01 g 9,9207 N06AF Monoamine oxidase inhibitors, non-selective 0,0111 N06AF04 Tranylcypromine (O) 54 g 0,01 g 0,0111 N06AX Other antidepressants 16,2013 N06AX03 Mianserin (O) 27 g 0,06 g 0,0009 35/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N06AX05 Trazodone (O) 30261 g 0,3 g 0,2075 N06AX11 Mirtazapine (O) 42300,45 g 0,03 g 2,9002 N06AX12 Bupropion (O) 194562 g 0,3 g 1,3340 N06AX14 Tianeptine (O) 22557,375 g 0,0375 g 1,2373 N06AX16 Venlafaxine (O) 240438,75 g 0,1 g 4,9455 N06AX18 Reboxetine (O) 1,12 g 0,008 g 0,0003 N06AX21 Duloxetine (O) 89776,92 g 0,06 g 3,0776 N06AX22 Agomelatine (O) 15804,6 g 0,025 g 1,3003 N06AX26 Vortioxetine (O) 5808,6 g 10 mg 1,1947 N06AX27 Esketamine (N) 11,844 g 8 mg 0,0030 PSYCHOSTIMULANTS, AGENTS USED FOR ADHD N06B 2,9768 AND NOOTROPICS N06BA Centrally acting sympathomimetics 2,6602 N06BA04 Methylphenidate (O) 36732,48 g 0,03 g 2,5184 N06BA07 Modafinil (O) 1299 g 0,3 g 0,0089 N06BA09 Atomoxetine (O) 5165,72 g 0,08 g 0,1328 N06BA12 Lisdexamfetamine dimesylate (O) 1088,1 g N06BC Xanthine derivatives N06BC81 Caffeine citrate (O, P) 53 g N06BC81 Caffeine citrate (P) 2,5 g N06BX Other psychostimulants and nootropics 0,3166 N06BX03 Piracetam (O) 352896 g 2,4 g 0,3024 N06BX13 Idebenone (O) 270 g 0,9 g 0,0006 N06BX18 Vinpocetine (O) 99 g 15 mg 0,0136 N06BX83 Aminobutyric acid (O) 31010 g N06D ANTI-DEMENTIA DRUGS 3,7389 N06DA Anticholinesterases 1,3503 N06DA02 Donepezil (O) 4922,4 g 7,5 mg 1,3500 N06DA03 Rivastigmine (O) 1,26 g 0,009 g 0,0003 N06DA04 Galantamine (O) 0,224 g 0,016 g <0,0001 N06DX Other anti-dementia drugs 2,3886 N06DX01 Memantine (O) 6454,04 g 0,02 g 0,6638 N06DX02 Ginkgo folium (O) 100632 g 0,12 g 1,7249 N06DX80 Cerebrolysin (P) 2,152 g N07 OTHER NERVOUS SYSTEM DRUGS 12,5625 N07A PARASYMPATHOMIMETICS 0,3781 N07AA Anticholinesterases 0,3781 N07AA01 neostigmine (P) 30,455 g 0,002 g 0,0313 N07AA02 Pyridostigmine bromide (O) 27729 g 0,18 g 0,3169 N07AA03 Distigmine bromide (O) 0,2 g 0,005 g 0,0001 N07AA80 Neostigmine+ Glycopyrronium (P) 14510 ml 1 ml 0,0298 N07AX Other parasympathomimetics N07AX01 Pilocarpine (O) 1,26 g N07B DRUGS USED IN ADDICTIVE DISORDERS 3,3609 N07BA Drugs used in nicotine dependence 1,7488 N07BA01 Nicotine (O) 16609,69 g 0,03 g 1,1388 N07BA01 Nicotine (TD) 4152,106 g 0,014 g 0,6100 N07BB Drugs used in alcohol dependence 0,4531 N07BB01 Disulfiram (O) 36510 g 0,2 g 0,3755 N07BB01 Disulfiram (P) 136 g N07BB03 Acamprosate (O) 279,72 g 2 g 0,0003 N07BB04 Naltrexone (O) 1750 g 50 mg 0,0720 N07BB05 nalmefene (O) 46,368 g 18 mg 0,0053 N07BC Drugs used in opioid dependence 1,1590 N07BC02 Methadone (O) 13523 g 0,025 g 1,1126 N07BC51 Buprenorphine+ Naloxone (SL) 180,537 g 8 mg 0,0464 N07C ANTIVERTIGO PREPARATIONS 8,7896 N07CA Antivertigo preparations 8,7896 N07CA01 Betahistine (O) 88644,48 g 0,024 g 7,5970 N07CA02 Cinnarizine (O) 48326,25 g 0,09 g 1,1044 N07CA03 Flunarizine (O) 9 g 0,01 g 0,0019 36/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day N07CA80 Cinnarizine+ Dimenhydrinate (O) 3774,88 g 90 mg 0,0863 N07X OTHER NERVOUS SYSTEM DRUGS 0,0339 N07XX Other nervous system drugs 0,0339 N07XX02 Riluzole (O) 1430,8 g 0,1 g 0,0294 N07XX04 Sodium oxybate (O) 180 g 7,5 g <0,0001 N07XX06 Tetrabenazine (O) 182 g 0,1 g 0,0037 N07XX07 Fampridine (O) 6,72 g 20 mg 0,0007 N07XX14 Edaravone (P) 6,9 g ANTIPARASITIC PRODUCTS, INSECTICIDES AND P 1,0614 REPELLENTS P01 ANTIPROTOZOALS 0,8513 AGENTS AGAINST AMOEBIASIS AND OTHER P01A 0,1870 PROTOZOAL DISEASES P01AB Nitroimidazole derivatives 0,1870 P01AB01 Metronidazole (O) 181845 g 2 g 0,1870 P01AB01 Metronidazole (O, V) 261 g Other agents against amoebiasis and other protozoal P01AX <0,0001 diseases P01AX11 Nitazoxanide (O) 6 g 1 g <0,0001 P01B ANTIMALARIALS 0,6643 P01BA Aminoquinolines 0,6490 P01BA02 Hydroxychloroquine (O) 162666 g 0,516 g 0,6484 P01BA03 Primaquine (O) 4,5 g 0,015 g 0,0006 P01BB Biguanides 0,0148 P01BB51 Proguanil+ Atovaquone (O) 1008 pieces 16 pieces 0,0001 P01BB51 Proguanil+ Atovaquone (O) 28500 pieces 4 pieces 0,0147 P01BD Diaminopyrimidines 0,0004 P01BD01 Pyrimethamine (O) 13,5 g 0,075 g 0,0004 P01BE Artemisinin and derivatives, plain 0,0001 P01BE03 Artesunate (P) 14,28 g 0,28 g 0,0001 P02 ANTHELMINTICS 0,2101 P02B ANTITREMATODALS 0,0001 P02BA Quinoline derivatives and related substances 0,0001 P02BA01 Praziquantel (O) 187,2 g 3 g 0,0001 P02C ANTINEMATODAL AGENTS 0,2100 P02CA Benzimidazole derivatives 0,2090 P02CA01 Mebendazole (O) 18880,4 g 0,2 g 0,1942 P02CA03 Albendazole (O) 2880 g 0,4 g 0,0148 P02CF Avermectines 0,0010 P02CF01 Ivermectin (O) 5,73 g 12 mg 0,0010 ECTOPARASITICIDES, INCL. SCABICIDES, P03 INSECTICIDES AND REPELLENTS P03A ECTOPARASITICIDES, INCL. SCABICIDES P03AC Pyrethrines, incl. synthetic compounds P03AC04 Permethrin (C) 311310 g P03AX Other ectoparasiticides, incl. scabicides P03AX01 Benzyl benzoate (C) 253650 g R RESPIRATORY SYSTEM 112,7122 R01 NASAL PREPARATIONS 48,5930 DECONGESTANTS AND OTHER NASAL R01A 45,1979 PREPARATIONS FOR TOPICAL USE R01AA Sympathomimetics, plain 28,2963 R01AA05 Oxymetazoline (N) 184,6875 g 0,4 mg 0,9497 R01AA07 Xylometazoline (N) 10636,285 g 0,8 mg 27,3466 R01AB Sympathomimetics, combinations excl. corticosteroids 5,5672 R01AB83 Xylometazoline+ Ipratropium bromide (N) 331170 ml 0,8 ml 0,8515 R01AB85 Xylometazoline+ Dexpanthenol (N) 1834160 ml 0,8 ml 4,7157 R01AC Antiallergic agents, excl. corticosteroids 0,4075 R01AC01 Cromoglicic acid (N) 0,3 g 0,04 g <0,0001 R01AC03 Azelastine (N) 110,95 g 0,56 mg 0,4075 37/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day R01AD Corticosteroids 10,9270 R01AD01 Beclometasone (N) 0,66 g 0,4 mg 0,0034 R01AD05 Budesonide (N) 38,86 g 0,2 mg 0,3996 R01AD08 Fluticasone (N) 91,833 g 0,2 mg 0,9444 R01AD09 Mometasone (N) 507,654 g 0,2 mg 5,2208 R01AD12 Fluticasone furoate (N) 203,1018 g 0,11 mg 3,7977 R01AD81 Fluticasone+ Azelastine (N) 1090800 dose 4 dose 0,5609 R01AX Other nasal preparations R01AX06 Mupirocin (N) 57 g R01AX83 Retinol+ Tocopherol (N) 145160 ml R01B NASAL DECONGESTANTS FOR SYSTEMIC USE 3,3951 R01BA Sympathomimetics 3,3951 R01BA02 Pseudoephedrine (O) 233819,64 g 0,24 g 2,0039 R01BA81 Pseudoephedrine+ Triprolidine (O) 45644,16 g 0,24 g 0,3912 R01BA84 Pseudoephedrine+ Guaifenesin (O) 4371,6 g 0,24 g 0,0375 R01BA89 Pseudoephedrine+ Loratadine (O) 15054,48 g 0,24 g 0,1290 R01BA93 Pseudoephedrine+ Cetirizine (O) 97258,56 g 0,24 g 0,8335 R02 THROAT PREPARATIONS 4,0793 R02A THROAT PREPARATIONS 4,0793 R02AA Antiseptics 3,3789 R02AA06 Cetylpyridinium chloride (O) 216 pieces R02AA82 Benzydamine+ Cetylpyridinium chloride (O) 1671090 ml R02AA82 Benzydamine+ Cetylpyridinium chloride (O) 3614032 pieces 6 pieces 1,2389 R02AA89 Povidone, iodinated+ Allantoin (O) 527070 ml R02AA92 Dequalinium+ Cinchocaine (O) 1959760 pieces 6 pieces 0,6718 R02AA94 Amylmetacresol+ Dichlorobenzyl alcohol (O) 672432 pieces 6 pieces 0,2305 Amylmetacresol+ Dichlorobenzyl alcohol+ Levomenthol R02AA95 2198400 pieces 6 pieces 0,7536 (O) Amylmetacresol+ Dichlorobenzyl alcohol+ Ascorbic acid R02AA96 1411872 pieces 6 pieces 0,4840 (O) R02AX Other throat preparations 0,7004 R02AX01 Flurbiprofen (O) 14982,31 g 44 mg 0,7004 R02AX80 Thymi herba+ Sage leaf (Salvia officinalis) (O) 42975 ml R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES 28,1110 R03A ADRENERGICS, INHALANTS 20,6345 R03AC Selective beta-2-adrenoceptor agonists 3,5820 R03AC02 Salbutamol (I) 916,728 g 0,8 mg 2,3570 R03AC02 Salbutamol (I) 1944,6 g 0,01 g 0,4000 R03AC04 Fenoterol (I) 55,96 g 0,6 mg 0,1918 R03AC12 Salmeterol (I) 2,712 g 0,1 mg 0,0558 R03AC13 Formoterol (I) 4,3049 g 0,024 mg 0,3689 R03AC18 Indacaterol (I) 15,2055 g 0,15 mg 0,2085 Adrenergics in combination with corticosteroids or other R03AK 12,8464 drugs, excl. anticholinergics R03AK06 Salmeterol+ Fluticasone (I) 448800 dose 4 dose 0,2308 R03AK06 Salmeterol+ Fluticasone (I) 1897200 dose 2 dose 1,9511 R03AK07 Formoterol+ Budesonide (I) 983880 dose 2 dose 1,0118 R03AK07 Formoterol+ Budesonide (I) 6624120 dose 4 dose 3,4062 R03AK08 Formoterol+ Beclometasone (I) 4172040 dose 4 dose 2,1453 R03AK10 Vilanterol+ Fluticasone furoate (I) 1975680 dose 1 dose 4,0637 R03AK13 Salbutamol+ Beclometasone (I) 72800 dose 4 dose 0,0374 Adrenergics in combinations with anticholinergics incl. R03AL 4,2061 triple combinations with corticosteroids R03AL01 Fenoterol+ Ipratropium bromide (I) 193320 ml 16 ml 0,0249 R03AL01 Fenoterol+ Ipratropium bromide (I) 2595400 dose 6 dose 0,8897 R03AL03 Vilanterol+ Umeclidinium (I) 434220 dose 1 dose 0,8931 R03AL04 Indacaterol+ Glycopyrronium (I) 133650 dose 1 dose 0,2749 R03AL05 Formoterol+ Aclidinium (I) 366480 dose 2 dose 0,3769 R03AL06 Olodaterol+ Tiotropium (I) 627900 dose 2 dose 0,6457 R03AL07 Formoterol+ Glycopyrronium (I) 308280 dose 4 dose 0,1585 R03AL08 Vilanterol+ Umeclidinium+ Fluticasone furoate (I) 132300 dose 1 dose 0,2721 38/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day R03AL09 Formoterol+ Glycopyrronium+ Beclometasone (I) 1070520 dose 4 dose 0,5505 R03AL11 Formoterol+ Glycopyrronium+ Budesonide (I) 232800 dose 4 dose 0,1197 OTHER DRUGS FOR OBSTRUCTIVE AIRWAY R03B 4,5684 DISEASES, INHALANTS R03BA Glucocorticoids 1,6311 R03BA01 Beclometasone (I) 0,2 g 1,5 mg 0,0003 R03BA02 Budesonide (I) 233,16 g 1,5 mg 0,3197 R03BA02 Budesonide (I) 273,104 g 0,8 mg 0,7022 R03BA05 Fluticasone (I) 177,642 g 0,6 mg 0,6090 R03BB Anticholinergics 2,9372 R03BB01 Ipratropium bromide (I) 17,116 g 0,12 mg 0,2934 R03BB01 Ipratropium bromide (I) 30,28 g 0,3 mg 0,2076 R03BB04 Tiotropium (I) 3,1293 g 0,005 mg 1,2873 R03BB05 Aclidinium (I) 119,7647 g 0,644 mg 0,3825 R03BB06 Glycopyrronium (I) 5,4635 g 44 mcg 0,2554 R03BB07 Umeclidinium (I) 13,6653 g 55 mcg 0,5110 R03C ADRENERGICS FOR SYSTEMIC USE 0,1271 R03CC Selective beta-2-adrenoceptor agonists 0,1271 R03CC02 Salbutamol (O) 741,18 g 0,012 g 0,1270 R03CC02 Salbutamol (P) 0,105 g 0,012 g <0,0001 OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE R03D 2,7811 AIRWAY DISEASES R03DA Xanthines 0,9773 R03DA04 Theophylline (O) 187340 g 0,4 g 0,9633 R03DA05 Aminophylline (O) 22,5 g 0,1 g 0,0005 R03DA05 Aminophylline (P) 3955,2 g 0,6 g 0,0136 R03DC Leukotriene receptor antagonists 1,7105 R03DC03 Montelukast (O) 8316,196 g 0,01 g 1,7105 R03DX Other systemic drugs for obstructive airway diseases 0,0933 R03DX05 Omalizumab (P) 244,95 g 0,016 g 0,0315 R03DX07 Roflumilast (O) 0,03 g 0,5 mg 0,0001 R03DX09 Mepolizumab (P) 61,1 g 3,6 mg 0,0349 R03DX10 Benralizumab (P) 7,02 g 0,54 mg 0,0267 R05 COUGH AND COLD PREPARATIONS 10,6552 EXPECTORANTS, EXCL. COMBINATIONS WITH R05C 10,4046 COUGH SUPPRESSANTS R05CA Expectorants R05CA12 Hederae helicis folium (O) 2412,8 g R05CA12 Hederae helicis folium (O) 350670 pieces R05CA12 Hederae helicis folium (O) 10077080 ml R05CA86 Iceland moss (O) 12608100 ml Distillate form a mixture of rectified essential oils: R05CA87 eucalyptus oil, sweet orange oil, common myrtle oil, 2963100 pieces lemon oil (O) R05CA88 Thymi herba+ Wild thyme+ Plantago (O) 366000 ml R05CA89 Thymi herba+ Hederae helicis folium (O) 582700 ml R05CA91 Thymi herba+ Marshmallow root (O) 408620 pieces R05CA91 Thymi herba+ Marshmallow root (O) 7109070 ml R05CA92 Thymi herba (O) 207760 pieces R05CB Mucolytics 10,4046 R05CB01 Acetylcysteine (I, P) 1011 g R05CB01 Acetylcysteine (O) 1552918,8 g 0,5 g 6,3882 R05CB01 Acetylcysteine (P) 6850,5 g R05CB02 Bromhexine (O) 9909,04 g 0,024 g 0,8492 R05CB03 Carbocisteine (O) 209465 g 1,5 g 0,2872 R05CB06 Ambroxol (O) 166825,5 g 0,12 g 2,8595 R05CB13 Dornase alfa (I) 24,855 g 2,5 mg 0,0204 COUGH SUPPRESSANTS, EXCL. COMBINATIONS R05D 0,1212 WITH EXPECTORANTS R05DB Other cough suppressants 0,1212 39/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day R05DB09 Oxeladin (O) 4714,45 g 0,08 g 0,1212 R05DB80 Marshmallow root+ Tiliae flos+ Plantago (O) 8748 g COUGH SUPPRESSANTS AND EXPECTORANTS, R05F 0,1293 COMBINATIONS R05FA Opium derivatives and expectorants 0,1293 R05FA80 Codeine+ Guaifenesin (O) 1886550 ml 30 ml 0,1293 R05X OTHER COLDPREPARATIONS R05XA Other cold combination preparations Gentian root+ Primula flowers+ Rumex acetosa+ R05XA80 2630920 pieces Sambucus nigra flower+ Verbena herb (O) Gentian root+ Primula flowers+ Rumex acetosa+ R05XA80 2804500 ml Sambucus nigra flower+ Verbena herb (O) R05XA82 Ibuprofen+ Pseudoephedrine (O) 5776,8 g R06 ANTIHISTAMINES FOR SYSTEMIC USE 21,2726 R06A ANTIHISTAMINES FOR SYSTEMIC USE 21,2726 R06AA Aminoalkyl ethers 0,4369 R06AA02 Diphenhydramine (P) 18,6 g R06AA04 Clemastine (O) 376,76 g 0,002 g 0,3875 R06AA04 Clemastine (P) 48,09 g 0,002 g 0,0495 R06AE Piperazine derivatives 11,1495 R06AE07 Cetirizine (O) 51785,925 g 0,01 g 10,6516 R06AE09 Levocetirizine (O) 1210,36 g 0,005 g 0,4979 R06AX Other antihistamines for systemic use 9,6861 R06AX02 Cyproheptadine (O) 0,12 g 0,012 g <0,0001 R06AX13 Loratadine (O) 19167,6 g 0,01 g 3,9425 R06AX17 Ketotifen (O) 2,28 g 0,002 g 0,0023 R06AX22 Ebastine (O) 7157,9 g 0,01 g 1,4723 R06AX27 Desloratadine (O) 3293,32 g 0,005 g 1,3548 R06AX28 Rupatadine (O) 966,08 g 0,01 g 0,1987 R06AX29 Bilastine (O) 26404,7 g 20 mg 2,7155 R07 OTHER RESPIRATORY SYSTEM PRODUCTS 0,0012 R07A OTHER RESPIRATORY SYSTEM PRODUCTS 0,0012 R07AA Lung surfactants 0,0003 R07AA81 Phospholipid fraction, porcine lung (endotrach) 22,2 g 0,16 g 0,0003 R07AX Other respiratory system products 0,0009 R07AX02 ivacaftor (O) 130,2 g 0,3 g 0,0009 R07AX32 Ivacaftor+ Tezacaftor+ Elexacaftor (O) 155,4 g S SENSORY ORGANS 35,0366 S01 OPHTHALMOLOGICALS 35,0366 S01A ANTIINFECTIVES S01AA Antibiotics S01AA01 Chloramphenicol (S) 253890 ml S01AA12 Tobramycin (S) 37000 ml S01AA12 Tobramycin (S) 55947,5 g S01AA13 Fusidic acid (S) 57820 g S01AD Antivirals S01AD03 Aciclovir (S) 3915 g S01AE Fluoroquinolones S01AE03 Ciprofloxacin (S) 11,88 g S01AE03 Ciprofloxacin (S) 13710 ml S01AE05 Levofloxacin (S) 34065 ml S01AE07 Moxifloxacin (S) 18235 ml S01AX Other antiinfectives S01AX15 Propamidine (S) 210 ml S01AX18 Povidone, iodinated (S) 552 ml S01B ANTIINFLAMMATORY AGENTS S01BA Corticosteroids, plain S01BA01 Dexamethasone (S) 265 pieces S01BA01 Dexamethasone (S) 22093 g S01BA01 Dexamethasone (S) 155020 ml S01BA02 Hydrocortisone (S) 3351 g 40/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day S01BA04 Prednisolone (S) 0,325 g S01BA09 Clobetasone (S) 49280 ml S01BA14 Loteprednol (S) 5675 ml S01BC Antiinflammatory agents, non-steroids S01BC03 Diclofenac (S) 30 ml S01BC05 Ketorolac (S) 10000 ml S01BC10 Nepafenac (S) 22305 ml S01BC11 Bromfenac (S) 19230 ml ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES S01C IN COMBINATION S01CA Corticosteroids and antiinfectives in combination S01CA80 Dexamethasone+ Neomycin+ Polymyxin B (S) 82025 ml S01CA81 Dexamethasone+ Tobramycin (S) 16495,5 g S01CA81 Dexamethasone+ Tobramycin (S) 41260 ml S01CA82 Dexamethasone+ Chloramphenicol (S) 55205,5 g S01CA82 Dexamethasone+ Chloramphenicol (S) 511320 ml S01CA84 Dexamethasone+ Levofloxacin (S) 7140 ml S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS 35,0366 S01EA Sympathomimetics in glaucoma therapy 0,0312 S01EA05 Brimonidine (S) 3030 ml 0,2 ml 0,0312 S01EB Parasympathomimetics 0,0191 S01EB01 Pilocarpine (S) 3200 ml 0,4 ml 0,0165 S01EB02 Carbachol (S) 510 ml 0,4 ml 0,0026 S01EC Carbonic anhydrase inhibitors 3,7624 S01EC01 Acetazolamide (O) 26065 g 0,75 g 0,0715 S01EC01 Acetazolamide (P) 336 g 0,75 g 0,0009 S01EC03 Dorzolamide (S) 150840 ml 0,3 ml 1,0342 S01EC04 Brinzolamide (S) 153490 ml 0,2 ml 1,5785 S01EC80 Brinzolamide+ Brimonidine (S) 104750 ml 0,2 ml 1,0773 S01ED Beta blocking agents 24,0230 S01ED01 Timolol (S) 25110 ml 0,2 ml 0,2582 S01ED01 Timolol (S) 233580 g 40 mg 12,0110 S01ED02 Betaxolol (S) 75795 ml 0,2 ml 0,7795 S01ED80 Timolol+ Dorzolamide (S) 304195 ml 0,2 ml 3,1284 S01ED81 Timolol+ Travoprost (S) 33010 ml 0,2 ml 0,3395 S01ED82 Timolol+ Bimatoprost (S) 100092 ml 0,2 ml 1,0294 S01ED83 Timolol+ Brinzolamide (S) 226220 ml 0,2 ml 2,3265 S01ED84 Timolol+ Latanoprost (S) 75582,5 ml 0,2 ml 0,7773 S01ED85 Timolol+ Tafluprost (S) 327994 ml 0,2 ml 3,3732 S01EE Prostaglandin analogues 7,2010 S01EE01 Latanoprost (S) 266235 ml 0,1 ml 5,4761 S01EE03 Bimatoprost (S) 153 ml 0,1 ml 0,0031 S01EE04 Travoprost (S) 51247,5 ml 0,1 ml 1,0541 S01EE05 Tafluprost (S) 97389 ml 0,3 ml 0,6677 S01F MYDRIATICS AND CYCLOPLEGICS S01FA Anticholinergics S01FA01 Atropine (S) 525 ml S01FA04 Cyclopentolate (S) 34070 ml S01FA06 Tropicamide (S) 15405 ml S01FA80 Tropicamide+ Phenylephrine+ Lidocaine (int.cam) 300 pieces S01FB Sympathomimetics excl. antiglaucoma preparations S01FB01 Phenylephrine (S) 9435 ml S01G DECONGESTANTS AND ANTIALLERGICS S01GA Sympathomimetics used as decongestants S01GA02 Tetryzoline (S) 209505 ml S01GX Other antiallergics S01GX01 Cromoglicic acid (S) 114020 ml S01GX07 Azelastine (S) 46938 ml S01GX09 Olopatadine (S) 48930 ml S01H LOCAL ANESTHETICS 41/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day S01HA Local anesthetics S01HA02 Oxybuprocaine (S) 500 ml S01HA03 Tetracaine (S) 27100 ml S01HA04 Proxymetacaine (S) 34980 ml S01J DIAGNOSTIC AGENTS S01JA Colouring agents S01JA01 Fluorescein (P) 4560 ml S01JA81 Fluorescein+ Oxybuprocaine+ Chlorobutanol (S) 2985 ml S01K SURGICAL AIDS S01KA Viscoelastic substances S01KA02 Hypromellose (S) 6540 ml S01L OCULAR VASCULAR DISORDER AGENTS S01LA Antineovascularisation agents S01LA05 aflibercept (S) 196 pieces S01LA06 Brolucizumab (S) 135 pieces S01X OTHER OPHTHALMOLOGICALS S01XA Other ophthalmologicals S01XA03 Sodium chloride (S) 658 g S01XA18 Ciclosporin (S) 18936 ml S01XA80 Retinol+ Dexpanthenol (S) 6849,5 g S01XA81 Carbomer (S) 174150 g S01XA82 Hypromellose (S) 205240 ml S01XA85 Hypromellose+ Dextran (S) 504105 ml S02 OTOLOGICALS CORTICOSTEROIDS AND ANTIINFECTIVES IN S02C COMBINATION S02CA Corticosteroids and antiinfectives in combination S02CA81 Dexamethasone+ Neomycin+ Acetic acid, glacial (A) 3840 ml S02CA82 Hydrocortisone+ Ciprofloxacin (A) 146870 ml S02D OTHER OTOLOGICALS S02DA Analgesics and anesthetics S02DA81 Phenazone+ Lidocaine (A) 2100 ml V VARIOUS 0,1892 V01 ALLERGENS V01A ALLERGENS V01AA Allergen extracts V01AA02 Grass pollen allergen extract (O) 146 pieces V01AA02 Grass pollen allergen extract (P) 243 pieces V01AA03 House dust mites (O) 115 pieces V01AA03 House dust mites (P) 327 pieces V01AA05 Tree pollen allergen extract (P) 289 pieces V01AA05 Tree pollen allergen extract (SL) 210 pieces V01AA07 Allergen extracts - insects (P) 594 pieces V01AA11 Allergen extracts - animals (O) 24 pieces V01AA80 Tree and grass pollen (O) 48 pieces V01AA80 Tree and grass pollen (P) 7 pieces V01AA83 Grass pollen allergen extract+ Flowers (O) 4 pieces V01AA84 Tree and flower pollen (O) 10 pieces V03 ALL OTHER THERAPEUTIC PRODUCTS 0,1892 V03A ALL OTHER THERAPEUTIC PRODUCTS 0,1892 V03AB Antidotes V03AB06 Sodium thiosulfate (P) 625 g V03AB14 Protamine sulfate (P) 266,75 g V03AB15 Naloxone (N) 3,492 g V03AB15 Naloxone (P) 2,558 g V03AB16 Ethanol (P) 10600 ml V03AB17 Methylthioninium chloride (P) 148,1 g V03AB19 Physostigmine (P) 0,16 g V03AB21 Potassium iodide (O) 12381,2 g V03AB24 Digitalis antitoxin (P) 2,8 g 42/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day V03AB25 Flumazenil (P) 0,09 g V03AB32 Glutathione (P) 4212 g V03AB33 Hydroxocobalamin (P) 100 g V03AB34 Fomepizole (P) 20 g V03AB35 Sugammadex (P) 148 g V03AB37 Idarucizumab (P) 210 g V03AB80 Sodium calcium edetate (P) 1050 g V03AC Iron chelating agents V03AC01 Deferoxamine (P) 65 g V03AC02 Deferiprone (O) 550 g V03AC03 Deferasirox (O) 3985,2 g Drugs for treatment of hyperkalemia and V03AE 0,1412 hyperphosphatemia V03AE01 Polystyrene sulfonate (O, R) 1638448,5 g 45 g 0,0749 V03AE02 Sevelamer (O) 147456 g 6,4 g 0,0474 V03AE03 Lanthanum (O) 20722,5 g 2,25 g 0,0189 V03AF Detoxifying agents for antineoplastic treatment 0,0480 V03AF01 Mesna (P) 4122 g V03AF03 Calcium folinate (O) 44,1 g 0,06 g 0,0015 V03AF07 Rasburicase (P) 0,729 g 0,014 g 0,0001 V03AF10 Sodium levofolinate (P) 676,65 g 0,03 g 0,0464 V03AH Drugs for treatment of hypoglycemia V03AH01 Diazoxide (O) 50 g V03AN Medical gases V03AN01 Oxygen (I) 464275000 ml V03AN05 Air, medicinal (I) 5630000 ml V03AX Other therapeutic products V03AX81 herbal preparation (C) 33000 g V03AX81 herbal preparation (O) 680190 pieces V03AX81 herbal preparation (O) 9012440 ml V03AX82 homeopathic preparations (A) 479 pieces V03AX82 homeopathic preparations (C) 13626 pieces V03AX82 homeopathic preparations (O) 1516295 pieces V04 DIAGNOSTIC AGENTS V04C OTHER DIAGNOSTIC AGENTS V04CD Tests for pituitary function V04CD01 Metyrapone (O) 25 g V04CD04 Corticorelin (P) 0,0002 g V04CF Tuberculosis diagnostics V04CF01 Tuberculin (P) 5520 U V04CJ Tests for thyreoidea function V04CJ02 Protirelin (P) 0,008 g V04CX Other diagnostic agents V04CX01 Indocyanine green (P) 7,9 g V04CX03 Methacholine (I) 67,554 g V04CX04 Mannitol (I) 102 pieces V04CX06 Hexaminolevulinate (P) 21,08 g V04CX09 Patent blue (P) 4 g V04CX87 Carbon monoxide+ Helium (I) 60000 ml Carbon monoxide+ Acetylene+ Methane+ Oxygen+ V04CX89 340000 ml Nitrogen (I) V07 ALL OTHER NON-THERAPEUTIC PRODUCTS V07A ALL OTHER NON-THERAPEUTIC PRODUCTS V07AB Solvents and diluting agents, incl. irrigating solutions V07AB80 Sodium chloride (P) 9892335 ml V07AB83 Water for injection (NA) 24650600 ml V07AB83 Water for injection (P) 2000 ml V08 CONTRAST MEDIA V08A X-RAY CONTRAST MEDIA, IODINATED 43/44  Estonian Statistics on Medicines 2022 DDD/1000/ ATC code ATC group / INN (rout of admin.) Quantity sold Unit DDD Unit day Watersoluble, nephrotropic, high osmolar X-ray contrast V08AA media V08AA01 Sodium amidotrizoate+ Meglumine Amidotrizoate (P) 4000 ml Watersoluble, nephrotropic, low osmolar X-ray contrast V08AB media V08AB02 Iohexol (P) 2051030 g V08AB05 Iopromide (P) 1234938,5 g V08AB09 Iodixanol (P) 3264700 g V08AD Non-watersoluble X-ray contrast media V08AD01 Ethyl esters of iodised fatty acids from poppyseed oil (P) 264 g V08B X-RAY CONTRAST MEDIA, NON-IODINATED V08BA Barium sulfate containing X-ray contrast media V08BA01 Barium sulfate (O) 283,2 pieces V08BA01 Barium sulfate (O) 134000 ml MAGNETIC RESONANCE IMAGING CONTRAST V08C MEDIA V08CA Paramagnetic contrast media V08CA01 Gadopentetic acid (P) 4780 ml V08CA02 Gadoteric acid (P) 75750 ml V08CA09 Gadobutrol (P) 116275 ml V08CA10 Gadoxetic acid (P) 6780 ml V08D ULTRASOUND CONTRAST MEDIA V08DA Ultrasound contrast media V08DA05 Sulfur hexafluoride (P) 275 ml V09 DIAGNOSTIC RADIOPHARMACEUTICALS V09A CENTRAL NERVOUS SYSTEM V09AB Iodine (123I) compounds V09AB03 Ioflupane (123I) (P) 455 ml V09F THYROID V09FX Various thyroid diagnostic radiopharmaceuticals V09FX01 Technetium (99mTc)pertechnetate (S) 71 pieces V10 THERAPEUTIC RADIOPHARMACEUTICALS V10X OTHER THERAPEUTIC RADIOPHARMACEUTICALS V10XA Iodine (131I) compounds V10XA01 Sodium iodide (131I) (O) 129 pieces 44/44